ZA200903175B - Spiro-piperidine derivatives - Google Patents

Spiro-piperidine derivatives

Info

Publication number
ZA200903175B
ZA200903175B ZA200903175A ZA200903175A ZA200903175B ZA 200903175 B ZA200903175 B ZA 200903175B ZA 200903175 A ZA200903175 A ZA 200903175A ZA 200903175 A ZA200903175 A ZA 200903175A ZA 200903175 B ZA200903175 B ZA 200903175B
Authority
ZA
South Africa
Prior art keywords
spiro
piperidine derivatives
piperidine
derivatives
Prior art date
Application number
ZA200903175A
Other languages
English (en)
Inventor
Caterina Bissantz
Christophe Grundschober
Raffaello Masciadri
Hasane Ratni
Mark Rogers-Evans
Patrick Schnider
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of ZA200903175B publication Critical patent/ZA200903175B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/10—Spiro-condensed systems
ZA200903175A 2006-12-07 2009-05-07 Spiro-piperidine derivatives ZA200903175B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06125645 2006-12-07

Publications (1)

Publication Number Publication Date
ZA200903175B true ZA200903175B (en) 2010-03-31

Family

ID=39201604

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200903175A ZA200903175B (en) 2006-12-07 2009-05-07 Spiro-piperidine derivatives

Country Status (21)

Country Link
US (2) US7432259B2 (xx)
EP (1) EP2099799B1 (xx)
JP (1) JP2010511654A (xx)
KR (1) KR101111022B1 (xx)
CN (1) CN101541797A (xx)
AR (1) AR064136A1 (xx)
AT (1) ATE469899T1 (xx)
AU (1) AU2007329066B2 (xx)
BR (1) BRPI0720246A2 (xx)
CA (1) CA2670671A1 (xx)
CL (1) CL2007003483A1 (xx)
DE (1) DE602007006989D1 (xx)
ES (1) ES2343286T3 (xx)
IL (1) IL198549A0 (xx)
MX (1) MX2009005507A (xx)
NO (1) NO20091766L (xx)
PE (1) PE20081489A1 (xx)
RU (1) RU2009119393A (xx)
TW (1) TW200843758A (xx)
WO (1) WO2008068159A1 (xx)
ZA (1) ZA200903175B (xx)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0616618A2 (pt) * 2005-09-28 2011-06-28 Hoffmann La Roche derivados de indol-3-il-carbonil-azaespiro como antagonistas de receptor de vasopressina
WO2010086259A1 (en) * 2009-01-30 2010-08-05 F. Hoffmann-La Roche Ag Piperidine derivatives as nk3 receptor antagonists
US8324250B2 (en) * 2009-03-19 2012-12-04 Hoffmann-La Roche Inc. Piperidine derivatives as NK3 receptor antagonists
EP3083633B1 (en) * 2013-12-19 2017-11-29 F.Hoffmann-La Roche Ag Spiro-oxazolones
SG11202001498QA (en) * 2017-09-05 2020-03-30 Blackthorn Therapeutics Inc Vasopressin receptor antagonists and products and methods related thereto
WO2020048826A1 (en) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft 5-substituted 1-oxa-3,9-diazaspiro[5.5]undecan-2-one compounds
TW202024083A (zh) 2018-09-03 2020-07-01 德商拜耳廠股份有限公司 3,9-二氮雜螺[5.5]十一烷化合物
WO2020048831A1 (en) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048830A1 (en) 2018-09-03 2020-03-12 Bayer Aktiengesellschaft 5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048828A1 (en) 2018-09-03 2020-03-12 Bayer Pharma Aktiengesellschaft 5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CO5150201A1 (es) 1998-09-07 2002-04-29 Hoffmann La Roche Derivados de piperidina
ATE255578T1 (de) 2000-05-12 2003-12-15 Solvay Pharm Bv Piperazin- und piperidinverbindungen
WO2004035549A1 (en) 2002-10-17 2004-04-29 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
BRPI0417267A (pt) * 2003-12-22 2007-04-17 Pfizer derivados de triazol como antagonistas de vasopressina
US7351706B2 (en) * 2006-01-05 2008-04-01 Hoffmann-La Roche Inc. Indol-3-yl-carbonyl-spiro-piperidine derivatives

Also Published As

Publication number Publication date
ATE469899T1 (de) 2010-06-15
US20080161298A1 (en) 2008-07-03
PE20081489A1 (es) 2008-10-30
IL198549A0 (en) 2010-02-17
AU2007329066B2 (en) 2012-04-12
CN101541797A (zh) 2009-09-23
MX2009005507A (es) 2009-06-03
TW200843758A (en) 2008-11-16
US7432259B2 (en) 2008-10-07
AR064136A1 (es) 2009-03-18
ES2343286T3 (es) 2010-07-27
CA2670671A1 (en) 2008-06-12
NO20091766L (no) 2009-07-06
US8022213B2 (en) 2011-09-20
BRPI0720246A2 (pt) 2013-12-31
WO2008068159A1 (en) 2008-06-12
CL2007003483A1 (es) 2008-07-04
KR20090080112A (ko) 2009-07-23
RU2009119393A (ru) 2011-01-20
DE602007006989D1 (en) 2010-07-15
EP2099799A1 (en) 2009-09-16
US20080161299A1 (en) 2008-07-03
AU2007329066A1 (en) 2008-06-12
JP2010511654A (ja) 2010-04-15
KR101111022B1 (ko) 2012-03-14
EP2099799B1 (en) 2010-06-02

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