MX2009005504A - Derivados de espiro piperidina como antagonistas del receptor via. - Google Patents
Derivados de espiro piperidina como antagonistas del receptor via.Info
- Publication number
- MX2009005504A MX2009005504A MX2009005504A MX2009005504A MX2009005504A MX 2009005504 A MX2009005504 A MX 2009005504A MX 2009005504 A MX2009005504 A MX 2009005504A MX 2009005504 A MX2009005504 A MX 2009005504A MX 2009005504 A MX2009005504 A MX 2009005504A
- Authority
- MX
- Mexico
- Prior art keywords
- spiro
- sup
- receptor antagonists
- piperidine derivatives
- via receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Abstract
La presente invención se refiere a nuevos derivados de indol-2-il-carbonil-espiro-piperidina que actúan como antagonistas del receptor V1a, su manufactura, composiciones farmacéuticas que los contienen y a su uso como medicamentos. Los compuestos activos de la presente invención son útiles para la prevención y/o tratamiento de ansiedad, trastornos depresivos y otras enfermedades. Los compuestos de la presente invención se representan mediante la fórmula general (I) en donde R1 a R11, X e Y son como se definió en la descripción.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06125634 | 2006-12-07 | ||
PCT/EP2007/062985 WO2008068185A1 (en) | 2006-12-07 | 2007-11-29 | Spiro-piperidine derivatives as via receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2009005504A true MX2009005504A (es) | 2009-06-03 |
Family
ID=39295880
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2009005504A MX2009005504A (es) | 2006-12-07 | 2007-11-29 | Derivados de espiro piperidina como antagonistas del receptor via. |
Country Status (21)
Country | Link |
---|---|
US (3) | US8202993B2 (es) |
EP (1) | EP2102207B1 (es) |
JP (1) | JP2010511661A (es) |
KR (1) | KR101050568B1 (es) |
CN (1) | CN101547923A (es) |
AR (1) | AR064135A1 (es) |
AT (1) | ATE469900T1 (es) |
AU (1) | AU2007328995B2 (es) |
BR (1) | BRPI0720004A2 (es) |
CA (1) | CA2670674A1 (es) |
CL (1) | CL2007003482A1 (es) |
DE (1) | DE602007006990D1 (es) |
ES (1) | ES2344131T3 (es) |
IL (1) | IL198544A (es) |
MX (1) | MX2009005504A (es) |
NO (1) | NO20091830L (es) |
PE (1) | PE20081252A1 (es) |
RU (1) | RU2009119394A (es) |
TW (1) | TW200838518A (es) |
WO (1) | WO2008068185A1 (es) |
ZA (1) | ZA200903496B (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2009006454A (es) | 2006-12-22 | 2009-06-26 | Hoffmann La Roche | Derivados de espiro-piperidina. |
SI2285808T1 (sl) | 2008-04-29 | 2014-03-31 | Novartis Ag | Spiro-indolni derivati za zdravljenje parazitskih bolezni |
EA201790919A1 (ru) * | 2014-11-14 | 2017-08-31 | Ф. Хоффманн-Ля Рош Аг | Спиротиазолоны |
EP3414247B1 (en) * | 2016-02-08 | 2021-04-21 | F. Hoffmann-La Roche AG | Spiroindolinones as ddr1 inhibitors |
US10538530B2 (en) | 2017-09-05 | 2020-01-21 | Blackthorn Therapeutics, Inc. | Vasopressin receptor antagonists and products and methods related thereto |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
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US3370091A (en) * | 1964-06-15 | 1968-02-20 | Hoffmann La Roche | 2 aminobenzhydrylhalides |
US3531467A (en) * | 1966-12-23 | 1970-09-29 | Hoffmann La Roche | Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives |
US4209625A (en) * | 1977-04-21 | 1980-06-24 | American Hoechst Corporation | Spiro[indoline-3,4'-piperidine]s |
DE3818830A1 (de) | 1988-06-03 | 1989-12-14 | Boehringer Mannheim Gmbh | Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel |
