ZA836448B - 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1-a)isoquinolines and methods of preparation - Google Patents

1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1-a)isoquinolines and methods of preparation

Info

Publication number
ZA836448B
ZA836448B ZA836448A ZA836448A ZA836448B ZA 836448 B ZA836448 B ZA 836448B ZA 836448 A ZA836448 A ZA 836448A ZA 836448 A ZA836448 A ZA 836448A ZA 836448 B ZA836448 B ZA 836448B
Authority
ZA
South Africa
Prior art keywords
aryl
isoquinolines
pyrazino
hexahydro
preparation
Prior art date
Application number
ZA836448A
Other languages
English (en)
Inventor
Ronald C Griffith
Original Assignee
Pennwalt Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pennwalt Corp filed Critical Pennwalt Corp
Publication of ZA836448B publication Critical patent/ZA836448B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/26Psychostimulants, e.g. nicotine, cocaine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D217/00Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/14Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring other than aralkyl radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA836448A 1982-10-18 1983-08-31 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1-a)isoquinolines and methods of preparation ZA836448B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/435,132 US4517187A (en) 1982-10-18 1982-10-18 1,3,4,6,7-11b-Hexahydro-7-phenyl-2H-pyrazino[2,1-a]isoquinolines methods of preparation, and use as antidepressants

Publications (1)

Publication Number Publication Date
ZA836448B true ZA836448B (en) 1984-07-25

Family

ID=23727113

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA836448A ZA836448B (en) 1982-10-18 1983-08-31 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1-a)isoquinolines and methods of preparation

Country Status (14)

Country Link
US (1) US4517187A (xx)
EP (1) EP0107825B1 (xx)
JP (1) JPS5989680A (xx)
KR (1) KR870000622B1 (xx)
AT (1) ATE32720T1 (xx)
AU (1) AU1955583A (xx)
CA (1) CA1219874A (xx)
DE (1) DE3375784D1 (xx)
DK (1) DK477783A (xx)
FI (1) FI833784A (xx)
IL (1) IL69586A (xx)
NO (1) NO833778L (xx)
NZ (1) NZ205425A (xx)
ZA (1) ZA836448B (xx)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678791A (en) * 1985-05-07 1987-07-07 Pennwalt Corporation 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4782058A (en) * 1985-04-26 1988-11-01 Pennwalt Corporation 1,3,4,6,7,11b-Hexahydro-6-phenyl-2H-pyrazino-(2,1-a)isoquinolines, for anti-histamine or anti-depression treatment
US4772705A (en) * 1985-07-25 1988-09-20 Pennwalt Corporation Processes for the preparation of trans 1,3,4,6,7,11b-hexahydro-7-aryl-2H-pyrazinol[2,1-a]isoquinolines
WO1990008148A1 (en) * 1989-01-23 1990-07-26 Pfizer Inc. Bis-aza-bicyclic anxiolytic agents
ATE209648T1 (de) * 1994-09-30 2001-12-15 Pfizer 2,7,-substituierte octahydro-1h-pyrido(1,2- a)pyrazin derivate
CA2953040A1 (en) * 2014-08-27 2016-03-03 F. Hoffmann-La Roche Ag Substituted pyrazino[2,1-a]isoquinoline derivatives for the treatment of cns disorders
CA3159791A1 (en) * 2019-10-31 2021-05-06 Holosmedic Hexahydro-2h-pyrazino[1,2-a]pyrazine-6,9-dione derivatives and pharmaceutical compositions for prevention or treatment of cancer comprising same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1050901A (xx) * 1964-02-06
US3684813A (en) * 1970-04-08 1972-08-15 Sterling Drug Inc Hexahydropyrazinoisoquinolines
US4162319A (en) * 1974-08-28 1979-07-24 Merck Patent Gesellschaft Mit Beschrankter Haftung Ring substituted pyrazino-isoquinoline derivatives and their preparation
DE2441261A1 (de) * 1974-08-28 1976-03-18 Merck Patent Gmbh Ringsubstituierte pyrazino-isochinolin-derivat und verfahren zu ihrer herstellung

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678791A (en) * 1985-05-07 1987-07-07 Pennwalt Corporation 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression

Also Published As

Publication number Publication date
EP0107825A1 (en) 1984-05-09
NZ205425A (en) 1986-05-09
FI833784A (fi) 1984-04-19
FI833784A0 (fi) 1983-10-17
NO833778L (no) 1984-04-24
EP0107825B1 (en) 1988-03-02
CA1219874A (en) 1987-03-31
DE3375784D1 (en) 1988-04-07
DK477783D0 (da) 1983-10-17
AU1955583A (en) 1984-05-03
US4517187A (en) 1985-05-14
KR870000622B1 (ko) 1987-03-26
IL69586A0 (en) 1983-11-30
JPS5989680A (ja) 1984-05-23
IL69586A (en) 1986-07-31
DK477783A (da) 1984-04-19
ATE32720T1 (de) 1988-03-15
KR840006656A (ko) 1984-12-01

Similar Documents

Publication Publication Date Title
MY102086A (en) Imidazoquinoline derivatives.
KR870700613A (ko) 신규 벤조티아진 유도체
EA199800170A1 (ru) Производные 2-(4-замещенного)бензиламино-2-метилпропанамида
ZA836448B (en) 1,3,4,6,7,11b-hexahydro-7-aryl-2h-pyrazino(2,1-a)isoquinolines and methods of preparation
MY8700521A (en) A fungicidal indanylbenzamide
AU6401480A (en) 1,2,3,4,5,6-hexahydro-3-methyl-6-phenylazepino (4,5-6) indole
ES8609302A1 (es) Un procedimiento para la preparacion de 4-amino-2-fenilqui- nolinas
SE8105689L (sv) Terapeutiska medel
ATE52776T1 (de) 1-phenyl-3-benzazepine.
FR2593810B1 (fr) Derives de la quinoleine, leur procede de preparation, leur application a titre de medicaments et les compositions les renfermant
EP0194164A3 (en) N-carboxyalcoyl-2-oxo-3-diaryl-5,6-triazines useful as therapeutic agents
AU579416B2 (en) 3-Amino-2,3-dihydro-1-benzoxepine-compounds and methods for their preparation and pharmaceutical preparations containing these compounds
DE3662892D1 (en) Bisthiol phosphates, process for their preparation, their use as pesticides and agents therefor