AR069789A1 - Pirazoles condensados, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento del sida o el arc. - Google Patents
Pirazoles condensados, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento del sida o el arc.Info
- Publication number
- AR069789A1 AR069789A1 ARP080105508A ARP080105508A AR069789A1 AR 069789 A1 AR069789 A1 AR 069789A1 AR P080105508 A ARP080105508 A AR P080105508A AR P080105508 A ARP080105508 A AR P080105508A AR 069789 A1 AR069789 A1 AR 069789A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- hydrogen
- treatment
- aids
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Pirazoles condensados y sus sales farmacéuticamente aceptables inhiben la transcriptasa inversa del VIH-1 y pueden utilizarse para la prevencion y tratamiento de infecciones del VIH-1 y para el tratamiento del SIDA y/o del ARC. Composiciones que contienen compuestos de la formula 1 utiles para la prevencion y tratamiento de infecciones del VIH-1 y para ej tratamiento del SIDA y/o del ARC. Reivindicacion 1: Un compuesto de la formula 1 en la que: X1 y X2 son con independencia CH o N; R1 es fluor o hidrogeno; R2 es hidrogeno, halogeno, alquilo C1-6, cicloalquilo C3-7, haloalquilo C1-6, alcoxi C1-6 o alquilsulfonilo C1-6; Ar es fenilo sustituido de una a tres veces por grupos elegidos con independencia de su aparicion entre el grupo formado por hidrogeno, halogeno, ciano, alquilo C1-6, alcoxi C1-6, haloalquilo C1-6 y cicloalquilo C3-7; R3 se elige con independencia de su aparicion entre el grupo formado por: (i) CH2OH; (ii) CH2O-C(=O)(CH2)nCO2R4 en el que n es un numero de 2 a 5; (iii) CH2O-C(=O)CH2OCH2CO2R4; (iv) CH2OCOR5; (v) CH2OC(=O)CHR6NH2; (vi) C(=O)R5; y (vii) CH2OP(=O)(OH)2; R4 es hidrogeno o alquilo C1-10; R5 es hidrogeno o alquilo C1-10, haloalquilo C1-10, aminoalquilo C1-10, alquil C1-3-amino-alquilo C1-10, di-alquil C1-3-amino-alquilo C1-10, alquenilo C2-10, cicloalquilo C3-7, alcoxi C1-6, aminoalcoxi C1-10, alquil C1-3-amino-alcoxilo C1-10, di-alquil C1-3-amino-alcoxi C1-10, NR7aR7b, fenilo o piridinilo; dicho anillo fenilo o piridinilo está opcionalmente sustituido con independencia de 1 a 3 veces por sustituyentes elegidos entre el grupo formado por halogeno, alquilo C1-10, alcoxi C1-3, nitro y ciano; R6 es alquilo C1-6 o la cadena lateral de un aminoácido de origen natural; R7a y R7b son con independencia hidrogeno, alquilo C1-6, aminoalquilo C1-10, alquil C1-3-amino-alquilo C1-10, di-alquil C1-3-amino-alquilo C1-10, o una sal farmacéuticamente aceptable del mismo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1614207P | 2007-12-21 | 2007-12-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR069789A1 true AR069789A1 (es) | 2010-02-17 |
Family
ID=40262294
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105508A AR069789A1 (es) | 2007-12-21 | 2008-12-18 | Pirazoles condensados, una composicion farmaceutica que los contiene y su uso en la preparacion de un medicamento para el tratamiento del sida o el arc. |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8063028B2 (es) |
| EP (1) | EP2225239B1 (es) |
| JP (1) | JP5411160B2 (es) |
| KR (2) | KR101610415B1 (es) |
| CN (1) | CN101903382B (es) |
| AR (1) | AR069789A1 (es) |
