NO20005448L - Indolderivater og deres anvendelse for behandling av maligne og andre sykdommer som er basert på patologisk celleproliferering - Google Patents
Indolderivater og deres anvendelse for behandling av maligne og andre sykdommer som er basert på patologisk celleprolifereringInfo
- Publication number
- NO20005448L NO20005448L NO20005448A NO20005448A NO20005448L NO 20005448 L NO20005448 L NO 20005448L NO 20005448 A NO20005448 A NO 20005448A NO 20005448 A NO20005448 A NO 20005448A NO 20005448 L NO20005448 L NO 20005448L
- Authority
- NO
- Norway
- Prior art keywords
- malignant
- treatment
- cell proliferation
- diseases based
- pathological cell
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
- C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D333/56—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19819835 | 1998-05-04 | ||
| DE19838506A DE19838506C2 (de) | 1998-05-04 | 1998-08-25 | Indolderivate und deren Verwendung zur Behandlung von malignen und anderen, auf pathologischen Zellproliferationen beruhenden Erkrankungen |
| PCT/DE1999/001214 WO1999057117A2 (de) | 1998-05-04 | 1999-04-22 | Indolderivate und deren verwendung zur behandlung von malignen und anderen, auf pathologischen zellproliferationen beruhenden erkrankungen |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| NO20005448L true NO20005448L (no) | 2000-10-27 |
| NO20005448D0 NO20005448D0 (no) | 2000-10-27 |
| NO317261B1 NO317261B1 (no) | 2004-09-27 |
Family
ID=26045937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NO20005448A NO317261B1 (no) | 1998-05-04 | 2000-10-27 | Indolderivater og deres anvendelse for behandling av maligne og andre sykdommer som er basert pa patologisk celleproliferering |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US6407102B1 (no) |
| EP (1) | EP1109785B1 (no) |
| JP (1) | JP2002514572A (no) |
| CN (1) | CN1151127C (no) |
| AT (1) | ATE230394T1 (no) |
| AU (1) | AU752464B2 (no) |
| BG (1) | BG104996A (no) |
| BR (1) | BR9911017A (no) |
| CA (1) | CA2330756C (no) |
| CZ (1) | CZ20003960A3 (no) |
| DE (1) | DE59903921D1 (no) |
| DK (1) | DK1109785T3 (no) |
| ES (1) | ES2190221T3 (no) |
| HK (1) | HK1038354A1 (no) |
| HU (1) | HUP0102563A3 (no) |
| IL (1) | IL139056A0 (no) |
| NO (1) | NO317261B1 (no) |
| NZ (1) | NZ507735A (no) |
| PL (1) | PL346840A1 (no) |
| SK (1) | SK16352000A3 (no) |
| TR (1) | TR200003206T2 (no) |
| WO (1) | WO1999057117A2 (no) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20003960A3 (cs) | 1998-05-04 | 2002-04-17 | Zentaris Ag | Deriváty indolu a jejich pouľití pro léčení maligních a jiných chorob vyvolaných patologickou proliferací buněk |
| US6719520B2 (en) | 1998-10-08 | 2004-04-13 | Smithkline Beecham Corporation | Method and compounds |
| ES2234300T3 (es) * | 1998-10-08 | 2005-06-16 | Smithkline Beecham Plc | 3-(3-cloro-4-hidroxifenilamino)-4-(2-nitrofenil)-1h-pirrol-2,5-diona como inhibidor de glucogeno cinasa-3 (gsk-3)sintetasa. |
| WO2002000641A2 (en) * | 2000-06-28 | 2002-01-03 | Eli Lilly And Company | Spla2 inhibitors |
| WO2002010131A1 (fr) | 2000-07-28 | 2002-02-07 | Sumitomo Pharmaceuticals Co., Ltd. | Derives du pyrrole |
| TW557298B (en) * | 2000-08-14 | 2003-10-11 | Ciba Sc Holding Ag | A compound, a photopolymerizible composition, a process for producing coatings and a method for causing a photoinitiator to accumulate at the surface of coatings |
| US20030032625A1 (en) * | 2001-03-29 | 2003-02-13 | Topo Target Aps | Succinimide and maleimide derivatives and their use as topoisomerase II catalytic inhibitors |
| DE10143079A1 (de) * | 2001-09-03 | 2003-05-15 | Zentaris Ag | Cyclische Indol- und Heteroindolderivate, deren Herstellung und Verwendung als Arzneimittel |
| US20050267303A1 (en) * | 2001-09-04 | 2005-12-01 | Zentaris Ag | Cyclic indole and heteroindole derivatives and methods for making and using as pharmaceuticals |
