HUP0102563A2 - Indolszármazékok és alkalmazásuk rosszindulatú és egyéb, patológiás sejtproliferáción alapuló megbetegedések kezelésére - Google Patents
Indolszármazékok és alkalmazásuk rosszindulatú és egyéb, patológiás sejtproliferáción alapuló megbetegedések kezeléséreInfo
- Publication number
- HUP0102563A2 HUP0102563A2 HU0102563A HUP0102563A HUP0102563A2 HU P0102563 A2 HUP0102563 A2 HU P0102563A2 HU 0102563 A HU0102563 A HU 0102563A HU P0102563 A HUP0102563 A HU P0102563A HU P0102563 A2 HUP0102563 A2 HU P0102563A2
- Authority
- HU
- Hungary
- Prior art keywords
- group
- general formula
- atom
- optionally substituted
- hydrogen atom
- Prior art date
Links
- 230000004663 cell proliferation Effects 0.000 title abstract 2
- 201000010099 disease Diseases 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 2
- 230000003211 malignant effect Effects 0.000 title abstract 2
- 230000001575 pathological effect Effects 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- 150000002475 indoles Chemical class 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 8
- 229910052757 nitrogen Inorganic materials 0.000 abstract 5
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 125000004849 alkoxymethyl group Chemical group 0.000 abstract 3
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005103 alkyl silyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- -1 carbamoylmethyl Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 125000003170 phenylsulfonyl group Chemical group C1(=CC=CC=C1)S(=O)(=O)* 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 1
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Abstract
A találmány (I) általános képletű tirozin-kináz inhibitorokra, -amelyek képletében Z (II) általános képletű csoport, A nitrogén-,oxigén- vagy kénatom, B és B' szén-, nitrogén-, oxigén- vagy kénatom,F és G telített vagy telítetlen, öt- és hattagú gyűrű, X (III) vagy(IV) általános képletű csoport, -CH2)-[CR14R15]m-(CH)n (III) ahol 1 ésn értéke 0, 1, 2, 3, 4, 5 vagy 6, m értéke 1 vagy 2, R14 és R15 együttoxigénatomot jelent, vagy R14 hidroxicsoport, és R15 hidrogénatom,vagy R14 és R15 hidrogénatom, R16 hidrogénatom, adott esetbenszubsztituált alkil-, aril- vagy alkoxi-metil-csoport, R2 és R13együtt (V) vagy (VI) általános képletű csoport, ahol <- egyes vagykettős kötés, o értéke 1 vagy 2, R2 és R13 hidrogénatom vagy (VII)általános képletű csoport, ahol R17 halogénatom vagy (VIII) általánosképletű csoport, ahol p értéke 0, 1 vagy 2, ahol ha p értéke 0, Yszén, oxigén- vagy nitrogénatom, és ha Y jelentése szén- vagynitrogénatom, akkor R18 hidrogénatom, adott esetben szubsztituáltalkil-, aril-, heterociklusos, alkoxi-karbonil-, karbamoil-metil-csoport, R2 és R13 együtt egy (IX) vagy (X) általános képletű csoport,ahol W szén- vagy nitrogénatom, q 0, 1, 2, 3, 4, 5 vagy 6, valamintRl9 és R20 hidrogénatom, adott esetben szubsztituált alkilcsoport, R1és R7 hidrogénatom, alkil-, amino-alkil-, fenil-szulfonil-,[(alkil-szilil)-metoxi]-metil-csoport, vagy adott esetben szubsztituáltcukorcsoport, R3, R4, R5, R6, R8, R9, R10 és R11 hidrogénatom, adottesetben szubsztituált alkil-, alkoxi-, alkoxi-metil-csoport,nitrocsoport, halogénatom vagy -O-(C=O)-R21 csoport, ahol R21szubsztituált alkil-, alkoxi-, alkoxi-metil-csoport -a vegyületekettartalmazó gyógyszerkészítményekre, valamint a vegyületekrosszindulatú és egyéb, patológiás sejtproliferáción alapulómegbetegedések kezelésére történő alkalmazására vonatkozik. Ó
