PE20081252A1 - Derivados de espiro-piperidina - Google Patents
Derivados de espiro-piperidinaInfo
- Publication number
- PE20081252A1 PE20081252A1 PE2007001736A PE2007001736A PE20081252A1 PE 20081252 A1 PE20081252 A1 PE 20081252A1 PE 2007001736 A PE2007001736 A PE 2007001736A PE 2007001736 A PE2007001736 A PE 2007001736A PE 20081252 A1 PE20081252 A1 PE 20081252A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- alcoxy
- spyro
- indol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Cardiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DERIVADOS DE ESPIRO-PIPERIDINA DE FORMULA (I) DONDE X ES C=O, CH2, O, NR7, EN DONDE R7 ES H O ALQUILO(C1-C6); Y ES O, CH2, C=O; O X-Y ES -C=C- O -CH2-CH2-; R1 ES H, ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON CN U OH, O -(ALQUILENO(C1-C6))-C(O)-NRaRb, DONDE Ra Y Rb SON CADA UNO H, ALQUILO(C1-C6), ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), ALCOXI(C1-C6), ENTRE OTROS; R3 ES H, HALOGENO O ALQUILO(C1-C6); R4 ES H, HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-6), ENTRE OTROS; R5 ES H, HALOGENO, ALCOXI(C1-C6), ENTRE OTROS; R6 ES H, NITRO, CN, HALOGENO, ENTRE OTROS; R8, R9, R10 Y R11 SON CADA UNO H, HALOGENO, ALQUILO(C1-C6), ALCOXI(C1-C6), ENTRE OTROS. SON COMPUESTOS PREFERIDOS: {5-CLORO-2-[(3-OXO-1'H,3H-ESPIRO[2-BENZOFURANO-1,4'-PIPERIDIN]-1'-IL)CARBONIL]-1H-INDOL-7-IL}ACETONITRILO, 2-{5-CLORO-2-[(3-OXO-1'H,3H-ESPIRO[2-BENZOFURANO-1,4'-PIPERIDIN]-1'-IL)CARBONIL]-1H-INDOL-1-IL}-N,N-DIMETILACETAMIDA, 1'-[(5-CLORO-1H-INDOL-2-IL)CARBONIL]-3H-ESPIRO[2-BENZOFURANO-1,4'-PIPERIDIN]-3-ONA, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE LA VASOPRESINA V1a SIENDO UTILES EN EL TRATAMIENTO DE ANSIEDAD, DEPRESION, DISMENORREA, FALLO CARDIACO CRONICO
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06125634 | 2006-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20081252A1 true PE20081252A1 (es) | 2008-09-04 |
Family
ID=39295880
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2007001736A PE20081252A1 (es) | 2006-12-07 | 2007-12-06 | Derivados de espiro-piperidina |
Country Status (21)
| Country | Link |
|---|---|
| US (3) | US20080146568A1 (es) |
| EP (1) | EP2102207B1 (es) |
| JP (1) | JP2010511661A (es) |
| KR (1) | KR101050568B1 (es) |
| CN (1) | CN101547923A (es) |
| AR (1) | AR064135A1 (es) |
| AT (1) | ATE469900T1 (es) |
| AU (1) | AU2007328995B2 (es) |
| BR (1) | BRPI0720004A2 (es) |
| CA (1) | CA2670674A1 (es) |
| CL (1) | CL2007003482A1 (es) |
| DE (1) | DE602007006990D1 (es) |
| ES (1) | ES2344131T3 (es) |
| IL (1) | IL198544A (es) |
| MX (1) | MX2009005504A (es) |
| NO (1) | NO20091830L (es) |
| PE (1) | PE20081252A1 (es) |
| RU (1) | RU2009119394A (es) |
| TW (1) | TW200838518A (es) |
| WO (1) | WO2008068185A1 (es) |
| ZA (1) | ZA200903496B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2009123133A (ru) | 2006-12-22 | 2011-01-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные спиро-пиперидина |
| EP2285808B1 (en) | 2008-04-29 | 2013-11-20 | Novartis AG | Spiro-indole derivatives for the treatment of parasitic diseases |
| EA201790919A1 (ru) * | 2014-11-14 | 2017-08-31 | Ф. Хоффманн-Ля Рош Аг | Спиротиазолоны |
| EP3414247B1 (en) * | 2016-02-08 | 2021-04-21 | F. Hoffmann-La Roche AG | Spiroindolinones as ddr1 inhibitors |
| AU2018330423B2 (en) * | 2017-09-05 | 2023-04-06 | Neumora Therapeutics, Inc. | Vasopressin receptor antagonists and products and methods related thereto |
Family Cites Families (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3370091A (en) * | 1964-06-15 | 1968-02-20 | Hoffmann La Roche | 2 aminobenzhydrylhalides |
| US3531467A (en) * | 1966-12-23 | 1970-09-29 | Hoffmann La Roche | Process for the preparation of 2,3,4,5-tetrahydro - 5 - aryl - 1h - 1,4 - benzodiazepine derivatives |