| AU (1) | AU2008340422B2 (es) |
| BR (1) | BRPI0821349A2 (es) |
| CA (1) | CA2709348C (es) |
| CL (1) | CL2008003786A1 (es) |
| ES (1) | ES2526649T3 (es) |
| IL (1) | IL205863A (es) |
| MX (1) | MX2010006397A (es) |
| PE (1) | PE20091177A1 (es) |
| RU (1) | RU2495878C2 (es) |
| TW (1) | TWI445533B (es) |
| WO (1) | WO2009080534A1 (es) |
| ZA (1) | ZA201003815B (es) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1713784A1 (en) * | 2004-02-12 | 2006-10-25 | Neurogen Corporation | Imidazo-pyridazines, triazolo-pyridazines and related benzodiazepine receptor ligands |
| JP2009529047A (ja) * | 2006-03-07 | 2009-08-13 | アレイ バイオファーマ、インコーポレイテッド | ヘテロ二環系ピラゾール化合物およびその使用 |
| CA2655128A1 (en) * | 2006-06-08 | 2007-12-21 | Array Biopharma Inc. | Quinoline compounds and methods of use |
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| JP2012509342A (ja) | 2008-11-20 | 2012-04-19 | オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド | 置換ピロロ［２，３−ｂ］−ピリジンおよび−ピラジン |
| ES2434247T3 (es) | 2008-12-22 | 2013-12-16 | Merck Patent Gmbh | Formas polimórficas novedosas de dihidrogenofosfato de 6-(1-metil-1H-pirazol-4-il)-2-{3-[5-(2-morfolin-4-il-etoxi)-pirimidin-2-il]-bencil}-2H-piridazin-3-ona y procesos de fabricación de las mismas |
| CN102666537A (zh) * | 2009-10-20 | 2012-09-12 | 艾格尔生物制药股份有限公司 | 治疗黄病毒科病毒感染的氮杂吲唑 |
| BR112012012085A2 (pt) | 2009-11-21 | 2016-05-17 | Hoffmann La Roche | compostos antivirais heterocíclicos |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| US20130072495A1 (en) * | 2010-05-14 | 2013-03-21 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
| US10872283B2 (en) | 2018-10-31 | 2020-12-22 | United Services Automobile Association (Usaa) | Wireless communications device with concealed value |
| AR117169A1 (es) * | 2018-11-28 | 2021-07-14 | Bayer Ag | (tio)amidas de piridazina como compuestos fungicidas |
| CN111153775B (zh) * | 2020-01-16 | 2023-04-28 | 江苏理工学院 | 一种三氯生甲酯的制备方法 |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4949314A (en) | 1966-08-16 | 1990-08-14 | The United States Of America As Represented By The Secretary Of The Navy | Method and means for increasing echo-ranging-search rate |
| US4518584A (en) | 1983-04-15 | 1985-05-21 | Cetus Corporation | Human recombinant interleukin-2 muteins |
| GB8327880D0 (en) | 1983-10-18 | 1983-11-16 | Ajinomoto Kk | Saccharomyces cerevisiae |
| US4530787A (en) | 1984-03-28 | 1985-07-23 | Cetus Corporation | Controlled oxidation of microbially produced cysteine-containing proteins |
| US4569790A (en) | 1984-03-28 | 1986-02-11 | Cetus Corporation | Process for recovering microbially produced interleukin-2 and purified recombinant interleukin-2 compositions |
| US4604377A (en) | 1984-03-28 | 1986-08-05 | Cetus Corporation | Pharmaceutical compositions of microbially produced interleukin-2 |
| IL76360A0 (en) | 1984-09-26 | 1986-01-31 | Takeda Chemical Industries Ltd | Mutual separation of proteins |
| US4752585A (en) | 1985-12-17 | 1988-06-21 | Cetus Corporation | Oxidation-resistant muteins |
| US4748234A (en) | 1985-06-26 | 1988-05-31 | Cetus Corporation | Process for recovering refractile bodies containing heterologous proteins from microbial hosts |