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19819835 | 1998-05-04 | ||
| DE19838506A DE19838506C2 (de) | 1998-05-04 | 1998-08-25 | Indolderivate und deren Verwendung zur Behandlung von malignen und anderen, auf pathologischen Zellproliferationen beruhenden Erkrankungen |
| PCT/DE1999/001214 WO1999057117A2 (de) | 1998-05-04 | 1999-04-22 | Indolderivate und deren verwendung zur behandlung von malignen und anderen, auf pathologischen zellproliferationen beruhenden erkrankungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP0102563A2 true HUP0102563A2 (hu) | 2001-11-28 |
| HUP0102563A3 HUP0102563A3 (en) | 2003-04-28 |
Family
ID=26045937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU0102563A HUP0102563A3 (en) | 1998-05-04 | 1999-04-22 | Indole derivatives and their use in the treatment of malignant and other diseases caused by pathological cell proliferation |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6407102B1 (hu) |
| EP (1) | EP1109785B1 (hu) |
| JP (1) | JP2002514572A (hu) |
| CN (1) | CN1151127C (hu) |
| AT (1) | ATE230394T1 (hu) |
| AU (1) | AU752464B2 (hu) |
| BG (1) | BG104996A (hu) |
| BR (1) | BR9911017A (hu) |
| CA (1) | CA2330756C (hu) |
| CZ (1) | CZ20003960A3 (hu) |
| DE (1) | DE59903921D1 (hu) |
| DK (1) | DK1109785T3 (hu) |
| ES (1) | ES2190221T3 (hu) |
| HK (1) | HK1038354A1 (hu) |
| HU (1) | HUP0102563A3 (hu) |
| IL (1) | IL139056A0 (hu) |
| NO (1) | NO317261B1 (hu) |
| NZ (1) | NZ507735A (hu) |
| PL (1) | PL346840A1 (hu) |
| SK (1) | SK16352000A3 (hu) |
| TR (1) | TR200003206T2 (hu) |
| WO (1) | WO1999057117A2 (hu) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SK16352000A3 (sk) | 1998-05-04 | 2002-07-02 | Zentaris Ag | Indolové deriváty, spôsob ich výroby, ich použitie na liečivá obsahujúce tieto zlúčeniny |
| US6719520B2 (en) | 1998-10-08 | 2004-04-13 | Smithkline Beecham Corporation | Method and compounds |
| JP2002527419A (ja) * | 1998-10-08 | 2002-08-27 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | Ｇｓｋ−３阻害物質としてのピロール−２，５−ジオン類 |
| WO2002000641A2 (en) * | 2000-06-28 | 2002-01-03 | Eli Lilly And Company | Spla2 inhibitors |
| AU2001275794A1 (en) | 2000-07-28 | 2002-02-13 | Sumitomo Pharmaceuticals Co. Ltd. | Pyrrole derivatives |
| TW557298B (en) * | 2000-08-14 | 2003-10-11 | Ciba Sc Holding Ag | A compound, a photopolymerizible composition, a process for producing coatings and a method for causing a photoinitiator to accumulate at the surface of coatings |
| US20030032625A1 (en) * | 2001-03-29 | 2003-02-13 | Topo Target Aps | Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors |
| DE10143079A1 (de) * | 2001-09-03 | 2003-05-15 | Zentaris Ag | Cyclische Indol- und Heteroindolderivate, deren Herstellung und Verwendung als Arzneimittel |
| US20050267303A1 (en) * | 2001-09-04 | 2005-12-01 | Zentaris Ag | Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals |
| EP1479384A1 (en) * | 2002-01-30 | 2004-11-24 | Sumitomo Pharmaceuticals Company, Limited | Fibrosis inhibitor |
| US6800655B2 (en) | 2002-08-20 | 2004-10-05 | Sri International | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| CA2565387A1 (en) * | 2004-05-03 | 2005-11-17 | Ilypsa, Inc. | Modulation of lysophosphatidylcholine and treatment of diet-induced conditions |
