ATE540920T1 - Aminobenzocycloheptenderivate, verfahren zu deren herstellung und deren verwendung in der therapie - Google Patents
Aminobenzocycloheptenderivate, verfahren zu deren herstellung und deren verwendung in der therapieInfo
- Publication number
- ATE540920T1 ATE540920T1 AT07866480T AT07866480T ATE540920T1 AT E540920 T1 ATE540920 T1 AT E540920T1 AT 07866480 T AT07866480 T AT 07866480T AT 07866480 T AT07866480 T AT 07866480T AT E540920 T1 ATE540920 T1 AT E540920T1
- Authority
- AT
- Austria
- Prior art keywords
- aminobenzocycloheptene
- therapy
- derivatives
- production
- compound
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- SRGHTELVPDTMSI-UHFFFAOYSA-N 1h-benzo[7]annulen-1-amine Chemical class C1=CC=CC=C2C(N)C=CC=C21 SRGHTELVPDTMSI-UHFFFAOYSA-N 0.000 title 1
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- QZDDFQLIQRYMBV-UHFFFAOYSA-N 2-[3-nitro-2-(2-nitrophenyl)-4-oxochromen-8-yl]acetic acid Chemical compound OC(=O)CC1=CC=CC(C(C=2[N+]([O-])=O)=O)=C1OC=2C1=CC=CC=C1[N+]([O-])=O QZDDFQLIQRYMBV-UHFFFAOYSA-N 0.000 abstract 1
- 102100022749 Aminopeptidase N Human genes 0.000 abstract 1
- 108010049990 CD13 Antigens Proteins 0.000 abstract 1
- 108010006035 Metalloproteases Proteins 0.000 abstract 1
- 102000005741 Metalloproteases Human genes 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C225/00—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones
- C07C225/20—Compounds containing amino groups and doubly—bound oxygen atoms bound to the same carbon skeleton, at least one of the doubly—bound oxygen atoms not being part of a —CHO group, e.g. amino ketones having amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
- C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
- C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/30—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/04—One of the condensed rings being a six-membered aromatic ring
- C07C2602/12—One of the condensed rings being a six-membered aromatic ring the other ring being at least seven-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/34—Benzoheptalenes; Hydrogenated benzoheptalenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0609615A FR2908131B1 (fr) | 2006-11-03 | 2006-11-03 | Derives d'aminobenzocycloheptene,leurs procedes de preparation et leur utilisation en therapeutique |
| PCT/FR2007/001812 WO2008059141A1 (fr) | 2006-11-03 | 2007-10-31 | Derives d' aminobenzocycloheptene, leurs procedes de preparation et leur utilisation en therapeutique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE540920T1 true ATE540920T1 (de) | 2012-01-15 |
Family
ID=38267701
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07866480T ATE540920T1 (de) | 2006-11-03 | 2007-10-31 | Aminobenzocycloheptenderivate, verfahren zu deren herstellung und deren verwendung in der therapie |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20100069504A1 (de) |
| EP (1) | EP2084125B1 (de) |
| JP (1) | JP2010508334A (de) |
| AT (1) | ATE540920T1 (de) |
| CA (1) | CA2668026A1 (de) |
| FR (1) | FR2908131B1 (de) |
| WO (1) | WO2008059141A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5546250B2 (ja) | 2006-12-29 | 2014-07-09 | ライジェル ファーマシューティカルズ， インコーポレイテッド | Ａｘｌインヒビターとして有用な多環式ヘテロアリール置換トリアゾール |
| PT2387395E (pt) | 2009-01-16 | 2015-02-04 | Rigel Pharmaceuticals Inc | Inibidores de axl para utilização em terapia de combinação para prevenir, tratar ou gerir cancro metastático |
| KR102415330B1 (ko) | 2018-01-08 | 2022-06-30 | 삼성전자주식회사 | 스토리지 장치의 동작 방법 및 시스템 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6635632B1 (en) * | 1996-12-23 | 2003-10-21 | Athena Neurosciences, Inc. | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds |
| CA2324475A1 (en) * | 1998-06-22 | 1999-12-29 | Elan Pharmaceuticals, Inc. | Cyclic amino acid compounds, pharmaceutical compositions comprising same, and methods for inhibiting .beta.-amyloid peptide release and/or its synthesis by use of such compounds |
-
2006
- 2006-11-03 FR FR0609615A patent/FR2908131B1/fr not_active Expired - Fee Related
-
2007
- 2007-10-31 AT AT07866480T patent/ATE540920T1/de active
- 2007-10-31 WO PCT/FR2007/001812 patent/WO2008059141A1/fr not_active Ceased
- 2007-10-31 JP JP2009535102A patent/JP2010508334A/ja not_active Withdrawn
- 2007-10-31 US US12/513,262 patent/US20100069504A1/en not_active Abandoned
- 2007-10-31 CA CA002668026A patent/CA2668026A1/fr not_active Abandoned
- 2007-10-31 EP EP07866480A patent/EP2084125B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010508334A (ja) | 2010-03-18 |
| EP2084125B1 (de) | 2012-01-11 |
| FR2908131A1 (fr) | 2008-05-09 |
| EP2084125A1 (de) | 2009-08-05 |
| FR2908131B1 (fr) | 2009-01-09 |
| US20100069504A1 (en) | 2010-03-18 |
| CA2668026A1 (fr) | 2008-05-22 |
| WO2008059141A1 (fr) | 2008-05-22 |
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