EP0450761A1 (en) | 1990-03-02 | 1991-10-09 | Merck & Co. Inc. | Spirocyclic oxytocin antagonists |
DK78692D0 (da) | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
AU5292393A (en) | 1992-10-07 | 1994-04-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
US5670509A (en) * | 1993-09-27 | 1997-09-23 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
IT1271026B (it) | 1994-10-21 | 1997-05-26 | Isagro Ricerca Srl | Derivati dell'acido b-amminopropionico ad attivita' fungicida |
US5576321A (en) | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
CN1208412A (zh) | 1995-12-14 | 1999-02-17 | 麦克公司 | 促性腺激素释放激素拮抗剂 |
GB9601724D0 (en) * | 1996-01-29 | 1996-03-27 | Merck Sharp & Dohme | Therapeutic agents |
US6166209A (en) | 1997-12-11 | 2000-12-26 | Hoffmann-La Roche Inc. | Piperidine derivatives |
CO5150201A1 (es) | 1998-09-07 | 2002-04-29 | Hoffmann La Roche | Derivados de piperidina |
TWI279402B (en) | 1999-08-20 | 2007-04-21 | Banyu Pharma Co Ltd | Spiro compounds having NPY antagonistic activities and agents containing the same |
GB0003397D0 (en) | 2000-02-14 | 2000-04-05 | Merck Sharp & Dohme | Therapeutic agents |
RU2261250C2 (ru) | 2000-05-12 | 2005-09-27 | Солвей Фармасьютикалс Б.В. | Соединения пиперазина и пиперидина |
ATE266031T1 (de) | 2000-09-29 | 2004-05-15 | Lilly Co Eli | Verfahren und verbindungen zur behandlung proliferativer erkrankungen |
EP1450796B1 (en) | 2001-11-27 | 2008-04-09 | F. Hoffmann-La Roche Ag | Benzothiazole derivatives |
FR2833948B1 (fr) | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
US20040152741A1 (en) | 2002-09-09 | 2004-08-05 | Nps Allelix Corporation | Arylglycine derivatives and their use as glycine transport inhibitors |
WO2004026855A1 (en) | 2002-09-20 | 2004-04-01 | H. Lundbeck A/S | Method for manufacture of dihydroisobenzofuran derivatives |
EP1551811A1 (en) | 2002-10-17 | 2005-07-13 | Amgen Inc. | Benzimidazole derivatives and their use as vanilloid receptor ligands |
WO2004069809A1 (en) | 2003-02-03 | 2004-08-19 | Janssen Pharmaceutica N.V. | Mercaptoimidazoles as ccr2 receptor antagonists |
US7244852B2 (en) * | 2003-02-27 | 2007-07-17 | Abbott Laboratories | Process for preparing 2-methylpyrrolidine and specific enantiomers thereof |
EP1615698B1 (en) * | 2003-04-11 | 2010-09-29 | High Point Pharmaceuticals, LLC | New amide derivatives and pharmaceutical use thereof |
EP1682136A4 (en) | 2003-11-04 | 2009-06-03 | Elixir Pharmaceuticals Inc | THERAPEUTIC COMPOUNDS AND CORRESPONDING USES THEREOF |
KR100854872B1 (ko) * | 2003-12-22 | 2008-08-28 | 화이자 인코포레이티드 | 바소프레신 길항제로서의 트리아졸 유도체 |
EP1716148A2 (en) | 2003-12-23 | 2006-11-02 | Arena Pharmaceuticals, Inc. | Novel spiroindoline or spiroisoquinoline compounds, methods of use and compositions thereof |
GB0400700D0 (en) * | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
WO2006013048A1 (en) | 2004-08-05 | 2006-02-09 | F.Hoffmann-La Roche Ag | Indole, indazole or indoline derivatives |
US8138342B2 (en) | 2004-10-12 | 2012-03-20 | High Point Pharmacueticals, LLC | 11β-hydroxysteroid dehydrogenase type 1 active spiro compounds |
US8599298B2 (en) * | 2004-10-13 | 2013-12-03 | Sony Corporation | Reproduction apparatus, imaging apparatus, screen display method, and user interface |
EP1885713A1 (en) | 2005-05-18 | 2008-02-13 | Pfizer Limited | 1, 2, 4 -triazole derivatives as vasopressin antagonists |
US8190027B2 (en) | 2006-07-12 | 2012-05-29 | Tellabs Operations, Inc. | Multifunctional and reconfigurable optical node and optical network |
