PE20060373A1 - Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 - Google Patents
Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2Info
- Publication number
- PE20060373A1 PE20060373A1 PE2005000715A PE2005000715A PE20060373A1 PE 20060373 A1 PE20060373 A1 PE 20060373A1 PE 2005000715 A PE2005000715 A PE 2005000715A PE 2005000715 A PE2005000715 A PE 2005000715A PE 20060373 A1 PE20060373 A1 PE 20060373A1
- Authority
- PE
- Peru
- Prior art keywords
- piperidinyl
- carboxamide
- inhibitors
- indazol
- kinase activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE Z ES ARILO O HETEROARILO SUSTITUIDO O NO CON HALO, ALQUILO C1-C6, CN, ENTRE OTROS; R1 ES H, HALO, WX; W ES UN ENLACE, ALQUILENO C1-C6; X ES ARILO, HETEROARILO, HETEROCICLOALQUILO, CICLOALQUILO C4-C7, ENTRE OTROS.SON COMPUESTOS PREFERIDOS: 4-[7-(AMINOCARBONIL)-5-FENIL-1H-INDAZOL-3-IL]-1-PIPERIDINCARBOXILATO DE 1,1-DIMETILETILO; HIDROCLORURO DE 5-FENIL-3-(4-PIPERIDINIL)-1H-INDAZOL-7-CARBOXAMIDA; 3-{1-[(1,2-DIMETIL-1H-IMIDAZOL-4-IL)SULFONIL]-4-PIPERIDINIL}-5FENIL-1H-INDAZOL-7-CARBOXAMIDA; ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE IKK2, UTILES EN EL TRATAMIENTO DE TRASTORNOS INFLAMATORIOS Y DE REPARACION TISULAR TALES COMO ARTRITIS REUMATOIDE, ASMA, ENFERMEDAD PULMONAR OBSTRUCTIVA CRONICA
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58265504P | 2004-06-24 | 2004-06-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20060373A1 true PE20060373A1 (es) | 2006-04-29 |
Family
ID=35782386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2005000715A PE20060373A1 (es) | 2004-06-24 | 2005-06-22 | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
Country Status (21)
Country | Link |
---|---|
US (1) | US8501780B2 (es) |
EP (1) | EP1758578B1 (es) |
JP (1) | JP5017105B2 (es) |
KR (1) | KR20070043940A (es) |
CN (1) | CN101005836A (es) |
AR (1) | AR050253A1 (es) |
AT (1) | ATE493396T1 (es) |
AU (1) | AU2005258332A1 (es) |
BR (1) | BRPI0512533A (es) |
CA (1) | CA2571712A1 (es) |
DE (1) | DE602005025632D1 (es) |
ES (1) | ES2358579T3 (es) |
IL (1) | IL179747A0 (es) |
MA (1) | MA28727B1 (es) |
MX (1) | MXPA06014481A (es) |
NO (1) | NO20070076L (es) |
PE (1) | PE20060373A1 (es) |
RU (1) | RU2007102576A (es) |
TW (1) | TW200616967A (es) |
WO (1) | WO2006002434A2 (es) |
ZA (1) | ZA200609759B (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
TW200626142A (en) * | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
PE20070173A1 (es) * | 2005-06-30 | 2007-03-14 | Smithkline Beecham Corp | Compuestos de indol carboxamidas como inhibidores de ikk2 |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
WO2007062318A2 (en) * | 2005-11-18 | 2007-05-31 | Smithkline Beecham Corporation | Chemical compounds |
BRPI0707718A2 (pt) * | 2006-02-10 | 2011-05-10 | Summit Corp Plc | uso de um composto |
JP5019768B2 (ja) * | 2006-03-23 | 2012-09-05 | 独立行政法人科学技術振興機構 | 新規低分子化合物およびその製造方法 |
PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
GB0715087D0 (en) * | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
GB0804591D0 (en) * | 2008-03-12 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
GB0804592D0 (en) * | 2008-03-12 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
