BR0011274A - Derivados tipo indol como inibidores de p38 quinase - Google Patents
Derivados tipo indol como inibidores de p38 quinaseInfo
- Publication number
- BR0011274A BR0011274A BR0011274-7A BR0011274A BR0011274A BR 0011274 A BR0011274 A BR 0011274A BR 0011274 A BR0011274 A BR 0011274A BR 0011274 A BR0011274 A BR 0011274A
- Authority
- BR
- Brazil
- Prior art keywords
- substituent
- independently
- uninterrupted
- chain
- hydrogen
- Prior art date
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 2
- 150000002475 indoles Chemical class 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 102000002574 p38 Mitogen-Activated Protein Kinases Human genes 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
- 125000001424 substituent group Chemical group 0.000 abstract 7
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 1
- 108091000080 Phosphotransferase Proteins 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 102000020233 phosphotransferase Human genes 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an alkyl or cycloalkyl radical attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Cardiology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: "DERIVADOS TIPO INDOL COMO INIBIDORES DE p38 QUINASE". A invenção é dirigida a métodos para inibir atividade de p38-a quinase usando compostos de fórmula (I), e os sais dos mesmos farmaceuticamente aceitáveis, ou uma composição farmacêutica dos mesmos, caracterizados pelo fato de que (a) representa uma ligação única ou dupla; UM Z^ 2^ é CA ou CR^ 8^A e o outro é CR^ 1^, Cr^ 1^~ 2~, NR^ 6^ ou N em que cada R^ 1^, R^ 6^ e R^ 8^ é de modo independente hidrogênio ou substituinte não interposto; A é -W~ i~-COX~ j~Y em que Y é COR^ 2^ ou um isóstere do mesmo e R^ 2^ é hidrogênio ou um substituinte não interposto, cada de W e X é um espaçador de 2-6 <134>, e cada de i e j é de modo independente 0 ou 1; Z^ 3^ é NR^ 7^ ou O; cada R^ 3^ é de modo independente um substituinte não interposto; n é 0-3; cada de L^ 1^ e L^ 2^ é um encadeador; cada R^ 4^ é de modo independente um substituinte não interposto; m é 0-4; Z^ 1^ é CR^ 5^ ou N em que R^ 5^ é hidrogênio ou um substituinte não interposto; cada de l e k é um inteiro de 0-2 em que a soma de 1 e k é 0-3; Ar é um grupamento aril substituído com 0-5 substituintes não interpostos, em que dois substituintes não interpostos podem formar uma cadeia fundida; e a distância entre o átomo de Ar ligado a L^ 2^ e o centro da cadeia <244> é 4,5-24 <134>.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/316,761 US6589954B1 (en) | 1998-05-22 | 1999-05-21 | Compounds and methods to treat cardiac failure and other disorders |
| US15459499P | 1999-09-17 | 1999-09-17 | |
| US20260800P | 2000-05-09 | 2000-05-09 | |
| PCT/US2000/014003 WO2000071535A1 (en) | 1999-05-21 | 2000-05-19 | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR0011274A true BR0011274A (pt) | 2002-02-26 |
Family
ID=27387611
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR0011274-7A BR0011274A (pt) | 1999-05-21 | 2000-05-19 | Derivados tipo indol como inibidores de p38 quinase |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP1178983B1 (pt) |
| JP (1) | JP2003500403A (pt) |
| KR (1) | KR100743377B1 (pt) |
| CN (1) | CN1310906C (pt) |
| AT (1) | ATE376547T1 (pt) |
| AU (2) | AU772295B2 (pt) |
| BG (1) | BG106091A (pt) |
| BR (1) | BR0011274A (pt) |
| CA (1) | CA2372567A1 (pt) |
| CZ (1) | CZ20014126A3 (pt) |
| DE (1) | DE60036868D1 (pt) |
| HR (1) | HRP20010854A2 (pt) |
| HU (1) | HUP0201261A3 (pt) |
| IL (1) | IL146309A0 (pt) |
