ES2137113A1 - Nuevos derivados de triazolo-piridazinas heterociclicos. - Google Patents
Nuevos derivados de triazolo-piridazinas heterociclicos.Info
- Publication number
- ES2137113A1 ES2137113A1 ES009701670A ES9701670A ES2137113A1 ES 2137113 A1 ES2137113 A1 ES 2137113A1 ES 009701670 A ES009701670 A ES 009701670A ES 9701670 A ES9701670 A ES 9701670A ES 2137113 A1 ES2137113 A1 ES 2137113A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- aromatic group
- triazolo
- pyrido
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Physical Education & Sports Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Nuevos derivados de triazolo-piridazinas heterocíclicos de fórmula (I): en donde R{sup,1 representa un átomo de hidrógeno o un grupo (CH{sub,2 ){sub,m -Y siendo m un número de 0 a 4 e Y representa una cadena hidrocarbonada, cíclica, heterocíclica saturada o un grupo aromático opcionalmente sustituido; R{sup,2 representa una cadena hidrocarbonada, cíclica o un grupo aromático opcionalmente sustituido; R{sup,3 es hidrógeno, halógeno, alquilo, alcoxi o nitro; y sales farmacéuticamente aceptables de los- mismos. Dichos compuestos son inhibidores de PDE 4 y tienen una actividad emética muy baja.
Priority Applications (38)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009701670A ES2137113B1 (es) | 1997-07-29 | 1997-07-29 | Nuevos derivados de triazolo-piridazinas heterociclicos. |
DE69802100T DE69802100T2 (de) | 1997-07-29 | 1998-07-13 | 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazinderivate und diese enthaltende pharmaceutische zubereitungen |
KR1020007000932A KR20010022353A (ko) | 1997-07-29 | 1998-07-13 | 1,2,4-트리아졸로[4,3-b]피리도[3,2-d]피리다진 유도체및 이를 포함하는 약제학적 조성물 |
PCT/EP1998/004340 WO1999006404A1 (en) | 1997-07-29 | 1998-07-13 | 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them |
CNB988081210A CN1135231C (zh) | 1997-07-29 | 1998-07-13 | 1,2,4-三唑并[4,3b]吡啶并[3,2-d]哒嗪衍生物和含有它们的药用组合物 |
NZ502356A NZ502356A (en) | 1997-07-29 | 1998-07-13 | 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazine derivatives and pharmaceutical use as phosphodiesterase 4 inhibitors |
UA2000010486A UA60339C2 (uk) | 1997-07-29 | 1998-07-13 | Похідна 1,2,4-триазоло[4,3-в]піридо[3,2-d]піридазину, спосіб її одержання та композиція, що її містить |
SK86-2000A SK284046B6 (sk) | 1997-07-29 | 1998-07-13 | Deriváty 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazínu, spôsob ich prípravy, ich použitie a farmaceutické prostriedky s ich obsahom |
HU0004708A HUP0004708A3 (en) | 1997-07-29 | 1998-07-13 | 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives, process for their preparation, their use and pharmaceutical compositions containing them |
AU88612/98A AU737709B2 (en) | 1997-07-29 | 1998-07-13 | 1,2,4-triazolo{4,3-b}pyrido{3,2-d}pyridazine derivatives and pharmaceutical compositions containing them |
TR2000/00243T TR200000243T2 (tr) | 1997-07-29 | 1998-07-13 | 1,2,4- triazol [4,3-B] pridol [3,2-D] piridazin türevleri ve bunları ihtiva eden farmasötik bileşimler. |
EEP200000052A EE04313B1 (et) | 1997-07-29 | 1998-07-13 | 1,2,4-triasolo[4,3-b]pürido[3,2-d]püridasiini derivaadid, nende valmistamismeetod ja farmatseutiline kompositsioon ning nende kasutamine |
PT78400158T PT1001955E (pt) | 1997-07-29 | 1998-07-13 | Derivados da 1,2,4-triazolo¬4,3-b|pirido¬3,2-d|piridazina e composicoes farmaceuticas que os contem |
IL13408198A IL134081A (en) | 1997-07-29 | 1998-07-13 | History - 6 Aril 1, 2, 4 - Triazolo b] - 3, 4] Pyrido d] -2, 3] Pyridazine, their preparation and pharmaceutical preparations containing them |
PL338214A PL191031B1 (pl) | 1997-07-29 | 1998-07-13 | Związek o wzorze (I), sposób jego wytwarzania, kompozycja go zawierająca oraz zastosowanie |
RU2000104863/04A RU2202552C2 (ru) | 1997-07-29 | 1998-07-13 | Производные 1,2,4-триазоло[4,3-b]пиридо[3,2-d]пиридазина, способ их получения, фармацевтическая композиция и способ ингибирования фосфодиэстеразы-4 |
AT98940218T ATE207069T1 (de) | 1997-07-29 | 1998-07-13 | 1,2,4-triazolo(4,3-b)pyrido(3,2- d)pyridazinderivate und diese enthaltende pharmaceutische zubereitungen |
