NO974151D0 - 6-substituerte pyrazolo (3,4-d) pyrimidin-4-oner og preparater og fremgangsmåter for anvendelse derav - Google Patents
6-substituerte pyrazolo (3,4-d) pyrimidin-4-oner og preparater og fremgangsmåter for anvendelse deravInfo
- Publication number
- NO974151D0 NO974151D0 NO974151A NO974151A NO974151D0 NO 974151 D0 NO974151 D0 NO 974151D0 NO 974151 A NO974151 A NO 974151A NO 974151 A NO974151 A NO 974151A NO 974151 D0 NO974151 D0 NO 974151D0
- Authority
- NO
- Norway
- Prior art keywords
- pyrimidin
- preparations
- ones
- methods
- substituted pyrazolo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/402,268 US5656629A (en) | 1995-03-10 | 1995-03-10 | 6-substituted pyrazolo (3,4-d)pyrimidin-4-ones and compositions and methods of use thereof |
PCT/US1996/002971 WO1996028429A1 (en) | 1995-03-10 | 1996-03-05 | 6-SUBSTITUTED PYRAZOLO [3,4-d] PYRIMIDIN-4-ONES AND COMPOSITIONS AND METHODS OF USE THEREOF |
Publications (2)
Publication Number | Publication Date |
---|---|
NO974151D0 true NO974151D0 (no) | 1997-09-09 |
NO974151L NO974151L (no) | 1997-11-04 |
Family
ID=23591222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO974151A NO974151L (no) | 1995-03-10 | 1997-09-09 | 6-substituerte pyrazolo [3,4-d] pyrimidin-4-oner og preparater og fremgangsmåter for anvendelse derav |
Country Status (13)
Country | Link |
---|---|
US (2) | US5656629A (no) |
EP (1) | EP0813527A4 (no) |
JP (1) | JPH11501923A (no) |
KR (1) | KR19980702891A (no) |
AU (1) | AU708750B2 (no) |
CA (1) | CA2211669A1 (no) |
CZ (1) | CZ280597A3 (no) |
HU (1) | HUP9801336A3 (no) |
NO (1) | NO974151L (no) |
NZ (1) | NZ306035A (no) |
PL (1) | PL322380A1 (no) |
WO (1) | WO1996028429A1 (no) |
ZA (1) | ZA961947B (no) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19500789A1 (de) * | 1995-01-13 | 1996-07-18 | Bayer Ag | Acylierte 5-Aminopyrazole |
DE19709877A1 (de) * | 1997-03-11 | 1998-09-17 | Bayer Ag | 1,5-Dihydro-pyrazolo[3,4-d]-pyrimidinon-derivate |
BR9810233A (pt) | 1997-04-25 | 2000-10-17 | Pfizer | Pirozolpirimidinonas que inibem fosfodiesterase da guanosina 3`, 5`- monosfofato cìclico do tipo 5 (cgmp pde5) para o tratamento da disfunção sexual. |
GB9722520D0 (en) | 1997-10-24 | 1997-12-24 | Pfizer Ltd | Compounds |
HUP0102543A3 (en) * | 1998-04-20 | 2002-01-28 | Pfizer | Pyrazolopyrimidinone cgmp pde5 inhibitors for the treatment of sexual dysfunction and medicaments containing them |
DE19838705A1 (de) | 1998-08-26 | 2000-03-02 | Bayer Ag | Neue Dihydro-(1,2,3)-triazolo-[4,5-d]pyrimidin-7-one |
GB9823103D0 (en) * | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
GB9823101D0 (en) | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
GB9823102D0 (en) | 1998-10-23 | 1998-12-16 | Pfizer Ltd | Pharmaceutically active compounds |
UA67802C2 (uk) * | 1998-10-23 | 2004-07-15 | Пфайзер Рісьоч Енд Дівелепмент Компані, Н.В./С.А. | Фармацевтична композиція з контрольованим вивільненням інгібітора цгмф фде-5 (варіанти), спосіб її одержання та спосіб лікування еректильної дисфункції |
US6225315B1 (en) * | 1998-11-30 | 2001-05-01 | Pfizer Inc | Method of treating nitrate-induced tolerance |
TWI265925B (en) | 1999-10-11 | 2006-11-11 | Pfizer | Pyrazolo[4,3-d]pyrimidin-7-ones useful in inhibiting type 5 cyclic guanosine 3',5'-monophosphate phosphodiesterases(cGMP PDE5), process and intermediates for their preparation, their uses and composition comprising them |