| MX (1) | MXPA01011976A (pt) |
| NO (1) | NO20015655L (pt) |
| NZ (1) | NZ515285A (pt) |
| PL (1) | PL352032A1 (pt) |
| SK (1) | SK16482001A3 (pt) |
| WO (1) | WO2000071535A1 (pt) |
Families Citing this family (56)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6541477B2 (en) | 1999-08-27 | 2003-04-01 | Scios, Inc. | Inhibitors of p38-a kinase |
| WO2001064676A2 (en) * | 2000-02-28 | 2001-09-07 | Scios, Inc. | INHIBITORS OF p38-α KINASE |
| US6573262B2 (en) | 2000-07-10 | 2003-06-03 | Bristol-Myers Sqibb Company | Composition and antiviral activity of substituted indoleoxoacetic piperazine derivatives |
| DE10037310A1 (de) * | 2000-07-28 | 2002-02-07 | Asta Medica Ag | Neue Indolderivate und deren Verwendung als Arzneimittel |
| EP1339708A2 (en) * | 2000-11-20 | 2003-09-03 | Scios Inc. | Indole-type inhibitors of p38 kinase |
| DE60125980T2 (de) | 2000-11-20 | 2007-10-25 | Scios Inc., Sunnyvale | P38kinase-inhibitoren vom piperidin/piperazin-typ |
| US20030207910A1 (en) | 2001-02-02 | 2003-11-06 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| EE05424B1 (et) * | 2001-02-02 | 2011-06-15 | Bristol-Myers Squibb Company | Asendatud asaindooloksoatseetpiperasiini derivaadid, neid sisaldav ravimpreparaat ning nende kasutamine ravis |
| US20040110785A1 (en) | 2001-02-02 | 2004-06-10 | Tao Wang | Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives |
| AU2002323475B2 (en) * | 2001-09-13 | 2006-09-28 | Synta Pharmaceuticals Corp | 2-aroylimidazole compounds for treating cancer |
| WO2003022280A2 (en) * | 2001-09-13 | 2003-03-20 | Synta Pharmaceuticals Corp. | 3-glyoxlylamideindoles for treating cancer |
| GB0124933D0 (en) | 2001-10-17 | 2001-12-05 | Glaxo Group Ltd | Chemical compounds |
| IL161667A0 (en) * | 2001-11-09 | 2004-09-27 | Scios Inc | Method and composition to treat cystic fibrosis |
| JPWO2003043988A1 (ja) * | 2001-11-22 | 2005-03-10 | 小野薬品工業株式会社 | ピペリジン−２−オン誘導体化合物およびその化合物を有効成分として含有する薬剤 |
| CA2479520A1 (en) * | 2002-04-05 | 2003-10-16 | Birgit Jung | P38 kinase inhibitors for treating mucus hypersecretion_ |
| GB0209818D0 (en) | 2002-04-30 | 2002-06-05 | Koninkl Philips Electronics Nv | Antenna arrangement |
| DE60310730T2 (de) | 2002-07-09 | 2007-05-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Pharmazeutische zusammensetzungen aus anticholinergica und p38 kinase hemmern zur behandlung von erkrankungen der atemwege |
| AU2003262911A1 (en) | 2002-08-29 | 2004-03-19 | Scios Inc. | Methods of promoting osteogenesis |
| WO2004022712A2 (en) * | 2002-09-03 | 2004-03-18 | Scios Inc. | INDOLE-TYPE DERIVATIVES AS INHIBITORS OF p38 KINASE |
| JP2006505552A (ja) * | 2002-10-09 | 2006-02-16 | サイオス インク． | ｐ３８キナーゼ阻害剤としてのアザインドール系誘導体 |
| US20040171659A1 (en) * | 2002-12-06 | 2004-09-02 | Satyanarayana Medicherla | Methods for treating diabetes |
| US7135575B2 (en) | 2003-03-03 | 2006-11-14 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| WO2004078116A2 (en) | 2003-03-03 | 2004-09-16 | Array Biopharma, Inc. | P38 inhibitors and methods of use thereof |
| AU2004247626B8 (en) | 2003-05-15 | 2011-05-19 | Arqule, Inc. | Imidazothiazoles and imidazoxazole derivatives as inhibitors of p38 |
| WO2004101529A1 (ja) * | 2003-05-19 | 2004-11-25 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環化合物およびその医薬用途 |
| GB0318814D0 (en) | 2003-08-11 | 2003-09-10 | Smithkline Beecham Corp | Novel compounds |
| US7244441B2 (en) | 2003-09-25 | 2007-07-17 | Scios, Inc. | Stents and intra-luminal prostheses containing map kinase inhibitors |
| GB0402138D0 (en) | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
