WO2006011024A3 - New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them - Google Patents

New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them Download PDF

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Publication number
WO2006011024A3
WO2006011024A3 PCT/IB2005/002061 IB2005002061W WO2006011024A3 WO 2006011024 A3 WO2006011024 A3 WO 2006011024A3 IB 2005002061 W IB2005002061 W IB 2005002061W WO 2006011024 A3 WO2006011024 A3 WO 2006011024A3
Authority
WO
WIPO (PCT)
Prior art keywords
preparation
treatment
pharmaceutical compositions
compositions containing
inflammatory
Prior art date
Application number
PCT/IB2005/002061
Other languages
French (fr)
Other versions
WO2006011024A9 (en
WO2006011024A2 (en
Inventor
Gopalan Balasubramanian
Laxmikant Atmaram Gharat
Neelima Khairatkar Joshi
Original Assignee
Glenmark Pharmaceuticals Ltd
Gopalan Balasubramanian
Laxmikant Atmaram Gharat
Neelima Khairatkar Joshi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Pharmaceuticals Ltd, Gopalan Balasubramanian, Laxmikant Atmaram Gharat, Neelima Khairatkar Joshi filed Critical Glenmark Pharmaceuticals Ltd
Publication of WO2006011024A2 publication Critical patent/WO2006011024A2/en
Publication of WO2006011024A3 publication Critical patent/WO2006011024A3/en
Publication of WO2006011024A9 publication Critical patent/WO2006011024A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/91—Dibenzofurans; Hydrogenated dibenzofurans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

The present invention relates to novel heterocyclic compounds, their analogs, their tautomers, their regioisomers, their stereoisomers, their enantiomers, their diastereomers, their polymorphs, their pharmaceutically acceptable salts, their appropriate oxides, their pharmaceutically acceptable solvates and their pharmaceutical compositions containing them. The present invention also relates to Phosphodiesterase type 4 (PDE4) inhibitor compounds which down regulate or inhibit the production of TNF-α and therefore are useful in the treatment of variety of allergic and inflammatory diseases including asthma and chronic obstructive pulmonary disease (COPD). The present invention also relates to a process for the preparation of the novel heterocyclic compounds.
PCT/IB2005/002061 2004-07-19 2005-07-18 New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them WO2006011024A2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US58947904P 2004-07-19 2004-07-19
US60/589,479 2004-07-19
IN809MU2004 2004-07-29
IN809/MUM/2004 2004-07-29

Publications (3)

Publication Number Publication Date
WO2006011024A2 WO2006011024A2 (en) 2006-02-02
WO2006011024A3 true WO2006011024A3 (en) 2006-03-30
WO2006011024A9 WO2006011024A9 (en) 2006-06-08

Family

ID=35517465

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/002061 WO2006011024A2 (en) 2004-07-19 2005-07-18 New tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them

Country Status (1)

Country Link
WO (1) WO2006011024A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2591784B1 (en) 2005-05-10 2016-09-14 Intermune, Inc. Pyridine-2-one-derivatives as modulators of stress-activated protein kinase system
MX2009002657A (en) * 2006-09-11 2009-08-18 Matrix Lab Ltd Dibenzofuran derivatives as inhibitors of pde-4 and pde-10.
WO2008065522A2 (en) * 2006-11-29 2008-06-05 Glenmark Pharmaceuticals S.A. Process for the synthesis of 4-difluoromethoxy-8-nitro-1-formyl dibenzo[b,d] furan-an intermediate for pde iv inhibitors
WO2009115874A2 (en) * 2008-03-17 2009-09-24 Matrix Laboratories Ltd. Novel heterocyclic compounds, pharmaceutical compositions containing them and processes for their preparation
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
WO2010084402A2 (en) * 2009-01-22 2010-07-29 Orchid Research Laboratories Ltd. Heterocyclic compounds as phosphodiesterase inhibitors
WO2011132051A2 (en) * 2010-04-19 2011-10-27 Glenmark Pharmaceuticals S.A. Tricycle compounds as phosphodiesterase-10 inhibitors
AR092742A1 (en) 2012-10-02 2015-04-29 Intermune Inc ANTIFIBROTIC PYRIDINONES
MX2016012808A (en) 2014-04-02 2017-01-05 Intermune Inc Anti-fibrotic pyridinones.
CN110256383B (en) * 2019-06-25 2021-01-15 浙江大学城市学院 Dibenzofuran acrylate compound and preparation method thereof
WO2023121238A1 (en) * 2021-12-21 2023-06-29 (주)메디픽 Substituted heterocyclic derivative compound and pharmaceutical composition for preventing or treating cancer comprising same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6314156A (en) * 1986-07-07 1988-01-21 Canon Inc Electrophotographic sensitive body
WO1996003377A1 (en) * 1994-07-27 1996-02-08 Sankyo Company, Limited Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors
WO1999058521A1 (en) * 1998-05-12 1999-11-18 American Home Products Corporation 11-aryl-benzo[b]naphtho[2,3-d]furans and 11-aryl-benzo[b]naphtho[2,3-d]thiophenes useful in the treatment of insulin resistance and hyperglycemia
US6110962A (en) * 1998-05-12 2000-08-29 American Home Products Corporation 11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia
WO2004037805A1 (en) * 2002-10-23 2004-05-06 Glenmark Pharmaceuticals Ltd. Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6314156A (en) * 1986-07-07 1988-01-21 Canon Inc Electrophotographic sensitive body
WO1996003377A1 (en) * 1994-07-27 1996-02-08 Sankyo Company, Limited Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors
WO1999058521A1 (en) * 1998-05-12 1999-11-18 American Home Products Corporation 11-aryl-benzo[b]naphtho[2,3-d]furans and 11-aryl-benzo[b]naphtho[2,3-d]thiophenes useful in the treatment of insulin resistance and hyperglycemia
US6110962A (en) * 1998-05-12 2000-08-29 American Home Products Corporation 11-aryl-benzo[B]naphtho[2,3-D]furans and 11-aryl-benzo[B]naphtho[2,3-D]thiophenes useful in the treatment of insulin resistance and hyperglycemia
WO2004037805A1 (en) * 2002-10-23 2004-05-06 Glenmark Pharmaceuticals Ltd. Novel tricyclic compounds useful for the treatment of inflammatory and allergic disorders: process for their preparation and pharmaceutical compositions containing them

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NIELSEN K F ET AL: "Fungal metabolite screening: database of 474 mycotoxins and fungal metabolites for dereplication by standardised liquid chromatography-UV-mass spectrometry methodology", JOURNAL OF CHROMATOGRAPHY A, ELSEVIER, AMSTERDAM, NL, vol. 1002, no. 1-2, 20 June 2003 (2003-06-20), pages 111 - 136, XP004431293, ISSN: 0021-9673 *
PATENT ABSTRACTS OF JAPAN vol. 012, no. 216 (P - 719) 21 June 1988 (1988-06-21) *

Also Published As

Publication number Publication date
WO2006011024A9 (en) 2006-06-08
WO2006011024A2 (en) 2006-02-02

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