| AU622926B2 (en) | 1988-09-09 | 1992-04-30 | Nippon Kayaku Kabushiki Kaisha | Pyrimidine or purine cyclobutane derivatives |
| US5925643A (en) | 1990-12-05 | 1999-07-20 | Emory University | Enantiomerically pure β-D-dioxolane-nucleosides |
| US5489697A (en) | 1994-08-03 | 1996-02-06 | Medichem Research, Inc. | Method for the preparation of (+)-calanolide A and intermediates thereof |
| CA2200316C (en) | 1994-09-26 | 2004-09-21 | Hirohiko Sugimoto | Imidazole derivative |
| IL117574A0 (en) | 1995-04-03 | 1996-07-23 | Bristol Myers Squibb Co | Processes for the preparation of cyclobutanone derivatives |
| GB0016787D0 (en) | 2000-07-07 | 2000-08-30 | Pfizer Ltd | Compounds useful in therapy |
| GB0024795D0 (en) | 2000-10-10 | 2000-11-22 | Hoffmann La Roche | Pyrazole derivatives for the treatment of viral diseases |
| NZ529403A (en) | 2001-04-10 | 2005-06-24 | Pfizer | Pyrazole derivatives for treating HIV |
| GB0113524D0 (en) | 2001-06-04 | 2001-07-25 | Hoffmann La Roche | Pyrazole derivatives |
| GB0124848D0 (en) * | 2001-10-16 | 2001-12-05 | Celltech R&D Ltd | Chemical compounds |
| CN102219750B (zh) | 2001-10-26 | 2013-05-29 | P.安杰莱蒂分子生物学研究所 | 关于hiv整合酶的n-取代的羟基嘧啶酮甲酰胺抑制剂 |
| FR2841551B1 (fr) | 2002-06-28 | 2006-01-13 | Rhodia Chimie Sa | Procede de synthese de derives a radical hydrogenofluoromethylene-sulfonyle |
| JP2006504803A (ja) | 2002-09-26 | 2006-02-09 | ファイザー・インク | ピラゾール誘導体 |
| GB0223234D0 (en) | 2002-10-07 | 2002-11-13 | Pfizer Ltd | Chemical compounds |
| GB0223232D0 (en) | 2002-10-07 | 2002-11-13 | Pfizer Ltd | Chemical compounds |
| TW200423930A (en) * | 2003-02-18 | 2004-11-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitors |
| EP1608629A1 (en) * | 2003-03-24 | 2005-12-28 | F. Hoffmann-La Roche Ag | Benzyl-pyridazinons as reverse transcriptase inhibitors |
| TW200505441A (en) * | 2003-03-24 | 2005-02-16 | Hoffmann La Roche | Non-nucleoside reverse transcriptase inhibitorsⅠ |
| WO2005090317A1 (en) * | 2004-03-23 | 2005-09-29 | F.Hoffmann-La Roche Ag | Non-nucleoside reverse transcriptase inhibitors |
| US7625949B2 (en) * | 2004-04-23 | 2009-12-01 | Roche Palo Alto Llc | Methods for treating retroviral infections |
| US7166738B2 (en) * | 2004-04-23 | 2007-01-23 | Roche Palo Alto Llc | Non-nucleoside reverse transcriptase inhibitors |
| RU2394028C2 (ru) | 2004-07-27 | 2010-07-10 | Ф.Хоффманн-Ля Рош Аг | Производные бензилтриазолона в качестве ненуклеозидных ингибиторов обратной транскриптазы |
| CA2577144C (en) * | 2004-09-30 | 2011-06-21 | Boehringer Ingelheim International Gmbh | Alkynyl compounds as non-nucleoside reverse transcriptase inhibitors |
| EP1836211B1 (en) | 2004-12-21 | 2010-03-03 | Pfizer Products Inc. | Macrolides |
| WO2006067587A2 (en) | 2004-12-22 | 2006-06-29 | Pfizer Limited | Nonnucleoside inhibitors of hiv-1 reverse transcriptase |
| WO2006099978A1 (en) * | 2005-03-24 | 2006-09-28 | F.Hoffmann-La Roche Ag | 1,2,4-triazole-5-one compounds as heterocyclic reverse transcriptase inhibitors |
| AR057455A1 (es) * | 2005-07-22 | 2007-12-05 | Merck & Co Inc | Inhibidores de la transcriptasa reversa de vih y composicion farmaceutica |
| BRPI0617205A2 (pt) * | 2005-09-30 | 2011-07-19 | Hoffmann La Roche | inibidores de nnrt |