EP2366699B1 (en) | 2008-10-02 | 2013-08-07 | Asahi Kasei Pharma Corporation | 8-substituted isoquinoline derivative and use thereof |
US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
WO2010120854A1 (en) * | 2009-04-15 | 2010-10-21 | Glaxosmithkline Llc | Chemical compounds |
JP2015214492A (ja) * | 2012-09-07 | 2015-12-03 | 大日本住友製薬株式会社 | 3−(4−ピペリジル)−インダゾール誘導体 |
JOP20190053A1 (ar) | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
KR102490953B1 (ko) | 2016-09-23 | 2023-01-19 | 노파르티스 아게 | 힘줄 및/또는 인대 손상에 사용하기 위한 인다졸 화합물 |
JOP20210324A1 (ar) * | 2019-06-27 | 2023-01-30 | Biogen Ma Inc | مشتقات من 2h-indazole واستخدامها في علاج مرض |
Family Cites Families (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4775761A (en) * | 1983-08-22 | 1988-10-04 | Hoechst-Roussel Pharmaceuticals, Inc. | 3-(piperidinyl)- and 3-(pyrrolidinyl)-1H-indazoles |
US5256673A (en) * | 1983-11-25 | 1993-10-26 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Indole-3-yl-A-tetrahydropyridyl or piperidyl compounds |
DE3342632A1 (de) | 1983-11-25 | 1985-06-05 | Merck Patent Gmbh, 6100 Darmstadt | Indolderivate |
EP0279263B1 (en) | 1987-02-10 | 1993-08-04 | Abbott Laboratories | Indole, benzofuran, benzothiophene containing lipoxygenase inhibiting compounds |
JPH0262875A (ja) * | 1988-05-23 | 1990-03-02 | Wakunaga Pharmaceut Co Ltd | 新規イソインドリン誘導体 |
PH30133A (en) | 1989-09-07 | 1997-01-21 | Abbott Lab | Indole-, benzofuran-, and benzothiophene-containing lipoxygenase inhibiting compounds |
US5254473A (en) * | 1990-03-16 | 1993-10-19 | Jp Laboratories | Solid state device for monitoring integral values of time and temperature of storage of perishables |
JP2963288B2 (ja) | 1992-01-14 | 1999-10-18 | 株式会社海洋バイオテクノロジー研究所 | 水中有害付着生物防除剤 |
US5330986A (en) * | 1992-11-24 | 1994-07-19 | Hoechst-Roussel Pharmaceuticals Inc. | Indole-7-carboxamide derivatives |
FR2701026B1 (fr) | 1993-02-02 | 1995-03-31 | Adir | Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
WO1994021627A1 (en) | 1993-03-18 | 1994-09-29 | Merck Sharp & Dohme Limited | Indole derivatives as dopamine d4 antagonists |
GB9305623D0 (en) | 1993-03-18 | 1993-05-05 | Merck Sharp & Dohme | Therapeutic agents |
ZA951822B (en) * | 1994-12-23 | 1996-09-26 | Glaxo Group Ltd | Chemical compounds |
DE19500689A1 (de) | 1995-01-12 | 1996-07-18 | Merck Patent Gmbh | Indolpiperidin-Derivate |
BR9609353A (pt) | 1995-06-07 | 1999-05-11 | Sugen Inc | Composição farmacêutica conveniente para administração em humanos processo para melhorar sintomas de uma desordem proliferativa celular e compostos |
GB9610811D0 (en) | 1996-05-23 | 1996-07-31 | Pharmacia Spa | Combinatorial solid phase synthesis of a library of indole derivatives |
US5846982A (en) | 1996-06-14 | 1998-12-08 | Eli Lilly And Company | Inhibition of serotonin reuptake |
EP1077213A3 (en) | 1996-06-14 | 2001-06-13 | Eli Lilly And Company | Inhibition of serotonin reuptake |
EP0922042A1 (en) | 1996-08-09 | 1999-06-16 | Smithkline Beecham Corporation | Novel piperazine containing compounds |
WO1998028292A1 (en) | 1996-12-23 | 1998-07-02 | Smithkline Beecham Corporation | Novel piperidine containing compounds |
PL338453A1 (en) | 1997-08-06 | 2000-11-06 | Lilly Co Eli | 2-acylaminopropanoamines as antagonists of the tachykinin receptor |
