ES2137113B1 - Nuevos derivados de triazolo-piridazinas heterociclicos. - Google Patents

Nuevos derivados de triazolo-piridazinas heterociclicos.

Info

Publication number
ES2137113B1
ES2137113B1 ES009701670A ES9701670A ES2137113B1 ES 2137113 B1 ES2137113 B1 ES 2137113B1 ES 009701670 A ES009701670 A ES 009701670A ES 9701670 A ES9701670 A ES 9701670A ES 2137113 B1 ES2137113 B1 ES 2137113B1
Authority
ES
Spain
Prior art keywords
triazolo
sup
piridazinas
heterociclicos
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES009701670A
Other languages
English (en)
Other versions
ES2137113A1 (es
Inventor
Ferrer Jordi Gracia
Crespo M Isabel Crespo
Noverola Armando Vega
Garcia Andres Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Almirall SA
Original Assignee
Almirall Prodesfarma SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES009701670A priority Critical patent/ES2137113B1/es
Application filed by Almirall Prodesfarma SA filed Critical Almirall Prodesfarma SA
Priority to DE69802100T priority patent/DE69802100T2/de
Priority to PT78400158T priority patent/PT1001955E/pt
Priority to EEP200000052A priority patent/EE04313B1/xx
Priority to CZ2000333A priority patent/CZ290208B6/cs
Priority to SK86-2000A priority patent/SK284046B6/sk
Priority to KR1020007000932A priority patent/KR20010022353A/ko
Priority to TR2000/00243T priority patent/TR200000243T2/xx
Priority to EP98940218A priority patent/EP1001955B1/en
Priority to AU88612/98A priority patent/AU737709B2/en
Priority to PCT/EP1998/004340 priority patent/WO1999006404A1/en
Priority to UA2000010486A priority patent/UA60339C2/uk
Priority to SI9830042T priority patent/SI1001955T1/xx
Priority to HU0004708A priority patent/HUP0004708A3/hu
Priority to IDW20000180A priority patent/ID24506A/id
Priority to PL338214A priority patent/PL191031B1/pl
Priority to JP2000505162A priority patent/JP4320118B2/ja
Priority to ES98940218T priority patent/ES2162466T3/es
Priority to RU2000104863/04A priority patent/RU2202552C2/ru
Priority to IL13408198A priority patent/IL134081A/en
Priority to HK00103595.3A priority patent/HK1024914B/en
Priority to CNB988081210A priority patent/CN1135231C/zh
Priority to DK98940218T priority patent/DK1001955T3/da
Priority to BRPI9810829-8A priority patent/BR9810829B1/pt
Priority to CA002298935A priority patent/CA2298935A1/en
Priority to AT98940218T priority patent/ATE207069T1/de
Priority to NZ502356A priority patent/NZ502356A/xx
Priority to ZA986248A priority patent/ZA986248B/xx
Priority to TW087111560A priority patent/TW542837B/zh
Priority to MYPI98003421A priority patent/MY118796A/en
Priority to CO98042905A priority patent/CO4970780A1/es
Priority to ARP980103719A priority patent/AR015927A1/es
Priority to EG88998A priority patent/EG24041A/xx
Priority to PE1998000682A priority patent/PE111099A1/es
Publication of ES2137113A1 publication Critical patent/ES2137113A1/es
Priority to NO20000394A priority patent/NO315118B1/no
Priority to BG104112A priority patent/BG64448B1/bg
Priority to US09/496,019 priority patent/US6407108B1/en
Application granted granted Critical
Publication of ES2137113B1 publication Critical patent/ES2137113B1/es
Priority to US10/038,777 priority patent/US20020183326A1/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Nuevos derivados de triazolo-piridazinas heterocíclicos de fórmula (I): en donde R{sup,1 representa un átomo de hidrógeno o un grupo (CH{sub,2 ){sub,m -Y siendo m un número de 0 a 4 e Y representa una cadena hidrocarbonada, cíclica, heterocíclica saturada o un grupo aromático opcionalmente sustituido; R{sup,2 representa una cadena hidrocarbonada, cíclica o un grupo aromático opcionalmente sustituido; R{sup,3 es hidrógeno, halógeno, alquilo, alcoxi o nitro; y sales farmacéuticamente aceptables de los- mismos. Dichos compuestos son inhibidores de PDE 4 y tienen una actividad emética muy baja.
ES009701670A 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos. Expired - Lifetime ES2137113B1 (es)

