MXPA04002682A - Compuestos pirazolilo sustituidos para el tratamiento de la inflamacion. - Google Patents

Compuestos pirazolilo sustituidos para el tratamiento de la inflamacion.

Info

Publication number
MXPA04002682A
MXPA04002682A MXPA04002682A MXPA04002682A MXPA04002682A MX PA04002682 A MXPA04002682 A MX PA04002682A MX PA04002682 A MXPA04002682 A MX PA04002682A MX PA04002682 A MXPA04002682 A MX PA04002682A MX PA04002682 A MXPA04002682 A MX PA04002682A
Authority
MX
Mexico
Prior art keywords
inflammation
treatment
substituted pyrazolo
pyrazolo compounds
compounds
Prior art date
Application number
MXPA04002682A
Other languages
English (en)
Inventor
J Hanson Gunnar
Original Assignee
Pharmacia Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia Corp filed Critical Pharmacia Corp
Publication of MXPA04002682A publication Critical patent/MXPA04002682A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Abstract

La presente invencion se refiere a derivados pirazolil sustituidos, composiciones que comprenden dichos intermediarios, metodos para producir los derivados pirazolil sustituidos y metodos para tratar el cancer, la inflamacion y las enfermedades asociadas con la inflamacion tal como la artritis.
MXPA04002682A 2001-09-19 2002-09-19 Compuestos pirazolilo sustituidos para el tratamiento de la inflamacion. MXPA04002682A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32329701P 2001-09-19 2001-09-19
US38322602P 2002-05-24 2002-05-24
PCT/US2002/029625 WO2003024936A1 (en) 2001-09-19 2002-09-19 Substituted pyrazolo compounds for the treatment of inflammation

Publications (1)

Publication Number Publication Date
MXPA04002682A true MXPA04002682A (es) 2004-06-18

Family

ID=26983875

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA04002682A MXPA04002682A (es) 2001-09-19 2002-09-19 Compuestos pirazolilo sustituidos para el tratamiento de la inflamacion.

Country Status (10)

Country Link
US (1) US7211597B2 (es)
EP (1) EP1427706B1 (es)
JP (1) JP2005510466A (es)
AT (1) ATE363473T1 (es)
BR (1) BR0212617A (es)
CA (1) CA2460939C (es)
DE (1) DE60220422T2 (es)
ES (1) ES2286275T3 (es)
MX (1) MXPA04002682A (es)
WO (1) WO2003024936A1 (es)

