MY145168A - Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists - Google Patents

Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists

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Publication number
MY145168A
MY145168A MYPI20051504A MY145168A MY 145168 A MY145168 A MY 145168A MY PI20051504 A MYPI20051504 A MY PI20051504A MY 145168 A MY145168 A MY 145168A
Authority
MY
Malaysia
Prior art keywords
antagonistic activity
combined
spiro
theireof
antagonistic
Prior art date
Application number
Inventor
Frans Eduard Janssens
Bruno Schoentjes
Sophie Coupa
Alain Philippe Poncelet
Yvan Rene Ferdinand Simonnet
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of MY145168A publication Critical patent/MY145168A/en

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Abstract

THIS INVENTION CONCERNS SUBSTITUTED DIAZA-SPIRO-[4.5J-DECANE DENVATIVES HAVING NEUROKININ ANTAGONISTIC ACTIVITY, IN PARTICULAR NK₁ ANTAGONISTIC ACTIVITY, A COMBINED NK₁/NK₂, ANTAGONISTIC ACTIVITY. A COMBINED NK₁/NK₃ ANTAGONISTIC ACTIVIY AND A COMBINED NK₁/NK₂/NK₃ ANTAGONISTIC ACTIVITY, THEIR PREPARATION, COMPOSITIONS COMPRISING THEM AND THEIR USE AS A MEDICINE, IN PARTICULAR FOR THE TREATMENT AND/OR PROPHYLAXIS OF SCHIZOPHRENIA, EMESIS. ANXIETY AND DEPRESSION, INITABLE BOWEL SYNDROME (IBS), CIRCADIAN RHYTHM DISTURBANCES, PRE-ECLAMPSIA, NOCICEPTION, PAM. IN PARTICULAR VISCERAL AND NEUROPATHIC PAIN, PANCREATITIS, NEUROGENIC INFLAMMATION, ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) AND MICTURITION DISORDERS SUCH AS URINARY INCONTINENCE. THE COMPAUNDS ACCORDING TO THE INVENTION CAN BE REPRESENTED BY GENERAL FORMULA (1) AND COMPRISES ALSO THE PHARMACEUTACALLY ACCEPTABLE ACID OR BASE ADDITION SALTS THEIREOF,THE STEREOCHEMICALLY ISOMERIC FORMS THEIREOF, THE N-OXIDE FORM THEREOF AND PRODRUGS THEREOF, WHEREIN ALL SUBSTITUENTS ARE DEFINED AS IN CLAIM 1.
MYPI20051504 2004-04-06 2005-04-04 Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists MY145168A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04050458 2004-04-06

Publications (1)

Publication Number Publication Date
MY145168A true MY145168A (en) 2011-12-30

Family

ID=40257300

Family Applications (1)

Application Number Title Priority Date Filing Date
MYPI20051504 MY145168A (en) 2004-04-06 2005-04-04 Substituted diaza-spiro-[4.5]-decane derivatives and their use as neurokinin antagonists

Country Status (2)

Country Link
MY (1) MY145168A (en)
PA (1) PA8628301A1 (en)

Also Published As

Publication number Publication date
PA8628301A1 (en) 2005-11-25

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