ATE266031T1 - Verfahren und verbindungen zur behandlung proliferativer erkrankungen - Google Patents
Verfahren und verbindungen zur behandlung proliferativer erkrankungenInfo
- Publication number
- ATE266031T1 ATE266031T1 AT01972948T AT01972948T ATE266031T1 AT E266031 T1 ATE266031 T1 AT E266031T1 AT 01972948 T AT01972948 T AT 01972948T AT 01972948 T AT01972948 T AT 01972948T AT E266031 T1 ATE266031 T1 AT E266031T1
- Authority
- AT
- Austria
- Prior art keywords
- compounds
- methods
- proliferative diseases
- treating proliferative
- formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23661600P | 2000-09-29 | 2000-09-29 | |
PCT/US2001/027728 WO2002028861A2 (en) | 2000-09-29 | 2001-09-24 | Methods and compounds for treating proliferative diseases |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE266031T1 true ATE266031T1 (de) | 2004-05-15 |
Family
ID=22890242
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT01972948T ATE266031T1 (de) | 2000-09-29 | 2001-09-24 | Verfahren und verbindungen zur behandlung proliferativer erkrankungen |
Country Status (10)
Country | Link |
---|---|
US (1) | US7109229B2 (de) |
EP (1) | EP1325011B1 (de) |
AT (1) | ATE266031T1 (de) |
AU (1) | AU2001292579A1 (de) |
DE (1) | DE60103171T2 (de) |
DK (1) | DK1325011T3 (de) |
ES (1) | ES2220811T3 (de) |
PT (1) | PT1325011E (de) |
TR (1) | TR200401316T4 (de) |
WO (1) | WO2002028861A2 (de) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050171182A1 (en) * | 2003-12-11 | 2005-08-04 | Roger Briesewitz | Methods and compositions for use in the treatment of mutant receptor tyrosine kinase driven cellular proliferative diseases |
US7241779B2 (en) * | 2003-12-23 | 2007-07-10 | Cephalon, Inc. | Fused pyrrolocarbazoles |
US7169802B2 (en) * | 2003-12-23 | 2007-01-30 | Cephalon, Inc. | Fused pyrrolocarbazoles |
CA2670674A1 (en) | 2006-12-07 | 2008-06-12 | F. Hoffmann-La Roche Ag | Spiro-piperidine derivatives as via receptor antagonists |
RU2009123133A (ru) | 2006-12-22 | 2011-01-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные спиро-пиперидина |
WO2010039997A2 (en) * | 2008-10-01 | 2010-04-08 | The University Of North Carolina At Chapel Hill | Hematopoietic protection against chemotherapeutic compounds using selective cyclin-dependent kinase 4/6 inhibitors |
CN102231983A (zh) * | 2008-10-01 | 2011-11-02 | 北卡罗来纳大学查珀尔希尔分校 | 使用选择性细胞周期蛋白依赖性激酶4/6抑制剂对抗电离辐射的造血防护 |
EP2367829B1 (de) | 2008-11-19 | 2013-01-02 | Cephalon, Inc. | Neue formen einer indazolo[5,4-a]pyrrolo[3,4-c]carbazolverbindung |
JP2012526850A (ja) | 2009-05-13 | 2012-11-01 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒル | サイクリン依存性キナーゼ阻害剤及びその用法 |
KR101815332B1 (ko) * | 2010-05-18 | 2018-01-04 | 세파론, 인코포레이티드 | 융합 피롤로카르바졸 유도체의 정제 방법 |
WO2011159726A2 (en) | 2010-06-14 | 2011-12-22 | The Scripps Research Institute | Reprogramming of cells to a new fate |
AU2011329763A1 (en) | 2010-11-17 | 2013-05-09 | Brigham And Women's Hospital | Protection of renal tissues from ischemia through inhibition of the proliferative kinases CDK4 and CDK6 |
