BRPI0506802A - derivados de indol e uso destes como inibidores de quinase em inibidores de ikk2 particulares - Google Patents
derivados de indol e uso destes como inibidores de quinase em inibidores de ikk2 particularesInfo
- Publication number
- BRPI0506802A BRPI0506802A BRPI0506802-9A BRPI0506802A BRPI0506802A BR PI0506802 A BRPI0506802 A BR PI0506802A BR PI0506802 A BRPI0506802 A BR PI0506802A BR PI0506802 A BRPI0506802 A BR PI0506802A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- indole derivatives
- kinase inhibitors
- particular ikk2
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Toxicology (AREA)
- Vascular Medicine (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
Abstract
DERIVADOS DE INDOL E USO DESTES COMO INIBIDORES DE QUINASE EM INIBIDORES DE IKK2 PARTICULARES Compostos de carboxamida indol da fórmula (I) : são fornecidos como inibidores de atividade quinase, em particular atividade IKK2, bem como composições e medicamentos contendo-as, para o uso em desordens inflamatórias e reparo do tecido.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0400895.9A GB0400895D0 (en) | 2004-01-15 | 2004-01-15 | Chemical compounds |
PCT/GB2005/000085 WO2005067923A1 (en) | 2004-01-15 | 2005-01-13 | Indole derivatives and use thereof as kinase inhibitors in particular ikk2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0506802A true BRPI0506802A (pt) | 2007-05-29 |
Family
ID=31726240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506802-9A BRPI0506802A (pt) | 2004-01-15 | 2005-01-13 | derivados de indol e uso destes como inibidores de quinase em inibidores de ikk2 particulares |
Country Status (24)
Country | Link |
---|---|
US (1) | US20080269200A1 (pt) |
EP (1) | EP1703905B1 (pt) |
JP (2) | JP4975447B2 (pt) |
KR (1) | KR20070026357A (pt) |
CN (1) | CN1933830A (pt) |
AT (1) | ATE413877T1 (pt) |
AU (1) | AU2005205090A1 (pt) |
BR (1) | BRPI0506802A (pt) |
CA (1) | CA2552953A1 (pt) |
DE (1) | DE602005010970D1 (pt) |
DK (1) | DK1703905T3 (pt) |
ES (1) | ES2317184T3 (pt) |
GB (1) | GB0400895D0 (pt) |
HK (1) | HK1098047A1 (pt) |
HR (1) | HRP20090071T3 (pt) |
IL (1) | IL176739A0 (pt) |
MA (1) | MA28279A1 (pt) |
NO (1) | NO20063676L (pt) |
PL (1) | PL1703905T3 (pt) |
PT (1) | PT1703905E (pt) |
RU (1) | RU2006129492A (pt) |
SI (1) | SI1703905T1 (pt) |
WO (1) | WO2005067923A1 (pt) |
ZA (1) | ZA200604855B (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20060373A1 (es) * | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
TW200626142A (en) * | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
TWI380973B (zh) * | 2005-06-30 | 2013-01-01 | Smithkline Beecham Corp | 化合物 |
WO2007114848A2 (en) * | 2005-10-25 | 2007-10-11 | Smithkline Beecham Corporation | Chemical compounds |
US20080269291A1 (en) * | 2005-11-18 | 2008-10-30 | Kerns Jeffrey K | Chemical Compounds |
US20080293802A1 (en) * | 2005-12-16 | 2008-11-27 | Smithline Beecham Corporation | Chemical Compounds |
JP5070067B2 (ja) * | 2007-01-15 | 2012-11-07 | 参天製薬株式会社 | IκBキナーゼβ阻害活性を有する新規インドール誘導体 |
PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
KR20100115789A (ko) | 2008-02-04 | 2010-10-28 | 머큐리 테라퓨틱스, 인코포레이티드 | Ampk 조절자 |
JPWO2009107391A1 (ja) * | 2008-02-27 | 2011-06-30 | 武田薬品工業株式会社 | 6員芳香環含有化合物 |
US8445529B2 (en) * | 2008-07-14 | 2013-05-21 | Santen Pharmaceutical Co., Ltd. | Indole derivative having, carbamoyl group, ureido group and substituted oxy group |
CN102341367B (zh) * | 2009-03-05 | 2014-05-07 | 住友化学株式会社 | 卤素取代苯二甲醇的制造方法 |
US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
US8765792B2 (en) | 2010-12-01 | 2014-07-01 | Glaxosmithkline Llc | Indoles |
WO2014036268A2 (en) * | 2012-08-29 | 2014-03-06 | Mount Sinai School Of Medicine | Indole derivatives as sumo activators |
FR3001219A1 (fr) * | 2013-01-22 | 2014-07-25 | Centre Nat Rech Scient | Inhibiteurs de kinases |
