MX2009005507A - Derivados de espiro-piperidina. - Google Patents
Derivados de espiro-piperidina.Info
- Publication number
- MX2009005507A MX2009005507A MX2009005507A MX2009005507A MX2009005507A MX 2009005507 A MX2009005507 A MX 2009005507A MX 2009005507 A MX2009005507 A MX 2009005507A MX 2009005507 A MX2009005507 A MX 2009005507A MX 2009005507 A MX2009005507 A MX 2009005507A
- Authority
- MX
- Mexico
- Prior art keywords
- sup
- spiro
- present
- piperidine derivatives
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Gastroenterology & Hepatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente invención se relaciona con nuevos derivados de indol-2-il-carbonil-espiro-piperidina que actúan como antagonistas del receptor de V1a, con su manufactura, con composiciones farmacéuticas que los contienen y con su uso como medicamentos. Los compuestos activos de la presente invención son útiles para la prevención y/o tratamiento de la ansiedad, trastornos depresivos y otras enfermedades. Los compuestos de la presente invención tienen la fórmula general (I), en donde R1 a R11 y X tienen los significados definidos en la descripción.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06125645 | 2006-12-07 | ||
PCT/EP2007/062857 WO2008068159A1 (en) | 2006-12-07 | 2007-11-27 | Spiro-piperidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005507A true MX2009005507A (es) | 2009-06-03 |
Family
ID=39201604
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005507A MX2009005507A (es) | 2006-12-07 | 2007-11-27 | Derivados de espiro-piperidina. |
Country Status (21)
Country | Link |
---|---|
US (2) | US7432259B2 (es) |
EP (1) | EP2099799B1 (es) |
JP (1) | JP2010511654A (es) |
KR (1) | KR101111022B1 (es) |
CN (1) | CN101541797A (es) |
AR (1) | AR064136A1 (es) |
AT (1) | ATE469899T1 (es) |
AU (1) | AU2007329066B2 (es) |
BR (1) | BRPI0720246A2 (es) |
CA (1) | CA2670671A1 (es) |
CL (1) | CL2007003483A1 (es) |
DE (1) | DE602007006989D1 (es) |
ES (1) | ES2343286T3 (es) |
IL (1) | IL198549A0 (es) |
MX (1) | MX2009005507A (es) |
NO (1) | NO20091766L (es) |
PE (1) | PE20081489A1 (es) |
RU (1) | RU2009119393A (es) |
TW (1) | TW200843758A (es) |
WO (1) | WO2008068159A1 (es) |
ZA (1) | ZA200903175B (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2418801C2 (ru) * | 2005-09-28 | 2011-05-20 | Ф. Хоффманн-Ля Рош Аг | Индол-3-ил-карбонил-азаспиропроизводные в качестве антагонистов рецептора вазопрессина |
ES2402000T3 (es) * | 2009-01-30 | 2013-04-26 | F. Hoffmann-La Roche Ag | Derivados piperidina como antagonistas del receptor NK3 |
US8324250B2 (en) * | 2009-03-19 | 2012-12-04 | Hoffmann-La Roche Inc. | Piperidine derivatives as NK3 receptor antagonists |
EA029167B1 (ru) * | 2013-12-19 | 2018-02-28 | Ф. Хоффманн-Ля Рош Аг | Спиро-оксазолоны |
CA3072766A1 (en) * | 2017-09-05 | 2019-03-14 | Blackthorn Therapeutics, Inc. | 2,6-diazaspiro[3.3]hepatan-2-yl derivatives and pharmaceutical compostions thereof useful as vasopressin receptor antagonists |
WO2020048826A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds |
WO2020048828A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Pharma Aktiengesellschaft | 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds |
WO2020048830A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds |
WO2020048829A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 3,9-diazaspiro[5.5]undecane compounds |
WO2020048831A1 (en) | 2018-09-03 | 2020-03-12 | Bayer Aktiengesellschaft | 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO5150201A1 (es) | 1998-09-07 | 2002-04-29 | Hoffmann La Roche | Derivados de piperidina |
DK1283838T3 (da) | 2000-05-12 | 2004-03-22 | Solvay Pharm Bv | Piperazin- og piperidinforbindelser |
CA2501539A1 (en) | 2002-10-17 | 2004-04-29 | Amgen Inc. | Benzimidazole derivatives and their use as vanilloid receptor ligands |
OA13347A (en) * | 2003-12-22 | 2007-04-13 | Pfizer | Triazole derivatives as vasopressin antagonists. |
US7351706B2 (en) | 2006-01-05 | 2008-04-01 | Hoffmann-La Roche Inc. | Indol-3-yl-carbonyl-spiro-piperidine derivatives |
-
2007
- 2007-11-27 KR KR1020097011663A patent/KR101111022B1/ko not_active IP Right Cessation
- 2007-11-27 CA CA002670671A patent/CA2670671A1/en not_active Abandoned
- 2007-11-27 BR BRPI0720246-6A patent/BRPI0720246A2/pt not_active IP Right Cessation
- 2007-11-27 DE DE602007006989T patent/DE602007006989D1/de active Active
- 2007-11-27 AU AU2007329066A patent/AU2007329066B2/en not_active Ceased
- 2007-11-27 CN CNA2007800432751A patent/CN101541797A/zh active Pending