| EP1479384A1 (en) * | 2002-01-30 | 2004-11-24 | Sumitomo Pharmaceuticals Company, Limited | Fibrosis inhibitor |
| US6800655B2 (en) | 2002-08-20 | 2004-10-05 | Sri International | Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventive agents |
| US7098231B2 (en) | 2003-01-22 | 2006-08-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| US7223785B2 (en) | 2003-01-22 | 2007-05-29 | Boehringer Ingelheim International Gmbh | Viral polymerase inhibitors |
| WO2005107767A2 (en) * | 2004-05-03 | 2005-11-17 | Ilypsa, Inc. | Modulation of lysophosphatidylcholine and treatment of diet-induced conditions |
| JP2009514892A (ja) * | 2005-11-03 | 2009-04-09 | イリプサ， インコーポレイテッド | 多価ホスホリパーゼインヒビターを含むホスホリパーゼインヒビター、および内腔に局在化されるホスホリパーゼインヒビターとしての使用を含むその使用 |
| CA2627349A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Azaindole compounds and use thereof as phospholipase-a2 inhibitors |
| MX2008005666A (es) * | 2005-11-03 | 2009-03-02 | Ilypsa Inc | Compuestos multivalentes de indol y uso de los mismos como inhibidores de fosfolipasa-a2. |
| MX2008005660A (es) * | 2005-11-03 | 2008-12-15 | Ilypsa Inc | Compuestos de indol que tienen sustituyentes c4-amida y uso de los mismos como inhibidores de la fosfolipasa a2. |
| AU2006311766A1 (en) * | 2005-11-03 | 2007-05-18 | Ilypsa, Inc. | Indole compounds having C4-acidic substituents and use thereof as phospholipase-A2 inhibitors |
| US20090142832A1 (en) * | 2007-11-29 | 2009-06-04 | James Dalton | Indoles, Derivatives, and Analogs Thereof and Uses Therefor |
| PL2448938T3 (pl) | 2009-06-29 | 2014-11-28 | Incyte Holdings Corp | Pirymidynony jako inhibitory PI3K |
| CN101704828A (zh) * | 2009-11-04 | 2010-05-12 | 中国科学院昆明植物研究所 | 山橙素类双吲哚化合物,其药物组合物及其制备方法和用途 |
| US8759359B2 (en) * | 2009-12-18 | 2014-06-24 | Incyte Corporation | Substituted heteroaryl fused derivatives as PI3K inhibitors |
| WO2011075630A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors |
| WO2011130342A1 (en) | 2010-04-14 | 2011-10-20 | Incyte Corporation | FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS |
| US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
| JP5961187B2 (ja) | 2010-12-20 | 2016-08-02 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉ３ｋ阻害剤としてのｎ−（１−（置換フェニル）エチル）−９ｈ−プリン−６−アミン |
| US9108984B2 (en) | 2011-03-14 | 2015-08-18 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors |
| US9126948B2 (en) | 2011-03-25 | 2015-09-08 | Incyte Holdings Corporation | Pyrimidine-4,6-diamine derivatives as PI3K inhibitors |
| HUE030869T2 (en) | 2011-09-02 | 2017-06-28 | Incyte Holdings Corp | Heterocyclic amines as inhibitors of PI3K |
| AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
| WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
| AU2016222556B2 (en) | 2015-02-27 | 2020-08-27 | Incyte Holdings Corporation | Salts of Pl3K inhibitor and processes for their preparation |
| WO2016183063A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Crystalline forms of a pi3k inhibitor |
| WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
| CN106317169B (zh) * | 2015-06-23 | 2019-07-02 | 首都医科大学 | 双吲哚-二肽衍生物,其合成,抗血栓活性和制备抗血栓剂的应用 |
| CN109790191B (zh) * | 2016-08-05 | 2022-04-08 | 香港大学 | 铂配合物及其使用方法 |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| WO2020245208A1 (en) | 2019-06-04 | 2020-12-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of cd9 as a biomarker and as a biotarget in glomerulonephritis or glomerulosclerosis |
| CN114761006A (zh) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | 对激酶抑制剂产生耐药性的癌症的治疗方法 |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3598583A (en) * | 1968-08-09 | 1971-08-10 | Itek Corp | Indomethylene dye bases and their utilization in photographic processes and compositions |
| FR2688220A1 (fr) * | 1992-03-06 | 1993-09-10 | Adir | Nouveaux derives de thiazolidine-2,4-dione, leur procede de preparation et les compositions pharmaceutiques qui les contiennent. |