EP3070085B1 (en) | 2013-02-04 | 2019-01-09 | Janssen Pharmaceutica NV | Flap modulators |
TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
SI3013337T1 (sl) * | 2013-06-26 | 2019-02-28 | Abbvie Inc. | Primarni karboksamidi kot inhibitorji BTK |
CN107148417B (zh) * | 2014-12-18 | 2020-09-08 | 豪夫迈·罗氏有限公司 | 苯并氮杂*磺酰胺化合物 |
US20170158702A1 (en) * | 2015-12-02 | 2017-06-08 | Kyras Therapeutics, Inc. | Multivalent ras binding compounds |
US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
CN110418787B (zh) * | 2017-06-07 | 2022-09-13 | 中国中医科学院中药研究所 | 一种吲哚乙酸类衍生物及其制备方法和医药用途 |
WO2024059220A2 (en) * | 2022-09-15 | 2024-03-21 | Vanderbilt University | 6,5 southwestern core compounds as mglu5 negative allosteric modulators and methods of making and using the same |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775761A (en) * | 1983-08-22 | 1988-10-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles |
US5256673A (en) * | 1983-11-25 | 1993-10-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds |
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-
2004
- 2004-01-15 GB GBGB0400895.9A patent/GB0400895D0/en not_active Ceased
-
2005
- 2005-01-13 SI SI200530567T patent/SI1703905T1/sl unknown
- 2005-01-13 KR KR1020067014178A patent/KR20070026357A/ko not_active Application Discontinuation
- 2005-01-13 BR BRPI0506802-9A patent/BRPI0506802A/pt not_active IP Right Cessation
- 2005-01-13 JP JP2006548393A patent/JP4975447B2/ja not_active Expired - Fee Related
- 2005-01-13 DE DE602005010970T patent/DE602005010970D1/de active Active
- 2005-01-13 WO PCT/GB2005/000085 patent/WO2005067923A1/en active Application Filing
- 2005-01-13 RU RU2006129492/04A patent/RU2006129492A/ru not_active Application Discontinuation
- 2005-01-13 AT AT05701855T patent/ATE413877T1/de not_active IP Right Cessation
- 2005-01-13 EP EP05701855A patent/EP1703905B1/en active Active
- 2005-01-13 CA CA002552953A patent/CA2552953A1/en not_active Abandoned
- 2005-01-13 CN CNA2005800083624A patent/CN1933830A/zh active Pending
- 2005-01-13 DK DK05701855T patent/DK1703905T3/da active
- 2005-01-13 PL PL05701855T patent/PL1703905T3/pl unknown
- 2005-01-13 US US10/597,154 patent/US20080269200A1/en not_active Abandoned
- 2005-01-13 PT PT05701855T patent/PT1703905E/pt unknown
- 2005-01-13 AU AU2005205090A patent/AU2005205090A1/en not_active Abandoned
- 2005-01-13 ES ES05701855T patent/ES2317184T3/es active Active
-
2006
- 2006-06-13 ZA ZA200604855A patent/ZA200604855B/xx unknown
- 2006-07-03 MA MA29154A patent/MA28279A1/fr unknown
- 2006-07-06 IL IL176739A patent/IL176739A0/en unknown
- 2006-08-15 NO NO20063676A patent/NO20063676L/no not_active Application Discontinuation
-
2007
- 2007-03-16 HK HK07102877.7A patent/HK1098047A1/xx not_active IP Right Cessation
-
2009
- 2009-02-05 HR HR20090071T patent/HRP20090071T3/xx unknown
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2011
- 2011-09-01 JP JP2011190903A patent/JP2012025761A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
SI1703905T1 (sl) | 2009-04-30 |
NO20063676L (no) | 2006-10-13 |
PL1703905T3 (pl) | 2009-04-30 |
PT1703905E (pt) | 2009-02-04 |
GB0400895D0 (en) | 2004-02-18 |
JP2007517848A (ja) | 2007-07-05 |
RU2006129492A (ru) | 2008-02-27 |
CN1933830A (zh) | 2007-03-21 |
IL176739A0 (en) | 2006-10-31 |
EP1703905B1 (en) | 2008-11-12 |
EP1703905A1 (en) | 2006-09-27 |
ZA200604855B (en) | 2007-11-28 |
US20080269200A1 (en) | 2008-10-30 |
HK1098047A1 (en) | 2007-07-13 |
CA2552953A1 (en) | 2005-07-28 |
JP2012025761A (ja) | 2012-02-09 |
DE602005010970D1 (de) | 2008-12-24 |
MA28279A1 (fr) | 2006-11-01 |
AU2005205090A1 (en) | 2005-07-28 |
WO2005067923A1 (en) | 2005-07-28 |
JP4975447B2 (ja) | 2012-07-11 |
HRP20090071T3 (en) | 2009-04-30 |
DK1703905T3 (da) | 2009-02-16 |
KR20070026357A (ko) | 2007-03-08 |
ATE413877T1 (de) | 2008-11-15 |
ES2317184T3 (es) | 2009-04-16 |
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