ATE207069T1 - 1,2,4-triazolo(4,3-b)pyrido(3,2- d)pyridazinderivate und diese enthaltende pharmaceutische zubereitungen - Google Patents

1,2,4-triazolo(4,3-b)pyrido(3,2- d)pyridazinderivate und diese enthaltende pharmaceutische zubereitungen

Info

Publication number
ATE207069T1
ATE207069T1 AT98940218T AT98940218T ATE207069T1 AT E207069 T1 ATE207069 T1 AT E207069T1 AT 98940218 T AT98940218 T AT 98940218T AT 98940218 T AT98940218 T AT 98940218T AT E207069 T1 ATE207069 T1 AT E207069T1
Authority
AT
Austria
Prior art keywords
triazolo
pyrido
pharmaceutical preparations
preparations containing
containing same
Prior art date
Application number
AT98940218T
Other languages
English (en)
Inventor
Ferrer Jordi Gracia
Crespo M Isabel Crespo
Noverola Armando Vega
Garcia Andres Fernandez
Original Assignee
Almirall Prodesfarma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma Sa filed Critical Almirall Prodesfarma Sa
Application granted granted Critical
Publication of ATE207069T1 publication Critical patent/ATE207069T1/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
AT98940218T 1997-07-29 1998-07-13 1,2,4-triazolo(4,3-b)pyrido(3,2- d)pyridazinderivate und diese enthaltende pharmaceutische zubereitungen ATE207069T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.
PCT/EP1998/004340 WO1999006404A1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them

Publications (1)

Publication Number Publication Date
ATE207069T1 true ATE207069T1 (de) 2001-11-15

Family

ID=8300216

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98940218T ATE207069T1 (de) 1997-07-29 1998-07-13 1,2,4-triazolo(4,3-b)pyrido(3,2- d)pyridazinderivate und diese enthaltende pharmaceutische zubereitungen

Country Status (36)

Country Link
US (2) US6407108B1 (de)
EP (1) EP1001955B1 (de)
JP (1) JP4320118B2 (de)
KR (1) KR20010022353A (de)
CN (1) CN1135231C (de)
AR (1) AR015927A1 (de)
AT (1) ATE207069T1 (de)
AU (1) AU737709B2 (de)
BG (1) BG64448B1 (de)
BR (1) BR9810829B1 (de)
CA (1) CA2298935A1 (de)
CO (1) CO4970780A1 (de)
CZ (1) CZ290208B6 (de)
DE (1) DE69802100T2 (de)
DK (1) DK1001955T3 (de)
EE (1) EE04313B1 (de)
EG (1) EG24041A (de)
ES (2) ES2137113B1 (de)
HK (1) HK1024914A1 (de)
HU (1) HUP0004708A3 (de)
ID (1) ID24506A (de)
IL (1) IL134081A (de)
MY (1) MY118796A (de)
NO (1) NO315118B1 (de)
NZ (1) NZ502356A (de)
PE (1) PE111099A1 (de)
PL (1) PL191031B1 (de)
PT (1) PT1001955E (de)
RU (1) RU2202552C2 (de)
SI (1) SI1001955T1 (de)
SK (1) SK284046B6 (de)
TR (1) TR200000243T2 (de)
TW (1) TW542837B (de)
UA (1) UA60339C2 (de)
WO (1) WO1999006404A1 (de)
ZA (1) ZA986248B (de)

