BRPI0506802A - derivados de indol e uso destes como inibidores de quinase em inibidores de ikk2 particulares - Google Patents
derivados de indol e uso destes como inibidores de quinase em inibidores de ikk2 particularesInfo
- Publication number
- BRPI0506802A BRPI0506802A BRPI0506802-9A BRPI0506802A BRPI0506802A BR PI0506802 A BRPI0506802 A BR PI0506802A BR PI0506802 A BRPI0506802 A BR PI0506802A BR PI0506802 A BRPI0506802 A BR PI0506802A
- Authority
- BR
- Brazil
- Prior art keywords
- inhibitors
- indole derivatives
- kinase inhibitors
- particular ikk2
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Virology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychiatry (AREA)
Abstract
DERIVADOS DE INDOL E USO DESTES COMO INIBIDORES DE QUINASE EM INIBIDORES DE IKK2 PARTICULARES Compostos de carboxamida indol da fórmula (I) : são fornecidos como inibidores de atividade quinase, em particular atividade IKK2, bem como composições e medicamentos contendo-as, para o uso em desordens inflamatórias e reparo do tecido.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB0400895.9A GB0400895D0 (en) | 2004-01-15 | 2004-01-15 | Chemical compounds |
PCT/GB2005/000085 WO2005067923A1 (en) | 2004-01-15 | 2005-01-13 | Indole derivatives and use thereof as kinase inhibitors in particular ikk2 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0506802A true BRPI0506802A (pt) | 2007-05-29 |
Family
ID=31726240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506802-9A BRPI0506802A (pt) | 2004-01-15 | 2005-01-13 | derivados de indol e uso destes como inibidores de quinase em inibidores de ikk2 particulares |
Country Status (24)
Country | Link |
---|---|
US (1) | US20080269200A1 (pt) |
EP (1) | EP1703905B1 (pt) |
JP (2) | JP4975447B2 (pt) |
KR (1) | KR20070026357A (pt) |
CN (1) | CN1933830A (pt) |
AT (1) | ATE413877T1 (pt) |
AU (1) | AU2005205090A1 (pt) |
BR (1) | BRPI0506802A (pt) |
CA (1) | CA2552953A1 (pt) |
DE (1) | DE602005010970D1 (pt) |
DK (1) | DK1703905T3 (pt) |
ES (1) | ES2317184T3 (pt) |
GB (1) | GB0400895D0 (pt) |
HK (1) | HK1098047A1 (pt) |
HR (1) | HRP20090071T3 (pt) |
IL (1) | IL176739A0 (pt) |
MA (1) | MA28279A1 (pt) |
NO (1) | NO20063676L (pt) |
PL (1) | PL1703905T3 (pt) |
PT (1) | PT1703905E (pt) |
RU (1) | RU2006129492A (pt) |
SI (1) | SI1703905T1 (pt) |
WO (1) | WO2005067923A1 (pt) |
ZA (1) | ZA200604855B (pt) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PE20060373A1 (es) * | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
TW200626142A (en) * | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
CN101247804B (zh) * | 2005-06-30 | 2012-09-26 | 史密丝克莱恩比彻姆公司 | 化学化合物 |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
US20080242685A1 (en) * | 2005-10-25 | 2008-10-02 | Smithkline Beecham Corporation | Chemical Compounds |
EP1948187A4 (en) * | 2005-11-18 | 2010-11-03 | Glaxosmithkline Llc | CHEMICAL COMPOUNDS |
EP1959737A4 (en) * | 2005-12-16 | 2010-12-08 | Glaxosmithkline Llc | CHEMICAL COMPOUNDS |
ES2397292T3 (es) * | 2007-01-15 | 2013-03-06 | Santen Pharmaceutical Co., Ltd | Nuevo derivado de indol que tiene actividad inhibidora de cinasa I B |
AR065804A1 (es) * | 2007-03-23 | 2009-07-01 | Smithkline Beecham Corp | Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento |
MX2010008376A (es) * | 2008-02-04 | 2011-02-22 | Mercury Therapeutics Inc | Moduladores ampk. |
EP2253618A1 (en) * | 2008-02-27 | 2010-11-24 | Takeda Pharmaceutical Company Limited | Compound having 6-membered aromatic ring |
CA2730281A1 (en) * | 2008-07-14 | 2010-01-21 | Santen Pharmaceutical Co., Ltd. | Novel indole derivative having, carbamoyl group, ureido group and substituted oxy group |
EP2404897A4 (en) * | 2009-03-05 | 2014-02-26 | Sumitomo Chemical Co | PROCESS FOR PREPARING HALOGEN-SUBSTITUTED BENCHENETIMETHANOL |
JP2012520257A (ja) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Ikk2阻害剤としてのインドール誘導体 |
US8765792B2 (en) | 2010-12-01 | 2014-07-01 | Glaxosmithkline Llc | Indoles |
WO2014036268A2 (en) * | 2012-08-29 | 2014-03-06 | Mount Sinai School Of Medicine | Indole derivatives as sumo activators |