| US4209625A (en) * | 1977-04-21 | 1980-06-24 | American Hoechst Corporation | Spiro[indoline-3,4'-piperidine]s |
| DE3818830A1 (de) * | 1988-06-03 | 1989-12-14 | Boehringer Mannheim Gmbh | Bicyclische carboxamide, verfahren zu ihrer herstellung, deren vorstufen, und diese verbindungen enthaltende arzneimittel |
| CA2037287A1 (en) * | 1990-03-02 | 1991-09-03 | Ben E. Evans | Spirocyclic oxytocin antagonists |
| DK78692D0 (da) | 1992-06-12 | 1992-06-12 | Lundbeck & Co As H | Dimere piperidin- og piperazinderivater |
| AU5292393A (en) | 1992-10-07 | 1994-04-26 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| US5670509A (en) * | 1993-09-27 | 1997-09-23 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| IT1271026B (it) | 1994-10-21 | 1997-05-26 | Isagro Ricerca Srl | Derivati dell'acido b-amminopropionico ad attivita' fungicida |
| US5576321A (en) | 1995-01-17 | 1996-11-19 | Eli Lilly And Company | Compounds having effects on serotonin-related systems |
| EA000992B1 (ru) | 1995-12-14 | 2000-08-28 | Мерк Энд Ко., Инк. | Антагонисты гормона, высвобождающего гонадотропин |
| GB9601724D0 (en) * | 1996-01-29 | 1996-03-27 | Merck Sharp & Dohme | Therapeutic agents |
| US6166209A (en) | 1997-12-11 | 2000-12-26 | Hoffmann-La Roche Inc. | Piperidine derivatives |
| CO5150201A1 (es) | 1998-09-07 | 2002-04-29 | Hoffmann La Roche | Derivados de piperidina |
| TWI279402B (en) | 1999-08-20 | 2007-04-21 | Banyu Pharma Co Ltd | Spiro compounds having NPY antagonistic activities and agents containing the same |
| GB0003397D0 (en) | 2000-02-14 | 2000-04-05 | Merck Sharp & Dohme | Therapeutic agents |
| SK286778B6 (sk) | 2000-05-12 | 2009-05-07 | Solvay Pharmaceuticals B. V. | Piperazínové a piperidínové zlúčeniny, spôsob ich prípravy a farmaceutické kompozície, ktoré ich obsahujú, a použitie týchto zlúčenín |
| DK1325011T3 (da) | 2000-09-29 | 2004-08-16 | Lilly Co Eli | Fremgangsmåder og forbindelser til behandling af proliferative sygdomme |
| BR0214455A (pt) | 2001-11-27 | 2004-11-03 | Hoffmann La Roche | Derivados benzotiazol |
| FR2833948B1 (fr) | 2001-12-21 | 2004-02-06 | Sod Conseils Rech Applic | Nouveaux derives de benzimidazole et leur utilisation en tant que medicament |
| US20040152741A1 (en) | 2002-09-09 | 2004-08-05 | Nps Allelix Corporation | Arylglycine derivatives and their use as glycine transport inhibitors |
| AU2003263155A1 (en) | 2002-09-20 | 2004-04-08 | H. Lundbeck A/S | Method for manufacture of dihydroisobenzofuran derivatives |
| EP1551811A1 (en) | 2002-10-17 | 2005-07-13 | Amgen Inc. | Benzimidazole derivatives and their use as vanilloid receptor ligands |
| AU2003215549A1 (en) | 2003-02-03 | 2004-08-30 | Janssen Pharmaceutica N.V. | Mercaptoimidazoles as ccr2 receptor antagonists |
| US7244852B2 (en) * | 2003-02-27 | 2007-07-17 | Abbott Laboratories | Process for preparing 2-methylpyrrolidine and specific enantiomers thereof |
| WO2004089896A1 (en) * | 2003-04-11 | 2004-10-21 | Novo Nordisk A/S | 11β-HYDROXYSTEROID DEHYDROGENASE TYPE 1 ACTIVE COMPOUNDS |
| US7504506B2 (en) | 2003-11-04 | 2009-03-17 | Elixir Pharmaceuticals, Inc. | Therapeutic compounds and uses thereof |
| EP1701959A1 (en) * | 2003-12-22 | 2006-09-20 | Pfizer Limited | Triazole derivatives as vasopressin antagonists |
| CA2546147A1 (en) | 2003-12-23 | 2005-07-14 | Arena Pharmaceuticals, Inc. | Novel spiroindoline or spiroisoquinoline compounds, methods of use and compositions thereof |
| GB0400700D0 (en) * | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
| RU2007106180A (ru) | 2004-08-05 | 2008-09-10 | Ф. Хоффманн-Ля Рош Аг (Ch) | Производные индола, индазола или индолина |
| EP1802623A1 (en) | 2004-10-12 | 2007-07-04 | Novo Nordisk A/S | 11beta-hydroxysteroid dehydrogenase type 1 active spiro compounds |