AR013669A1 (es) | 1997-10-07 | 2001-01-10 | Smithkline Beecham Corp | Compuestos y metodos |
DE19756036A1 (de) | 1997-12-17 | 1999-06-24 | Merck Patent Gmbh | Amid- und Harnstoffderivate |
DE19807993A1 (de) | 1998-02-26 | 1999-09-02 | Bayer Ag | Verwendung von ß-Carbolinderivaten zur Bekämpfung von TNF-alpha-abhängigen Krankheiten |
JP4342101B2 (ja) | 1998-02-27 | 2009-10-14 | キッセイ薬品工業株式会社 | インドール誘導体および当該誘導体を含有する医薬品組成物 |
US6589954B1 (en) * | 1998-05-22 | 2003-07-08 | Scios, Inc. | Compounds and methods to treat cardiac failure and other disorders |
JP2002519348A (ja) | 1998-06-30 | 2002-07-02 | イーライ・リリー・アンド・カンパニー | 5−ht1fアゴニスト |
DE19928424A1 (de) | 1999-06-23 | 2000-12-28 | Aventis Pharma Gmbh | Substituierte Benzimidazole |
CZ302775B6 (cs) | 1999-06-23 | 2011-11-02 | Sanofi - Aventis Deutschland GmbH | Substituovaný benzimidazol |
JP2003506483A (ja) * | 1999-08-13 | 2003-02-18 | ベラ・ファーマシューティカルズ・インコーポレイテッド | シクロベンザプリンおよびその組成物による全般性不安障害の処置 |
DE19951360A1 (de) | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
BR0015401A (pt) | 1999-11-08 | 2002-07-02 | Wyeth Corp | [(indol-3-il)-cicloalquil]-3-azetidinas substituìdas para o tratamento de distúrbios do sistema nervoso central |
US6245799B1 (en) * | 1999-11-08 | 2001-06-12 | American Home Products Corp | [(Indol-3-yl)-cycloalkyl]-3-substituted azetidines for the treatment of central nervous system disorders |
GB0003154D0 (en) | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
EP1209158A1 (en) | 2000-11-18 | 2002-05-29 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines |
EP1268477B1 (en) | 2000-03-15 | 2010-04-21 | Sanofi-Aventis Deutschland GmbH | Substituted beta-carbolines with ikb-kinase inhibiting activity |
EP1134221A1 (en) | 2000-03-15 | 2001-09-19 | Aventis Pharma Deutschland GmbH | Substituted beta-carbolines as lkB kinase inhibitors |
CA2407370A1 (en) * | 2000-04-24 | 2001-11-01 | Bristol-Myers Squibb Company | Heterocycles that are inhibitors of impdh enzyme |
TWI306859B (en) | 2000-04-28 | 2009-03-01 | Acadia Pharm Inc | Muscarinic agonists |
EP1293206A4 (en) | 2000-05-15 | 2005-09-21 | Kissei Pharmaceutical | LIQUID PREPARATION BASED ON WATER |
US6414013B1 (en) | 2000-06-19 | 2002-07-02 | Pharmacia & Upjohn S.P.A. | Thiophene compounds, process for preparing the same, and pharmaceutical compositions containing the same background of the invention |
US6897231B2 (en) * | 2000-07-31 | 2005-05-24 | Signal Pharmaceuticals, Inc. | Indazole derivatives as JNK inhibitors and compositions and methods related thereto |
US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
ATE324372T1 (de) | 2000-08-14 | 2006-05-15 | Ortho Mcneil Pharm Inc | Substituierte pyrazole |
EP1311502A1 (en) | 2000-08-17 | 2003-05-21 | Celltech R&D Limited | Bicyclic heteroaromatic derivatives for the treatment of immune and inflammatory disorders |
US6868504B1 (en) * | 2000-08-31 | 2005-03-15 | Micron Technology, Inc. | Interleaved delay line for phase locked and delay locked loops |
RU2003106192A (ru) * | 2000-09-06 | 2004-07-27 | Орто-Макнейл Фармасьютикал, Инк. (Us) | Способ лечения аллергий |
JP4272338B2 (ja) | 2000-09-22 | 2009-06-03 | バイエル アクチェンゲゼルシャフト | ピリジン誘導体 |
