PE20020855A1 - Derivados de piperazina azaindoloxoacetico sustituidos con actividad antiviral - Google Patents

Derivados de piperazina azaindoloxoacetico sustituidos con actividad antiviral

Info

Publication number
PE20020855A1
PE20020855A1 PE2002000075A PE2002000075A PE20020855A1 PE 20020855 A1 PE20020855 A1 PE 20020855A1 PE 2002000075 A PE2002000075 A PE 2002000075A PE 2002000075 A PE2002000075 A PE 2002000075A PE 20020855 A1 PE20020855 A1 PE 20020855A1
Authority
PE
Peru
Prior art keywords
alkyl
cycloalkyl
heteroaryl
aryl
antiviral activity
Prior art date
Application number
PE2002000075A
Other languages
English (en)
Inventor
Tao Wang
Zhongxing Zhang
John F Kadow
Zhiwei Yin
Nicholas A Meanwell
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of PE20020855A1 publication Critical patent/PE20020855A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants

Abstract

SE REFIERE A DERIVADOS DE AZAINDOLOXOACETIL-PIPERAZIN DIAMIDA DE FORMULA I DONDE Q ES UN GRUPO a, b; R1, R2, R3, R4 SON H, HALOGENO, CIANO, NITRO, COOR8, B, D, E; UNO DE R1-R4 ES B, E; m ES 1-2; R5 ES H, (CH2)nR44; n ES 0-6; R6 ES O, A ES ALCOXI C1-C6, ARILO, HETEROARILO, W ES UN GRUPO c; B ES ARILO, HETEROARILO, ENTRE OTROS; q ES 0-2; D ES ALQUILO C1-C6, CICLOALQUILO C3-C7, ALQUENILO C2-C6, ENTRE OTROS; E ES ALQUILO C1-C6, CICLOALQUILO C3-C7, ALQUENILO C2-C6, ENTRE OTROS; F ES ALQUILO C1-C6, CICLOALQUILO C3-C7, ARILO, HETERARILO, ENTRE OTROS; G ES ALQUILO C1-C6, CICLOALQUILO C3-C7, ARILO, HETEROARILO, OH, ENTRE OTROS; R7 ES ARILO, HETEROARILO, HETEROALICICLICO; R8 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS; R9, R10, R11, R12, R13, R14, R15, R16 SON H, ALQUILO C1-C6; X ES NR5, O, S; R40, R41 SON H, ALQUILO C1-C6, CICLOALQUILO C3-C7, ENTRE OTROS; R42 Y R43 SON H, ALQUILO C1-C6, ALCOXI C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R44 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; T ES S, O; Ar ES FENILO, HETEROARILO, Ra Y Rb SON H, ALQUILO C1-C6, FENILO; R46 ES H, OR7, NR40R41; R50 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; R51 ES H, ALQUILO C1-C6, CICLOALQUILO C3-C6, ENTRE OTROS; Y ES O, S, NR50R51. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS UN ANTIVIRAL CONTRA EL SIDA, UN AGENTE ANTIINFECCIOSO, UN INMUNOMODULADOR, INHIBIDORES DE ENTRADA DEL VIH. LOS COMPUESTOS TIENEN ACTIVIDAD ANTIVIRAL Y PUEDEN SER UTILES PARA EL TRATAMIENTO DEL VIH, SIDA
PE2002000075A 2001-02-02 2002-02-01 Derivados de piperazina azaindoloxoacetico sustituidos con actividad antiviral PE20020855A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26618301P 2001-02-02 2001-02-02
US31440601P 2001-08-23 2001-08-23

Publications (1)

Publication Number Publication Date
PE20020855A1 true PE20020855A1 (es) 2002-09-27

Family

ID=26951680

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2002000075A PE20020855A1 (es) 2001-02-02 2002-02-01 Derivados de piperazina azaindoloxoacetico sustituidos con actividad antiviral

Country Status (32)