ME03557B (de) | 2013-03-15 | 2020-07-20 | G1 Therapeutics Inc | Vorübergehender schutz von normalen zellen während einer chemotherapie |
JP6435315B2 (ja) | 2013-03-15 | 2018-12-05 | ジー1、セラピューティクス、インコーポレイテッドG1 Therapeutics, Inc. | 高活性抗新生物薬及び抗増殖剤 |
US9717735B2 (en) | 2014-04-17 | 2017-08-01 | G1 Therapeutics, Inc. | Tricyclic lactams for use in HSPC-sparing treatments for RB-positive abnormal cellular proliferation |
EP3191098A4 (de) | 2014-09-12 | 2018-04-25 | G1 Therapeutics, Inc. | Kombinationen und dosierschemen zur behandlung von rb-positiven tumoren |
WO2016040848A1 (en) | 2014-09-12 | 2016-03-17 | G1 Therapeutics, Inc. | Treatment of rb-negative tumors using topoisomerase inhibitors in combination with cyclin dependent kinase 4/6 inhibitors |
WO2017161253A1 (en) | 2016-03-18 | 2017-09-21 | Tufts Medical Center | Compositions and methods for treating and preventing metabolic disorders |
WO2018183921A1 (en) | 2017-04-01 | 2018-10-04 | The Broad Institute, Inc. | Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer |
US20220154282A1 (en) | 2019-03-12 | 2022-05-19 | The Broad Institute, Inc. | Detection means, compositions and methods for modulating synovial sarcoma cells |
US10988479B1 (en) | 2020-06-15 | 2021-04-27 | G1 Therapeutics, Inc. | Morphic forms of trilaciclib and methods of manufacture thereof |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4217964A1 (de) | 1992-05-30 | 1993-12-02 | Goedecke Ag | Indolocarbazol-Imide und deren Verwendung |
US5679694A (en) * | 1992-07-20 | 1997-10-21 | The Wellcome Foundation Ltd. | Tetracyclic compounds, intermediates for their preparation and their use as antitumor agents |
-
2001
- 2001-09-24 AT AT01972948T patent/ATE266031T1/de not_active IP Right Cessation
- 2001-09-24 US US10/344,245 patent/US7109229B2/en not_active Expired - Fee Related
- 2001-09-24 WO PCT/US2001/027728 patent/WO2002028861A2/en active IP Right Grant
- 2001-09-24 EP EP01972948A patent/EP1325011B1/de not_active Expired - Lifetime
- 2001-09-24 AU AU2001292579A patent/AU2001292579A1/en not_active Abandoned
- 2001-09-24 DK DK01972948T patent/DK1325011T3/da active
- 2001-09-24 PT PT01972948T patent/PT1325011E/pt unknown
- 2001-09-24 DE DE60103171T patent/DE60103171T2/de not_active Expired - Fee Related
- 2001-09-24 TR TR2004/01316T patent/TR200401316T4/xx unknown
- 2001-09-24 ES ES01972948T patent/ES2220811T3/es not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1325011B1 (de) | 2004-05-06 |
US20040048915A1 (en) | 2004-03-11 |
PT1325011E (pt) | 2004-09-30 |
WO2002028861A3 (en) | 2002-08-01 |
TR200401316T4 (tr) | 2004-07-21 |
AU2001292579A1 (en) | 2002-04-15 |
DE60103171T2 (de) | 2004-11-11 |
EP1325011A2 (de) | 2003-07-09 |
US7109229B2 (en) | 2006-09-19 |
WO2002028861A2 (en) | 2002-04-11 |
DK1325011T3 (da) | 2004-08-16 |
WO2002028861A8 (en) | 2003-11-20 |
ES2220811T3 (es) | 2004-12-16 |
DE60103171D1 (de) | 2004-06-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification |
Ref document number: 1325011 Country of ref document: EP |
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REN | Ceased due to non-payment of the annual fee |