CA2387353A1 (en) | 1999-10-11 | 2001-04-19 | Charlotte Moira Norfor Allerton | Pharmaceutically active compounds |
US6777416B2 (en) | 1999-12-24 | 2004-08-17 | Bayer Aktiengesellschaft | Isoxazolo pyrimidinones and the use thereof |
PE20020394A1 (es) | 2000-08-18 | 2002-06-21 | Agouron Pharma | Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2 |
MXPA03006717A (es) * | 2001-01-31 | 2003-10-24 | Merck Patent Gmbh | Formulacion farmaceutica que comprende pirazolo (4,3-d) pirimidinas y nitratos o tienopirimidinas y nitratos. |
AU2002252179A1 (en) * | 2001-03-01 | 2002-09-19 | Conforma Therapeutics Corp. | Methods for treating genetically-defined proliferative disorders with hsp90 inhibitors |
DE10135815A1 (de) * | 2001-07-23 | 2003-02-06 | Bayer Ag | Verwendung von 2-Alkoxyphenyl-substituierten Imidazotriazinonen |
JP4397691B2 (ja) * | 2001-10-30 | 2010-01-13 | コンフォーマ・セラピューティクス・コーポレイション | Hsp90阻害活性を有するプリン類似体 |
US20070129334A1 (en) * | 2001-10-30 | 2007-06-07 | Conforma Therapeutics Corporation | Orally Active Purine-Based Inhibitors of Heat Shock Protein 90 |
JP4467979B2 (ja) * | 2001-12-06 | 2010-05-26 | メルク・シャープ・エンド・ドーム・コーポレイション | 有糸分裂キネシン阻害剤 |
EP1458726B1 (en) * | 2001-12-06 | 2009-07-15 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
FR2842809A1 (fr) * | 2002-07-26 | 2004-01-30 | Greenpharma Sas | NOUVELLES PYRAZOLO[1,5-a]-1,3,5-TRIAZINES SUBSTITUEES ET LEURS ANALOGUES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT, UTILISATION A TITRE DE MEDICAMENT ET PROCEDES POUR LEUR PREPARATION |
DE10238724A1 (de) | 2002-08-23 | 2004-03-04 | Bayer Ag | Alkyl-substituierte Pyrazolpyrimidine |
DE10238722A1 (de) * | 2002-08-23 | 2004-03-11 | Bayer Ag | Selektive Phosphodiesterase 9A-Inhibitoren als Arzneimittel zur Verbesserung kognitiver Prozesse |
DE10238723A1 (de) | 2002-08-23 | 2004-03-11 | Bayer Ag | Phenyl-substituierte Pyrazolyprimidine |
DE602004021585D1 (de) | 2003-04-29 | 2009-07-30 | Pfizer Ltd | 5,7-DIAMINOPYRAZOLOi4,3-D PYRIMIDINE ZUR VERWENDUNG IN DER BEHANDLUNG VON BLUTHOCHDRUCK |
US20040220186A1 (en) * | 2003-04-30 | 2004-11-04 | Pfizer Inc. | PDE9 inhibitors for treating type 2 diabetes,metabolic syndrome, and cardiovascular disease |
DE10320785A1 (de) * | 2003-05-09 | 2004-11-25 | Bayer Healthcare Ag | 6-Arylmethyl-substituierte Pyrazolopyrimidine |
US8044060B2 (en) | 2003-05-09 | 2011-10-25 | Boehringer Ingelheim International Gmbh | 6-cyclylmethyl- and 6-alkylmethyl pyrazolo[3,4-D]pyrimidines, methods for their preparation and methods for their use to treat impairments of perception, concentration learning and/or memory |
DE10328479A1 (de) * | 2003-06-25 | 2005-01-13 | Bayer Ag | 6-Arylamino-5-cyano-4-pyrimidinone |
US7138401B2 (en) * | 2003-09-18 | 2006-11-21 | Conforma Therapeutics Corporation | 2-aminopurine analogs having HSP90-inhibiting activity |
US7572799B2 (en) | 2003-11-24 | 2009-08-11 | Pfizer Inc | Pyrazolo[4,3-d]pyrimidines as Phosphodiesterase Inhibitors |
DE102004001873A1 (de) * | 2004-01-14 | 2005-09-29 | Bayer Healthcare Ag | Cyanopyrimidinone |
RU2006134021A (ru) * | 2004-02-27 | 2008-04-10 | Ф.Хоффманн-Ля Рош Аг (Ch) | Производные гетероарил-конденсированного пиразола |