CA2615726C (en) * | 2005-07-14 | 2014-05-27 | Caterina Bissantz | Indol-3-yl-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists |
WO2007028638A1 (en) | 2005-09-09 | 2007-03-15 | Euro-Celtique S.A. | Fused and spirocycle compounds and the use thereof |
MX2009006454A (es) * | 2006-12-22 | 2009-06-26 | Hoffmann La Roche | Derivados de espiro-piperidina. |
ATE486877T1 (de) * | 2006-12-29 | 2010-11-15 | Hoffmann La Roche | Azaspiroderivate |
CN101583615B (zh) * | 2007-01-12 | 2012-07-04 | 弗·哈夫曼-拉罗切有限公司 | 螺哌啶甘氨酰胺衍生物 |
-
2007
- 2007-11-29 WO PCT/EP2007/062985 patent/WO2008068185A1/en active Application Filing
- 2007-11-29 ES ES07847502T patent/ES2344131T3/es active Active
- 2007-11-29 BR BRPI0720004-8A patent/BRPI0720004A2/pt not_active IP Right Cessation
- 2007-11-29 DE DE602007006990T patent/DE602007006990D1/de active Active
- 2007-11-29 AT AT07847502T patent/ATE469900T1/de active
- 2007-11-29 CN CNA2007800448317A patent/CN101547923A/zh active Pending
- 2007-11-29 KR KR1020097011665A patent/KR101050568B1/ko not_active IP Right Cessation
- 2007-11-29 RU RU2009119394/04A patent/RU2009119394A/ru not_active Application Discontinuation
- 2007-11-29 JP JP2009539707A patent/JP2010511661A/ja active Pending
- 2007-11-29 CA CA002670674A patent/CA2670674A1/en not_active Abandoned
- 2007-11-29 AU AU2007328995A patent/AU2007328995B2/en not_active Expired - Fee Related
- 2007-11-29 EP EP07847502A patent/EP2102207B1/en not_active Not-in-force
- 2007-11-29 MX MX2009005504A patent/MX2009005504A/es active IP Right Grant
- 2007-11-30 US US11/947,953 patent/US8202993B2/en not_active Expired - Fee Related
- 2007-11-30 US US11/947,967 patent/US20080139554A1/en not_active Abandoned
- 2007-11-30 US US11/947,934 patent/US20080146568A1/en not_active Abandoned
- 2007-12-04 CL CL200703482A patent/CL2007003482A1/es unknown
- 2007-12-04 TW TW096146114A patent/TW200838518A/zh unknown
- 2007-12-05 AR ARP070105426A patent/AR064135A1/es unknown
- 2007-12-06 PE PE2007001736A patent/PE20081252A1/es not_active Application Discontinuation
-
2009
- 2009-05-04 IL IL198544A patent/IL198544A/en not_active IP Right Cessation
- 2009-05-11 NO NO20091830A patent/NO20091830L/no not_active Application Discontinuation
- 2009-05-20 ZA ZA200903496A patent/ZA200903496B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
AU2007328995B2 (en) | 2012-04-26 |
EP2102207A1 (en) | 2009-09-23 |
US20080146568A1 (en) | 2008-06-19 |
AU2007328995A1 (en) | 2008-06-12 |
TW200838518A (en) | 2008-10-01 |
ZA200903496B (en) | 2010-03-31 |
BRPI0720004A2 (pt) | 2013-12-17 |
WO2008068185A1 (en) | 2008-06-12 |
EP2102207B1 (en) | 2010-06-02 |
KR101050568B1 (ko) | 2011-07-19 |
IL198544A0 (en) | 2010-02-17 |
DE602007006990D1 (de) | 2010-07-15 |
JP2010511661A (ja) | 2010-04-15 |
PE20081252A1 (es) | 2008-09-04 |
ES2344131T3 (es) | 2010-08-18 |
CA2670674A1 (en) | 2008-06-12 |
CN101547923A (zh) | 2009-09-30 |
AR064135A1 (es) | 2009-03-18 |
KR20090079255A (ko) | 2009-07-21 |
ATE469900T1 (de) | 2010-06-15 |
US20080139554A1 (en) | 2008-06-12 |
RU2009119394A (ru) | 2011-01-20 |
IL198544A (en) | 2012-06-28 |
NO20091830L (no) | 2009-07-06 |
CL2007003482A1 (es) | 2008-07-04 |
US20080139553A1 (en) | 2008-06-12 |
US8202993B2 (en) | 2012-06-19 |
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Legal Events
Date | Code | Title | Description |
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HH | Correction or change in general | ||
FG | Grant or registration |