- 2007-11-27 MX MX2009005507A patent/MX2009005507A/es active IP Right Grant
- 2007-11-27 EP EP07847384A patent/EP2099799B1/en not_active Not-in-force
- 2007-11-27 RU RU2009119393/04A patent/RU2009119393A/ru not_active Application Discontinuation
- 2007-11-27 JP JP2009539698A patent/JP2010511654A/ja not_active Ceased
- 2007-11-27 AT AT07847384T patent/ATE469899T1/de active
- 2007-11-27 ES ES07847384T patent/ES2343286T3/es active Active
- 2007-11-27 WO PCT/EP2007/062857 patent/WO2008068159A1/en active Application Filing
- 2007-11-30 US US11/947,822 patent/US7432259B2/en not_active Expired - Fee Related
- 2007-11-30 US US11/947,836 patent/US8022213B2/en not_active Expired - Fee Related
- 2007-12-04 CL CL200703483A patent/CL2007003483A1/es unknown
- 2007-12-04 TW TW096146110A patent/TW200843758A/zh unknown
- 2007-12-05 AR ARP070105427A patent/AR064136A1/es unknown
- 2007-12-06 PE PE2007001737A patent/PE20081489A1/es not_active Application Discontinuation
-
2009
- 2009-05-04 IL IL198549A patent/IL198549A0/en unknown
- 2009-05-05 NO NO20091766A patent/NO20091766L/no not_active Application Discontinuation
- 2009-05-07 ZA ZA200903175A patent/ZA200903175B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE602007006989D1 (en) | 2010-07-15 |
WO2008068159A1 (en) | 2008-06-12 |
AR064136A1 (es) | 2009-03-18 |
RU2009119393A (ru) | 2011-01-20 |
KR20090080112A (ko) | 2009-07-23 |
ATE469899T1 (de) | 2010-06-15 |
CA2670671A1 (en) | 2008-06-12 |
CN101541797A (zh) | 2009-09-23 |
IL198549A0 (en) | 2010-02-17 |
CL2007003483A1 (es) | 2008-07-04 |
ES2343286T3 (es) | 2010-07-27 |
ZA200903175B (en) | 2010-03-31 |
NO20091766L (no) | 2009-07-06 |
AU2007329066B2 (en) | 2012-04-12 |
PE20081489A1 (es) | 2008-10-30 |
EP2099799A1 (en) | 2009-09-16 |
US8022213B2 (en) | 2011-09-20 |
AU2007329066A1 (en) | 2008-06-12 |
TW200843758A (en) | 2008-11-16 |
JP2010511654A (ja) | 2010-04-15 |
US7432259B2 (en) | 2008-10-07 |
US20080161299A1 (en) | 2008-07-03 |
BRPI0720246A2 (pt) | 2013-12-31 |
KR101111022B1 (ko) | 2012-03-14 |
EP2099799B1 (en) | 2010-06-02 |
US20080161298A1 (en) | 2008-07-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2008080844A9 (en) | Azaspiro derivatives | |
MX2009005507A (es) | Derivados de espiro-piperidina. | |
MX2009007411A (es) | Derivados de espiropiperidina-glicinamida. | |
NO20074592L (no) | Acetylenyl-pyrazolo-pyrimidinderivater som mGluR2-antagonister | |
MX2009006540A (es) | Derivados de ester y amida de indazolilo para el tratamiento de enfermedades mediadas por un receptor de glucocorticoides. | |
HK1098460A1 (en) | Fused hetrocyclic compounds and their use as metabotropic receptor antagonists for the treatment of gastrointestinal disorders | |
MY147588A (en) | (3-amino-1,2,3,4-tetrahydro-9h-carbazol-9-yl)-acetic acid derivatives | |
BR0315547A (pt) | Derivados de quinolina como antagonistas de crth2 | |
MX2010004026A (es) | Piperidino-dihidrotienopirimidinas sustituidas. | |
MX2010005861A (es) | Agonistas novedosos de los receptores de glucocorticoides. | |
IL176546A0 (en) | Imidazoline derivatives having cb1-antagonistic activity | |
TW200731975A (en) | Novel combinations of medicaments for the treatment of respiratory diseases | |
GEP20135744B (en) | Quinuclidine carbonate derivatives and medicinal compositions containing the same | |
MX2009006454A (es) | Derivados de espiro-piperidina. | |
ES2193875A1 (es) | Derivados de benzoxazinona, su preparacion y su aplicacion como medicamentos. | |
MX2009005544A (es) | Indoles. | |
MY183111A (en) | 3-(heteroaryl-amino)-1,2,3,4-tetrahydro-9h-carbazole derivatives and their use as prostaglandin d2 receptor modulators | |
MX2009006010A (es) | Derivados de amina y su uso en enfermedades mediadas por el adrenoreceptor beta 2. | |
TW200640465A (en) | New pharmaceutically active compounds for the treatment of respiratory diseases | |
MX2009005541A (es) | Indoles que actuan como antagonistas del receptor v1a. | |
MX2009005504A (es) | Derivados de espiro piperidina como antagonistas del receptor via. | |
MX2009006446A (es) | Derivados de espiro-piperidina. | |
MX2009006920A (es) | Indoles. | |
UA93878C2 (ru) | Производная бензилпиперазина, ee применение при лечении разных расстройств и фармацевтическая композиция, которая ee содержит | |
UA98126C2 (ru) | Производные индазолильного эстера и амида для лечения расстройств, опосредованных глюкокортикоидным рецептором |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
HH | Correction or change in general | ||
FG | Grant or registration |