CA2424303A1 (en) | 2000-10-03 | 2002-04-11 | Bristol-Myers Squibb Company | Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same |
US6869956B2 (en) * | 2000-10-03 | 2005-03-22 | Bristol-Myers Squibb Company | Methods of treating inflammatory and immune diseases using inhibitors of IκB kinase (IKK) |
WO2002030353A2 (en) | 2000-10-12 | 2002-04-18 | Smithkline Beecham Corporation | NF-λB INHIBITORS |
WO2002030423A1 (en) | 2000-10-12 | 2002-04-18 | Smithkline Beecham Corporation | NF-λB INHIBITORS |
CN1503673A (zh) | 2000-10-26 | 2004-06-09 | �㽭�пؼ����ɷ�����˾ | 消炎药 |
JP2002193938A (ja) | 2000-12-01 | 2002-07-10 | Bayer Ag | 4−アリールピリジン誘導体 |
US7122544B2 (en) | 2000-12-06 | 2006-10-17 | Signal Pharmaceuticals, Llc | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto |
ATE368658T1 (de) | 2000-12-22 | 2007-08-15 | Wyeth Corp | Hetorocyclindazole und -azaindazole verbindungen als 5-hydroxytryptamine-6 liganden |
EP1363993A4 (en) | 2001-02-01 | 2008-11-12 | Bristol Myers Squibb Co | METHOD FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISEASES USING I KAPPA B KINASE (IKK) |
DE10112151A1 (de) | 2001-03-14 | 2002-09-19 | Merck Patent Gmbh | Substituierte Benzofuran-2-carbonsäureamide |
WO2002094265A1 (en) | 2001-05-24 | 2002-11-28 | Leo Pharma A/S | A method of modulating nf-$g(k)b activity |
CA2447021C (en) | 2001-05-24 | 2010-08-10 | Leo Pharma A/S | Pyridyl cyanoguanidine compounds |
US20030045515A1 (en) | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
MXPA03011244A (es) * | 2001-06-07 | 2004-02-27 | Hoffmann La Roche | Nuevos derivados de indol con afinidad por el receptor 5-ht6. |
US6638679B2 (en) | 2001-07-12 | 2003-10-28 | Kodak Polychrome Graphics, Llc | Photosensitive compositions having mixtures of alkoxy and non-alkoxy diazonium salt containing compounds |
SE0102617D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
SE0102616D0 (sv) | 2001-07-25 | 2001-07-25 | Astrazeneca Ab | Novel compounds |
US20030127204A1 (en) | 2001-09-06 | 2003-07-10 | Varnell Daniel F. | Amphoteric polymer resins that increase the rate of sizing development |
US20030109550A1 (en) | 2001-09-19 | 2003-06-12 | Michael Clare | Substituted indazole compounds for the treatment of inflammation |
EP1427706B1 (en) | 2001-09-19 | 2007-05-30 | Pharmacia Corporation | Substituted pyrazolo compounds for the treatment of inflammation |
MXPA04002667A (es) | 2001-09-19 | 2004-06-18 | Pharmacia Corp | Compuestos de pirazolilo sustituido para el tratamiento de la inflacion. |
WO2003027075A2 (en) | 2001-09-19 | 2003-04-03 | Pharmacia Corporation | Substituted pyrazolyl benzenesulfamide compounds for the treatment of inflammation |
CA2464924A1 (en) | 2001-10-30 | 2003-05-08 | Pharmacia Corporation | Heteroaromatic carboxamide derivatives for the treatment of inflammation |
DK1476136T3 (da) | 2002-02-14 | 2006-10-09 | Glaxo Group Ltd | Farmaceutisk præparat, der omfatter N-[(1-N-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a]indol-10-carboxamid eller salt, og fremgangsmåde derfor, der omfatter törgranulering |
WO2003084959A1 (en) | 2002-04-03 | 2003-10-16 | Bristol-Myers Squibb Company | Thiopene-based tricyclic compounds and pharmaceutical compositions comprising same |
