PE20081844A1 - DERIVADOS DE INDOL-3-IL-CARBONIL-AZASPIROPIPERIDINA COMO ANTAGONISTAS DEL RECEPTOR V1a - Google Patents
DERIVADOS DE INDOL-3-IL-CARBONIL-AZASPIROPIPERIDINA COMO ANTAGONISTAS DEL RECEPTOR V1aInfo
- Publication number
- PE20081844A1 PE20081844A1 PE2008000047A PE2008000047A PE20081844A1 PE 20081844 A1 PE20081844 A1 PE 20081844A1 PE 2008000047 A PE2008000047 A PE 2008000047A PE 2008000047 A PE2008000047 A PE 2008000047A PE 20081844 A1 PE20081844 A1 PE 20081844A1
- Authority
- PE
- Peru
- Prior art keywords
- indol
- alkyl
- carbonyl
- azaspiropiperidine
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/20—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Abstract
SE REFIERE A DERIVADOS DE INDOL-3-IL-CARBONIL-AZASPIROPIPERIDINA DE FORMULA (I), EN DONDE U ES O Y V ES CH2, o U ES O Y V ES C=O, o U ES CH2 Y V ES O, o U ES CH2 y V ES O; o U-V ES -CH=CH-, ENTRE OTROS; UNA O DOS VARIABLES W, X, Y y Z SON NITROGENO, SIENDO EL RESTO DE LAS VARIABLES CR8; R1 ES H, ALQUILO(C1-C12), HALOALQUILO(C2-C6), -(CRiRii)m-Ra; ENTRE OTROS; R2 ES H, ALQUILO(C1-C6), -C(O)Rn, NRjRK; R3, R4, R5 Y R6 SON INDEPENDIENTEMENTE H, HALO, ALQUILO(C1-C6), HALOALQUILO(C1-C6), ENTRE OTROS; O R1 Y R6 JUNTO CON EL INDOL AL QUE ESTAN UNIDOS FORMAN UN HETEROCICLO DE 6 MIEMBROS OPCIONALMENTE SUSTITUIDOS; R7 ES H O ALQUILO(C1-C6). SON SELECCIONADOS 1'-[(6-CLORO-1H-INDOL-3-IL)CARBONIL]-7H-SPIRO[FURO-[3,4-b]PIRIDINA-5,4'-PIPERIDINA], (2S)-2-{[6-CLORO-3-(1'H,7H-SPIRO[FURO-[3,4-b]PIRIDINA-5,4'-PIPERIDIN]-1'-ILCARBONIL)-1H-INDOL-1-IL-]METIL}-PIRROLIDINA-1-CARBOXILATO DE TREC-BUTILO. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON ANTAGONISTAS DEL RECEPTOR DE V1a, POR LO QUE SON UTILES EN EL TRATAMIENTO DE DISMENORREA, HIPERTENSION, FALLO CARDIACO CRONICA, ANSIEDAD, TRASTORNOS DEPRESIVOS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06127334 | 2006-12-29 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20081844A1 true PE20081844A1 (es) | 2009-01-26 |
Family
ID=39201403
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2008000047A PE20081844A1 (es) | 2006-12-29 | 2008-01-02 | DERIVADOS DE INDOL-3-IL-CARBONIL-AZASPIROPIPERIDINA COMO ANTAGONISTAS DEL RECEPTOR V1a |
Country Status (22)
Country | Link |
---|---|
US (3) | US8039624B2 (es) |
EP (1) | EP2125827B1 (es) |
JP (1) | JP2010514727A (es) |
KR (1) | KR101129861B1 (es) |
CN (1) | CN101589046B (es) |
AR (1) | AR064547A1 (es) |
AT (1) | ATE486877T1 (es) |
AU (1) | AU2007341379B2 (es) |
BR (1) | BRPI0720827A2 (es) |
CA (1) | CA2674154A1 (es) |
CL (1) | CL2007003832A1 (es) |
DE (1) | DE602007010359D1 (es) |
DK (1) | DK2125827T3 (es) |
ES (1) | ES2351949T3 (es) |
MX (1) | MX2009006921A (es) |
NO (1) | NO20092342L (es) |
PE (1) | PE20081844A1 (es) |
PL (1) | PL2125827T3 (es) |
PT (1) | PT2125827E (es) |
RU (1) | RU2009124419A (es) |
TW (1) | TW200835483A (es) |
WO (1) | WO2008080844A1 (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008068185A1 (en) * | 2006-12-07 | 2008-06-12 | F. Hoffmann-La Roche Ag | Spiro-piperidine derivatives as via receptor antagonists |
MX2009006454A (es) * | 2006-12-22 | 2009-06-26 | Hoffmann La Roche | Derivados de espiro-piperidina. |
AR077280A1 (es) | 2009-06-29 | 2011-08-17 | Incyte Corp | Pirimidinonas como inhibidores de pi3k, y composiciones farmaceuticas que los comprenden |
AR078948A1 (es) * | 2009-11-30 | 2011-12-14 | Lilly Co Eli | Compuestos de espiropiperidina, composicion farmaceutica que lo comprenden y su uso para preparar un medicamento util para tratar la diabetes |
WO2011075630A1 (en) * | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted fused aryl and heteroaryl derivatives as pi3k inhibitors |
WO2011075643A1 (en) | 2009-12-18 | 2011-06-23 | Incyte Corporation | Substituted heteroaryl fused derivatives as pi3k inhibitors |
EP2558463A1 (en) | 2010-04-14 | 2013-02-20 | Incyte Corporation | Fused derivatives as i3 inhibitors |
US9062055B2 (en) | 2010-06-21 | 2015-06-23 | Incyte Corporation | Fused pyrrole derivatives as PI3K inhibitors |
TW201249844A (en) | 2010-12-20 | 2012-12-16 | Incyte Corp | N-(1-(substituted-phenyl)ethyl)-9H-purin-6-amines as PI3K inhibitors |
WO2012125629A1 (en) | 2011-03-14 | 2012-09-20 | Incyte Corporation | Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors |
WO2012135009A1 (en) | 2011-03-25 | 2012-10-04 | Incyte Corporation | Pyrimidine-4,6-diamine derivatives as pi3k inhibitors |
ES2464598T3 (es) | 2011-07-22 | 2014-06-03 | Université Joseph Fourier | Nuevos derivados bis-indólicos, procedimiento para su preparación, y sus utilizaciones como fármaco |
SI2751109T1 (sl) | 2011-09-02 | 2017-03-31 | Incyte Holdings Corporation | Heterociklilamini kot inhibitorji pi3k |
CN102568615B (zh) * | 2011-12-13 | 2013-05-22 | 华中科技大学 | 一种小型精密调平装置 |
AR090548A1 (es) | 2012-04-02 | 2014-11-19 | Incyte Corp | Azaheterociclobencilaminas biciclicas como inhibidores de pi3k |
WO2015191677A1 (en) | 2014-06-11 | 2015-12-17 | Incyte Corporation | Bicyclic heteroarylaminoalkyl phenyl derivatives as pi3k inhibitors |
CN117800973A (zh) | 2015-02-27 | 2024-04-02 | 因赛特控股公司 | Pi3k抑制剂的盐及其制备方法 |
WO2016183060A1 (en) | 2015-05-11 | 2016-11-17 | Incyte Corporation | Process for the synthesis of a phosphoinositide 3-kinase inhibitor |
US9988401B2 (en) | 2015-05-11 | 2018-06-05 | Incyte Corporation | Crystalline forms of a PI3K inhibitor |
UY38934A (es) | 2019-10-29 | 2021-05-31 | Biogen Ma Inc | Inhibidores de o-glucoproteína-2-acetamido-2-deoxi-3-d-glucopiranosidasa espirocíclica |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2761992B1 (fr) * | 1997-04-09 | 1999-06-11 | Hoechst Marion Roussel Inc | Nouveaux steroides 4-halogenes, leur procede et intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
TWI279402B (en) * | 1999-08-20 | 2007-04-21 | Banyu Pharma Co Ltd | Spiro compounds having NPY antagonistic activities and agents containing the same |
GB0003397D0 (en) | 2000-02-14 | 2000-04-05 | Merck Sharp & Dohme | Therapeutic agents |
KR100854872B1 (ko) * | 2003-12-22 | 2008-08-28 | 화이자 인코포레이티드 | 바소프레신 길항제로서의 트리아졸 유도체 |
GB0400700D0 (en) * | 2004-01-13 | 2004-02-18 | Pfizer Ltd | Compounds useful in therapy |
GB0504556D0 (en) * | 2005-03-04 | 2005-04-13 | Pfizer Ltd | Novel pharmaceuticals |
-
2007
- 2007-12-19 AT AT07857806T patent/ATE486877T1/de active
- 2007-12-19 MX MX2009006921A patent/MX2009006921A/es active IP Right Grant
- 2007-12-19 KR KR1020097015840A patent/KR101129861B1/ko not_active IP Right Cessation
- 2007-12-19 PL PL07857806T patent/PL2125827T3/pl unknown
- 2007-12-19 AU AU2007341379A patent/AU2007341379B2/en not_active Expired - Fee Related
- 2007-12-19 RU RU2009124419/04A patent/RU2009124419A/ru not_active Application Discontinuation
- 2007-12-19 CN CN2007800479989A patent/CN101589046B/zh not_active Expired - Fee Related
- 2007-12-19 EP EP07857806A patent/EP2125827B1/en not_active Not-in-force
- 2007-12-19 WO PCT/EP2007/064183 patent/WO2008080844A1/en active Application Filing
- 2007-12-19 JP JP2009543443A patent/JP2010514727A/ja active Pending
- 2007-12-19 ES ES07857806T patent/ES2351949T3/es active Active
- 2007-12-19 PT PT07857806T patent/PT2125827E/pt unknown
- 2007-12-19 CA CA002674154A patent/CA2674154A1/en not_active Abandoned
- 2007-12-19 BR BRPI0720827-8A patent/BRPI0720827A2/pt not_active IP Right Cessation
- 2007-12-19 DE DE602007010359T patent/DE602007010359D1/de active Active
- 2007-12-19 DK DK07857806.9T patent/DK2125827T3/da active
- 2007-12-20 US US11/960,823 patent/US8039624B2/en not_active Expired - Fee Related
- 2007-12-20 US US11/960,779 patent/US8034937B2/en not_active Expired - Fee Related
- 2007-12-20 US US11/960,799 patent/US8044202B2/en not_active Expired - Fee Related
- 2007-12-26 TW TW096150410A patent/TW200835483A/zh unknown
- 2007-12-27 CL CL200703832A patent/CL2007003832A1/es unknown
- 2007-12-27 AR ARP070105915A patent/AR064547A1/es not_active Application Discontinuation
-
2008
- 2008-01-02 PE PE2008000047A patent/PE20081844A1/es not_active Application Discontinuation
-
2009
- 2009-06-18 NO NO20092342A patent/NO20092342L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DK2125827T3 (da) | 2010-12-20 |
PL2125827T3 (pl) | 2011-04-29 |
MX2009006921A (es) | 2009-07-06 |
DE602007010359D1 (de) | 2010-12-16 |
WO2008080844A9 (en) | 2009-10-08 |
CA2674154A1 (en) | 2008-07-10 |
ATE486877T1 (de) | 2010-11-15 |
AR064547A1 (es) | 2009-04-08 |
CL2007003832A1 (es) | 2008-07-25 |
CN101589046B (zh) | 2011-09-21 |
EP2125827B1 (en) | 2010-11-03 |
US20080161332A1 (en) | 2008-07-03 |
RU2009124419A (ru) | 2011-02-10 |
US8039624B2 (en) | 2011-10-18 |
TW200835483A (en) | 2008-09-01 |
US20080281103A1 (en) | 2008-11-13 |
EP2125827A1 (en) | 2009-12-02 |
NO20092342L (no) | 2009-07-02 |
AU2007341379B2 (en) | 2012-05-24 |
US8044202B2 (en) | 2011-10-25 |
PT2125827E (pt) | 2010-11-22 |
BRPI0720827A2 (pt) | 2014-03-04 |
ES2351949T3 (es) | 2011-02-14 |
KR101129861B1 (ko) | 2012-04-24 |
CN101589046A (zh) | 2009-11-25 |
US8034937B2 (en) | 2011-10-11 |
KR20090094172A (ko) | 2009-09-03 |
AU2007341379A1 (en) | 2008-07-10 |
WO2008080844A1 (en) | 2008-07-10 |
US20080161333A1 (en) | 2008-07-03 |
JP2010514727A (ja) | 2010-05-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC | Refusal |