| CA2627043A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Multivalent indole compounds and use thereof as phospholipase-a2 inhibitors |
| US20090318492A1 (en) * | 2005-11-03 | 2009-12-24 | Han-Ting Chang | Indole compounds having c4-acidic substituents and use thereof as phospholipase-a2 inhibitors |
| WO2007056184A2 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Azaindole compounds and use thereof as phospholipase-a2 inhibitors |
| US20070135383A1 (en) * | 2005-11-03 | 2007-06-14 | Han-Ting Chang | Phospholipase inhibitors, including multi-valent phospholipase inhibitors, and use thereof, including as lumen-localized phospholipase inhibitors |
| US20090306171A1 (en) * | 2005-11-03 | 2009-12-10 | Han-Ting Chang | Indole compounds having c4-amide substituents and use thereof as phospholipase-a2 inhibitors |
| US20090142832A1 (en) * | 2007-11-29 | 2009-06-04 | James Dalton | Indoles, Derivatives, and Analogs Thereof and Uses Therefor |
| SI2448938T1 (sl) | 2009-06-29 | 2014-08-29 | Incyte Corporation Experimental Station | Pirimidinoni kot zaviralci pi3k |
| CN101704828A (zh) * | 2009-11-04 | 2010-05-12 | 中国科学院昆明植物研究所 | 山橙素类双吲哚化合物,其药物组合物及其制备方法和用途 |
| WO2011075643A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
| TW201130842A (en) * | 2009-12-18 | 2011-09-16 | Incyte Corp | Substituted fused aryl and heteroaryl derivatives as PI3K inhibitors |
| US9193721B2 (en) | 2010-04-14 | 2015-11-24 | Incyte Holdings Corporation | Fused derivatives as PI3Kδ inhibitors |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| ES2764848T3 (es) | 2010-12-20 | 2020-06-04 | Incyte Holdings Corp | N-(1-(fenilo sustituido)etilo)-9H-purina-6-aminas como inhibidores de PI3K |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
| HUE030869T2 (hu) | 2011-09-02 | 2017-06-28 | Incyte Holdings Corp | Heterociklusos aminok, mint PI3K inhibitorok |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| TWI748941B (zh) | 2015-02-27 | 2021-12-11 | 美商英塞特公司 | Ｐｉ３ｋ抑制劑之鹽及製備方法 |
| WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| CN106317169B (zh) * | 2015-06-23 | 2019-07-02 | 首都医科大学 | 双吲哚-二肽衍生物,其合成,抗血栓活性和制备抗血栓剂的应用 |
| CN109790191B (zh) * | 2016-08-05 | 2022-04-08 | 香港大学 | 铂配合物及其使用方法 |
| CN114364798A (zh) | 2019-03-21 | 2022-04-15 | 欧恩科斯欧公司 | 用于治疗癌症的Dbait分子与激酶抑制剂的组合 |
| WO2020245208A1 (en) | 2019-06-04 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
| WO2021089791A1 (en) | 2019-11-08 | 2021-05-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the treatment of cancers that have acquired resistance to kinase inhibitors |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598583A (en) * | 1968-08-09 | 1971-08-10 | Itek Corp | Indomethylene dye bases and their utilization in photographic processes and compositions |
| FR2688220A1 (fr) * | 1992-03-06 | 1993-09-10 | Adir | Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| WO1994024117A1 (en) * | 1993-04-22 | 1994-10-27 | Nippon Shinyaku Co., Ltd. | Benzofurancarboxylic acid derivative and pharmaceutical composition |
| US5656643A (en) | 1993-11-08 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| CA2179650C (en) * | 1993-12-23 | 2007-10-30 | William Francis Heath, Jr. | Bisindolemaleimides and their use as protein kinase c inhibitors |
| JPH08295688A (ja) * | 1995-04-28 | 1996-11-12 | Sharp Corp | ビスアゾ化合物、その中間体及びそれらの製造方法、並びにビスアゾ化合物を含有する電子写真感光体 |