CZ2000333A CZ290208B6 (cs) | 1997-07-29 | 1998-07-13 | Derivát 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazinu, způsob jeho přípravy, jeho pouľití a farmaceutický prostředek, který ho obsahuje |
BRPI9810829-8A BR9810829B1 (pt) | 1997-07-29 | 1998-07-13 | composto heterocìclico, processo para preparar o mesmo, composição farmacêutica, e, uso de um composto ou de uma composição farmacêutica. |
JP2000505162A JP4320118B2 (ja) | 1997-07-29 | 1998-07-13 | 1,2,4−トリアゾロ[4,3−b]ピリド[3,2−d]ピリダジン誘導体およびそれらを含有する製薬組成物 |
SI9830042T SI1001955T1 (en) | 1997-07-29 | 1998-07-13 | 1,2,4-triazolo 4,3-b)pyrido 3,2-d)pyridazine derivatives and pharmaceutical compositions containing them |
IDW20000180A ID24506A (id) | 1997-07-29 | 1998-07-13 | Turunan-turunan 1,2,4-triazolo [4,3-b] pirido [3,2-d]-piridazina dan komposisi-komposisi farmasi yang mengandung senyawa tersebut |
DK98940218T DK1001955T3 (da) | 1997-07-29 | 1998-07-13 | 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazinderivater og farmaceutiske præparater, der indeholder dem |
EP98940218A EP1001955B1 (en) | 1997-07-29 | 1998-07-13 | 1,2,4-triazolo 4,3-b]pyrido 3,2-d]pyridazine derivatives and pharmaceutical compositions containing them |
ES98940218T ES2162466T3 (es) | 1997-07-29 | 1998-07-13 | Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen. |
CA002298935A CA2298935A1 (en) | 1997-07-29 | 1998-07-13 | 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them |
ZA986248A ZA986248B (en) | 1997-07-29 | 1998-07-14 | New heterocylic compounds |
TW087111560A TW542837B (en) | 1997-07-29 | 1998-07-16 | 1,2,4-triazolo[4,3-b]pyrrido[3,2-d]pyridazine derivatives, process for their preparation and their use in medicine |
MYPI98003421A MY118796A (en) | 1997-07-29 | 1998-07-27 | 1,2,4-triazolo [4,3-b] pyrido [3,2-d] pyridazine derivatives and pharmaceutical compositions containing them |
CO98042905A CO4970780A1 (es) | 1997-07-29 | 1998-07-28 | Nuevos compuestos heterociclicos de piridazina |
ARP980103719A AR015927A1 (es) | 1997-07-29 | 1998-07-29 | Compuesto de 1,2,4-triazolo[4,3-b)pirido[3,2-d)piridazina, procedimiento para su preparacion, composicion que lo comprende y su uso para preparar un medicamento. |
EG88998A EG24041A (en) | 1997-07-29 | 1998-07-29 | New heterocyclic compounds |
PE1998000682A PE111099A1 (es) | 1997-07-29 | 1998-07-30 | Nuevos compuestos heterociclicos |
NO20000394A NO315118B1 (no) | 1997-07-29 | 2000-01-26 | 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazinderivater samt farmasöytiske sammensetninger inneholdende slike |
BG104112A BG64448B1 (en) | 1997-07-29 | 2000-01-27 | 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them |
US09/496,019 US6407108B1 (en) | 1997-07-29 | 2000-01-28 | 1,2,4-triazolo(4,3-b)pyrido(3,2-d)pyridazine derivatives and pharmaceutical compositions containing them |
HK00103595A HK1024914A1 (en) | 1997-07-29 | 2000-06-15 | 1,2,4-triazolo 4,3-b]pyrido 3,2-d]pyridazine derivatives and pharmaceutical compositions containing them |
US10/038,777 US20020183326A1 (en) | 1997-07-29 | 2002-01-08 | 1,2,4-triazolo[4,3-B]pyrido[3,2-D]pyridazine derivatives and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES009701670A ES2137113B1 (es) | 1997-07-29 | 1997-07-29 | Nuevos derivados de triazolo-piridazinas heterociclicos. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2137113A1 true ES2137113A1 (es) | 1999-12-01 |
ES2137113B1 ES2137113B1 (es) | 2000-09-16 |
Family
ID=8300216
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES009701670A Expired - Lifetime ES2137113B1 (es) | 1997-07-29 | 1997-07-29 | Nuevos derivados de triazolo-piridazinas heterociclicos. |
ES98940218T Expired - Lifetime ES2162466T3 (es) | 1997-07-29 | 1998-07-13 | Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES98940218T Expired - Lifetime ES2162466T3 (es) | 1997-07-29 | 1998-07-13 | Derivados de 1,2,4-triazolo(4,3-b)pirido(3,2-d)piridazina y composiciones farmaceuticas que los contienen. |
Country Status (36)
Country | Link |
---|---|
US (2) | US6407108B1 (es) |
EP (1) | EP1001955B1 (es) |
JP (1) | JP4320118B2 (es) |
KR (1) | KR20010022353A (es) |
CN (1) | CN1135231C (es) |
AR (1) | AR015927A1 (es) |
AT (1) | ATE207069T1 (es) |
AU (1) | AU737709B2 (es) |