| CN101291905A (zh) * | 2005-10-19 | 2008-10-22 | 弗·哈夫曼-拉罗切有限公司 | 苯乙酰胺nnrt抑制剂 |
| ATE425138T1 (de) * | 2005-10-19 | 2009-03-15 | Hoffmann La Roche | N-phenyl-phenylacetamid-nichtnukleosidinhibitor n reverser transkriptase |
| US20090306373A1 (en) * | 2005-12-20 | 2009-12-10 | Gamber Gabriel G | 4,7-dihydrothieno[2,3-b]pyridine compounds and pharmaceutical compositions |
| ES2360893T3 (es) * | 2006-08-16 | 2011-06-10 | F. Hoffmann-La Roche Ag | Inhibidores no nucleósidos de la transcriptasa inversa. |
| BRPI0810496A2 (pt) * | 2007-04-09 | 2018-11-06 | Hoffmann La Roche | inibidores de transcriptase reversa de não-nucleosídeo |
-
2008
- 2008-12-11 AU AU2008340422A patent/AU2008340422B2/en not_active Ceased
- 2008-12-11 WO PCT/EP2008/067274 patent/WO2009080534A1/en active Application Filing
- 2008-12-11 BR BRPI0821349A patent/BRPI0821349A2/pt not_active IP Right Cessation
- 2008-12-11 EP EP08865894.3A patent/EP2225239B1/en not_active Not-in-force
- 2008-12-11 ES ES08865894.3T patent/ES2526649T3/es active Active
- 2008-12-11 KR KR1020107013573A patent/KR101610415B1/ko not_active IP Right Cessation
- 2008-12-11 JP JP2010538588A patent/JP5411160B2/ja not_active Expired - Fee Related
- 2008-12-11 RU RU2010129548/04A patent/RU2495878C2/ru not_active IP Right Cessation
- 2008-12-11 KR KR1020157015293A patent/KR101610607B1/ko not_active IP Right Cessation
- 2008-12-11 MX MX2010006397A patent/MX2010006397A/es active IP Right Grant
- 2008-12-11 CA CA2709348A patent/CA2709348C/en not_active Expired - Fee Related
- 2008-12-11 CN CN2008801215821A patent/CN101903382B/zh not_active Expired - Fee Related
- 2008-12-18 CL CL2008003786A patent/CL2008003786A1/es unknown
- 2008-12-18 PE PE2008002137A patent/PE20091177A1/es not_active Application Discontinuation
- 2008-12-18 TW TW097149409A patent/TWI445533B/zh not_active IP Right Cessation
- 2008-12-18 AR ARP080105508A patent/AR069789A1/es unknown
- 2008-12-22 US US12/341,594 patent/US8063028B2/en not_active Expired - Fee Related
-
2010
- 2010-05-20 IL IL205863A patent/IL205863A/en not_active IP Right Cessation
- 2010-05-27 ZA ZA2010/03815A patent/ZA201003815B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2495878C2 (ru) | 2013-10-20 |
| TW200930372A (en) | 2009-07-16 |
| IL205863A (en) | 2016-08-31 |
| KR101610415B1 (ko) | 2016-04-07 |
| KR20100095606A (ko) | 2010-08-31 |
| MX2010006397A (es) | 2010-07-05 |
| EP2225239B1 (en) | 2014-10-22 |
| JP5411160B2 (ja) | 2014-02-12 |
| JP2011506535A (ja) | 2011-03-03 |
| EP2225239A1 (en) | 2010-09-08 |
| KR101610607B1 (ko) | 2016-04-07 |
| TWI445533B (zh) | 2014-07-21 |
| IL205863A0 (en) | 2010-11-30 |
| US8063028B2 (en) | 2011-11-22 |
| ES2526649T3 (es) | 2015-01-14 |
| RU2010129548A (ru) | 2012-01-27 |
| ZA201003815B (en) | 2011-02-23 |
| US20090170856A1 (en) | 2009-07-02 |
| CA2709348A1 (en) | 2009-07-02 |
| PE20091177A1 (es) | 2009-08-03 |
| CA2709348C (en) | 2016-07-19 |
| WO2009080534A1 (en) | 2009-07-02 |
| BRPI0821349A2 (pt) | 2019-09-24 |
| CN101903382B (zh) | 2012-11-28 |
| AU2008340422A1 (en) | 2009-07-02 |
| AU2008340422B2 (en) | 2014-06-19 |
| CN101903382A (zh) | 2010-12-01 |
| KR20150070440A (ko) | 2015-06-24 |
| CL2008003786A1 (es) | 2010-02-19 |
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