| WO2006041171A1 (ja) * | 2004-10-13 | 2006-04-20 | Sony Corporation | 再生装置、撮像装置、画面表示方法およびユーザインターフェース |
| EP1885713A1 (en) | 2005-05-18 | 2008-02-13 | Pfizer Limited | 1, 2, 4 -triazole derivatives as vasopressin antagonists |
| US8190027B2 (en) * | 2006-07-12 | 2012-05-29 | Tellabs Operations, Inc. | Multifunctional and reconfigurable optical node and optical network |
| WO2007006688A1 (en) | 2005-07-14 | 2007-01-18 | F. Hoffmann-La Roche Ag | Indol-3-carbonyl-spiro-piperidine derivatives as v1a receptor antagonists |
| US8193208B2 (en) | 2005-09-09 | 2012-06-05 | Purdue Pharma L.P. | Fused and spirocycle compounds and the use thereof |
| RU2009123133A (ru) * | 2006-12-22 | 2011-01-27 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные спиро-пиперидина |
| CN101589046B (zh) * | 2006-12-29 | 2011-09-21 | 弗·哈夫曼-拉罗切有限公司 | 氮杂螺环衍生物 |
| KR101129791B1 (ko) * | 2007-01-12 | 2012-03-23 | 에프. 호프만-라 로슈 아게 | 스파이로피페리딘 글리신아마이드 유도체 |
-
2007
- 2007-11-29 BR BRPI0720004-8A patent/BRPI0720004A2/pt not_active IP Right Cessation
- 2007-11-29 EP EP07847502A patent/EP2102207B1/en not_active Not-in-force
- 2007-11-29 AU AU2007328995A patent/AU2007328995B2/en not_active Expired - Fee Related
- 2007-11-29 JP JP2009539707A patent/JP2010511661A/ja active Pending
- 2007-11-29 AT AT07847502T patent/ATE469900T1/de active
- 2007-11-29 ES ES07847502T patent/ES2344131T3/es active Active
- 2007-11-29 MX MX2009005504A patent/MX2009005504A/es active IP Right Grant
- 2007-11-29 WO PCT/EP2007/062985 patent/WO2008068185A1/en active Application Filing
- 2007-11-29 KR KR1020097011665A patent/KR101050568B1/ko not_active IP Right Cessation
- 2007-11-29 CN CNA2007800448317A patent/CN101547923A/zh active Pending
- 2007-11-29 RU RU2009119394/04A patent/RU2009119394A/ru not_active Application Discontinuation
- 2007-11-29 DE DE602007006990T patent/DE602007006990D1/de active Active
- 2007-11-29 CA CA002670674A patent/CA2670674A1/en not_active Abandoned
- 2007-11-30 US US11/947,934 patent/US20080146568A1/en not_active Abandoned
- 2007-11-30 US US11/947,967 patent/US20080139554A1/en not_active Abandoned
- 2007-11-30 US US11/947,953 patent/US8202993B2/en not_active Expired - Fee Related
- 2007-12-04 TW TW096146114A patent/TW200838518A/zh unknown
- 2007-12-04 CL CL200703482A patent/CL2007003482A1/es unknown
- 2007-12-05 AR ARP070105426A patent/AR064135A1/es unknown
- 2007-12-06 PE PE2007001736A patent/PE20081252A1/es not_active Application Discontinuation
-
2009
- 2009-05-04 IL IL198544A patent/IL198544A/en not_active IP Right Cessation
- 2009-05-11 NO NO20091830A patent/NO20091830L/no not_active Application Discontinuation
- 2009-05-20 ZA ZA200903496A patent/ZA200903496B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2102207B1 (en) | 2010-06-02 |
| CN101547923A (zh) | 2009-09-30 |
| WO2008068185A1 (en) | 2008-06-12 |
| DE602007006990D1 (de) | 2010-07-15 |
| KR20090079255A (ko) | 2009-07-21 |
| AU2007328995A1 (en) | 2008-06-12 |
| ES2344131T3 (es) | 2010-08-18 |
| US20080146568A1 (en) | 2008-06-19 |
| US20080139554A1 (en) | 2008-06-12 |
| AR064135A1 (es) | 2009-03-18 |
| US8202993B2 (en) | 2012-06-19 |
| JP2010511661A (ja) | 2010-04-15 |
| CA2670674A1 (en) | 2008-06-12 |
| EP2102207A1 (en) | 2009-09-23 |
| NO20091830L (no) | 2009-07-06 |
| US20080139553A1 (en) | 2008-06-12 |
| ATE469900T1 (de) | 2010-06-15 |
| ZA200903496B (en) | 2010-03-31 |
| AU2007328995B2 (en) | 2012-04-26 |
| RU2009119394A (ru) | 2011-01-20 |
| IL198544A (en) | 2012-06-28 |
| BRPI0720004A2 (pt) | 2013-12-17 |
| KR101050568B1 (ko) | 2011-07-19 |
| CL2007003482A1 (es) | 2008-07-04 |
| IL198544A0 (en) | 2010-02-17 |
| TW200838518A (en) | 2008-10-01 |
| MX2009005504A (es) | 2009-06-03 |
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