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FR2792938B1 (fr) 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
PL200923B1 (pl) 1999-08-21 2009-02-27 Nycomed Gmbh Lek zawierający inhibitor PDE w połączeniu z agonistą receptoraß₂ -adrenergicznego oraz zastosowanie połączenia roflumilastu i salmeterolu
WO2002080974A1 (fr) * 2001-04-04 2002-10-17 Sankyo Company, Limited Utilisation medicale d'inhibiteur de production de cytokine
CA2459757C (en) * 2001-09-19 2011-08-30 Altana Pharma Ag Combination
FR2832711B1 (fr) * 2001-11-26 2004-01-30 Warner Lambert Co Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
CN100572381C (zh) * 2002-11-06 2009-12-23 Aska制药株式会社 吡唑并二氮杂萘衍生物
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
RU2246496C1 (ru) * 2003-09-12 2005-02-20 Тец Виктор Вениаминович Вещество с противовирусной и антибактериальной активностью на основе производных 2,8-дитиоксо-1h-пирано[2,3-d, 6,5-d`] дипиримидина и их 10-аза-аналогов
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
US8008317B2 (en) * 2005-06-10 2011-08-30 Merck Sharp & Dohme Corp. Inhibitors of akt activtiy
EP2258357A3 (de) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenese mit Acetylcholinesterasehemmer
WO2007025177A2 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
AU2006289838B2 (en) * 2005-09-15 2011-08-18 Aska Pharmaceutical Co., Ltd. Heterocyclic compound, and production process and use thereof
US7985756B2 (en) 2005-10-21 2011-07-26 Braincells Inc. Modulation of neurogenesis by PDE inhibition
WO2007053596A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
JP2009536667A (ja) 2006-05-09 2009-10-15 ブレインセルス，インコーポレイティド ５ｈｔ受容体介在性の神経新生
WO2007134136A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. Neurogenesis by modulating angiotensin
WO2008021781A1 (en) 2006-08-07 2008-02-21 Incyte Corporation Triazolotriazines as kinase inhibitors
BRPI0716604A2 (pt) 2006-09-08 2013-04-09 Braincells Inc combinaÇÕes contendo um derivado de 4-acilaminopiridina
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
SI3034075T1 (sl) 2006-11-22 2018-12-31 Incyte Holdings Corporation Imidazotriazini in imidazopirimidini kot inhibitorji kinaze
US20110112079A1 (en) * 2008-01-09 2011-05-12 Thomas Craig J Phosphodiesterase inhibitors
NZ589622A (en) 2008-05-21 2012-10-26 Incyte Corp Salts of 2-fluoro-N-methyl-4-[7-(quinolin-6-yl-methyl)-imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
EP2196465A1 (de) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea-Derivate als PDE4 Hemmern
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2226323A1 (de) 2009-02-27 2010-09-08 Almirall, S.A. Neuartige Tetrahydropyrazol[3,4-c]isochinolin-5-amin-Derivate
US9682991B2 (en) 2009-12-31 2017-06-20 Fundación Centro Nacional De Investigaciones Oncologicas Carlos Iii Tricyclic compounds for use as kinase inhibitors
CA2788398C (en) 2010-02-03 2018-02-27 Incyte Corporation Imidazo[1,2-b][1,2,4]triazines as c-met inhibitors
EP2380890A1 (de) 2010-04-23 2011-10-26 Almirall, S.A. Neue 7,8-Dihydro-1,6-Naphthyridin-5(6H)-on-Derivate als PDE4 Inhibitoren
EP2394998A1 (de) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl Derivate als PDE4 Inhibitoren
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

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DE3122670A1 (de) 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
FI81350C (fi) * 1982-01-18 1990-10-10 Lepetit Spa Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.
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TW365606B (en) * 1991-10-09 1999-08-01 Syntex Inc Pyrido pyridazinone and pyridazinthione compounds
GB9514465D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds

Also Published As

Publication number Publication date
WO1999006404A1 (en) 1999-02-11
RU2202552C2 (ru) 2003-04-20
AR015927A1 (es) 2001-05-30
IL134081A0 (en) 2001-04-30
CN1135231C (zh) 2004-01-21
KR20010022353A (ko) 2001-03-15
TW542837B (en) 2003-07-21
AU8861298A (en) 1999-02-22
EE04313B1 (et) 2004-06-15
EP1001955A1 (de) 2000-05-24
NO20000394D0 (no) 2000-01-26
TR200000243T2 (tr) 2000-07-21
MY118796A (en) 2005-01-31
CZ2000333A3 (cs) 2000-05-17
BG64448B1 (en) 2005-02-28
AU737709B2 (en) 2001-08-30
PE111099A1 (es) 1999-11-18
PL338214A1 (en) 2000-10-09
IL134081A (en) 2004-02-08
ES2137113B1 (es) 2000-09-16
SI1001955T1 (en) 2002-02-28
CZ290208B6 (cs) 2002-06-12
CN1266434A (zh) 2000-09-13
BR9810829B1 (pt) 2009-08-11
PL191031B1 (pl) 2006-03-31
DE69802100T2 (de) 2002-03-14
NO20000394L (no) 2000-03-27
US20020183326A1 (en) 2002-12-05
HK1024914A1 (en) 2000-10-27
BR9810829A (pt) 2000-07-25
NZ502356A (en) 2001-03-30
EP1001955B1 (de) 2001-10-17
NO315118B1 (no) 2003-07-14
SK284046B6 (sk) 2004-08-03
HUP0004708A2 (hu) 2001-07-30
CO4970780A1 (es) 2000-11-07
JP4320118B2 (ja) 2009-08-26
JP2001512121A (ja) 2001-08-21
SK862000A3 (en) 2000-07-11
PT1001955E (pt) 2002-02-28
ES2162466T3 (es) 2001-12-16
CA2298935A1 (en) 1999-02-11
EE200000052A (et) 2000-10-16
EG24041A (en) 2008-04-03
BG104112A (en) 2001-01-31
US6407108B1 (en) 2002-06-18
UA60339C2 (uk) 2003-10-15
DK1001955T3 (da) 2001-11-19
DE69802100D1 (de) 2001-11-22
HUP0004708A3 (en) 2002-11-28
ZA986248B (en) 1999-02-05
ID24506A (id) 2000-07-20
ES2137113A1 (es) 1999-12-01

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