WO2003087087A2 (en) | 2002-04-09 | 2003-10-23 | Astex Technology Limited | Heterocyclic compounds and their use as modulators of p38 map kinase |
AR039280A1 (es) * | 2002-04-11 | 2005-02-16 | Smithkline Beecham Corp | Compuesto de aminotiofeno y su uso para preparar una composicion farmaceutica |
CA2485298C (en) | 2002-05-09 | 2008-03-11 | Pharmacia Corporation | Substituted pyrazolyl compounds for the treatment of inflammation |
US20040034084A1 (en) * | 2002-05-24 | 2004-02-19 | Celgene Corporation | Methods for using JNK inhibitors for treating or preventing disease-related wasting |
AU2003227522A1 (en) | 2002-05-30 | 2003-12-19 | Neurosearch A/S | 3-substituted quinuclidines and their use |
AU2003237330A1 (en) | 2002-06-06 | 2003-12-22 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses |
WO2003104218A1 (en) | 2002-06-06 | 2003-12-18 | Smithkline Beecham Corporation | Nf-:b inhibitors |
DE10237722A1 (de) | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
MXPA05002297A (es) | 2002-08-29 | 2005-06-08 | Boehringer Ingelheim Pharma | Derivados-3(sulfoamidoetil)-indol para uso como compuestos mimeticos de glucocorticoides en el tratamiento de enfermedades inflamatorias, alergicas y proliferativas. |
US6911445B2 (en) | 2002-09-12 | 2005-06-28 | Wyeth | Antidepressant cycloalkylamine derivatives of heterocycle-fused benzodioxans |
US6919334B2 (en) | 2002-09-12 | 2005-07-19 | Wyeth | Antidepressant azaheterocyclymethyl derivatives of 4,5-dihydroimidazo[1,4,5-de][1,4]benzoxazine |
US7135479B2 (en) | 2002-09-12 | 2006-11-14 | Wyeth | Antidepressant azaheterocyclylmethyl derivatives of heterocycle-fused benzodioxans |
AU2003298693B2 (en) | 2002-11-22 | 2010-09-30 | Smithkline Beecham Corporation | Novel chemical compounds |
AU2003286180B2 (en) * | 2002-12-02 | 2009-11-12 | F. Hoffmann-La Roche Ag | Indazole derivatives as CRF antagonists |
JP2006510676A (ja) * | 2002-12-06 | 2006-03-30 | スミスクライン・ビーチャム・コーポレイション | NF−κB阻害剤 |
DE10259244A1 (de) | 2002-12-17 | 2004-07-01 | Merck Patent Gmbh | N-(Indolethyl-)cycloamin-Verbindungen |
WO2004075846A2 (en) | 2003-02-25 | 2004-09-10 | Bristol-Myers Squibb Company | Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same |
GB0308466D0 (en) | 2003-04-11 | 2003-05-21 | Novartis Ag | Organic compounds |
US7329764B2 (en) | 2003-07-31 | 2008-02-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Substitute benzothiophene compounds |
WO2005035527A1 (en) | 2003-10-14 | 2005-04-21 | Pharmacia Corporation | Substituted pyrazinone compounds for the treatment of inflammation |
US20060004043A1 (en) * | 2003-11-19 | 2006-01-05 | Bhagwat Shripad S | Indazole compounds and methods of use thereof |
US7572914B2 (en) * | 2003-12-19 | 2009-08-11 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
GB0400895D0 (en) | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
DE102004012069A1 (de) * | 2004-03-12 | 2005-09-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue aryl-haltige 5-Acylindolinone, deren Herstellung und deren Verwendung als Arzneimittel |
PE20060373A1 (es) | 2004-06-24 | 2006-04-29 | Smithkline Beecham Corp | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 |
TW200626142A (en) * | 2004-09-21 | 2006-08-01 | Glaxo Group Ltd | Chemical compounds |