| GB0402140D0 (en) | 2004-01-30 | 2004-03-03 | Smithkline Beecham Corp | Novel compounds |
| US7829560B2 (en) | 2004-07-08 | 2010-11-09 | Arqule, Inc. | 1,4-disubstituted naphthalenes as inhibitors of P38 MAP kinase |
| US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
| US8178672B2 (en) | 2004-10-19 | 2012-05-15 | Arqule, Inc. | Synthesis of imidazooxazole and imidazothiazole inhibitors of p38 MAP kinase |
| US20060100432A1 (en) | 2004-11-09 | 2006-05-11 | Matiskella John D | Crystalline materials of 1-(4-benzoyl-piperazin-1-yl)-2-[4-methoxy-7-(3-methyl-[1,2,4]triazol-1-yl)-1H-pyrrolo[2,3-c]pyridin-3-yl]-ethane-1,2-dione |
| PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
| EP1676574A3 (en) | 2004-12-30 | 2006-07-26 | Johnson & Johnson Vision Care, Inc. | Methods for promoting survival of transplanted tissues and cells |
| GB2431927B (en) * | 2005-11-04 | 2010-03-17 | Amira Pharmaceuticals Inc | 5-Lipoxygenase-activating protein (FLAP) inhibitors |
| US7977359B2 (en) | 2005-11-04 | 2011-07-12 | Amira Pharmaceuticals, Inc. | 5-lipdxygenase-activating protein (FLAP) inhibitors |
| US8399666B2 (en) | 2005-11-04 | 2013-03-19 | Panmira Pharmaceuticals, Llc | 5-lipoxygenase-activating protein (FLAP) inhibitors |
| US7851476B2 (en) | 2005-12-14 | 2010-12-14 | Bristol-Myers Squibb Company | Crystalline forms of 1-benzoyl-4-[2-[4-methoxy-7-(3-methyl-1H-1,2,4-triazol-1-YL)-1-[(phosphonooxy)methyl]-1H-pyrrolo[2,3-C]pyridin-3-YL]-1,2-dioxoethyl]-piperazine |
| CN101415685B (zh) | 2006-01-31 | 2011-08-24 | 阿雷生物药品公司 | 激酶抑制剂及其使用方法 |
| US7807671B2 (en) | 2006-04-25 | 2010-10-05 | Bristol-Myers Squibb Company | Diketo-piperazine and piperidine derivatives as antiviral agents |
| WO2008024391A1 (en) * | 2006-08-22 | 2008-02-28 | Scios Inc. | Pharmaceutical formulations of an indole-type derivative and related methods of use |
| EP1992344A1 (en) | 2007-05-18 | 2008-11-19 | Institut Curie | P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation |
| AR072008A1 (es) * | 2008-06-13 | 2010-07-28 | Merck & Co Inc | Compuestos heterobiciclicos como agentes de inhibicion de quinasa p38 |
| EP2445877B1 (en) | 2008-12-03 | 2014-07-23 | Nanotherapeutics, Inc. | Bicyclic compounds and methods of making and using same |
| PL2648516T3 (pl) | 2010-12-06 | 2019-04-30 | Aclaris Therapeutics Inc | Podstawione związki pirydynono-pirydynylowe |
| US9359300B2 (en) | 2010-12-06 | 2016-06-07 | Confluence Life Sciences, Inc. | Methyl/difluorophenyl-methoxy substituted pyridinone-pyridinyl compounds, methyl-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds, and methyl-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| US8563558B2 (en) | 2010-12-06 | 2013-10-22 | Confluence Life Sciences, Inc. | Substituted pyridine urea compounds |
| US8507499B2 (en) | 2010-12-06 | 2013-08-13 | Confluence Life Sciences, Inc. | Substituted indole/indazole-pyrimidinyl compounds |
| WO2013086208A1 (en) | 2011-12-06 | 2013-06-13 | Confluence Life Sciences, Inc. | Substituted pyrimidinone-phenyl-pyrimidinyl compounds |
| CA2917344C (en) | 2013-06-07 | 2021-09-07 | Confluence Life Sciences, Inc. | Methyl/fluoro-pyridinyl-methoxy substituted pyridinone-pyridinyl compounds and fluoro-pyrimidinyl-methoxy substituted pyridinone-pyridinyl compounds |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| CN114732910A (zh) | 2017-10-05 | 2022-07-12 | 弗尔康医疗公司 | P38激酶抑制剂降低dux4和下游基因表达以用于治疗fshd |
| US10342786B2 (en) | 2017-10-05 | 2019-07-09 | Fulcrum Therapeutics, Inc. | P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD |
