DE69529670D1 - Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen - Google Patents

Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen

Info

Publication number
DE69529670D1
DE69529670D1 DE69529670T DE69529670T DE69529670D1 DE 69529670 D1 DE69529670 D1 DE 69529670D1 DE 69529670 T DE69529670 T DE 69529670T DE 69529670 T DE69529670 T DE 69529670T DE 69529670 D1 DE69529670 D1 DE 69529670D1
Authority
DE
Germany
Prior art keywords
compositions containing
pharmaceutical compositions
oxazolidinone derivatives
present
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69529670T
Other languages
English (en)
Other versions
DE69529670T2 (de
Inventor
Hiroyoshi Yamada
Kiyotaka Munesada
Mikio Taniguchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of DE69529670D1 publication Critical patent/DE69529670D1/de
Publication of DE69529670T2 publication Critical patent/DE69529670T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/30—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D263/34—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/36—One oxygen atom
    • C07D263/38—One oxygen atom attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69529670T 1994-03-15 1995-03-14 Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen Expired - Lifetime DE69529670T2 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP4394994 1994-03-15
JP14656594 1994-06-28
JP6235167A JPH0873455A (ja) 1994-03-15 1994-09-29 オキサゾリジノン誘導体及びこれを有効成分とする医薬組成物
PCT/US1995/002972 WO1995025106A1 (en) 1994-03-15 1995-03-14 Oxazolidinone derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
DE69529670D1 true DE69529670D1 (de) 2003-03-27
DE69529670T2 DE69529670T2 (de) 2003-09-18

Family

ID=27291734

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69529670T Expired - Lifetime DE69529670T2 (de) 1994-03-15 1995-03-14 Oxazolidinon derivate und diese enthaltende pharmazeutische zusammensetzungen

Country Status (14)