Priority Applications (38)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.
CNB988081210A CN1135231C (zh) 1997-07-29 1998-07-13 1,2,4-三唑并[4,3b]吡啶并[3,2-d]哒嗪衍生物和含有它们的药用组合物
BRPI9810829-8A BR9810829B1 (pt) 1997-07-29 1998-07-13 composto heterocìclico, processo para preparar o mesmo, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica.
CZ2000333A CZ290208B6 (cs) 1997-07-29 1998-07-13 Derivát 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazinu, způsob jeho přípravy, jeho pouľití a farmaceutický prostředek, který ho obsahuje
SK86-2000A SK284046B6 (sk) 1997-07-29 1998-07-13 Deriváty 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazínu, spôsob ich prípravy, ich použitie a farmaceutické prostriedky s ich obsahom
KR1020007000932A KR20010022353A (ko) 1997-07-29 1998-07-13 1,2,4-트리아졸로[4,3-ｂ]피리도[3,2-ｄ]피리다진 유도체및 이를 포함하는 약제학적 조성물
TR2000/00243T TR200000243T2 (tr) 1997-07-29 1998-07-13 1,2,4- triazol [4,3-B] pridol [3,2-D] piridazin türevleri ve bunları ihtiva eden farmasötik bileşimler.
EP98940218A EP1001955B1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo 4,3-b]pyrido 3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
AU88612/98A AU737709B2 (en) 1997-07-29 1998-07-13 1,2,4-triazolo{4,3-b}pyrido{3,2-d}pyridazine derivatives and pharmaceutical compositions containing them
PCT/EP1998/004340 WO1999006404A1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
UA2000010486A UA60339C2 (uk) 1997-07-29 1998-07-13 Похідна 1,2,4-триазоло[4,3-в]піридо[3,2-d]піридазину, спосіб її одержання та композиція, що її містить
SI9830042T SI1001955T1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo 4,3-b)pyrido 3,2-d)pyridazine derivatives and pharmaceutical compositions containing them
HU0004708A HUP0004708A3 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives, process for their preparation, their use and pharmaceutical compositions containing them
IDW20000180A ID24506A (id) 1997-07-29 1998-07-13 Turunan-turunan 1,2,4-triazolo [4,3-b] pirido [3,2-d]-piridazina dan komposisi-komposisi farmasi yang mengandung senyawa tersebut
PL338214A PL191031B1 (pl) 1997-07-29 1998-07-13 Związek o wzorze (I), sposób jego wytwarzania, kompozycja go zawierająca oraz zastosowanie
JP2000505162A JP4320118B2 (ja) 1997-07-29 1998-07-13 １，２，４−トリアゾロ［４，３−ｂ］ピリド［３，２−ｄ］ピリダジン誘導体およびそれらを含有する製薬組成物
ES98940218T ES2162466T3 (es) 1997-07-29 1998-07-13 Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.
RU2000104863/04A RU2202552C2 (ru) 1997-07-29 1998-07-13 Производные 1,2,4-триазоло[4,3-b]пиридо[3,2-d]пиридазина, способ их получения, фармацевтическая композиция и способ ингибирования фосфодиэстеразы-4
IL13408198A IL134081A (en) 1997-07-29 1998-07-13 History - 6 Aril 1, 2, 4 - Triazolo b] - 3, 4] Pyrido d] -2, 3] Pyridazine, their preparation and pharmaceutical preparations containing them
HK00103595.3A HK1024914B (en) 1997-07-29 1998-07-13 1,2,4-triazolo 4,3-b]pyrido 3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
DE69802100T DE69802100T2 (de) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazinderivate und diese enthaltende pharmaceutische zubereitungen
PT78400158T PT1001955E (pt) 1997-07-29 1998-07-13 Derivados da 1,2,4-triazolo¬4,3-b|pirido¬3,2-d|piridazina e composicoes farmaceuticas que os contem
EEP200000052A EE04313B1 (et) 1997-07-29 1998-07-13 1,2,4-triasolo[4,3-b]pürido[3,2-d]püridasiini derivaadid, nende valmistamismeetod ja farmatseutiline kompositsioon ning nende kasutamine
CA002298935A CA2298935A1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
AT98940218T ATE207069T1 (de) 1997-07-29 1998-07-13 1,2,4-triazolo(4,3-b)pyrido(3,2- d)pyridazinderivate und diese enthaltende pharmaceutische zubereitungen
NZ502356A NZ502356A (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazine derivatives and pharmaceutical use as phosphodiesterase 4 inhibitors
DK98940218T DK1001955T3 (da) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazinderivater og farmaceutiske præparater, der indeholder dem
ZA986248A ZA986248B (en) 1997-07-29 1998-07-14 New heterocylic compounds
TW087111560A TW542837B (en) 1997-07-29 1998-07-16 1,2,4-triazolo[4,3-b]pyrrido[3,2-d]pyridazine derivatives, process for their preparation and their use in medicine
MYPI98003421A MY118796A (en) 1997-07-29 1998-07-27 1,2,4-triazolo [4,3-b] pyrido [3,2-d] pyridazine derivatives and pharmaceutical compositions containing them
CO98042905A CO4970780A1 (es) 1997-07-29 1998-07-28 Nuevos compuestos heterociclicos de piridazina
ARP980103719A AR015927A1 (es) 1997-07-29 1998-07-29 Compuesto de 1,2,4-triazolo[4,3-b)pirido[3,2-d)piridazina, procedimiento para su preparacion, composicion que lo comprende y su uso para preparar un medicamento.
EG88998A EG24041A (en) 1997-07-29 1998-07-29 New heterocyclic compounds
PE1998000682A PE111099A1 (es) 1997-07-29 1998-07-30 Nuevos compuestos heterociclicos
NO20000394A NO315118B1 (no) 1997-07-29 2000-01-26 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazinderivater samt farmasöytiske sammensetninger inneholdende slike
BG104112A BG64448B1 (en) 1997-07-29 2000-01-27 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them
US09/496,019 US6407108B1 (en) 1997-07-29 2000-01-28 1,2,4-triazolo(4,3-b)pyrido(3,2-d)pyridazine derivatives and pharmaceutical compositions containing them
US10/038,777 US20020183326A1 (en) 1997-07-29 2002-01-08 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazine derivatives and pharmaceutical compositions containing them