US7897607B2 (en) | 2004-04-07 | 2011-03-01 | Takeda Pharmaceutical Company Limited | Cyclic compounds |
JP2008534609A (ja) * | 2005-03-30 | 2008-08-28 | コンフォーマ・セラピューティクス・コーポレイション | Hsp90阻害剤としてのアルキニルピロロピリミジンおよび関連類似体 |
AU2006283940A1 (en) * | 2005-08-25 | 2007-03-01 | F. Hoffmann-La Roche Ag | P38 MAP kinase inhibitors and methods for using the same |
EP1937258A2 (en) * | 2005-09-23 | 2008-07-02 | Conforma Therapeutics Corporation | Anti-tumor methods using multi drug resistance independent synthetic hsp90 inhibitors |
KR101009860B1 (ko) | 2005-10-11 | 2011-01-19 | 에프. 호프만-라 로슈 아게 | 이미다조 벤조다이아제핀 유도체 |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
KR20090042227A (ko) | 2006-06-06 | 2009-04-29 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
WO2009064802A2 (en) * | 2007-11-13 | 2009-05-22 | Eli Lilly & Co. | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
CA2706018C (en) * | 2007-11-30 | 2015-11-24 | Boehringer Ingelheim International Gmbh | 1, 5-dihydro-pyrazolo [3,4-d]pyrimidin-4-one derivatives and their use as pde9a modulators for the treatment of cns disorders |
US8846693B2 (en) | 2007-12-06 | 2014-09-30 | Intra-Cellular Therapies, Inc. | Optionally substituted pyrazolo[3,4-d]pyrimidine-4,6-diones |
UA105362C2 (en) | 2008-04-02 | 2014-05-12 | Бьорингер Ингельхайм Интернациональ Гмбх | 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
US9079905B2 (en) | 2008-09-08 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Compounds for the treatment of CNS disorders |
CN102238873A (zh) | 2008-12-06 | 2011-11-09 | 细胞内治疗公司 | 有机化合物 |
PE20110944A1 (es) | 2008-12-06 | 2012-01-25 | Intra Cellular Therapies Inc | DERIVADOS DE PIRAZOLO[3,4-d]PIRIMIDINA COMO INHIBIDORES PDE1 |
EA201170772A1 (ru) | 2008-12-06 | 2012-03-30 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
MY156377A (en) * | 2009-03-31 | 2016-02-15 | Boehringer Ingelheim Int | 1-heterocycl-1, 5-dihydro-pyrazolo [3 , 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators |
AR077859A1 (es) * | 2009-08-12 | 2011-09-28 | Boehringer Ingelheim Int | Compuestos para el tratamiento de trastornos del snc |
WO2011153136A1 (en) | 2010-05-31 | 2011-12-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
JP5894148B2 (ja) | 2010-05-31 | 2016-03-23 | イントラ−セルラー・セラピーズ・インコーポレイテッドIntra−Cellular Therapies, Inc. | 有機化合物 |
GEP20156217B (en) | 2010-08-12 | 2015-01-12 | Boehringer Ingelheim Int | 6-cycloalkyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a inhibitors |
US8809345B2 (en) | 2011-02-15 | 2014-08-19 | Boehringer Ingelheim International Gmbh | 6-cycloalkyl-pyrazolopyrimidinones for the treatment of CNS disorders |
EP2508511A1 (en) | 2011-04-07 | 2012-10-10 | Laboratoire Biodim | Inhibitors of viral replication, their process of preparation and their therapeutical uses |
CN102786525B (zh) | 2012-08-08 | 2014-12-17 | 中山大学 | N-取代吡唑并[3,4-d]嘧啶酮类化合物、其制备方法及其应用 |
US9783552B2 (en) | 2013-12-11 | 2017-10-10 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
EP3079701B1 (en) * | 2013-12-11 | 2021-08-11 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
US9546175B2 (en) | 2014-08-07 | 2017-01-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
WO2016049500A1 (en) | 2014-09-25 | 2016-03-31 | Duke University | Kinase inhibitors and related methods of use |
