ES8301480A1 - Un procedimiento para la produccion de derivados de 11-piperazinil-5h--pirrolo 1,2-b, 1,2,5 benzotriazepina. - Google Patents

Un procedimiento para la produccion de derivados de 11-piperazinil-5h--pirrolo 1,2-b, 1,2,5 benzotriazepina.

Info

Publication number
ES8301480A1
ES8301480A1 ES498008A ES498008A ES8301480A1 ES 8301480 A1 ES8301480 A1 ES 8301480A1 ES 498008 A ES498008 A ES 498008A ES 498008 A ES498008 A ES 498008A ES 8301480 A1 ES8301480 A1 ES 8301480A1
Authority
ES
Spain
Prior art keywords
pyrrolobenzotriazepines
new
production
pharmaceutical compositions
compositions containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498008A
Other languages
English (en)
Other versions
ES498008A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES498008A0 publication Critical patent/ES498008A0/es
Publication of ES8301480A1 publication Critical patent/ES8301480A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C243/00—Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/50—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

PROCEDIMIENTO PARA LA PRODUCCION DE DERIVADOS DE 11-PIPERACINIL-5H-PIRROLO<014>1,2-B<015><014>1,2,5<015>BENZOTRIZAEPINA, DE FORMULA GENERAL (I), DONDE R Y R PUEDEN SER, INDEPENDIENTEMENTE, HIDROGENO, HALOGENO, ALQUILO, ALCOXI O TRIFLUORMETILO; R ES HIDROGENO, ALQUILO, HIDROXIALQUILO O UN ESTER DEL MISMO; Y R ES HIDROGENO, ALQUILO, ALQUENILO O BENCILO. CONSISTE EN SOMETER A UNA REACCION DE CICLACION UN DERIVADO DE 1-<014>2-(N-1-PIRROLIL)AMINO<015>-FENILAMINOCARBONIL-PIPERAZINA EN PRESENCIA DE UN ACIDO MINERAL Y, SI SE DESEA, EN UN DISOLVENTE INERTE. TRATANDO LOS COMPUESTOS OBTENIDOS CON UN ACIDO SE OBTIENEN LAS CORRESPONDIENTES SALES DE ADICION DE ACIDO. DE APLICACION EN FARMACIA POR SUS PROPIEDADES ANTIDEPRESIVAS.
ES498008A 1979-12-21 1980-12-19 Un procedimiento para la produccion de derivados de 11-piperazinil-5h--pirrolo 1,2-b, 1,2,5 benzotriazepina. Expired ES8301480A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH1141579 1979-12-21

Publications (2)

Publication Number Publication Date
ES498008A0 ES498008A0 (es) 1982-12-01
ES8301480A1 true ES8301480A1 (es) 1982-12-01

Family

ID=4373279

Family Applications (1)

Application Number Title Priority Date Filing Date
ES498008A Expired ES8301480A1 (es) 1979-12-21 1980-12-19 Un procedimiento para la produccion de derivados de 11-piperazinil-5h--pirrolo 1,2-b, 1,2,5 benzotriazepina.

Country Status (12)

Country Link
US (1) US4450108A (es)
EP (1) EP0031115A1 (es)
JP (1) JPS56108790A (es)
AU (1) AU6559780A (es)
DK (1) DK546180A (es)
ES (1) ES8301480A1 (es)
FI (1) FI803908L (es)
IL (1) IL61773A (es)
PH (1) PH16593A (es)
PT (1) PT72237B (es)
YU (1) YU321880A (es)
ZA (1) ZA807943B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4459232A (en) * 1981-12-07 1984-07-10 Ciba-Geigy Corporation Imidazo[1,2-c][1,3]benzodiazepines
US4460587A (en) * 1981-12-07 1984-07-17 Ciba-Geigy Corporation 5-Diazacycloalkyl imidazo[1,2-c][1,3]benzodiazepines
US4588727A (en) * 1984-07-02 1986-05-13 Hoechst-Roussel Pharmaceuticals Inc. Intermediates for pyrrolo[1,2-b][1,2,5]triazepines
US4517195A (en) * 1984-07-02 1985-05-14 Hoechst-Roussel Pharmaceuticals Inc. Pyrrolo[1,2-b][1,2,5]triazepines and pharmaceutical compositions thereof
US4879382A (en) * 1988-07-25 1989-11-07 Hoechst-Roussel Pharmaceuticals, Inc. Pyrido(3,4-f)pyrrolo(1,2-b)(1,2,5)triazepines
US5015637A (en) * 1990-05-25 1991-05-14 Hoechst-Roussel Pharmaceutical Inc. Pyrido[3,4-b]pyrrolo[1,2-e][1,4,5]oxadiazepines

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7403657A (es) * 1973-03-23 1974-09-25
US3984562A (en) * 1975-02-24 1976-10-05 American Cyanamid Company Substituted benzodiazepines and method of use
US4097597A (en) * 1977-02-23 1978-06-27 Abbott Laboratories Dibenzo b,e! 1,4!diazepines

Also Published As

Publication number Publication date
AU6559780A (en) 1981-06-25
IL61773A0 (en) 1981-01-30
JPS56108790A (en) 1981-08-28
ZA807943B (en) 1982-07-28
US4450108A (en) 1984-05-22
ES498008A0 (es) 1982-12-01
FI803908L (fi) 1981-06-22
YU321880A (en) 1983-12-31
PT72237A (en) 1981-01-01
EP0031115A1 (en) 1981-07-01
DK546180A (da) 1981-06-22
PH16593A (en) 1983-11-22
IL61773A (en) 1984-03-30
PT72237B (en) 1982-03-26

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