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.

Publications (2)

Publication Number Publication Date
ES2137113A1 ES2137113A1 (es) 1999-12-01
ES2137113B1 true ES2137113B1 (es) 2000-09-16

Family

ID=8300216

Family Applications (2)

Application Number Title Priority Date Filing Date
ES009701670A Expired - Lifetime ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.
ES98940218T Expired - Lifetime ES2162466T3 (es) 1997-07-29 1998-07-13 Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES98940218T Expired - Lifetime ES2162466T3 (es) 1997-07-29 1998-07-13 Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen.

Country Status (35)

Country Link
US (2) US6407108B1 (es)
EP (1) EP1001955B1 (es)
JP (1) JP4320118B2 (es)
KR (1) KR20010022353A (es)
CN (1) CN1135231C (es)
AR (1) AR015927A1 (es)
AT (1) ATE207069T1 (es)
AU (1) AU737709B2 (es)
BG (1) BG64448B1 (es)
BR (1) BR9810829B1 (es)
CA (1) CA2298935A1 (es)
CO (1) CO4970780A1 (es)
CZ (1) CZ290208B6 (es)
DE (1) DE69802100T2 (es)
DK (1) DK1001955T3 (es)
EE (1) EE04313B1 (es)
EG (1) EG24041A (es)
ES (2) ES2137113B1 (es)
HU (1) HUP0004708A3 (es)
ID (1) ID24506A (es)
IL (1) IL134081A (es)
MY (1) MY118796A (es)
NO (1) NO315118B1 (es)
NZ (1) NZ502356A (es)
PE (1) PE111099A1 (es)
PL (1) PL191031B1 (es)
PT (1) PT1001955E (es)
RU (1) RU2202552C2 (es)
SI (1) SI1001955T1 (es)
SK (1) SK284046B6 (es)
TR (1) TR200000243T2 (es)
TW (1) TW542837B (es)
UA (1) UA60339C2 (es)
WO (1) WO1999006404A1 (es)
ZA (1) ZA986248B (es)

Families Citing this family (38)

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FR2792938B1 (fr) * 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
SI1212089T1 (sl) 1999-08-21 2006-08-31 Altana Pharma Ag Sinergisticna kombinacija roflumilasta in salmeterola
WO2002080974A1 (en) * 2001-04-04 2002-10-17 Sankyo Company, Limited Novel medicinal use of cytokine production inhibitor
WO2003024489A2 (en) * 2001-09-19 2003-03-27 Altana Pharma Ag Combination of a nsaid and a pde-4 inhibitor
FR2832711B1 (fr) * 2001-11-26 2004-01-30 Warner Lambert Co Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
ATE524471T1 (de) * 2002-11-06 2011-09-15 Aska Pharm Co Ltd Pyrazolonaphthyridinderivat
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
JP2006522151A (ja) 2003-04-01 2006-09-28 アプライド リサーチ システムズ エーアールエス ホールディング ナームロゼ フェンノートシャップ 不妊症におけるホスホジエステラーゼ阻害剤
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
RU2246496C1 (ru) * 2003-09-12 2005-02-20 Тец Виктор Вениаминович Вещество с противовирусной и антибактериальной активностью на основе производных 2,8-дитиоксо-1h-пирано[2,3-d, 6,5-d`] дипиримидина и их 10-аза-аналогов
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
MX2007015578A (es) * 2005-06-10 2008-03-06 Merck & Co Inc Inhibidores de la actividad akt.
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
US7678363B2 (en) 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
CN101268073B (zh) 2005-09-15 2011-10-19 Aska制药株式会社 杂环化合物、制备方法及其用途
EP2377530A3 (en) 2005-10-21 2012-06-20 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
EP1942879A1 (en) 2005-10-31 2008-07-16 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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