AR067271A1 - Derivados de triazolona inhibidores no nucleosidos de la transcriptasa inversa, utiles para el tratamiento de enfermedades mediadas por el vih o el arc y composiciones farmaceuticas que los contienen. - Google Patents

Derivados de triazolona inhibidores no nucleosidos de la transcriptasa inversa, utiles para el tratamiento de enfermedades mediadas por el vih o el arc y composiciones farmaceuticas que los contienen.

Info

Publication number
AR067271A1
AR067271A1 ARP080101247A ARP080101247A AR067271A1 AR 067271 A1 AR067271 A1 AR 067271A1 AR P080101247 A ARP080101247 A AR P080101247A AR P080101247 A ARP080101247 A AR P080101247A AR 067271 A1 AR067271 A1 AR 067271A1
Authority
AR
Argentina
Prior art keywords
nucleosid
illnesses
hiv
inhibitors
arc
Prior art date
Application number
ARP080101247A
Other languages
English (en)
Inventor
Zachary Kevin Sweeney
Michael Welch
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR067271A1 publication Critical patent/AR067271A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D249/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Reivindicacion 1: Un compuesto de la formula (1) en la que: X es CH2 o NH; Y es CH2 u O, con la condicion de que por lo menos uno de X o Y sea CH2; R1 es hidrogeno o alquilo C1-6; R2 es C(=O)Ar u OAr; R3 y R4 son con independencia entre sí hidrogeno, halogeno, alquilo C1-6, alcoxi C1-6 o cicloalquilo C3-5; R5 es hidrogeno, CH2OH, CH2OC(=O)(CH2)nC(=O)OH, CH2OC(=O)-alquilo C1-6 en el que n es un numero de 2 a 5, o CH2OC(=O)-CHR5aNH2 en el que R5a es fenilo o alquilo inferior C1-6; Ar es fenilo sustituido por 1-3 grupos elegidos con independencia entre sí entre halogeno, ciano, haloalquilo C1-6, cicloalquilo C3-5 y alquilo C1-6 o las sales farmacéuticamente aceptables del mismo.
ARP080101247A 2007-03-29 2008-03-27 Derivados de triazolona inhibidores no nucleosidos de la transcriptasa inversa, utiles para el tratamiento de enfermedades mediadas por el vih o el arc y composiciones farmaceuticas que los contienen. AR067271A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US92063507P 2007-03-29 2007-03-29

Publications (1)

Publication Number Publication Date
AR067271A1 true AR067271A1 (es) 2009-10-07

Family

ID=39591446

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080101247A AR067271A1 (es) 2007-03-29 2008-03-27 Derivados de triazolona inhibidores no nucleosidos de la transcriptasa inversa, utiles para el tratamiento de enfermedades mediadas por el vih o el arc y composiciones farmaceuticas que los contienen.

Country Status (15)

Country Link
US (1) US7906540B2 (es)
EP (1) EP2142520A1 (es)
JP (1) JP2010522706A (es)
KR (1) KR20090127178A (es)
CN (1) CN101657433A (es)
AR (1) AR067271A1 (es)
AU (1) AU2008233929A1 (es)
BR (1) BRPI0809617A2 (es)
CA (1) CA2682637A1 (es)
CL (1) CL2008000862A1 (es)
IL (1) IL200748A0 (es)
MX (1) MX2009009920A (es)
PE (1) PE20090067A1 (es)
TW (1) TW200901985A (es)
WO (1) WO2008119662A1 (es)

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AR095079A1 (es) 2013-03-12 2015-09-16 Hoffmann La Roche Derivados de octahidro-pirrolo[3,4-c]-pirrol y piridina-fenilo
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MY187449A (en) 2013-11-26 2021-09-22 Hoffmann La Roche New octahydro-cyclobuta [1,2-c;3,4-c']dipyrrol-2-yl
HUE046820T2 (hu) 2014-03-26 2020-03-30 Hoffmann La Roche Biciklusos vegyületek autotaxin (ATX) és lizofoszfatidsav (LPA) termelésgátlókként
JP6554481B2 (ja) 2014-03-26 2019-07-31 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ オートタキシン（ａｔｘ）及びリゾホスファチジン酸（ｌｐａ）産生の阻害剤としての縮合［１，４］ジアゼピン化合物
MA41898A (fr) 2015-04-10 2018-02-13 Hoffmann La Roche Dérivés de quinazolinone bicyclique
CR20180058A (es) 2015-09-04 2018-02-26 Hoffmann La Roche Nuevos derivados de fenoximetilo
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KR20180054830A (ko) 2015-09-24 2018-05-24 에프. 호프만-라 로슈 아게 오토탁신(atx) 억제제로서의 이환형 화합물
CN107922415B (zh) 2015-09-24 2022-04-15 豪夫迈·罗氏有限公司 新的作为双重atx/ca抑制剂的二环化合物
MX2018001890A (es) 2015-09-24 2018-06-20 Hoffmann La Roche Compuestos biciclicos como inhibidores de autotaxina (atx).
WO2018167113A1 (en) 2017-03-16 2018-09-20 F. Hoffmann-La Roche Ag New bicyclic compounds as atx inhibitors
CR20190423A (es) 2017-03-16 2019-11-01 Hoffmann La Roche Nuevos compuestos biciclícos como inhibidores dobles de atx/ca
KR20190110740A (ko) * 2018-03-21 2019-10-01 주식회사유한양행 신규의 아릴 또는 헤테로아릴 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
KR20190110736A (ko) * 2018-03-21 2019-10-01 주식회사유한양행 신규의 트라이아졸론 유도체 또는 이의 염 및 이를 포함하는 약학 조성물
MX2021007069A (es) * 2018-12-14 2021-10-01 Yuhan Corp 3,3-difluoroalilaminas o sales de las mismas y composiciones farmaceuticas que comprenden las mismas.
TW202039486A (zh) 2018-12-14 2020-11-01 南韓商柳韓洋行股份有限公司 三唑并吡啶-3-酮化物或其鹽及包含彼之醫藥組合物
CN111440147B (zh) * 2020-05-19 2023-03-07 苏州卫生职业技术学院 N-(2-甲基-5-氨基苯基)-4-(3-吡啶基)-2-嘧啶胺的合成方法
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CN112220771B (zh) * 2020-11-10 2023-03-31 成都大学 扎西他滨渗透泵型控释片及其制备方法

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Also Published As

Publication number Publication date
PE20090067A1 (es) 2009-01-26
JP2010522706A (ja) 2010-07-08
CA2682637A1 (en) 2008-10-09
TW200901985A (en) 2009-01-16
CL2008000862A1 (es) 2008-11-14
IL200748A0 (en) 2010-05-17
BRPI0809617A2 (pt) 2014-09-16
WO2008119662A1 (en) 2008-10-09
MX2009009920A (es) 2009-10-19
AU2008233929A1 (en) 2008-10-09
US7906540B2 (en) 2011-03-15
US20080249151A1 (en) 2008-10-09
KR20090127178A (ko) 2009-12-09
EP2142520A1 (en) 2010-01-13
CN101657433A (zh) 2010-02-24

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