ATE52776T1 - 1-phenyl-3-benzazepine. - Google Patents

1-phenyl-3-benzazepine.

Info

Publication number
ATE52776T1
ATE52776T1 AT86309847T AT86309847T ATE52776T1 AT E52776 T1 ATE52776 T1 AT E52776T1 AT 86309847 T AT86309847 T AT 86309847T AT 86309847 T AT86309847 T AT 86309847T AT E52776 T1 ATE52776 T1 AT E52776T1
Authority
AT
Austria
Prior art keywords
alkyl
hydrogen
compounds
so2nr
trifluoromethyl
Prior art date
Application number
AT86309847T
Other languages
English (en)
Inventor
William Edward Bondinell
Ku Thomas Wen-Fu
Iii Herbert Stowell Ormsbee
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Application granted granted Critical
Publication of ATE52776T1 publication Critical patent/ATE52776T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nutrition Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
AT86309847T 1985-12-20 1986-12-17 1-phenyl-3-benzazepine. ATE52776T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/811,790 US4707483A (en) 1985-12-20 1985-12-20 1-phenyl-3-benzazepines and their use for treating gastrointestinal motility disorders
EP86309847A EP0230755B1 (de) 1985-12-20 1986-12-17 1-Phenyl-3-benzazepine

Publications (1)

Publication Number Publication Date
ATE52776T1 true ATE52776T1 (de) 1990-06-15

Family

ID=25207588

Family Applications (1)

Application Number Title Priority Date Filing Date
AT86309847T ATE52776T1 (de) 1985-12-20 1986-12-17 1-phenyl-3-benzazepine.

Country Status (10)

Country Link
US (1) US4707483A (de)
EP (1) EP0230755B1 (de)
JP (1) JPS62158256A (de)
AT (1) ATE52776T1 (de)
AU (1) AU586724B2 (de)
CA (1) CA1263385A (de)
DE (1) DE3671224D1 (de)
DK (1) DK619786A (de)
PT (1) PT83941B (de)
ZA (1) ZA869500B (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0244088A3 (de) * 1986-04-03 1989-03-15 Smithkline Beecham Corporation 1-Phenyl-3-benzazepin-Verbindungen und diese enthaltende Arzneimittel zur Behandlung von Störungen des gastrointestinalen Bewegungsvermögens
ZA882080B (en) * 1987-03-27 1989-04-26 Schering Corp Substituted benzazepines,their preparation and pharmaceutical compositions containing them
FR2636330B1 (fr) * 1988-09-13 1990-11-30 Sanofi Sa Procede de preparation de derives de morphinane
GB9903671D0 (en) * 1999-02-17 1999-04-14 Cenes Ltd Dopamine D-1 receptor agonist compounds
KR20010113006A (ko) * 2000-06-15 2001-12-24 주정호 항암제로서 유용한 ｎ-치환된 벤즈아제피닐우레아 유도체및 그의 제조방법
WO2005035504A2 (en) * 2003-05-22 2005-04-21 Schering Corporation 5-h -benzo [d] naphth [2, 1-b] azepine derivative as selective d1/d5 receptor antagonists for the treatment of obesity and cns disorders

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3393192A (en) * 1965-04-26 1968-07-16 Schering Corp Novel benzazepines
US3496166A (en) * 1967-12-22 1970-02-17 Ciba Geigy Corp 3-substituted 1-aryl-3-benzazepines
CA974989A (en) * 1968-03-11 1975-09-23 Wallace And Tiernan Inc. Process for preparing 1,2,4,5-tetrahydro-3h,3-benzazepines and products obtained thereby
US4206210A (en) * 1977-01-19 1980-06-03 Smithkline Corporation Alkylthio-7,8-dihdroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines having dopaminergic activity
US4104379A (en) * 1977-01-19 1978-08-01 Smithkline Corporation Substituted 1-alkylthiophenyl-2,3,4,5-tetrahydro-1H-3-benzazepine compounds
US4265890A (en) * 1978-07-07 1981-05-05 Smithkline Corporation 6-Phenyl thio- and 6-cyclohexyl thio-2,3,4,5-tetrahydro-1H-3-benzazepines
US4284556A (en) * 1980-01-31 1981-08-18 Smithkline Corporation 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines
NZ203064A (en) * 1982-02-24 1985-05-31 Smithkline Beckman Corp R-or s-6-chloro-7,8-dihydroxy-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1h-3-benzazepine
US4514394A (en) * 1983-05-25 1985-04-30 Smithkline Beckman Corporation Anti-hypertensive use of 1-(4'-branched alkylsulfonylphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines
CA1234110A (en) * 1983-08-12 1988-03-15 Joel G. Berger Benzazepine derivatives, pharmaceutical compositions containing them and processes for the preparation of such compounds and compositions

Also Published As

Publication number Publication date
DE3671224D1 (de) 1990-06-21
AU586724B2 (en) 1989-07-20
US4707483A (en) 1987-11-17
AU6678086A (en) 1987-06-25
PT83941B (en) 1988-10-25
EP0230755B1 (de) 1990-05-16
EP0230755A1 (de) 1987-08-05
DK619786A (da) 1987-06-21
DK619786D0 (da) 1986-12-19
ZA869500B (en) 1987-09-30
PT83941A (en) 1987-01-01
CA1263385A (en) 1989-11-28
JPS62158256A (ja) 1987-07-14

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