NO20070076L - Nye indazolkarboksamider og deres anvendelse - Google Patents
Nye indazolkarboksamider og deres anvendelseInfo
- Publication number
- NO20070076L NO20070076L NO20070076A NO20070076A NO20070076L NO 20070076 L NO20070076 L NO 20070076L NO 20070076 A NO20070076 A NO 20070076A NO 20070076 A NO20070076 A NO 20070076A NO 20070076 L NO20070076 L NO 20070076L
- Authority
- NO
- Norway
- Prior art keywords
- compound
- ikk2
- compounds
- treatment
- activity
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/18—Antioxidants, e.g. antiradicals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Abstract
Oppfinnelsen vedrører nye indazolkarboksamid-derivater. Spesifikt er oppfinnelsen rettet på forbindelser med Formel I: hvori R1 og Z er definert i beskrivelsen og farmasøytisk akseptable salter derav. Forbindelsene ifølge oppfinnelsen er inhibitorer av IKK2 og kan være anvendelige ved behandling av sykdommer som har sammenheng med uheldig IKK2 (også kjent som IKKß)aktivitet, slik som rheumatoid artritt, astma, og COPD (kronisk obstruktiv pulmonær sykdom). Følgelig er oppfinnelsen videre rettet på farmasøytiske blandinger omfattende en forbindelse ifølge oppfinnelsen. Oppfinnelsen vedrører dertil videre metoder som inhiberer IKK2-aktivitet og behandling av sykdommer som har sammenheng med denne ved bruk av en forbindelse ifølge oppfinnelsen eller en farmasøytisk blanding inneholdende en forbindelse ifølge oppfinnelsen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US58265504P | 2004-06-24 | 2004-06-24 | |
PCT/US2005/022870 WO2006002434A2 (en) | 2004-06-24 | 2005-06-24 | Novel indazole carboxamides and their use |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20070076L true NO20070076L (no) | 2007-02-26 |
Family
ID=35782386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20070076A NO20070076L (no) | 2004-06-24 | 2007-01-05 | Nye indazolkarboksamider og deres anvendelse |
Country Status (21)
Country | Link |
---|---|
US (1) | US8501780B2 (no) |
EP (1) | EP1758578B1 (no) |
JP (1) | JP5017105B2 (no) |
KR (1) | KR20070043940A (no) |
CN (1) | CN101005836A (no) |
AR (1) | AR050253A1 (no) |
AT (1) | ATE493396T1 (no) |
AU (1) | AU2005258332A1 (no) |
BR (1) | BRPI0512533A (no) |
CA (1) | CA2571712A1 (no) |
DE (1) | DE602005025632D1 (no) |
ES (1) | ES2358579T3 (no) |
IL (1) | IL179747A0 (no) |
MA (1) | MA28727B1 (no) |
MX (1) | MXPA06014481A (no) |
NO (1) | NO20070076L (no) |
PE (1) | PE20060373A1 (no) |
RU (1) | RU2007102576A (no) |
TW (1) | TW200616967A (no) |
WO (1) | WO2006002434A2 (no) |
ZA (1) | ZA200609759B (no) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0400895D0 (en) * | 2004-01-15 | 2004-02-18 | Smithkline Beecham Corp | Chemical compounds |
AR050253A1 (es) | 2004-06-24 | 2006-10-11 | Smithkline Beecham Corp | Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento |
PE20060748A1 (es) * | 2004-09-21 | 2006-10-01 | Smithkline Beecham Corp | Derivados de indolcarboxamida como inhibidores de quinasa ikk2 |
US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
TWI380973B (zh) * | 2005-06-30 | 2013-01-01 | Smithkline Beecham Corp | 化合物 |
US20080269291A1 (en) * | 2005-11-18 | 2008-10-30 | Kerns Jeffrey K | Chemical Compounds |
JP2009526035A (ja) * | 2006-02-10 | 2009-07-16 | スムミト コーポレーション ピーエルシー | デュシェンヌ型筋ジストロフィーの治療 |
JP5019768B2 (ja) * | 2006-03-23 | 2012-09-05 | 独立行政法人科学技術振興機構 | 新規低分子化合物およびその製造方法 |
PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
GB0715087D0 (en) * | 2007-08-03 | 2007-09-12 | Summit Corp Plc | Drug combinations for the treatment of duchenne muscular dystrophy |
GB0804591D0 (en) * | 2008-03-12 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
GB0804592D0 (en) * | 2008-03-12 | 2008-04-16 | Glaxo Group Ltd | Novel compounds |
CN102171204B (zh) | 2008-10-02 | 2014-08-20 | 旭化成制药株式会社 | 8位取代异喹啉衍生物及其用途 |
US8354539B2 (en) | 2009-03-10 | 2013-01-15 | Glaxo Group Limited | Indole derivatives as IKK2 inhibitors |
WO2010120854A1 (en) * | 2009-04-15 | 2010-10-21 | Glaxosmithkline Llc | Chemical compounds |
JP2015214492A (ja) * | 2012-09-07 | 2015-12-03 | 大日本住友製薬株式会社 | 3−(4−ピペリジル)−インダゾール誘導体 |
SG11201901146SA (en) | 2016-09-23 | 2019-04-29 | Novartis Ag | Indazole compounds for use in tendon and/or ligament injuries |
JOP20190053A1 (ar) | 2016-09-23 | 2019-03-21 | Novartis Ag | مركبات أزا إندازول للاستخدام في إصابات الأوتار و/ أو الرباط |
PE20220517A1 (es) * | 2019-06-27 | 2022-04-07 | Biogen Ma Inc | Derivados de 2h-indazol y su uso en el tratamiento de enfermedades |
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- 2005-06-22 PE PE2005000715A patent/PE20060373A1/es not_active Application Discontinuation
- 2005-06-22 TW TW094120713A patent/TW200616967A/zh unknown
- 2005-06-24 CA CA002571712A patent/CA2571712A1/en not_active Abandoned
- 2005-06-24 AT AT05769167T patent/ATE493396T1/de not_active IP Right Cessation
- 2005-06-24 BR BRPI0512533-2A patent/BRPI0512533A/pt not_active IP Right Cessation
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- 2005-06-24 JP JP2007518364A patent/JP5017105B2/ja not_active Expired - Fee Related
- 2005-06-24 DE DE602005025632T patent/DE602005025632D1/de active Active
- 2005-06-24 CN CNA200580028413XA patent/CN101005836A/zh active Pending
- 2005-06-24 WO PCT/US2005/022870 patent/WO2006002434A2/en active Application Filing
- 2005-06-24 AU AU2005258332A patent/AU2005258332A1/en not_active Abandoned
- 2005-06-24 EP EP05769167A patent/EP1758578B1/en active Active
- 2005-06-24 ES ES05769167T patent/ES2358579T3/es active Active
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- 2005-06-24 KR KR1020067027143A patent/KR20070043940A/ko not_active Application Discontinuation
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- 2006-12-29 MA MA29580A patent/MA28727B1/fr unknown
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Also Published As
Publication number | Publication date |
---|---|
US8501780B2 (en) | 2013-08-06 |
MXPA06014481A (es) | 2007-03-01 |
DE602005025632D1 (de) | 2011-02-10 |
EP1758578B1 (en) | 2010-12-29 |
CN101005836A (zh) | 2007-07-25 |
ES2358579T3 (es) | 2011-05-11 |
EP1758578A2 (en) | 2007-03-07 |
CA2571712A1 (en) | 2006-01-05 |
KR20070043940A (ko) | 2007-04-26 |
BRPI0512533A (pt) | 2008-03-25 |
WO2006002434A3 (en) | 2006-06-15 |
ATE493396T1 (de) | 2011-01-15 |
MA28727B1 (fr) | 2007-07-02 |
WO2006002434A2 (en) | 2006-01-05 |
RU2007102576A (ru) | 2008-07-27 |
IL179747A0 (en) | 2007-05-15 |
EP1758578A4 (en) | 2009-05-27 |
ZA200609759B (en) | 2007-10-31 |
PE20060373A1 (es) | 2006-04-29 |
US20070281933A1 (en) | 2007-12-06 |
TW200616967A (en) | 2006-06-01 |
AU2005258332A1 (en) | 2006-01-05 |
JP2008504296A (ja) | 2008-02-14 |
JP5017105B2 (ja) | 2012-09-05 |
AR050253A1 (es) | 2006-10-11 |
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