Country Link
EP (1) EP0750618B1 (de)
JP (2) JPH0873455A (de)
KR (1) KR100340365B1 (de)
CN (1) CN1143961A (de)
AT (1) ATE232862T1 (de)
AU (1) AU681953B2 (de)
CA (1) CA2183972C (de)
DE (1) DE69529670T2 (de)
DK (1) DK0750618T3 (de)
ES (1) ES2191048T3 (de)
LV (1) LV13155B (de)
NZ (1) NZ283011A (de)
PT (1) PT750618E (de)
WO (1) WO1995025106A1 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69614847T2 (de) * 1995-05-11 2002-04-04 Upjohn Co Spirocyclische und bicyclische diazinyl- und carbazinyloxazolidinone
EP1019385B1 (de) * 1995-09-15 2004-01-14 PHARMACIA & UPJOHN COMPANY Aminoaryl oxazolidinone n-oxide
GB9601666D0 (en) * 1996-01-27 1996-03-27 Zeneca Ltd Chemical compounds
GB9702213D0 (en) 1996-02-24 1997-03-26 Zeneca Ltd Chemical compounds
EP1114819B1 (de) * 1996-04-11 2008-01-09 Pharmacia & Upjohn Company LLC Verfahren zur Herstellung von Oxazolidinonen
GB9609919D0 (en) 1996-05-11 1996-07-17 Zeneca Ltd Chemical compounds
DE19709443C1 (de) * 1997-03-07 1998-10-08 Clariant Gmbh Verfahren zur Herstellung von N-Carboxyalkyl-3-fluor-4-dialkylaminoanilinen und N-Carboxymethyl-3-fluor-4-morpholinoanilin und N-Carboxyisobutyl-3-fluor-4-morpholinoanilin
DE19750968A1 (de) * 1997-03-07 1998-09-10 Clariant Gmbh Verfahren zur Herstellung von N-Carboxyalkyl-3-fluor-4-dialkylaminoanilinen
US6037354A (en) 1997-06-18 2000-03-14 Merck & Co., Inc. Alpha 1a adrenergic receptor antagonists
GB9717807D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
GB9717804D0 (en) 1997-08-22 1997-10-29 Zeneca Ltd Chemical compounds
KR100467309B1 (ko) * 1997-09-04 2005-07-18 씨제이 주식회사 옥사졸리디논유도체및그의제조방법및항균제조성물
KR100463111B1 (ko) * 1997-10-30 2005-06-13 씨제이 주식회사 신규한옥사졸리디논유도체및제조방법및그를함유하는항균제조성물
EP1030852B1 (de) * 1997-11-12 2003-09-17 PHARMACIA & UPJOHN COMPANY Oxazolidinone derivate und pharmazeutische zusammensetzungen
GB9725244D0 (en) 1997-11-29 1998-01-28 Zeneca Ltd Chemical compounds
US6069141A (en) * 1998-02-13 2000-05-30 Pharmacia & Upjohn Company Substituted aminophenyl isoxazoline derivatives useful as antimicrobials
AU2001269370B2 (en) 2000-07-17 2005-10-27 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
EP1358185A2 (de) 2001-02-07 2003-11-05 Ortho-Mcneil Pharmaceutical, Inc. Antibakteriell wirksame pyridoarylphenyloxazolidinone und entsprechende zusammensetzungen und methoden
US7186855B2 (en) 2001-06-11 2007-03-06 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6818787B2 (en) 2001-06-11 2004-11-16 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US8048917B2 (en) 2005-04-06 2011-11-01 Xenoport, Inc. Prodrugs of GABA analogs, compositions and uses thereof
US6956040B2 (en) 2001-07-16 2005-10-18 Ranbaxy Laboratories Limited Oxazolidinone piperazinyl derivatives as potential antimicrobials
EP1409464A4 (de) * 2001-07-16 2005-11-02 Ranbaxy Lab Ltd Oxazolidinonderivate als potentielle antimikrobielle mittel
KR100445437B1 (ko) * 2002-02-08 2004-08-21 한국과학기술연구원 네오마이신-옥사졸리디논 헤테로 이합체, 그의 제조방법및 그의 용도
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
AR038536A1 (es) 2002-02-25 2005-01-19 Upjohn Co N-aril-2-oxazolidinona-5- carboxamidas y sus derivados
WO2004007489A2 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antibacterial substituted cyanomethyl (ene) piperidinophenyl oxazolidinones, process or their preparation, and pharmaceutical compositions containing them
CA2492743A1 (en) * 2002-07-11 2004-01-22 Wockhardt Limited Antimicrobial oxazolidinones, process of their preparation, and pharmaceutical compositions containing them
AU2003249983A1 (en) * 2002-07-18 2004-02-09 Actelion Pharmaceuticals Ltd Piperidines useful for the treatment of central nervous system disorders
WO2004014897A1 (en) 2002-08-12 2004-02-19 Pharmacia & Upjohn Company Llc N-aryl-2-oxazolidinones and their derivatives
EP1565186B1 (de) 2002-11-21 2006-11-02 Pharmacia & Upjohn Company LLC N-(4-(piperazin-1-yl)-phenyl-2-oxazolidinon-5-carbonsäureamid-derivate und verwandte verbindungen als antibakterielle mittel
CA2536480A1 (en) * 2003-08-25 2005-03-03 Warner-Lambert Company Llc Novel antimicrobial aryloxazolidinone compounds
US7687627B2 (en) * 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
CN100545150C (zh) * 2003-09-12 2009-09-30 中国科学院上海药物研究所 含吡啶环的噁唑烷酮类化合物、制备方法及用途
US7304050B2 (en) 2003-09-16 2007-12-04 Pfizer Inc. Antibacterial agents
US20090018123A1 (en) * 2005-06-20 2009-01-15 Milind D Sindkhedkar Oxazolidinones Bearing Antimicrobial Activity Composition and Methods of Preparation
CA2651634C (en) * 2006-05-09 2013-07-30 Wockhardt Ltd Substituted piperidino phenyloxazolidinones
WO2008038092A2 (en) * 2006-09-25 2008-04-03 Wockhardt Research Centre Substituted piperidinophenyl oxazolidinones
JP5738268B2 (ja) * 2009-03-27 2015-06-24 カウンシル・オヴ・サイエンティフィック・アンド・インダストリアル・リサーチ 殺真菌薬として有用な置換１，４−ジオキサ−８−アザスピロ［４，５］デカン類およびその調製方法
JP2014500247A (ja) 2010-11-03 2014-01-09 ウォックハート リミテッド リン酸モノ−（１−｛４−［（ｓ）―５−（アセチルアミノメチル）−２−オキソ−オキサゾリジン−３−イル］−２，６−ジフルオロフェニル｝−４−メトキシメチルピペリジン−４−イル）エステルの調製方法
EP2762479A4 (de) * 2011-09-29 2015-04-22 Xuanzhu Pharma Co Ltd Biarylheterocyclensubstituiertes oxazolidinon-antibakterikum
CN104364240B (zh) * 2012-06-08 2017-02-22 四川贝力克生物技术有限责任公司 一种用于预防或治疗分支杆菌疾病的药物
WO2015173664A1 (en) 2014-05-14 2015-11-19 Wockhardt Limited Process for the preparation of (5s)-n-{3-[3,5-difluoro-4-(4-hydroxy-4-methoxymethyl-piperidin-1-yl)-phenyl]-2-oxo-oxazolidin-5-ylmethyl}-acetamide
US20210267953A1 (en) * 2018-07-25 2021-09-02 Cadila Healthcare Limited Substituted oxazolidinones for the treatment of mammalian infections
MX2022016063A (es) 2020-06-18 2023-04-11 Akagera Medicines Inc Compuestos de oxazolidinona, composiciones de liposomas que comprenden compuestos de oxazolidinona y metodos de uso de los mismos.

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
ATE146783T1 (de) * 1991-11-01 1997-01-15 Upjohn Co Substituierte aryl- und heteroaryl- phenyloxazolidinone
SK283420B6 (sk) * 1992-05-08 2003-07-01 Pharmacia & Upjohn Company Antimikrobiálne oxazolidinóny obsahujúce substituované diazínové skupiny

Also Published As

Publication number Publication date
ATE232862T1 (de) 2003-03-15
EP0750618A1 (de) 1997-01-02
CN1143961A (zh) 1997-02-26
JPH09512785A (ja) 1997-12-22
AU681953B2 (en) 1997-09-11
WO1995025106A1 (en) 1995-09-21
NZ283011A (en) 1997-09-22
CA2183972C (en) 2005-07-05
JPH0873455A (ja) 1996-03-19
JP3628329B2 (ja) 2005-03-09
PT750618E (pt) 2003-06-30
MX9604072A (es) 1997-09-30
DE69529670T2 (de) 2003-09-18
KR100340365B1 (ko) 2002-11-23
LV13155B (en) 2004-06-20
EP0750618B1 (de) 2003-02-19
DK0750618T3 (da) 2003-06-10
CA2183972A1 (en) 1995-09-21
AU2099995A (en) 1995-10-03
ES2191048T3 (es) 2003-09-01

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Legal Events

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8364 No opposition during term of opposition