ATE52776T1 - 1-phenyl-3-benzazepine. - Google Patents
1-phenyl-3-benzazepine.Info
- Publication number
- ATE52776T1 ATE52776T1 AT86309847T AT86309847T ATE52776T1 AT E52776 T1 ATE52776 T1 AT E52776T1 AT 86309847 T AT86309847 T AT 86309847T AT 86309847 T AT86309847 T AT 86309847T AT E52776 T1 ATE52776 T1 AT E52776T1
- Authority
- AT
- Austria
- Prior art keywords
- alkyl
- hydrogen
- compounds
- so2nr
- trifluoromethyl
- Prior art date
Links
- ABVQLNWUASCTKR-UHFFFAOYSA-N 5-phenyl-3h-3-benzazepine Chemical compound C=1NC=CC2=CC=CC=C2C=1C1=CC=CC=C1 ABVQLNWUASCTKR-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 208000017228 Gastrointestinal motility disease Diseases 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/811,790 US4707483A (en) | 1985-12-20 | 1985-12-20 | 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders |
| EP86309847A EP0230755B1 (de) | 1985-12-20 | 1986-12-17 | 1-Phenyl-3-benzazepine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE52776T1 true ATE52776T1 (de) | 1990-06-15 |
Family
ID=25207588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT86309847T ATE52776T1 (de) | 1985-12-20 | 1986-12-17 | 1-phenyl-3-benzazepine. |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US4707483A (de) |
| EP (1) | EP0230755B1 (de) |
| JP (1) | JPS62158256A (de) |
| AT (1) | ATE52776T1 (de) |
| AU (1) | AU586724B2 (de) |
| CA (1) | CA1263385A (de) |
| DE (1) | DE3671224D1 (de) |
| DK (1) | DK619786A (de) |
| PT (1) | PT83941B (de) |
| ZA (1) | ZA869500B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0244088A3 (de) * | 1986-04-03 | 1989-03-15 | Smithkline Beecham Corporation | 1-Phenyl-3-benzazepin-Verbindungen und diese enthaltende Arzneimittel zur Behandlung von Störungen des gastrointestinalen Bewegungsvermögens |
| PH27337A (en) * | 1987-03-27 | 1993-06-08 | Schering Corp | Substituted benzazepines their preparation and pharmaceutical compositions containing them |
| FR2636330B1 (fr) * | 1988-09-13 | 1990-11-30 | Sanofi Sa | Procede de preparation de derives de morphinane |
| GB9903671D0 (en) * | 1999-02-17 | 1999-04-14 | Cenes Ltd | Dopamine D-1 receptor agonist compounds |
| KR20010113006A (ko) * | 2000-06-15 | 2001-12-24 | 주정호 | 항암제로서 유용한 ｎ-치환된 벤즈아제피닐우레아 유도체및 그의 제조방법 |
| JP2006526021A (ja) * | 2003-05-22 | 2006-11-16 | シェーリング コーポレイション | 肥満およびｃｎｓ障害を治療する選択的ｄ１／ｄ５レセプタアンタゴニストとしての５ｈ−ベンゾ［ｄ］ナフト［２，１−ｂ］アゼピン誘導体 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3393192A (en) * | 1965-04-26 | 1968-07-16 | Schering Corp | Novel benzazepines |
| US3496166A (en) * | 1967-12-22 | 1970-02-17 | Ciba Geigy Corp | 3-substituted 1-aryl-3-benzazepines |
| CA974989A (en) * | 1968-03-11 | 1975-09-23 | Wallace And Tiernan Inc. | Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby |
| US4104379A (en) * | 1977-01-19 | 1978-08-01 | Smithkline Corporation | Substituted 1-alkylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds |
| US4206210A (en) * | 1977-01-19 | 1980-06-03 | Smithkline Corporation | Alkylthio-7,8-dihdroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having dopaminergic activity |
| US4265890A (en) * | 1978-07-07 | 1981-05-05 | Smithkline Corporation | 6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3-benzazepines |
| US4284556A (en) * | 1980-01-31 | 1981-08-18 | Smithkline Corporation | 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines |
| NZ203064A (en) * | 1982-02-24 | 1985-05-31 | Smithkline Beckman Corp | R-or s-6-chloro-7,8-dihydroxy-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine |
| US4514394A (en) * | 1983-05-25 | 1985-04-30 | Smithkline Beckman Corporation | Anti-hypertensive use of 1-(4'-branched alkylsulfonylphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines |
| CA1234110A (en) * | 1983-08-12 | 1988-03-15 | Joel G. Berger | Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions |
-
1985
- 1985-12-20 US US06/811,790 patent/US4707483A/en not_active Expired - Fee Related
-
1986
- 1986-12-16 PT PT83941A patent/PT83941B/pt unknown
- 1986-12-17 AT AT86309847T patent/ATE52776T1/de active
- 1986-12-17 DE DE8686309847T patent/DE3671224D1/de not_active Expired - Fee Related
- 1986-12-17 EP EP86309847A patent/EP0230755B1/de not_active Expired - Lifetime
- 1986-12-18 ZA ZA869500A patent/ZA869500B/xx unknown
- 1986-12-19 CA CA000525852A patent/CA1263385A/en not_active Expired
- 1986-12-19 AU AU66780/86A patent/AU586724B2/en not_active Ceased
- 1986-12-19 DK DK619786A patent/DK619786A/da not_active Application Discontinuation
- 1986-12-20 JP JP61305159A patent/JPS62158256A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU6678086A (en) | 1987-06-25 |
| DK619786D0 (da) | 1986-12-19 |
| AU586724B2 (en) | 1989-07-20 |
| CA1263385A (en) | 1989-11-28 |
| JPS62158256A (ja) | 1987-07-14 |
| DE3671224D1 (de) | 1990-06-21 |
| US4707483A (en) | 1987-11-17 |
| ZA869500B (en) | 1987-09-30 |
| EP0230755B1 (de) | 1990-05-16 |
| PT83941A (en) | 1987-01-01 |
| EP0230755A1 (de) | 1987-08-05 |
| DK619786A (da) | 1987-06-21 |
| PT83941B (en) | 1988-10-25 |
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