| AU6581094A (en) * | 1993-04-22 | 1994-11-08 | Nippon Shinyaku Co. Ltd. | Benzofurancarboxylic acid derivative and pharmaceutical composition |
| US5656643A (en) | 1993-11-08 | 1997-08-12 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Bis mono-and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase |
| EP1449529B1 (en) * | 1993-12-23 | 2010-01-27 | Eli Lilly And Company | Protein Kinase C Inhibitors |
| JPH08295688A (ja) * | 1995-04-28 | 1996-11-12 | Sharp Corp | ビスアゾ化合物、その中間体及びそれらの製造方法、並びにビスアゾ化合物を含有する電子写真感光体 |
| DE19547263C2 (de) * | 1995-12-07 | 1999-04-29 | Cardiotec Inc | Amidinohydrazone vom Benzo[b]furan abgeleiteter Ketone, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| CZ20003960A3 (cs) | 1998-05-04 | 2002-04-17 | Zentaris Ag | Deriváty indolu a jejich pouľití pro léčení maligních a jiných chorob vyvolaných patologickou proliferací buněk |
-
1999
- 1999-04-22 CZ CZ20003960A patent/CZ20003960A3/cs unknown
- 1999-04-22 AT AT99927711T patent/ATE230394T1/de not_active IP Right Cessation
- 1999-04-22 DK DK99927711T patent/DK1109785T3/da active
- 1999-04-22 DE DE59903921T patent/DE59903921D1/de not_active Expired - Fee Related
- 1999-04-22 AU AU44975/99A patent/AU752464B2/en not_active Ceased
- 1999-04-22 PL PL99346840A patent/PL346840A1/xx not_active Application Discontinuation
- 1999-04-22 CN CNB998058033A patent/CN1151127C/zh not_active Expired - Fee Related
- 1999-04-22 WO PCT/DE1999/001214 patent/WO1999057117A2/de not_active Application Discontinuation
- 1999-04-22 CA CA002330756A patent/CA2330756C/en not_active Expired - Fee Related
- 1999-04-22 SK SK1635-2000A patent/SK16352000A3/sk unknown
- 1999-04-22 JP JP2000547087A patent/JP2002514572A/ja not_active Withdrawn
- 1999-04-22 ES ES99927711T patent/ES2190221T3/es not_active Expired - Lifetime
- 1999-04-22 EP EP99927711A patent/EP1109785B1/de not_active Expired - Lifetime
- 1999-04-22 IL IL13905699A patent/IL139056A0/xx not_active IP Right Cessation
- 1999-04-22 BR BR9911017-2A patent/BR9911017A/pt not_active IP Right Cessation
- 1999-04-22 HU HU0102563A patent/HUP0102563A3/hu unknown
- 1999-04-22 TR TR2000/03206T patent/TR200003206T2/xx unknown
- 1999-05-04 US US09/305,115 patent/US6407102B1/en not_active Expired - Fee Related
-
2000
- 2000-10-24 NZ NZ507735A patent/NZ507735A/xx unknown
- 2000-10-27 NO NO20005448A patent/NO317261B1/no unknown
- 2000-11-28 BG BG104996A patent/BG104996A/xx unknown
-
2001
- 2001-12-27 HK HK01109122A patent/HK1038354A1/xx not_active IP Right Cessation
-
2002
- 2002-05-03 US US10/137,653 patent/US6812243B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| IL139056A0 (en) | 2001-11-25 |
| HUP0102563A3 (en) | 2003-04-28 |
| DE59903921D1 (de) | 2003-02-06 |
| NO317261B1 (no) | 2004-09-27 |
| US20030008898A1 (en) | 2003-01-09 |
| AU752464B2 (en) | 2002-09-19 |
| AU4497599A (en) | 1999-11-23 |
| US6407102B1 (en) | 2002-06-18 |
| NO20005448D0 (no) | 2000-10-27 |
| ES2190221T3 (es) | 2003-07-16 |
| BG104996A (en) | 2001-07-31 |
| HUP0102563A2 (hu) | 2001-11-28 |
| HK1038354A1 (en) | 2002-03-15 |
| WO1999057117A2 (de) | 1999-11-11 |
| SK16352000A3 (sk) | 2002-07-02 |
| JP2002514572A (ja) | 2002-05-21 |
| CZ20003960A3 (cs) | 2002-04-17 |
| US6812243B2 (en) | 2004-11-02 |
| DK1109785T3 (da) | 2003-04-22 |
| PL346840A1 (en) | 2002-02-25 |
| CN1310705A (zh) | 2001-08-29 |
| CA2330756A1 (en) | 1999-11-11 |
| CA2330756C (en) | 2007-10-02 |
| EP1109785A2 (de) | 2001-06-27 |
| EP1109785B1 (de) | 2003-01-02 |
| TR200003206T2 (tr) | 2001-07-23 |
| ATE230394T1 (de) | 2003-01-15 |
| WO1999057117A3 (de) | 2001-04-12 |
| NZ507735A (en) | 2003-04-29 |
| CN1151127C (zh) | 2004-05-26 |
| BR9911017A (pt) | 2001-02-06 |
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| BRPI0508881A (pt) | derivados de imidazol | |
| DK1104419T3 (da) | N-substituerede azabicyloheptan-derivater, deres fremstilling og anvendelse | |
| ATE243698T1 (de) | 1,2-dihydro-1-oxo-pyrazino(1,2-)indolederivate |