TW226996B - Novel isatin and oxindole derivatives which are acetylcholinesterase inhibitors, a process and intermediates for preparing said derivatives and a pharmaceutical composition thereof
- Google Patents
Novel isatin and oxindole derivatives which are acetylcholinesterase inhibitors, a process and intermediates for preparing said derivatives and a pharmaceutical composition thereof
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra AbfiledCriticalAstra Ab
Application grantedgrantedCritical
Publication of TW226996BpublicationCriticalpatent/TW226996B/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
The present invention relates to compounds having the general formula (1) in which: X represents one or more substituents independentlyselected from hydrogen, lower alkyl, aryl, aryloxy, CN, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, alkylsulphonamido, NHCOR where R is lower alkyl or aryl, NR1R2 where R1 and R2 areindependently hydrogen or lower alkyl or together form a ring, CO2R where R is lower alkyl, or cycloalkyl, cycloalkenyl or bicycloalkyl either optionally further substituted by lower alkyl; Y is CO or CR3R4 where R3 and R4 are independently hydrogen, lower alkyl, lower alkoxy or together form a cyclic acetal; Z is N or CH; stereo and optical isomers and racemates thereof where such isomers exist, as well as pharmaceutically acceptable acid addition salts thereof and solvates thereof; having therapeutic activity, intermediates for their preparation, processes for their preparation, pharmaceutical formulations containing the compounds and medicinal use of the compounds and similar known compounds.
TW081109950A1992-12-181992-12-11Novel isatin and oxindole derivatives which are acetylcholinesterase inhibitors, a process and intermediates for preparing said derivatives and a pharmaceutical composition thereof
TW226996B
(en)
Novel isatin and oxindole derivatives which are acetylcholinesterase inhibitors, a process and intermediates for preparing said derivatives and a pharmaceutical composition thereof
Indoline derivatives, their pharmaceutical acceptable salts which are antagonists of vasopressin vi-receptors, method for their synthesis, intermediate compounds and pharmaceutical composition
Derivatives of 1-aryl-2-aminomethyl-cyclopropane-carboxamides (Z), their preparation and their use as medicines in the treatment of disorders of the central nervous system.
Spiro(cyclohexane-1,1'(3'H)-isobenzofuran)s, processes and intermediates for their preparation and pharmaceutical compositions containing them.
Novel isatin and oxindole derivatives which are acetylcholinesterase inhibitors, a process and intermediates for preparing said derivatives and a pharmaceutical composition thereof