| DE19547263C2 (de) * | 1995-12-07 | 1999-04-29 | Cardiotec Inc | Amidinohydrazone vom Benzo[b]furan abgeleiteter Ketone, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| SK16352000A3 (sk) | 1998-05-04 | 2002-07-02 | Zentaris Ag | Indolové deriváty, spôsob ich výroby, ich použitie na liečivá obsahujúce tieto zlúčeniny |
-
1999
- 1999-04-22 SK SK1635-2000A patent/SK16352000A3/sk unknown
- 1999-04-22 IL IL13905699A patent/IL139056A0/xx not_active IP Right Cessation
- 1999-04-22 HU HU0102563A patent/HUP0102563A3/hu unknown
- 1999-04-22 CN CNB998058033A patent/CN1151127C/zh not_active Expired - Fee Related
- 1999-04-22 BR BR9911017-2A patent/BR9911017A/pt not_active IP Right Cessation
- 1999-04-22 DK DK99927711T patent/DK1109785T3/da active
- 1999-04-22 JP JP2000547087A patent/JP2002514572A/ja not_active Withdrawn
- 1999-04-22 ES ES99927711T patent/ES2190221T3/es not_active Expired - Lifetime
- 1999-04-22 WO PCT/DE1999/001214 patent/WO1999057117A2/de not_active Application Discontinuation
- 1999-04-22 AU AU44975/99A patent/AU752464B2/en not_active Ceased
- 1999-04-22 PL PL99346840A patent/PL346840A1/xx not_active Application Discontinuation
- 1999-04-22 AT AT99927711T patent/ATE230394T1/de not_active IP Right Cessation
- 1999-04-22 EP EP99927711A patent/EP1109785B1/de not_active Expired - Lifetime
- 1999-04-22 CA CA002330756A patent/CA2330756C/en not_active Expired - Fee Related
- 1999-04-22 CZ CZ20003960A patent/CZ20003960A3/cs unknown
- 1999-04-22 DE DE59903921T patent/DE59903921D1/de not_active Expired - Fee Related
- 1999-04-22 TR TR2000/03206T patent/TR200003206T2/xx unknown
- 1999-05-04 US US09/305,115 patent/US6407102B1/en not_active Expired - Fee Related
-
2000
- 2000-10-24 NZ NZ507735A patent/NZ507735A/xx unknown
- 2000-10-27 NO NO20005448A patent/NO317261B1/no unknown
- 2000-11-28 BG BG104996A patent/BG104996A/xx unknown
-
2001
- 2001-12-27 HK HK01109122A patent/HK1038354A1/xx not_active IP Right Cessation
-
2002
- 2002-05-03 US US10/137,653 patent/US6812243B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999057117A3 (de) | 2001-04-12 |
| CA2330756C (en) | 2007-10-02 |
| IL139056A0 (en) | 2001-11-25 |
| DE59903921D1 (de) | 2003-02-06 |
| CN1310705A (zh) | 2001-08-29 |
| DK1109785T3 (da) | 2003-04-22 |
| US6407102B1 (en) | 2002-06-18 |
| HK1038354A1 (en) | 2002-03-15 |
| EP1109785A2 (de) | 2001-06-27 |
| CZ20003960A3 (cs) | 2002-04-17 |
| TR200003206T2 (tr) | 2001-07-23 |
| ATE230394T1 (de) | 2003-01-15 |
| NZ507735A (en) | 2003-04-29 |
| US20030008898A1 (en) | 2003-01-09 |
| PL346840A1 (en) | 2002-02-25 |
| AU752464B2 (en) | 2002-09-19 |
| WO1999057117A2 (de) | 1999-11-11 |
| CN1151127C (zh) | 2004-05-26 |
| NO317261B1 (no) | 2004-09-27 |
| EP1109785B1 (de) | 2003-01-02 |
| US6812243B2 (en) | 2004-11-02 |
| AU4497599A (en) | 1999-11-23 |
| BR9911017A (pt) | 2001-02-06 |
| NO20005448L (no) | 2000-10-27 |
| ES2190221T3 (es) | 2003-07-16 |
| NO20005448D0 (no) | 2000-10-27 |
| BG104996A (en) | 2001-07-31 |
| CA2330756A1 (en) | 1999-11-11 |
| HUP0102563A3 (en) | 2003-04-28 |
| SK16352000A3 (sk) | 2002-07-02 |
| JP2002514572A (ja) | 2002-05-21 |
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| Date | Code | Title | Description |
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| FD9A | Lapse of provisional protection due to non-payment of fees |