MX2009009920A - Inhibidores no nucleosidos de transcriptasa inversa. - Google Patents

Inhibidores no nucleosidos de transcriptasa inversa.

Info

Publication number
MX2009009920A
MX2009009920A MX2009009920A MX2009009920A MX2009009920A MX 2009009920 A MX2009009920 A MX 2009009920A MX 2009009920 A MX2009009920 A MX 2009009920A MX 2009009920 A MX2009009920 A MX 2009009920A MX 2009009920 A MX2009009920 A MX 2009009920A
Authority
MX
Mexico
Prior art keywords
reverse transcriptase
treatment
transcriptase inhibitors
nucleoside reverse
hiv
Prior art date
Application number
MX2009009920A
Other languages
English (en)
Inventor
Zachary Kevin Sweeney
Michael Welch
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009009920A publication Critical patent/MX2009009920A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Los compuestos de la fórmula I, en donde R1, R2, R3, R4, R5, X, Y, y Ar tienen los significados aquí definidos o las sales farmacéuticamente aceptables de los mismos inhiben la transcriptasa inversa del VIH-1 proporcionan un método para la prevención y tratamiento de las infecciones del VIH-1 y para el tratamiento del SIDA y/o del ARC. La presente invención se refiere además a composiciones que contienen compuestos de la fórmula I útiles para la prevención y el tratamiento de infecciones del VIH-1 y el tratamiento del SIDA y/o del ARC. (ver fórmula (I)).
MX2009009920A 2007-03-29 2008-03-18 Inhibidores no nucleosidos de transcriptasa inversa. MX2009009920A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US92063507P 2007-03-29 2007-03-29
PCT/EP2008/053207 WO2008119662A1 (en) 2007-03-29 2008-03-18 Non-nucleoside reverse transcriptase inhibitors

Publications (1)

Publication Number Publication Date
MX2009009920A true MX2009009920A (es) 2009-10-19

Family

ID=39591446

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009009920A MX2009009920A (es) 2007-03-29 2008-03-18 Inhibidores no nucleosidos de transcriptasa inversa.

Country Status (15)

Country Link
US (1) US7906540B2 (es)
EP (1) EP2142520A1 (es)
JP (1) JP2010522706A (es)
KR (1) KR20090127178A (es)
CN (1) CN101657433A (es)
AR (1) AR067271A1 (es)
AU (1) AU2008233929A1 (es)
BR (1) BRPI0809617A2 (es)
CA (1) CA2682637A1 (es)
CL (1) CL2008000862A1 (es)
IL (1) IL200748A0 (es)
MX (1) MX2009009920A (es)
PE (1) PE20090067A1 (es)
TW (1) TW200901985A (es)
WO (1) WO2008119662A1 (es)

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AU2014274536B2 (en) * 2008-05-30 2016-07-28 R-Tech Ueno, Ltd. Benzene or thiophene derivative and use thereof as vap-1 inhibitor
TWI490214B (zh) * 2008-05-30 2015-07-01 艾德克 上野股份有限公司 苯或噻吩衍生物及該等作為ｖａｐ－１抑制劑之用途
US9487476B2 (en) * 2011-10-12 2016-11-08 Yale University Catechol diethers as potent anti-HIV agents
US9505728B2 (en) 2012-03-09 2016-11-29 Inception 2, Inc. Triazolone compounds and uses thereof
SG11201407534PA (en) 2012-06-13 2014-12-30 Hoffmann La Roche New diazaspirocycloalkane and azaspirocycloalkane
AU2013322838B2 (en) 2012-09-25 2018-02-01 F. Hoffmann-La Roche Ag New bicyclic derivatives
CN104918922B (zh) 2012-12-20 2017-04-26 因森普深2公司 三唑酮化合物及其用途
AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
EA201690230A1 (ru) 2013-09-06 2016-07-29 Инсепшн 2, Инк. Соединения триазолона и их применения
RS56776B1 (sr) 2013-11-26 2018-04-30 Hoffmann La Roche Derivati oktahidro-ciklobuta [1,2-c;3,4-c']dipirola kao inhibitori autotaksina
WO2015144609A1 (en) 2014-03-26 2015-10-01 F. Hoffmann-La Roche Ag Condensed [1,4]diazepine compounds as autotaxin (atx) and lysophosphatidic acid (lpa) production inhibitors
CN110204550B (zh) 2014-03-26 2022-05-17 豪夫迈·罗氏有限公司 作为自分泌运动因子(atx)和溶血磷脂酸(lpa)生产抑制剂的二环化合物
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
MX2020004504A (es) 2015-09-04 2021-11-10 Hoffmann La Roche Derivados de fenoximetilo.
KR20180054634A (ko) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 신규한 이환형 화합물
RU2018112230A (ru) 2015-09-24 2019-10-30 Ф. Хоффманн-Ля Рош Аг Бициклические соединения в качестве ингибиторов atx
JP6845230B2 (ja) 2015-09-24 2021-03-17 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ デュアルａｔｘ／ｃａ阻害剤としての新規な二環式化合物
CA2983782A1 (en) 2015-09-24 2017-03-30 F. Hoffmann-La Roche Ag Bicyclic compounds as atx inhibitors
EP3596060B1 (en) 2017-03-16 2023-09-20 F. Hoffmann-La Roche AG New bicyclic compounds as atx inhibitors
KR20190129924A (ko) 2017-03-16 2019-11-20 에프. 호프만-라 로슈 아게 이중 오토탁신(atx)/탄산 무수화효소(ca) 억제제로서 유용한 헤테로환형 화합물
KR20190110740A (ko) * 2018-03-21 2019-10-01 주식회사유한양행 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
KR20190110736A (ko) * 2018-03-21 2019-10-01 주식회사유한양행 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
TW202039486A (zh) 2018-12-14 2020-11-01 南韓商柳韓洋行股份有限公司 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物
TWI835945B (zh) * 2018-12-14 2024-03-21 南韓商柳韓洋行股份有限公司 3,3-二氟烯丙胺化物或其鹽及包含彼的醫藥組合物
CN111440147B (zh) * 2020-05-19 2023-03-07 苏州卫生职业技术学院 N-(2-甲基-5-氨基苯基)-4-(3-吡啶基)-2-嘧啶胺的合成方法
GB2598624A (en) * 2020-09-07 2022-03-09 Lorico Aurelio Use of triazole analogues for inhibition of a tripartite VOR protein complex in multicellular organisms
CN112220771B (zh) * 2020-11-10 2023-03-31 成都大学 扎西他滨渗透泵型控释片及其制备方法

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Also Published As

Publication number Publication date
TW200901985A (en) 2009-01-16
IL200748A0 (en) 2010-05-17
AU2008233929A1 (en) 2008-10-09
KR20090127178A (ko) 2009-12-09
US7906540B2 (en) 2011-03-15
CA2682637A1 (en) 2008-10-09
JP2010522706A (ja) 2010-07-08
CN101657433A (zh) 2010-02-24
EP2142520A1 (en) 2010-01-13
US20080249151A1 (en) 2008-10-09
AR067271A1 (es) 2009-10-07
WO2008119662A1 (en) 2008-10-09
BRPI0809617A2 (pt) 2014-09-16
PE20090067A1 (es) 2009-01-26
CL2008000862A1 (es) 2008-11-14

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Legal Events

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FA Abandonment or withdrawal