TR200003206T2 - İndol türevleri ve patolojik hücre çoğalmasının neden olduğu habis hastalıklar ve diğer hastalıkların tedavisinde kullanımları. - Google Patents

İndol türevleri ve patolojik hücre çoğalmasının neden olduğu habis hastalıklar ve diğer hastalıkların tedavisinde kullanımları.

Info

Publication number
TR200003206T2
TR200003206T2 TR2000/03206T TR200003206T TR200003206T2 TR 200003206 T2 TR200003206 T2 TR 200003206T2 TR 2000/03206 T TR2000/03206 T TR 2000/03206T TR 200003206 T TR200003206 T TR 200003206T TR 200003206 T2 TR200003206 T2 TR 200003206T2
Authority
TR
Turkey
Prior art keywords
diseases
cell proliferation
treatment
pathological cell
indole derivatives
Prior art date
Application number
TR2000/03206T
Other languages
English (en)
Inventor
Mahboobi Siavosh
Kuhr Sabine
Pongratz Herwig
Popp Alfred
Hufsky Harald
D. B�Hmer Frank
Teller Steffen
Uecker Andrea
Beckers Thomas
Original Assignee
Zentaris Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19838506A external-priority patent/DE19838506C2/de
Application filed by Zentaris Ag filed Critical Zentaris Ag
Publication of TR200003206T2 publication Critical patent/TR200003206T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/56—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems

Abstract

Bulus, (I) formülünün bis-indolil bilesiklerinin tirosin kinaz inhibitörlerine, bahsedilen inhibitörleri ihtiva eden tibbi maddelere ve bunlarin patolojik hücre çogalmasinin neden oldugu habis hastaliklar ve diger hastaliklarin tedavi edilmesinde kullanimlarina iliskindir.
TR2000/03206T 1998-05-04 1999-04-22 İndol türevleri ve patolojik hücre çoğalmasının neden olduğu habis hastalıklar ve diğer hastalıkların tedavisinde kullanımları. TR200003206T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19819835 1998-05-04
DE19838506A DE19838506C2 (de) 1998-05-04 1998-08-25 Indolderivate und deren Verwendung zur Behandlung von malignen und anderen, auf pathologischen Zellproliferationen beruhenden Erkrankungen

Publications (1)

Publication Number Publication Date
TR200003206T2 true TR200003206T2 (tr) 2001-07-23

Family

ID=26045937

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03206T TR200003206T2 (tr) 1998-05-04 1999-04-22 İndol türevleri ve patolojik hücre çoğalmasının neden olduğu habis hastalıklar ve diğer hastalıkların tedavisinde kullanımları.

Country Status (22)

Country Link
US (2) US6407102B1 (tr)
EP (1) EP1109785B1 (tr)
JP (1) JP2002514572A (tr)
CN (1) CN1151127C (tr)
AT (1) ATE230394T1 (tr)
AU (1) AU752464B2 (tr)
BG (1) BG104996A (tr)
BR (1) BR9911017A (tr)
CA (1) CA2330756C (tr)
CZ (1) CZ20003960A3 (tr)
DE (1) DE59903921D1 (tr)
DK (1) DK1109785T3 (tr)
ES (1) ES2190221T3 (tr)
HK (1) HK1038354A1 (tr)
HU (1) HUP0102563A3 (tr)
IL (1) IL139056A0 (tr)
NO (1) NO317261B1 (tr)
NZ (1) NZ507735A (tr)
PL (1) PL346840A1 (tr)
SK (1) SK16352000A3 (tr)
TR (1) TR200003206T2 (tr)
WO (1) WO1999057117A2 (tr)

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US9108984B2 (en) 2011-03-14 2015-08-18 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as PI3K inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
KR101982475B1 (ko) 2011-09-02 2019-05-27 인사이트 홀딩스 코포레이션 Ｐｉ３ｋ 억제제로서 헤테로시클릴아민
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
ES2843522T3 (es) 2015-02-27 2021-07-19 Incyte Corp Sales del inhibidor de PI3K y procesos para su preparación
US9988401B2 (en) 2015-05-11 2018-06-05 Incyte Corporation Crystalline forms of a PI3K inhibitor
US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
CN106317169B (zh) * 2015-06-23 2019-07-02 首都医科大学 双吲哚-二肽衍生物,其合成,抗血栓活性和制备抗血栓剂的应用
WO2018024172A1 (en) * 2016-08-05 2018-02-08 The University Of Hong Kong Platinum complexes and methods of use thereof
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Also Published As

Publication number Publication date
BG104996A (en) 2001-07-31
NO317261B1 (no) 2004-09-27
NO20005448D0 (no) 2000-10-27
SK16352000A3 (sk) 2002-07-02
NZ507735A (en) 2003-04-29
HUP0102563A3 (en) 2003-04-28
CN1151127C (zh) 2004-05-26
AU752464B2 (en) 2002-09-19
HUP0102563A2 (hu) 2001-11-28
PL346840A1 (en) 2002-02-25
WO1999057117A3 (de) 2001-04-12
AU4497599A (en) 1999-11-23
EP1109785B1 (de) 2003-01-02
HK1038354A1 (en) 2002-03-15
ES2190221T3 (es) 2003-07-16
CN1310705A (zh) 2001-08-29
CA2330756A1 (en) 1999-11-11
CA2330756C (en) 2007-10-02
CZ20003960A3 (cs) 2002-04-17
DE59903921D1 (de) 2003-02-06
JP2002514572A (ja) 2002-05-21
NO20005448L (no) 2000-10-27
US6812243B2 (en) 2004-11-02
DK1109785T3 (da) 2003-04-22
US20030008898A1 (en) 2003-01-09
US6407102B1 (en) 2002-06-18
IL139056A0 (en) 2001-11-25
EP1109785A2 (de) 2001-06-27
BR9911017A (pt) 2001-02-06
WO1999057117A2 (de) 1999-11-11
ATE230394T1 (de) 2003-01-15

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