NO20065022L - Substituerte 4-alkyl- og 4-alkanoyl-piperidinderivater og deres anvendelse som neurokininantagonister - Google Patents

Substituerte 4-alkyl- og 4-alkanoyl-piperidinderivater og deres anvendelse som neurokininantagonister

Info

Publication number
NO20065022L
NO20065022L NO20065022A NO20065022A NO20065022L NO 20065022 L NO20065022 L NO 20065022L NO 20065022 A NO20065022 A NO 20065022A NO 20065022 A NO20065022 A NO 20065022A NO 20065022 L NO20065022 L NO 20065022L
Authority
NO
Norway
Prior art keywords
antagonistic activity
alkanoyl
substituted
alkyl
piperidine derivatives
Prior art date
Application number
NO20065022A
Other languages
English (en)
Inventor
Joseph Elisabeth Leenaerts
Francois Maria Sommen
Benoit Christian Albert Boeck
Frans Eduard
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of NO20065022L publication Critical patent/NO20065022L/no

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Oppfinnelsen vedrører substituerte 4-alkyl- og 4-alkanoyl-piperidinderivater som har neurokininantagonistisk aktivitet, spesielt NKi-antagonistisk aktivitet og en kombinert NK1/NK3- antagonistisk aktivitet, sammensetninger omfattende dem og deres anvendelse som en medisin, spesielt for behandlingen og/eller profylaksen av schizofreni, emese, angst og depresjon, irritabelt tarmsyndrom (IBS), sirkadianske rytmeforstyrrelser, preeklampsi, nocisepsjon, smerte, spesielt visceral og nevropatisk smerte, pankreatitt, nevrogen inflammasjon, astma, kronisk obstruktiv lungesykdom (KOL) og urineringslidelser slik som urininkontinens. Forbindelsene ifølge oppfinnelsen kan representeres ved generell formel (I) og omfatter også de farmasøytisk akseptable syre- eller baseaddisjonssalter derav, de stereokjemisk isomere former derav, iV-oksidformen derav og prodroger derav, hvori alle substituenter er definert som i krav 1.
NO20065022A 2004-04-08 2006-11-03 Substituerte 4-alkyl- og 4-alkanoyl-piperidinderivater og deres anvendelse som neurokininantagonister NO20065022L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04101467 2004-04-08
PCT/EP2005/051509 WO2005097774A1 (en) 2004-04-08 2005-04-04 Substituted 4-alkyl- and 4-alkanoyl-piperidine derivatives and their use as neurokinin antagonists

Publications (1)

Publication Number Publication Date
NO20065022L true NO20065022L (no) 2006-11-03

Family

ID=34928945

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20065022A NO20065022L (no) 2004-04-08 2006-11-03 Substituerte 4-alkyl- og 4-alkanoyl-piperidinderivater og deres anvendelse som neurokininantagonister

Country Status (23)

