FI833784A0 - 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino/2,1-a/isokinoliner och foerfaranden foer framstaellning dessa - Google Patents

1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino/2,1-a/isokinoliner och foerfaranden foer framstaellning dessa

Info

Publication number
FI833784A0
FI833784A0 FI833784A FI833784A FI833784A0 FI 833784 A0 FI833784 A0 FI 833784A0 FI 833784 A FI833784 A FI 833784A FI 833784 A FI833784 A FI 833784A FI 833784 A0 FI833784 A0 FI 833784A0
Authority
FI
Finland
Prior art keywords
aryl
isoquinoliner
pyrazino
hexahydro
och
Prior art date
Application number
FI833784A
Other languages
English (en)
Other versions
FI833784A (fi
Inventor
Ronald C Griffith
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of FI833784A0 publication Critical patent/FI833784A0/fi
Publication of FI833784A publication Critical patent/FI833784A/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
FI833784A 1982-10-18 1983-10-17 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino/2,1-a/isokinoliner och foerfaranden foer framstaellning dessa FI833784A (fi)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/435,132 US4517187A (en) 1982-10-18 1982-10-18 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants

Publications (2)

Publication Number Publication Date
FI833784A0 true FI833784A0 (fi) 1983-10-17
FI833784A FI833784A (fi) 1984-04-19

Family

ID=23727113

Family Applications (1)

Application Number Title Priority Date Filing Date
FI833784A FI833784A (fi) 1982-10-18 1983-10-17 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino/2,1-a/isokinoliner och foerfaranden foer framstaellning dessa

Country Status (14)

Country Link
US (1) US4517187A (fi)
EP (1) EP0107825B1 (fi)
JP (1) JPS5989680A (fi)
KR (1) KR870000622B1 (fi)
AT (1) ATE32720T1 (fi)
AU (1) AU1955583A (fi)
CA (1) CA1219874A (fi)
DE (1) DE3375784D1 (fi)
DK (1) DK477783A (fi)
FI (1) FI833784A (fi)
IL (1) IL69586A (fi)
NO (1) NO833778L (fi)
NZ (1) NZ205425A (fi)
ZA (1) ZA836448B (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782058A (en) * 1985-04-26 1988-11-01 Pennwalt Corporation 1,3,4,6,7,11b-Hexahydro-6-phenyl-2H-pyrazino-(2,1-a)isoquinolines, for anti-histamine or anti-depression treatment
US4678791A (en) * 1985-05-07 1987-07-07 Pennwalt Corporation 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression
US4772705A (en) * 1985-07-25 1988-09-20 Pennwalt Corporation Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
AU681310B2 (en) * 1994-09-30 1997-08-21 Pfizer Inc. 2,7-substituted octahydro-1h-pyrido{1,2-a}pyrazine derivatives
CA2953040A1 (en) * 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders
CA3159791A1 (en) * 2019-10-31 2021-05-06 Holosmedic Hexahydro-2h-pyrazino[1,2-a]pyrazine-6,9-dione derivatives and pharmaceutical compositions for prevention or treatment of cancer comprising same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1050901A (fi) * 1964-02-06
US3684813A (en) * 1970-04-08 1972-08-15 Sterling Drug Inc Hexahydropyrazinoisoquinolines
US4162319A (en) * 1974-08-28 1979-07-24 Merck Patent Gesellschaft Mit Beschrankter Haftung Ring substituted pyrazino-isoquinoline derivatives and their preparation
DE2441261A1 (de) * 1974-08-28 1976-03-18 Merck Patent Gmbh Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung

Also Published As

Publication number Publication date
IL69586A0 (en) 1983-11-30
NZ205425A (en) 1986-05-09
ZA836448B (en) 1984-07-25
CA1219874A (en) 1987-03-31
JPS5989680A (ja) 1984-05-23
US4517187A (en) 1985-05-14
DK477783D0 (da) 1983-10-17
DK477783A (da) 1984-04-19
IL69586A (en) 1986-07-31
NO833778L (no) 1984-04-24
AU1955583A (en) 1984-05-03
FI833784A (fi) 1984-04-19
EP0107825A1 (en) 1984-05-09
KR870000622B1 (ko) 1987-03-26
EP0107825B1 (en) 1988-03-02
KR840006656A (ko) 1984-12-01
ATE32720T1 (de) 1988-03-15
DE3375784D1 (en) 1988-04-07

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Legal Events

Date Code Title Description
FD Application lapsed

Owner name: PENNWALT CORPORATION