Country Link
US (1) US20030069266A1 (es)
EP (1) EP1363705B9 (es)
JP (1) JP4328527B2 (es)
KR (1) KR20030079979A (es)
CN (1) CN100384423C (es)
AR (1) AR034292A1 (es)
BG (1) BG66359B1 (es)
BR (1) BRPI0206636B8 (es)
CA (1) CA2437524C (es)
CY (1) CY1113194T1 (es)
CZ (1) CZ303750B6 (es)
DK (1) DK1363705T3 (es)
EE (1) EE05424B1 (es)
ES (1) ES2387981T3 (es)
HK (1) HK1056698A1 (es)
HR (1) HRP20030694A2 (es)
HU (1) HU229305B1 (es)
IL (2) IL157029A0 (es)
IS (1) IS2912B (es)
MX (1) MXPA03006939A (es)
MY (1) MY137480A (es)
NO (1) NO326510B1 (es)
NZ (1) NZ527193A (es)
PE (1) PE20020855A1 (es)
PL (1) PL364279A1 (es)
PT (1) PT1363705E (es)
RS (1) RS52489B (es)
RU (1) RU2303038C2 (es)
SK (1) SK287900B6 (es)
TW (1) TWI318978B (es)
WO (1) WO2002062423A1 (es)
ZA (1) ZA200305885B (es)

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DE602005010698D1 (de) 2004-06-09 2008-12-11 Glaxo Group Ltd Pyrrolopyridinderivate
CA2579127C (en) 2004-09-03 2011-08-02 Yuhan Corporation Pyrrolo[3,2-b]pyridine derivatives and processes for the preparation thereof
US20060100209A1 (en) * 2004-11-09 2006-05-11 Chong-Hui Gu Formulations of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione
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EP2046753A2 (en) * 2006-07-06 2009-04-15 Brystol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type i inhibitors
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Also Published As

Publication number Publication date
BG66359B1 (bg) 2013-09-30
MY137480A (en) 2009-01-30
CZ20032316A3 (cs) 2004-01-14
EP1363705B9 (en) 2012-11-07
IS6899A (is) 2003-07-30
JP4328527B2 (ja) 2009-09-09
BRPI0206636B8 (pt) 2021-05-25
NO326510B1 (no) 2008-12-22
AR034292A1 (es) 2004-02-18
SK9592003A3 (en) 2004-08-03
CN1612763A (zh) 2005-05-04
IL157029A0 (en) 2004-02-08
BG108021A (bg) 2004-04-30
HK1056698A1 (en) 2004-02-27
EP1363705B1 (en) 2012-06-13
IS2912B (is) 2014-11-15
BRPI0206636B1 (pt) 2018-05-02
HUP0304062A3 (en) 2010-06-28
TWI318978B (en) 2010-01-01
NO20033436D0 (no) 2003-08-01
ZA200305885B (en) 2005-01-26
CZ303750B6 (cs) 2013-04-17
RU2003127077A (ru) 2005-03-20
US20030069266A1 (en) 2003-04-10
ES2387981T3 (es) 2012-10-05
JP2004522755A (ja) 2004-07-29
NZ527193A (en) 2004-05-28
CA2437524A1 (en) 2002-08-15
MXPA03006939A (es) 2003-11-18
RS52489B (en) 2013-02-28
RU2303038C2 (ru) 2007-07-20
KR20030079979A (ko) 2003-10-10
NO20033436L (no) 2003-10-01
YU60903A (sh) 2006-05-25
EP1363705A1 (en) 2003-11-26
CA2437524C (en) 2010-04-27
HUP0304062A2 (hu) 2004-04-28
IL157029A (en) 2015-11-30
DK1363705T3 (da) 2012-09-24
CY1113194T1 (el) 2016-04-13
HRP20030694A2 (en) 2005-04-30
PT1363705E (pt) 2012-08-17
BR0206636A (pt) 2004-02-25
EE05424B1 (et) 2011-06-15
SK287900B6 (sk) 2012-03-02
WO2002062423A1 (en) 2002-08-15
EP1363705A4 (en) 2009-08-12
HU229305B1 (en) 2013-10-28
CN100384423C (zh) 2008-04-30
PL364279A1 (en) 2004-12-13
EE200300359A (et) 2003-12-15

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