NO20063676L - Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer - Google Patents

Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer

Info

Publication number
NO20063676L
NO20063676L NO20063676A NO20063676A NO20063676L NO 20063676 L NO20063676 L NO 20063676L NO 20063676 A NO20063676 A NO 20063676A NO 20063676 A NO20063676 A NO 20063676A NO 20063676 L NO20063676 L NO 20063676L
Authority
NO
Norway
Prior art keywords
inhibitors
indole derivatives
kinase inhibitors
particular ikk2
kinase
Prior art date
Application number
NO20063676A
Other languages
English (en)
Inventor
Paul Bamborough
Lan Robert Baldwin
John Andrew Christopher
Jeffrey K Kerns
Timothy Longstaff
David Drysdale Miller
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of NO20063676L publication Critical patent/NO20063676L/no

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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • C07D209/04—Indoles; Hydrogenated indoles
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    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Indolkarboksamid forbindelser med Formel (I) er tilveiebrakt som inhibitorer av kinaseaktivitet, særlig IKK2-aktivitet, så vel som sammensetninger og medikamenter som inneholder dem, for anvendelse ved inflammasjons- og vevsrepareringsforstyrrelser.
NO20063676A 2004-01-15 2006-08-15 Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer NO20063676L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0400895.9A GB0400895D0 (en) 2004-01-15 2004-01-15 Chemical compounds
PCT/GB2005/000085 WO2005067923A1 (en) 2004-01-15 2005-01-13 Indole derivatives and use thereof as kinase inhibitors in particular ikk2 inhibitors

Publications (1)

Publication Number Publication Date
NO20063676L true NO20063676L (no) 2006-10-13

Family

ID=31726240

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20063676A NO20063676L (no) 2004-01-15 2006-08-15 Indolderivater og anvendelse derav som kinaseinhibitorer i spesielle IKK2 inhibitorer

Country Status (24)

Country Link
US (1) US20080269200A1 (no)
EP (1) EP1703905B1 (no)
JP (2) JP4975447B2 (no)
KR (1) KR20070026357A (no)
CN (1) CN1933830A (no)
AT (1) ATE413877T1 (no)
AU (1) AU2005205090A1 (no)
BR (1) BRPI0506802A (no)
CA (1) CA2552953A1 (no)
DE (1) DE602005010970D1 (no)
DK (1) DK1703905T3 (no)
ES (1) ES2317184T3 (no)
GB (1) GB0400895D0 (no)
HK (1) HK1098047A1 (no)
HR (1) HRP20090071T3 (no)
IL (1) IL176739A0 (no)
MA (1) MA28279A1 (no)
NO (1) NO20063676L (no)
PL (1) PL1703905T3 (no)
PT (1) PT1703905E (no)
RU (1) RU2006129492A (no)
SI (1) SI1703905T1 (no)
WO (1) WO2005067923A1 (no)
ZA (1) ZA200604855B (no)

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PE20060748A1 (es) * 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
NZ563687A (en) * 2005-06-30 2011-07-29 Smithkline Beecham Corp 3-[1-(ethylsulfonyl)-4-piperidinyl]-5-[2-(1-methylethyl)-2,3-dihydro-1H-isoindol-5-yl]-1H-indole-7-carboxamide for inhibiting IKK2 (aka IKKbeta)
US20080242685A1 (en) * 2005-10-25 2008-10-02 Smithkline Beecham Corporation Chemical Compounds
WO2007062318A2 (en) * 2005-11-18 2007-05-31 Smithkline Beecham Corporation Chemical compounds
US20080293802A1 (en) * 2005-12-16 2008-11-27 Smithline Beecham Corporation Chemical Compounds
RU2470918C2 (ru) * 2007-01-15 2012-12-27 Сантен Фармасьютикал Ко., Лтд. НОВЫЕ ПРОИЗВОДНЫЕ ИНДОЛА, ОБЛАДАЮЩИЕ ИНГИБИРУЮЩЕЙ АКТИВНОСТЬЮ В ОТНОШЕНИИ IκB КИНАЗЫ β
AR065804A1 (es) * 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
BRPI0905952A2 (pt) * 2008-02-04 2015-06-30 Mercury Therapeutics Composto e sais do mesmo e compição farmacêutica
JPWO2009107391A1 (ja) * 2008-02-27 2011-06-30 武田薬品工業株式会社 ６員芳香環含有化合物
RU2503661C2 (ru) * 2008-07-14 2014-01-10 Сантен Фармасьютикал Ко., Лтд. Новое производное индола, содержащее карбамоильную группу, уреидную группу и замещенную оксигруппу
CN102341367B (zh) * 2009-03-05 2014-05-07 住友化学株式会社 卤素取代苯二甲醇的制造方法
WO2010102968A1 (en) 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
JP5908493B2 (ja) * 2010-12-01 2016-04-26 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーＧｌａｘｏＳｍｉｔｈＫｌｉｎｅ ＬＬＣ インドール
WO2014036268A2 (en) * 2012-08-29 2014-03-06 Mount Sinai School Of Medicine Indole derivatives as sumo activators
FR3001219A1 (fr) * 2013-01-22 2014-07-25 Centre Nat Rech Scient Inhibiteurs de kinases
TWI644899B (zh) 2013-02-04 2018-12-21 健生藥品公司 Ｆｌａｐ調節劑
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EP3013337B1 (en) * 2013-06-26 2018-10-31 Abbvie Inc. Primary carboxamides as btk inhibitors
CN107148417B (zh) * 2014-12-18 2020-09-08 豪夫迈·罗氏有限公司 苯并氮杂*磺酰胺化合物
WO2017096045A1 (en) * 2015-12-02 2017-06-08 Kyras Therapeutics, Inc. Multivalent ras binding compounds
US11352328B2 (en) 2016-07-12 2022-06-07 Arisan Therapeutics Inc. Heterocyclic compounds for the treatment of arenavirus
WO2018223819A1 (zh) * 2017-06-07 2018-12-13 中国中医科学院中药研究所 一种吲哚乙酸类衍生物及其制备方法和医药用途

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RU2006129492A (ru) 2008-02-27
DE602005010970D1 (de) 2008-12-24
US20080269200A1 (en) 2008-10-30
KR20070026357A (ko) 2007-03-08
HRP20090071T3 (en) 2009-04-30
BRPI0506802A (pt) 2007-05-29
DK1703905T3 (da) 2009-02-16
ZA200604855B (en) 2007-11-28
GB0400895D0 (en) 2004-02-18
JP2007517848A (ja) 2007-07-05
ES2317184T3 (es) 2009-04-16
WO2005067923A1 (en) 2005-07-28
ATE413877T1 (de) 2008-11-15
EP1703905B1 (en) 2008-11-12
EP1703905A1 (en) 2006-09-27
MA28279A1 (fr) 2006-11-01
PT1703905E (pt) 2009-02-04
JP2012025761A (ja) 2012-02-09
IL176739A0 (en) 2006-10-31
PL1703905T3 (pl) 2009-04-30
CN1933830A (zh) 2007-03-21
JP4975447B2 (ja) 2012-07-11
SI1703905T1 (sl) 2009-04-30
CA2552953A1 (en) 2005-07-28
HK1098047A1 (en) 2007-07-13

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