ES8802496A1 - Procedimiento para preparar dihidropiridinas - Google Patents

Procedimiento para preparar dihidropiridinas

Info

Publication number
ES8802496A1
ES8802496A1 ES557630A ES557630A ES8802496A1 ES 8802496 A1 ES8802496 A1 ES 8802496A1 ES 557630 A ES557630 A ES 557630A ES 557630 A ES557630 A ES 557630A ES 8802496 A1 ES8802496 A1 ES 8802496A1
Authority
ES
Spain
Prior art keywords
ring
bears
unsubstituted
alkyl
substituents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES557630A
Other languages
English (en)
Other versions
ES557630A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES557630A0 publication Critical patent/ES557630A0/es
Publication of ES8802496A1 publication Critical patent/ES8802496A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/44—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/84—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen directly attached to ring carbon atoms
    • C07D211/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Neurology (AREA)
  • Urology & Nephrology (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

LAS DIHIDROPIRIDINAS (I), DONDE NO EXCLUSIVAMENT, R1 Y R2 SON ALQUILO, ALQUENILO O ALCOXIALQUILO HASTA C6 Y R3 Y R4 SON ALQUILO C1-6, AR ES FENILO, NAFTILO O UN HETEROCICLO DE 5 O 6 MIEMBROS, X ES -OO -S-, Y ALQUILENO O ALQUENILENO C2-12, P 0 O 1 Y EL ANILLO BENCENICO A PUEDE ESTAR INSUSTITUIDO O SUSTITUIDO POR CIANO, NITRO O =N-O-N=; SE OBTIENEN HACIENDO REACCIONAR UN COMPUESTO (II) CON UNA AMINA H2NCH2 CHOH (CH2O)P-AR, EN UN DISOLVENTE ADECUADO HASTA TEMPERATURA DE REFLUJO. POSEEN ACTIVIDAD DE BLOQUEO BETA-ADRENERGICOS Y/O BLOQUEO DE CANAL LENTO DE CALCIO POR LO QUE SON APLICABLES EN EL TRATAMIENTO DE ENFERMEDADES CARDIACAS COMO LA ANGINA DE PECHO; ADEMAS SIN HIPERTENSORES. *FORMULA* O
ES557630A 1985-02-11 1987-07-16 Procedimiento para preparar dihidropiridinas Expired ES8802496A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858503425A GB8503425D0 (en) 1985-02-11 1985-02-11 Alkanolamine derivatives

Publications (2)

Publication Number Publication Date
ES557630A0 ES557630A0 (es) 1988-07-01
ES8802496A1 true ES8802496A1 (es) 1988-07-01

Family

ID=10574270

Family Applications (2)

Application Number Title Priority Date Filing Date
ES551844A Expired ES8802139A1 (es) 1985-02-11 1986-02-11 Procedimiento para preparar dihidropiridinas.
ES557630A Expired ES8802496A1 (es) 1985-02-11 1987-07-16 Procedimiento para preparar dihidropiridinas

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES551844A Expired ES8802139A1 (es) 1985-02-11 1986-02-11 Procedimiento para preparar dihidropiridinas.

Country Status (21)

Country Link
US (1) US4873254A (es)
EP (1) EP0194751B1 (es)
JP (1) JPH0819100B2 (es)
KR (1) KR860006443A (es)
AU (1) AU5339486A (es)
CS (1) CS273172B2 (es)
DD (1) DD250533A5 (es)
DE (1) DE3684803D1 (es)
DK (1) DK66186A (es)
ES (2) ES8802139A1 (es)
FI (1) FI860621A (es)
GB (2) GB8503425D0 (es)
GR (1) GR860369B (es)
HU (1) HU196179B (es)
NO (1) NO860465L (es)
NZ (1) NZ215083A (es)
PH (1) PH22683A (es)
PL (2) PL153857B1 (es)
PT (1) PT82008B (es)
SU (1) SU1590041A3 (es)
ZA (1) ZA86967B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6112662A (ja) * 1984-06-28 1986-01-21 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体及びその製法
US4782160A (en) * 1986-12-08 1988-11-01 Yamanouchi Pharmaceutical Co., Ltd. 1,4-dihydropyridine derivatives
GB9102031D0 (en) * 1991-01-30 1991-03-13 Fujisawa Pharmaceutical Co Dihydropyridine compounds,and process for their preparation
WO2000005209A1 (en) * 1998-07-23 2000-02-03 Lin, Tong-Ho GUAIACOXYPROPANOLAMINES WITH α/β-ADRENERGIC BLOCKING ACTIVITY
CL2008003120A1 (es) 2007-11-01 2009-10-09 Acucela Inc Compuestos derivados de fenilalquil-, fenilalquenil-, fenilalquinil- amina, feniltioalquilamina, fenilaminoalquilamina, fenilalcoxiamina y fenilalquilguanidina; composicion farmaceutica; y uso de los compuestos para tratar un trastorno o enfermedad oftalmologica tal como retinopatia, maculopatia, retinitis pigmentosa, uveitis, entre otras.

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2228363A1 (de) * 1972-06-10 1974-01-03 Bayer Ag 1,4-dihydropyridine, verfahren zu ihrer herstellung sowie ihre verwendung als arzneimittel
GB1409865A (en) * 1973-02-13 1975-10-15 Science Union & Cie Dihydropyridines derivatives their preparation and pharmaceu tical compositions containing them
US4500527A (en) * 1983-06-22 1985-02-19 Usv Pharmaceutical Corporation Antihypertensive 4[(3-alkylamino-2-hydroxypropyl)-oxyiminomethyl phenyl]-1,4-dihydropyridines
JPS6112662A (ja) * 1984-06-28 1986-01-21 Yamanouchi Pharmaceut Co Ltd ジヒドロピリジン誘導体及びその製法

Also Published As

Publication number Publication date
HUT40415A (en) 1986-12-28
JPS61233669A (ja) 1986-10-17
KR860006443A (ko) 1986-09-11
HU196179B (en) 1988-10-28
JPH0819100B2 (ja) 1996-02-28
GR860369B (en) 1986-06-02
SU1590041A3 (ru) 1990-08-30
AU5339486A (en) 1986-08-14
DD250533A5 (de) 1987-10-14
ES551844A0 (es) 1988-04-01
PL153857B1 (en) 1991-06-28
DE3684803D1 (de) 1992-05-21
FI860621A (fi) 1986-08-12
NZ215083A (en) 1989-10-27
NO860465L (no) 1986-08-12
ES557630A0 (es) 1988-07-01
PL265252A1 (en) 1988-06-09
PT82008B (pt) 1988-07-01
EP0194751B1 (en) 1992-04-15
ZA86967B (en) 1986-11-26
US4873254A (en) 1989-10-10
PL257902A1 (en) 1988-03-03
ES8802139A1 (es) 1988-04-01
PH22683A (en) 1988-11-14
GB8602704D0 (en) 1986-03-12
GB8503425D0 (en) 1985-03-13
PT82008A (en) 1986-03-01
FI860621A0 (fi) 1986-02-11
CS273172B2 (en) 1991-03-12
CS91186A2 (en) 1990-07-12
DK66186A (da) 1986-08-12
DK66186D0 (da) 1986-02-11
EP0194751A1 (en) 1986-09-17
PL149828B1 (en) 1990-03-31

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Legal Events

Date Code Title Description
MM4A Patent lapsed

Effective date: 19960506