MX2007012448A (es) | 2005-04-06 | 2007-10-19 | Astrazeneca Ab | Heterociclos sustituidos y su uso como inhibidores de chk1, pdk1 y pak. |
AU2006321284B2 (en) | 2005-04-13 | 2012-06-21 | Neuraxon, Inc. | Substituted indole compounds having NOS inhibitory activity |
US8063071B2 (en) * | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
ES2372701T3 (es) * | 2005-07-22 | 2012-01-25 | Shionogi & Co., Ltd. | Derivado de indol que tiene actividad antagonista del receptor de pgd2. |
US20080262040A1 (en) * | 2005-10-25 | 2008-10-23 | Smithkline Beecham Corporation | Chemical Compounds |
EP1940296A2 (en) * | 2005-10-25 | 2008-07-09 | SmithKline Beecham Corporation | Chemical compounds |
WO2007062318A2 (en) * | 2005-11-18 | 2007-05-31 | Smithkline Beecham Corporation | Chemical compounds |
JP2009519968A (ja) * | 2005-12-16 | 2009-05-21 | スミスクライン・ビーチャム・コーポレイション | 化学物質 |
JP5255559B2 (ja) * | 2006-03-31 | 2013-08-07 | アボット・ラボラトリーズ | インダゾール化合物 |
PE20080925A1 (es) * | 2006-09-22 | 2008-09-04 | Glaxo Group Ltd | DERIVADOS DE PIRROLO[2,3-b]PIRIDINA COMO INHIBIDORES DE QUINASA, EN PARTICULAR INHIBIDORES IKK2 (O IKK BETA) |
PE20081889A1 (es) * | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
GB0710528D0 (en) * | 2007-06-01 | 2007-07-11 | Glaxo Group Ltd | Novel compounds |
GB0804592D0 (en) | 2008-03-12 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
EP2408769A1 (en) | 2009-03-17 | 2012-01-25 | Glaxo Group Limited | Pyrimidine derivatives used as itk inhibitors |
-
2005
- 2005-06-22 PE PE2005000715A patent/PE20060373A1/es not_active Application Discontinuation
- 2005-06-22 TW TW094120713A patent/TW200616967A/zh unknown
- 2005-06-22 AR ARP050102576A patent/AR050253A1/es unknown
- 2005-06-24 EP EP05769167A patent/EP1758578B1/en active Active
- 2005-06-24 KR KR1020067027143A patent/KR20070043940A/ko not_active Application Discontinuation
- 2005-06-24 WO PCT/US2005/022870 patent/WO2006002434A2/en active Application Filing
- 2005-06-24 CN CNA200580028413XA patent/CN101005836A/zh active Pending
- 2005-06-24 JP JP2007518364A patent/JP5017105B2/ja not_active Expired - Fee Related
- 2005-06-24 CA CA002571712A patent/CA2571712A1/en not_active Abandoned
- 2005-06-24 MX MXPA06014481A patent/MXPA06014481A/es unknown
- 2005-06-24 BR BRPI0512533-2A patent/BRPI0512533A/pt not_active IP Right Cessation
- 2005-06-24 AU AU2005258332A patent/AU2005258332A1/en not_active Abandoned
- 2005-06-24 AT AT05769167T patent/ATE493396T1/de not_active IP Right Cessation
- 2005-06-24 DE DE602005025632T patent/DE602005025632D1/de active Active
- 2005-06-24 ES ES05769167T patent/ES2358579T3/es active Active
- 2005-06-24 US US11/570,060 patent/US8501780B2/en not_active Expired - Fee Related
- 2005-06-24 RU RU2007102576/04A patent/RU2007102576A/ru not_active Application Discontinuation
-
2006
- 2006-11-23 ZA ZA200609759A patent/ZA200609759B/en unknown
- 2006-11-30 IL IL179747A patent/IL179747A0/en unknown
- 2006-12-29 MA MA29580A patent/MA28727B1/fr unknown
-
2007
- 2007-01-05 NO NO20070076A patent/NO20070076L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
MXPA06014481A (es) | 2007-03-01 |
EP1758578A4 (en) | 2009-05-27 |
NO20070076L (no) | 2007-02-26 |
MA28727B1 (fr) | 2007-07-02 |