BG (1) | BG64448B1 (es) |
BR (1) | BR9810829B1 (es) |
CA (1) | CA2298935A1 (es) |
CO (1) | CO4970780A1 (es) |
CZ (1) | CZ290208B6 (es) |
DE (1) | DE69802100T2 (es) |
DK (1) | DK1001955T3 (es) |
EE (1) | EE04313B1 (es) |
EG (1) | EG24041A (es) |
ES (2) | ES2137113B1 (es) |
HK (1) | HK1024914A1 (es) |
HU (1) | HUP0004708A3 (es) |
ID (1) | ID24506A (es) |
IL (1) | IL134081A (es) |
MY (1) | MY118796A (es) |
NO (1) | NO315118B1 (es) |
NZ (1) | NZ502356A (es) |
PE (1) | PE111099A1 (es) |
PL (1) | PL191031B1 (es) |
PT (1) | PT1001955E (es) |
RU (1) | RU2202552C2 (es) |
SI (1) | SI1001955T1 (es) |
SK (1) | SK284046B6 (es) |
TR (1) | TR200000243T2 (es) |
TW (1) | TW542837B (es) |
UA (1) | UA60339C2 (es) |
WO (1) | WO1999006404A1 (es) |
ZA (1) | ZA986248B (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2792938B1 (fr) * | 1999-04-28 | 2001-07-06 | Warner Lambert Co | NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV |
CA2715683A1 (en) | 1999-08-21 | 2001-03-01 | Nycomed Gmbh | Synergistic combination |
WO2002080974A1 (fr) * | 2001-04-04 | 2002-10-17 | Sankyo Company, Limited | Utilisation medicale d'inhibiteur de production de cytokine |
PL210463B1 (pl) * | 2001-09-19 | 2012-01-31 | Nycomed Gmbh | Zastosowanie kombinacji roflumilastu z diklofenakiem w leczeniu zapalnych chorób stawów |
FR2832711B1 (fr) * | 2001-11-26 | 2004-01-30 | Warner Lambert Co | Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation |
ES2372600T3 (es) * | 2002-11-06 | 2012-01-24 | Aska Pharmaceutical Co., Ltd. | Derivado de pirazolonaftiridina. |
ES2211344B1 (es) | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
US20050187278A1 (en) * | 2003-08-28 | 2005-08-25 | Pharmacia Corporation | Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors |
RU2246496C1 (ru) * | 2003-09-12 | 2005-02-20 | Тец Виктор Вениаминович | Вещество с противовирусной и антибактериальной активностью на основе производных 2,8-дитиоксо-1h-пирано[2,3-d, 6,5-d`] дипиримидина и их 10-аза-аналогов |
ES2251866B1 (es) | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
NZ563423A (en) * | 2005-06-10 | 2010-05-28 | Merck Sharp & Dohme | Inhibitors of AKT activity |
JP2009506069A (ja) | 2005-08-26 | 2009-02-12 | ブレインセルス,インコーポレイティド | ムスカリン性受容体調節による神経発生 |
EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
KR20080046728A (ko) | 2005-09-15 | 2008-05-27 | 아스카 세이야쿠 가부시키가이샤 | 복소환 화합물, 그의 제조 방법 및 용도 |
CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
TW200817410A (en) | 2006-08-07 | 2008-04-16 | Incyte Corp | Triazolotriazines as kinase inhibitors |
WO2008030651A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
ME02372B (me) | 2006-11-22 | 2016-06-20 | Incyte Holdings Corp | Imidazotriazini i imidazopiramidini kao inhibitori kinaze |
US20110112079A1 (en) * | 2008-01-09 | 2011-05-12 | Thomas Craig J | Phosphodiesterase inhibitors |
TWI472529B (zh) | 2008-05-21 | 2015-02-11 | Incyte Corp | 2-氟-N-甲基-4-〔7-(喹啉-6-基-甲基)-咪唑并〔1,2-b〕〔1,2,4〕三-2-基〕苯甲醯胺之鹽類及其相關製備方法 |
EP2196465A1 (en) | 2008-12-15 | 2010-06-16 | Almirall, S.A. | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
EP2226323A1 (en) | 2009-02-27 | 2010-09-08 | Almirall, S.A. | New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives |
CN102791715B (zh) | 2009-12-31 | 2016-04-27 | 卡洛斯三世国家癌症研究中心基金会 | 用作激酶抑制剂的三环化合物 |
EP2531509B1 (en) | 2010-02-03 | 2016-10-05 | Incyte Holdings Corporation | Imidazo[1,2-b][1,2,4]triazines as c-met inhibitors |
EP2380890A1 (en) | 2010-04-23 | 2011-10-26 | Almirall, S.A. | New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors |
EP2394998A1 (en) | 2010-05-31 | 2011-12-14 | Almirall, S.A. | 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors |
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WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
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WO1991012251A1 (en) * | 1990-02-19 | 1991-08-22 | Chugai Seiyaku Kabushiki Kaisha | Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom |
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GB9514465D0 (en) | 1995-07-14 | 1995-09-13 | Glaxo Lab Sa | Chemical compounds |
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