| JP2023519890A (ja) | 2020-03-27 | 2023-05-15 | アクラリス セラピューティクス，インコーポレイテッド | 免疫状態の処置のためのｍｋ２経路阻害剤の経口組成物 |
| WO2023030487A1 (zh) * | 2021-09-03 | 2023-03-09 | 深圳零一生命科技有限责任公司 | 吲哚类化合物及其制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283248A (en) * | 1989-11-21 | 1994-02-01 | Hoffmann-La Roche Inc. | Amino substituted pyrimido[1,6-2]benzimidazoles |
| CA2028530A1 (en) * | 1989-11-21 | 1991-05-22 | Christian Hubschwerlen | Substituted pyrimidobenzimidazole derivatives |
| WO1998006715A1 (en) * | 1996-08-09 | 1998-02-19 | Smithkline Beecham Corporation | Novel piperazine containing compounds |
| US6093742A (en) * | 1997-06-27 | 2000-07-25 | Vertex Pharmaceuticals, Inc. | Inhibitors of p38 |
| JP2002515891A (ja) * | 1997-12-19 | 2002-05-28 | スミスクライン・ビーチャム・コーポレイション | 新規なピペリジン含有化合物 |
| EP1080078B1 (en) * | 1998-05-22 | 2006-02-01 | Scios Inc. | Heterocyclic compounds and methods to treat cardiac failure and other disorders |
| CN1261098C (zh) * | 1998-08-28 | 2006-06-28 | 西奥斯股份有限公司 | p38－α激酶的抑制剂 |
-
2000
- 2000-05-19 IL IL14630900A patent/IL146309A0/xx active IP Right Grant
- 2000-05-19 SK SK1648-2001A patent/SK16482001A3/sk unknown
- 2000-05-19 PL PL00352032A patent/PL352032A1/xx unknown
- 2000-05-19 CZ CZ20014126A patent/CZ20014126A3/cs unknown
- 2000-05-19 KR KR1020017014870A patent/KR100743377B1/ko not_active IP Right Cessation
- 2000-05-19 CA CA002372567A patent/CA2372567A1/en not_active Abandoned
- 2000-05-19 BR BR0011274-7A patent/BR0011274A/pt not_active Application Discontinuation
- 2000-05-19 MX MXPA01011976A patent/MXPA01011976A/es not_active Application Discontinuation
- 2000-05-19 DE DE60036868T patent/DE60036868D1/de not_active Expired - Lifetime
- 2000-05-19 JP JP2000619792A patent/JP2003500403A/ja active Pending
- 2000-05-19 NZ NZ515285A patent/NZ515285A/xx not_active IP Right Cessation
- 2000-05-19 CN CNB00807724XA patent/CN1310906C/zh not_active Expired - Fee Related
- 2000-05-19 AT AT00939322T patent/ATE376547T1/de not_active IP Right Cessation
- 2000-05-19 AU AU54424/00A patent/AU772295B2/en not_active Ceased
- 2000-05-19 EP EP00939322A patent/EP1178983B1/en not_active Expired - Lifetime
- 2000-05-19 WO PCT/US2000/014003 patent/WO2000071535A1/en active IP Right Grant
- 2000-05-19 HU HU0201261A patent/HUP0201261A3/hu unknown
-
2001
- 2001-11-08 BG BG106091A patent/BG106091A/xx unknown
- 2001-11-19 HR HR20010854A patent/HRP20010854A2/hr not_active Application Discontinuation
- 2001-11-20 NO NO20015655A patent/NO20015655L/no unknown
-
2004
- 2004-07-22 AU AU2004203356A patent/AU2004203356A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| DE60036868D1 (de) | 2007-12-06 |
| WO2000071535A1 (en) | 2000-11-30 |
| AU772295B2 (en) | 2004-04-22 |
| EP1178983B1 (en) | 2007-10-24 |
| KR20020019919A (ko) | 2002-03-13 |
| BG106091A (en) | 2002-06-28 |
| NO20015655D0 (no) | 2001-11-20 |
| IL146309A0 (en) | 2002-07-25 |
| HUP0201261A2 (en) | 2002-08-28 |
| CN1351599A (zh) | 2002-05-29 |
| HUP0201261A3 (en) | 2003-12-29 |
| AU2004203356A1 (en) | 2004-08-19 |
| HRP20010854A2 (en) | 2003-04-30 |
| NZ515285A (en) | 2004-01-30 |
| EP1178983A1 (en) | 2002-02-13 |
| CA2372567A1 (en) | 2000-11-30 |
| MXPA01011976A (es) | 2002-05-06 |
| PL352032A1 (en) | 2003-07-28 |
| AU5442400A (en) | 2000-12-12 |
| CZ20014126A3 (cs) | 2002-03-13 |
| JP2003500403A (ja) | 2003-01-07 |
| ATE376547T1 (de) | 2007-11-15 |
| SK16482001A3 (sk) | 2002-04-04 |
| KR100743377B1 (ko) | 2007-07-30 |
| CN1310906C (zh) | 2007-04-18 |
| NO20015655L (no) | 2002-01-18 |
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