FR3001219A1 (fr) * | 2013-01-22 | 2014-07-25 | Centre Nat Rech Scient | Inhibiteurs de kinases |
US9079866B2 (en) | 2013-02-04 | 2015-07-14 | Janssen Pharmaceutica Nv | Flap modulators |
TWI644899B (zh) | 2013-02-04 | 2018-12-21 | 健生藥品公司 | Flap調節劑 |
TWI642657B (zh) * | 2013-06-26 | 2018-12-01 | 艾伯維有限公司 | 作為btk抑制劑的初級甲醯胺 |
EP3233835B1 (en) * | 2014-12-18 | 2019-01-23 | F.Hoffmann-La Roche Ag | Benzazepine sulfonamide compounds |
WO2017096045A1 (en) * | 2015-12-02 | 2017-06-08 | Kyras Therapeutics, Inc. | Multivalent ras binding compounds |
US11352328B2 (en) | 2016-07-12 | 2022-06-07 | Arisan Therapeutics Inc. | Heterocyclic compounds for the treatment of arenavirus |
CN110418787B (zh) * | 2017-06-07 | 2022-09-13 | 中国中医科学院中药研究所 | 一种吲哚乙酸类衍生物及其制备方法和医药用途 |
WO2024059220A2 (en) * | 2022-09-15 | 2024-03-21 | Vanderbilt University | 6,5 southwestern core compounds as mglu5 negative allosteric modulators and methods of making and using the same |
Family Cites Families (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775761A (en) * | 1983-08-22 | 1988-10-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles |
US5256673A (en) * | 1983-11-25 | 1993-10-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds |
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-
2004
- 2004-01-15 GB GBGB0400895.9A patent/GB0400895D0/en not_active Ceased
-
2005
- 2005-01-13 KR KR1020067014178A patent/KR20070026357A/ko not_active Application Discontinuation
- 2005-01-13 AT AT05701855T patent/ATE413877T1/de not_active IP Right Cessation
- 2005-01-13 CA CA002552953A patent/CA2552953A1/en not_active Abandoned
- 2005-01-13 AU AU2005205090A patent/AU2005205090A1/en not_active Abandoned
- 2005-01-13 PL PL05701855T patent/PL1703905T3/pl unknown
- 2005-01-13 PT PT05701855T patent/PT1703905E/pt unknown
- 2005-01-13 CN CNA2005800083624A patent/CN1933830A/zh active Pending
- 2005-01-13 US US10/597,154 patent/US20080269200A1/en not_active Abandoned
- 2005-01-13 BR BRPI0506802-9A patent/BRPI0506802A/pt not_active IP Right Cessation
- 2005-01-13 DK DK05701855T patent/DK1703905T3/da active
- 2005-01-13 RU RU2006129492/04A patent/RU2006129492A/ru not_active Application Discontinuation
- 2005-01-13 DE DE602005010970T patent/DE602005010970D1/de active Active
- 2005-01-13 EP EP05701855A patent/EP1703905B1/en active Active
- 2005-01-13 WO PCT/GB2005/000085 patent/WO2005067923A1/en active Application Filing
- 2005-01-13 ES ES05701855T patent/ES2317184T3/es active Active
- 2005-01-13 JP JP2006548393A patent/JP4975447B2/ja not_active Expired - Fee Related
- 2005-01-13 SI SI200530567T patent/SI1703905T1/sl unknown
-
2006
- 2006-06-13 ZA ZA200604855A patent/ZA200604855B/xx unknown
- 2006-07-03 MA MA29154A patent/MA28279A1/fr unknown
- 2006-07-06 IL IL176739A patent/IL176739A0/en unknown
- 2006-08-15 NO NO20063676A patent/NO20063676L/no not_active Application Discontinuation
-
2007
- 2007-03-16 HK HK07102877.7A patent/HK1098047A1/xx not_active IP Right Cessation
-
2009
- 2009-02-05 HR HR20090071T patent/HRP20090071T3/xx unknown
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- 2011-09-01 JP JP2011190903A patent/JP2012025761A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
KR20070026357A (ko) | 2007-03-08 |
NO20063676L (no) | 2006-10-13 |
ATE413877T1 (de) | 2008-11-15 |
CN1933830A (zh) | 2007-03-21 |
SI1703905T1 (sl) | 2009-04-30 |
ZA200604855B (en) | 2007-11-28 |
GB0400895D0 (en) | 2004-02-18 |
IL176739A0 (en) | 2006-10-31 |
CA2552953A1 (en) | 2005-07-28 |
MA28279A1 (fr) | 2006-11-01 |
US20080269200A1 (en) | 2008-10-30 |
HRP20090071T3 (en) | 2009-04-30 |
ES2317184T3 (es) | 2009-04-16 |
HK1098047A1 (en) | 2007-07-13 |
WO2005067923A1 (en) | 2005-07-28 |
PL1703905T3 (pl) | 2009-04-30 |
EP1703905A1 (en) | 2006-09-27 |
DK1703905T3 (da) | 2009-02-16 |
RU2006129492A (ru) | 2008-02-27 |
JP4975447B2 (ja) | 2012-07-11 |
JP2007517848A (ja) | 2007-07-05 |
AU2005205090A1 (en) | 2005-07-28 |
JP2012025761A (ja) | 2012-02-09 |
PT1703905E (pt) | 2009-02-04 |
EP1703905B1 (en) | 2008-11-12 |
DE602005010970D1 (de) | 2008-12-24 |
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