KR20070043940A (ko) | 2007-04-26 |
CN101005836A (zh) | 2007-07-25 |
ATE493396T1 (de) | 2011-01-15 |
EP1758578A2 (en) | 2007-03-07 |
BRPI0512533A (pt) | 2008-03-25 |
JP5017105B2 (ja) | 2012-09-05 |
AR050253A1 (es) | 2006-10-11 |
US20070281933A1 (en) | 2007-12-06 |
DE602005025632D1 (de) | 2011-02-10 |
JP2008504296A (ja) | 2008-02-14 |
RU2007102576A (ru) | 2008-07-27 |
TW200616967A (en) | 2006-06-01 |
CA2571712A1 (en) | 2006-01-05 |
WO2006002434A2 (en) | 2006-01-05 |
US8501780B2 (en) | 2013-08-06 |
AU2005258332A1 (en) | 2006-01-05 |
IL179747A0 (en) | 2007-05-15 |
ZA200609759B (en) | 2007-10-31 |
ES2358579T3 (es) | 2011-05-11 |
WO2006002434A3 (en) | 2006-06-15 |
EP1758578B1 (en) | 2010-12-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
PE20060373A1 (es) | Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2 | |
PE20060748A1 (es) | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 | |
NO20063928L (no) | Substituerte kinolinforbindelser | |
PE20070217A1 (es) | Derivados de isoquinolona sustituidos con piperidinilo | |
BRPI0406762A (pt) | Derivados de n-(1-benzil-2-oxo-2-(1-piperazinil)etil)-1-piperidincarb oxamida e compostos relacionados como antagonistas de cgrp, para tratamento de dores de cabeça | |
NO20082000L (no) | Pyrimidinamidforbindelser som PGDS-inhibitorer | |
PE20070646A1 (es) | COMPUESTOS CON ESTRUCTURA DE CINAMIDA DE TIPO MORFOLINA COMO INHIBIDORES DE LA PRODUCCION DE ß-AMILOIDE | |
NO20063599L (no) | Ytterligere heterosykliske forbindelser og deres anvendelse som metabotrofiske glutamatreseptorantagonister | |
PE20090288A1 (es) | Derivados de quinoxalina como inhibidores de la pi3 quinasa | |
EA200801245A1 (ru) | [4-(6-галоген-7-замещенные-2,4-диоксо-1,4-дигидро-2н-хиназолин-3-ил)фенил]-5-хлортиофен-2-илсульфонилмочевины и формы и способы, связанные с ними | |
NO20084418L (no) | Azolopyridin-3-on derivater som inhibitorer av endoteliallipase | |
NO20076502L (no) | Pyrrolopyridiner nyttige som inhibitorer av proteinkinase | |
PE20040589A1 (es) | Tiazolidinonas y su preparacion como medicamentos | |
WO2010018109A3 (en) | Substituted aminotetralines | |
NO20081434L (no) | 5-(fenylisoksazolyletoksy)-triazol-3-yl substituert pyridinsammensetninger for behandling av neurologisk, psykiatrisk eller smerteforstyrrelser | |
AR071314A1 (es) | Antagonistas de receptor de cgrp | |
PE20070795A1 (es) | Compuestos pirazol-urea-heterociclicos como inhibidores de cinasa | |
TNSN07251A1 (en) | 2-phenyl-indoles as prostaglandin d2 receptor antagonists | |
MX2009010270A (es) | Indol carboxamidas como inhibidores de quinasas ikappa2. | |
PE20070619A1 (es) | TIENO(2,3-b)PIRIDIN-5-CARBONITRILOS COMO INHIBIDORES DE PROTEINAS QUINASA | |
PE20090595A1 (es) | Derivados de quinoliniloxipiperidina y pirrolidina como antagonistas del receptor h1 | |
WO2010018112A3 (en) | Monoaryl aminotetralines | |
EA201071269A1 (ru) | 3,4-замещенные пиперидиновые производные в качестве ингибиторов ренина | |
TR200103490T2 (tr) | Antihistaminik ve antialerjik maddeler olarak indolilpiperidin türevleri | |
EA200800183A1 (ru) | Новые производные индолкарбоксамида, содержащая их фармацевтическая композиция и способ лечения |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |