AR074596A1 - Derivados de (3-oxo) piridazin-4-ilurea - Google Patents
Derivados de (3-oxo) piridazin-4-ilureaInfo
- Publication number
- AR074596A1 AR074596A1 ARP090104810A ARP090104810A AR074596A1 AR 074596 A1 AR074596 A1 AR 074596A1 AR P090104810 A ARP090104810 A AR P090104810A AR P090104810 A ARP090104810 A AR P090104810A AR 074596 A1 AR074596 A1 AR 074596A1
- Authority
- AR
- Argentina
- Prior art keywords
- group
- alkyl
- monocyclic
- groups
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se describen derivados de (3-oxo)piridazin-4-ilurea que tienen la estructura de fórmula (1); así como composiciones farmacéuticas que los comprenden y su uso en terapia como inhibidores de la fosfodiesterasa IV (PDE4). Reivindicación 1: Un compuesto de fórmula (1) donde R1 se selecciona del grupo que consiste en un grupo -alquil C1-4-cicloalquilo C3-5 y un grupo C1-4 opcionalmente sustituido con uno o más átomos de halógeno, R2 se selecciona del grupo que consiste en un grupo arilo C5-10, y un grupo heteroarilo de 5 a 10 miembros que contiene al menos un heteroátomo seleccionado de N, S y O, donde los grupos arilo y heteroarilo están opcionalmente sustituidos con uno o más sustituyentes seleccionados de átomos de halógeno, grupos alquilo C1-4 y alcoxi C1-4, X se selecciona del grupo que consiste en un enlace directo, -O-, -O-CH2-, -S-, y -S(O)2-, G1 se selecciona del grupo que consiste en un átomo de nitrógeno y un grupo -CH=, G2 se selecciona del grupo que consiste en un átomo de nitrógeno y un grupo -CR3=, R3 y R4 independientemente se seleccionan del grupo que consiste en un átomo de hidrógeno, un átomo de halógeno, un grupo hidroxi, un grupo ciano, un grupo alquilo C1-4 lineal o ramificado, un grupo hidroxialquilo C1-4 lineal o ramificado, un grupo metilsulfonilo, sulfoniloxi, trifluorometilo, trifluorometoxi, ciclopropiloxi, un grupo formilo, un grupo -CH2N(CH3)2, -O-(CH2)1-3-Rb, -O-(CH2)1-5NRaRb, -(CH2)0-4-C(O)ORb, -(CH2)0-4C(O)NRaRb, -(CH2)0-2-CO-NH-(CH2)1-3-Rb y -(CH2)0-2-CO-NH-(CH2)1-8-NRaRb donde Ra representa un átomo de hidrógeno o un grupo alquilo C1-4, Rb representa un átomo de hidrógeno, un grupo alquilo C1-4, carboxialquilo C1-4, hidroxialquilo C1-2, carbamoílo, cicloalquilo C3-10 monocíclico o policíclico, carbocíclico C3-10 no aromático insaturado monocíclico o policíclico, un grupo arilo C5-10 monocíclico o policíclico, heteroarilo de 5 a 10 miembros monocíclico o policíclico, o un grupo heterocíclico de 5 a 10 miembros monocíclico o policíclico, grupos cicloalquilo, carbocíclico no aromático insaturado, arilo, heteroarilo y heterocíclico que están opcionalmente sustituidos con uno o más sustituyentes seleccionados del grupo que consiste en átomos de halógeno, grupos hidroxi, bencilo, alquilo C1-2, hidroxialquilo C1-6, dialquilamino C1-4 o grupos carboxi, o Ra y Rb junto con el átomo de nitrógeno al que están unidos forman un anillo heterocíclico saturado o insaturado de 4 a 6 miembros que contiene opcionalmente un heteroátomo adicional seleccionado de N y O, y opcionalmente sustituido con un grupo alquilo C1-4, carbamoilo o un grupo alcoxi C1-2-alquilo C1-2; n es un número entero de 1 a 3 o sus sales y N-óxidos farmacéuticamente aceptables.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08382077A EP2196465A1 (en) | 2008-12-15 | 2008-12-15 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
AR074596A1 true AR074596A1 (es) | 2011-01-26 |
Family
ID=40404496
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP090104810A AR074596A1 (es) | 2008-12-15 | 2009-12-11 | Derivados de (3-oxo) piridazin-4-ilurea |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP2196465A1 (es) |
AR (1) | AR074596A1 (es) |
TW (1) | TW201026681A (es) |
UY (1) | UY32239A (es) |
WO (1) | WO2010069504A1 (es) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
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EP2386555A1 (en) | 2010-05-13 | 2011-11-16 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities |
EP2457900A1 (en) | 2010-11-25 | 2012-05-30 | Almirall, S.A. | New pyrazole derivatives having CRTh2 antagonistic behaviour |
EP2463289A1 (en) | 2010-11-26 | 2012-06-13 | Almirall, S.A. | Imidazo[1,2-b]pyridazine derivatives as JAK inhibitors |
EP2518071A1 (en) | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Imidazopyridine derivatives as PI3K inhibitors |
EP2518070A1 (en) | 2011-04-29 | 2012-10-31 | Almirall, S.A. | Pyrrolotriazinone derivatives as PI3K inhibitors |
EP2526945A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | New CRTH2 Antagonists |
EP2527344A1 (en) | 2011-05-25 | 2012-11-28 | Almirall, S.A. | Pyridin-2(1H)-one derivatives useful as medicaments for the treatment of myeloproliferative disorders, transplant rejection, immune-mediated and inflammatory diseases |
EP2548876A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists |
EP2548863A1 (en) | 2011-07-18 | 2013-01-23 | Almirall, S.A. | New CRTh2 antagonists. |
EP2554544A1 (en) | 2011-08-01 | 2013-02-06 | Almirall, S.A. | Pyridin-2(1h)-one derivatives as jak inhibitors |
EP2592078A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
EP2592077A1 (en) | 2011-11-11 | 2013-05-15 | Almirall, S.A. | New cyclohexylamine derivatives having beta2 adrenergic agonist and M3 muscarinic antagonist activities |
UA113750C2 (xx) * | 2011-12-27 | 2017-03-10 | Склад (+)-2-$1-(3-етокси-4-метоксифеніл)-2-метансульфонілетил]-4-ацетиламіноізоіндолін-1,3-діону | |
WO2013097052A1 (en) | 2011-12-30 | 2013-07-04 | Abbott Laboratories | Bromodomain inhibitors |
EP2641900A1 (en) | 2012-03-20 | 2013-09-25 | Almirall, S.A. | Novel polymorphic Crystal forms of 5-(2-{[6-(2,2-difluoro-2-phenylethoxy) hexyl]amino}-1-(R)-hydroxyethyl)-8-hydroxyquinolin-2(1h)-one, heminapadisylate as agonist of the ß2 adrenergic receptor. |
EP2668941A1 (en) | 2012-05-31 | 2013-12-04 | Almirall, S.A. | Novel dosage form and formulation of abediterol |
KR20150023722A (ko) * | 2012-06-12 | 2015-03-05 | 애브비 인코포레이티드 | 피리디논 및 피리다지논 유도체 |
WO2014060431A1 (en) | 2012-10-16 | 2014-04-24 | Almirall, S.A. | Pyrrolotriazinone derivatives as pi3k inhibitors |
WO2014080291A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Biaryl derivatives as bromodomain inhibitors |
WO2014080290A2 (en) | 2012-11-21 | 2014-05-30 | Rvx Therapeutics Inc. | Cyclic amines as bromodomain inhibitors |
EP2738172A1 (en) | 2012-11-28 | 2014-06-04 | Almirall, S.A. | New bicyclic compounds as crac channel modulators |
US9255105B2 (en) * | 2012-12-06 | 2016-02-09 | Enaltec Labs Private Limited | Process of preparing alcaftadine |
LT2931275T (lt) | 2012-12-17 | 2022-06-27 | Almirall S.A. | Aklidiniumas, skirtas naudoti fizinio aktyvumo kasdieniniame gyvenime padidinimui pacientui, sergančiam lėtine obstrukcine plaučių liga |
AP2015008573A0 (en) | 2012-12-18 | 2015-07-31 | Almirall Sa | New cyclohexyl and quinuclidinyl carbamate derivatives having beta 2 adrenergic agonist and M3 muscarinic antagonsit activity |
MX2015007921A (es) * | 2012-12-21 | 2016-03-03 | Zenith Epigenetics Corp | Compuestos heterociclicos novedosos como inhibidores de bromodominio. |
UY35332A (es) | 2013-02-15 | 2014-11-28 | Almirall Sa | Derivados de pirrolotriazina como inhibidores de pi3k |
TWI643853B (zh) | 2013-02-27 | 2018-12-11 | 阿爾米雷爾有限公司 | 同時具有β2腎上腺素受體促效劑和M3毒蕈鹼受體拮抗劑活性之2-氨基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽類 |
US9662311B2 (en) | 2013-06-21 | 2017-05-30 | Zenith Epigenetics Ltd. | Substituted bicyclic compounds as bromodomain inhibitors |
WO2015002754A2 (en) | 2013-06-21 | 2015-01-08 | Zenith Epigenetics Corp. | Novel bicyclic bromodomain inhibitors |
EP2848615A1 (en) | 2013-07-03 | 2015-03-18 | Almirall, S.A. | New pyrazole derivatives as CRAC channel modulators |
TWI641373B (zh) | 2013-07-25 | 2018-11-21 | 阿爾米雷爾有限公司 | 具有蕈毒鹼受體拮抗劑和β2腎上腺素受體促效劑二者之活性的2-胺基-1-羥乙基-8-羥基喹啉-2(1H)-酮衍生物之鹽 |
TW201517906A (zh) | 2013-07-25 | 2015-05-16 | Almirall Sa | 含有maba化合物和皮質類固醇之組合 |
KR20160038008A (ko) | 2013-07-31 | 2016-04-06 | 제니쓰 에피제네틱스 코포레이션 | 브로모도메인 억제제로서 신규 퀴나졸리논 |
WO2015058160A1 (en) | 2013-10-18 | 2015-04-23 | Quanticel Pharmaceuticals, Inc. | Bromodomain inhibitors |
CN103664770A (zh) * | 2013-12-06 | 2014-03-26 | 辽宁师范大学 | 5-[2-(5-羧基-吡啶基)]-1,3-苯二羧酸的合成方法 |
CN103664796A (zh) * | 2013-12-06 | 2014-03-26 | 辽宁师范大学 | 5-[2-(5-羧基-嘧啶基)]-1,3-苯二羧酸的合成方法 |
TW201617343A (zh) | 2014-09-26 | 2016-05-16 | 阿爾米雷爾有限公司 | 具有β2腎上腺素促效劑及M3蕈毒拮抗劑活性之新穎雙環衍生物 |
CA2966298A1 (en) | 2014-12-01 | 2016-06-09 | Zenith Epigenetics Ltd. | Substituted pyridinones as bromodomain inhibitors |
US10179125B2 (en) | 2014-12-01 | 2019-01-15 | Zenith Epigenetics Ltd. | Substituted pyridines as bromodomain inhibitors |
CA2966449A1 (en) | 2014-12-11 | 2016-06-16 | Zenith Epigenetics Ltd. | Substituted heterocycles as bromodomain inhibitors |
CA2966450A1 (en) | 2014-12-17 | 2016-06-23 | Olesya KHARENKO | Inhibitors of bromodomains |
WO2016139361A1 (en) | 2015-03-05 | 2016-09-09 | Boehringer Ingelheim International Gmbh | New pyridinones and isoquinolinones as inhibitors of the bromodomain brd9 |
AR104259A1 (es) | 2015-04-15 | 2017-07-05 | Celgene Quanticel Res Inc | Inhibidores de bromodominio |
WO2017070708A1 (en) | 2015-10-23 | 2017-04-27 | Array Biopharma, Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2h)-one compounds as inhibitors of fgfr tyrosine kinases |
WO2017089347A1 (en) | 2015-11-25 | 2017-06-01 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of braf inhibitor resistant melanomas |
EP3442972B1 (en) | 2016-04-15 | 2020-03-04 | AbbVie Inc. | Bromodomain inhibitors |
EP3445750A4 (en) | 2016-04-18 | 2019-11-27 | Celgene Quanticel Research, Inc. | THERAPEUTIC COMPOUNDS |
US10150754B2 (en) | 2016-04-19 | 2018-12-11 | Celgene Quanticel Research, Inc. | Histone demethylase inhibitors |
AU2019250361B2 (en) | 2018-04-12 | 2023-03-23 | Bayer Aktiengesellschaft | Heteroaryl-triazole compounds as pesticides |
CA3102762A1 (en) | 2018-06-04 | 2019-12-12 | Ohio State Innovation Foundation | Eaat2 activators and methods of using thereof |
TWI817191B (zh) | 2020-09-04 | 2023-10-01 | 南韓商Lg化學股份有限公司 | 新穎聯芳基衍生物及其作為針對二醯基甘油醯基轉移酶2之抑制劑之用途 |
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-
2008
- 2008-12-15 EP EP08382077A patent/EP2196465A1/en not_active Withdrawn
-
2009
- 2009-11-11 UY UY0001032239A patent/UY32239A/es unknown
- 2009-11-18 TW TW098139129A patent/TW201026681A/zh unknown
- 2009-12-09 WO PCT/EP2009/008794 patent/WO2010069504A1/en active Application Filing
- 2009-12-11 AR ARP090104810A patent/AR074596A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
WO2010069504A1 (en) | 2010-06-24 |
EP2196465A1 (en) | 2010-06-16 |
TW201026681A (en) | 2010-07-16 |
UY32239A (es) | 2010-05-31 |
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