Country Link
US (1) US20070213346A1 (no)
EP (1) EP1737838B1 (no)
JP (1) JP2007532516A (no)
KR (1) KR20070007347A (no)
CN (1) CN1938291B (no)
AR (1) AR048532A1 (no)
AT (1) ATE396185T1 (no)
AU (1) AU2005231986B2 (no)
BR (1) BRPI0509720A (no)
CA (1) CA2561967A1 (no)
DE (1) DE602005007002D1 (no)
EA (1) EA010312B1 (no)
ES (1) ES2307169T3 (no)
IL (1) IL178461A0 (no)
JO (1) JO2525B1 (no)
MX (1) MXPA06011683A (no)
MY (1) MY142773A (no)
NO (1) NO20065022L (no)
NZ (1) NZ550098A (no)
PA (1) PA8628901A1 (no)
TW (1) TWI358298B (no)
WO (1) WO2005097774A1 (no)
ZA (1) ZA200608356B (no)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4769257B2 (ja) * 2005-02-23 2011-09-07 シェーリング コーポレイション ケモカインレセプターのインヒビターとして有用なピペリジニルピペラジン誘導体
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
TW200841879A (en) 2007-04-27 2008-11-01 Eisai R&D Man Co Ltd Pyridine derivatives substituted by heterocyclic ring and phosphonoamino group, and anti-fungal agent containing same
US8513287B2 (en) 2007-12-27 2013-08-20 Eisai R&D Management Co., Ltd. Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same
EP2623101B1 (en) 2009-04-02 2021-04-21 Merck Patent GmbH Piperidine and piperazine derivatives as autotaxin inhibitors
ES2436566T3 (es) 2009-04-02 2014-01-03 Shionogi & Co., Ltd. Compuestos de acrilamida y utilización de los mismos
AU2010311321B2 (en) * 2009-10-30 2014-11-27 Prexton Therapeutics S.A. Novel oxime derivatives and their use as allosteric modulators of metabotropic glutamate receptors
EP3044207B1 (en) * 2013-09-12 2017-10-18 F. Hoffmann-La Roche AG Indol-carboxamide derivatives
ES2753539T3 (es) * 2015-05-18 2020-04-13 Nerre Therapeutics Ltd Antagonista del receptor NK-1/NK-3 para el tratamiento de los sofocos
PT3765024T (pt) 2018-03-14 2024-02-19 Kandy Therapeutics Ltd Formulação farmacêutica inovadora que compreende antagonistas duplos dos recetores nk-1/nk-3
EP3983370B1 (en) 2019-06-12 2023-08-02 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides
US20220306490A1 (en) * 2019-06-12 2022-09-29 Nouryon Chemicals International B.V. Method for isolating carboxylic acid from an aqueous side stream
EP3983368B1 (en) 2019-06-12 2023-08-02 Nouryon Chemicals International B.V. Process for the production of diacyl peroxides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ321575A (en) * 1995-10-30 1999-05-28 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4- substituted piperazine derivatives
TW382017B (en) * 1995-12-27 2000-02-11 Janssen Pharmaceutica Nv 1-(1,2-disubstituted piperidinyl)-4-(fused imidazole)-piperidine derivatives
GB0025354D0 (en) * 2000-10-17 2000-11-29 Glaxo Group Ltd Chemical compounds
US6642226B2 (en) * 2001-02-06 2003-11-04 Hoffman-La Roche Inc. Substituted phenyl-piperidine methanone compounds
CA2509090C (en) * 2002-12-23 2012-01-24 Janssen Pharmaceutica N.V. Substituted 4-(4-piperidin-4-yl-piperazin-1-yl)-azepane derivatives and their use as neurokinin antagonists

Also Published As

Publication number Publication date
CN1938291A (zh) 2007-03-28
JO2525B1 (en) 2010-03-17
NZ550098A (en) 2009-10-30
AU2005231986B2 (en) 2011-02-24
TW200603797A (en) 2006-02-01
AR048532A1 (es) 2006-05-03
TWI358298B (en) 2012-02-21
MXPA06011683A (es) 2006-12-14
EA010312B1 (ru) 2008-08-29
AU2005231986A1 (en) 2005-10-20
BRPI0509720A (pt) 2007-09-25
ATE396185T1 (de) 2008-06-15
EP1737838A1 (en) 2007-01-03
KR20070007347A (ko) 2007-01-15
EP1737838B1 (en) 2008-05-21
ES2307169T3 (es) 2008-11-16
DE602005007002D1 (de) 2008-07-03
ZA200608356B (en) 2008-07-30
PA8628901A1 (es) 2006-09-08
CA2561967A1 (en) 2005-10-20
CN1938291B (zh) 2011-11-16
EA200601880A1 (ru) 2007-02-27
MY142773A (en) 2010-12-31
IL178461A0 (en) 2007-02-11
JP2007532516A (ja) 2007-11-15
WO2005097774A1 (en) 2005-10-20
US20070213346A1 (en) 2007-09-13

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