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CA2502429A1 (en) 2002-10-31 2004-05-21 Amgen Inc. Antiinflammation agents
WO2004092167A1 (en) * 2003-04-09 2004-10-28 Millennium Pharmaceuticals, Inc. Beta-carbolines useful for treating inflammatory disease
US7132428B2 (en) 2003-07-03 2006-11-07 Aventis Pharmaceuticals Inc. Pyrazoloisoquinoline derivative as kinase inhibitors for the treatment of various disorders
JP2007521227A (ja) * 2003-07-03 2007-08-02 アベンティス・ファーマスーティカルズ・インコーポレイテツド キナーゼ阻害剤としてのピラゾロイソキノリン誘導体
US7572914B2 (en) * 2003-12-19 2009-08-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
CA2561859A1 (en) 2004-04-09 2005-11-24 Millennium Pharmaceuticals, Inc. Beta-carbolines useful for treating inflammatory disease
WO2005105788A1 (en) * 2004-04-23 2005-11-10 Takeda San Diego, Inc. Indole derivatives and use thereof as kinase inhibitors
TW200616967A (en) 2004-06-24 2006-06-01 Smithkline Beecham Corp Novel indazole carboxamides and their use
ATE486878T1 (de) * 2004-08-18 2010-11-15 4Sc Ag Benzothienopyridine zur verwendung als inhibitoren von eg5-kinesin
WO2006023931A2 (en) * 2004-08-18 2006-03-02 Takeda San Diego, Inc. Kinase inhibitors
PE20060748A1 (es) 2004-09-21 2006-10-01 Smithkline Beecham Corp Derivados de indolcarboxamida como inhibidores de quinasa ikk2
US7713973B2 (en) * 2004-10-15 2010-05-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
US20080114017A1 (en) * 2005-01-27 2008-05-15 Matthias Vennemann Novel Indolopyridines, Benzofuranopyridines and Benzothienopyridines
EP1856117A1 (en) * 2005-01-28 2007-11-21 Nycomed GmbH Indolopyridines, benzofuranopyridines and benzothienopyridines
TW200738638A (en) * 2005-06-23 2007-10-16 Merck & Co Inc Tyrosine kinase inhibitors
RU2408584C2 (ru) 2005-06-23 2011-01-10 Мерк Шарп Энд Домэ Корп. Ингибиторы тирозинкиназы
ES2370419T3 (es) * 2005-06-23 2011-12-15 Merck Sharp & Dohme Corp. Inhibidores de tirosina quinasa.
WO2007005534A2 (en) 2005-06-30 2007-01-11 Smithkline Beecham Corporation Chemical compounds
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
US8119655B2 (en) * 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
AU2006306496A1 (en) * 2005-10-21 2007-05-03 Merck Sharp & Dohme Corp. Tyrosine kinase inhibitors
JP2009513580A (ja) * 2005-10-21 2009-04-02 メルク エンド カムパニー インコーポレーテッド チロシンキナーゼ阻害剤
US20090246169A1 (en) * 2006-02-22 2009-10-01 Matthias Vennemann Indolopyridines as eg5 kinesin modulators
WO2007096393A1 (en) * 2006-02-22 2007-08-30 4Sc Ag Indolopyridines as eg5 kinesin modulators
UY30377A1 (es) 2006-06-02 2008-01-02 Elan Pharm Inc Inhibidores triciclicos fusionados de sulfonamida de gama-secretasa
TW200813021A (en) * 2006-07-10 2008-03-16 Merck & Co Inc Tyrosine kinase inhibitors
JP2009542777A (ja) * 2006-07-13 2009-12-03 ４エスツェー アクチェンゲゼルシャフト ベンゾピラノピラゾール
GEP20135728B (en) 2006-10-09 2013-01-25 Takeda Pharmaceuticals Co Kinase inhibitors
EP2223925A1 (en) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
PE20081889A1 (es) 2007-03-23 2009-03-05 Smithkline Beecham Corp Indol carboxamidas como inhibidores de ikk2
EP2278999A4 (en) 2008-04-21 2015-04-22 Otonomy Inc EARLY TREATMENT FORMULATIONS FOR THE TREATMENT OF EARLY DISEASES AND DRESSES
US20110212053A1 (en) * 2008-06-19 2011-09-01 Dapeng Qian Phosphatidylinositol 3 kinase inhibitors
WO2010049366A1 (en) * 2008-10-27 2010-05-06 Glaxo Group Limited Tricyclic compounds as glutamate receptor modulators
US8354539B2 (en) 2009-03-10 2013-01-15 Glaxo Group Limited Indole derivatives as IKK2 inhibitors
EP2904119B1 (en) 2012-10-02 2020-06-17 The General Hospital Corporation d/b/a Massachusetts General Hospital Methods relating to dna-sensing pathway related conditions
AU2014302712B2 (en) * 2013-06-24 2018-11-29 Merck Patent Gmbh Pyrazole compounds as modulators of FSHR and uses thereof
WO2015196335A1 (en) * 2014-06-23 2015-12-30 Tocopherx, Inc. Pyrazole compounds as modulators of fshr and uses thereof
CN109689027A (zh) 2016-06-29 2019-04-26 奥德纳米有限公司 甘油三酯耳用制剂及其用途
CN110914277B (zh) * 2017-07-10 2022-08-09 上海瑛派药业有限公司 咪唑并[1,2-b]嘧啶并[4,5-d]哒嗪-5(6H)-酮类化合物及其应用

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Also Published As

Publication number Publication date
BR0212617A (pt) 2005-02-09
CA2460939C (en) 2008-07-29
EP1427706A1 (en) 2004-06-16
WO2003024936A1 (en) 2003-03-27
EP1427706B1 (en) 2007-05-30
DE60220422T2 (de) 2008-02-07
JP2005510466A (ja) 2005-04-21
ATE363473T1 (de) 2007-06-15
US20030114432A1 (en) 2003-06-19
ES2286275T3 (es) 2007-12-01
DE60220422D1 (de) 2007-07-12
CA2460939A1 (en) 2003-03-27
US7211597B2 (en) 2007-05-01

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