NO20054878L - 2-Fenoksy- og 2-fenylsulfonamidderivater med CCR3-antagonistisk aktivitet for behandling av astma og andre inflammasjons- eller immunologiske forstyrrelser - Google Patents

2-Fenoksy- og 2-fenylsulfonamidderivater med CCR3-antagonistisk aktivitet for behandling av astma og andre inflammasjons- eller immunologiske forstyrrelser

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Publication number
NO20054878L
NO20054878L NO20054878A NO20054878A NO20054878L NO 20054878 L NO20054878 L NO 20054878L NO 20054878 A NO20054878 A NO 20054878A NO 20054878 A NO20054878 A NO 20054878A NO 20054878 L NO20054878 L NO 20054878L
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Norway
Prior art keywords
treatment
asthma
inflammatory
antagonistic activity
immunological disorders
Prior art date
Application number
NO20054878A
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English (en)
Other versions
NO332932B1 (no
Inventor
Yingfu Li
Nagahiro Yoshida
Klaus Urbahns
Toshiya Moriwaki
Kevin Bacon
Hiromi Sugimoto
Keiko Fukushima
Ken-Taro Hashimoto
Makiko Marumo
Noriko Nunami
Naoki Tsuno
Original Assignee
Actimis Pharmaceuticals Inc
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Publication date
Application filed by Actimis Pharmaceuticals Inc filed Critical Actimis Pharmaceuticals Inc
Publication of NO20054878L publication Critical patent/NO20054878L/no
Publication of NO332932B1 publication Critical patent/NO332932B1/no

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    • C07D487/04—Ortho-condensed systems
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
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Abstract

Foreliggende oppfinnelse angår et benzensulfonamidderivat med formel (I), som er anvendelig som en aktiv ingrediens i farmasøytiske preparater. Benzensulfon-amidderivatene ifølge oppfinnelsen har CCR3(CC-type kjemokinreseptor)-antagonistisk aktivitet og kan være anvendelige for profylakse og behandling av sykdommer assosiert med CCR3-aktivitet, særlig for behandling av astma, atopisk dermatitt, allergisk rinitt og andre inflammasjons-/immunologiske forstyrrelser. I nevnte formel representerer X O eller S; R4 representerer formlene (a), (b), (c), (d), (e), (f), (g), (h), (i) eller (j) og andre substituenter er som definert i krav 1.
NO20054878A 2003-03-24 2005-10-21 Benzensulfonamidderivater, anvendelse derav og sammensetning inneholdende et slikt derivat NO332932B1 (no)

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