EP3562828A1 (en) * | 2016-12-28 | 2019-11-06 | Dart NeuroScience LLC | Substituted pyrazolopyrimidinone compounds as pde2 inhibitors |
US11434247B1 (en) | 2017-11-27 | 2022-09-06 | Dart Neuroscience Llc | Substituted furanopyrimidine compounds as PDE1 inhibitors |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3211732A (en) * | 1965-10-12 | Pyrazolob:x-d]pyrlil/hdines | ||
US3165520A (en) * | 1965-01-12 | Certificate of correction | ||
CA754565A (en) * | 1967-03-14 | A. Burch Homer | 4-substituted-1-alkyl-6-(2-furyl)-1h-pyrazolo(3,4-d)pyrimidines | |
CH398626A (de) * | 1960-05-11 | 1966-03-15 | Ciba Geigy | Verfahren zur Herstellung neuer Pyrazolopyrimidine |
GB937722A (en) * | 1960-05-11 | 1963-09-25 | Ciba Ltd | New pyrazolopyrimidines and process for the preparation thereof |
FR206F (no) * | 1965-07-20 | |||
GB1284084A (en) * | 1969-04-17 | 1972-08-02 | Delmar Chem | PROCESS FOR MAKING 1H-PYRAZOLO[3,4-d]PYRIMIDINES |
BE758050A (fr) * | 1969-10-28 | 1971-04-27 | Geigy Ag J R | Derives 5-nitro-furyliques et medicaments contenant de tels composes |
US3732225A (en) * | 1970-07-23 | 1973-05-08 | Squibb & Sons Inc | Pyrazolo(3,4-d)pyrimidine derivatives |
DE2116973A1 (de) * | 1971-04-07 | 1972-12-14 | Bayer Ag, 5090 Leverkusen | Polymerisierbare Anthranilsäureester |
US3847908A (en) * | 1973-03-05 | 1974-11-12 | Squibb & Sons Inc | 6-styrylpyrazolo(3,4-d)pyrimidinones and pyrimidines |
US4260758A (en) * | 1979-09-17 | 1981-04-07 | Burroughs Wellcome Co. | Pyrazolo (3,4-d) pyrimidines and methods of making |
US4666908A (en) * | 1985-04-05 | 1987-05-19 | Warner-Lambert Company | 5-Substituted pyrazolo[4,3-d]pyrimidine-7-ones and methods of use |
WO1988000192A1 (en) * | 1986-06-26 | 1988-01-14 | Warner-Lambert Company | 5-SUBSTITUTED PYRAZOLO[4,3-d]PYRIMIDIN-7-ONES |
US5075310A (en) * | 1988-07-01 | 1991-12-24 | Smith Kline & French Laboratories, Ltd. | Pyrimidone derivatives as bronchodilators |
GB9008166D0 (en) * | 1990-04-10 | 1990-06-06 | Thompson Andrew | Improved high performance carpet tile backing |
GB9013750D0 (en) * | 1990-06-20 | 1990-08-08 | Pfizer Ltd | Therapeutic agents |
GB9114760D0 (en) * | 1991-07-09 | 1991-08-28 | Pfizer Ltd | Therapeutic agents |
GB9121028D0 (en) * | 1991-10-03 | 1991-11-13 | Pfizer Ltd | Therapeutic agents |
US5294612A (en) * | 1992-03-30 | 1994-03-15 | Sterling Winthrop Inc. | 6-heterocyclyl pyrazolo [3,4-d]pyrimidin-4-ones and compositions and method of use thereof |
GB9213623D0 (en) * | 1992-06-26 | 1992-08-12 | Pfizer Ltd | Therapeutic agents |
-
1995
- 1995-03-10 US US08/402,268 patent/US5656629A/en not_active Expired - Fee Related
-
1996
- 1996-03-05 CA CA002211669A patent/CA2211669A1/en not_active Abandoned
- 1996-03-05 WO PCT/US1996/002971 patent/WO1996028429A1/en not_active Application Discontinuation
- 1996-03-05 NZ NZ306035A patent/NZ306035A/xx unknown
- 1996-03-05 JP JP8527681A patent/JPH11501923A/ja active Pending
- 1996-03-05 PL PL96322380A patent/PL322380A1/xx unknown
- 1996-03-05 CZ CZ972805A patent/CZ280597A3/cs unknown
- 1996-03-05 KR KR1019970706299A patent/KR19980702891A/ko not_active Application Discontinuation
- 1996-03-05 AU AU54188/96A patent/AU708750B2/en not_active Ceased
- 1996-03-05 EP EP96911244A patent/EP0813527A4/en not_active Withdrawn
- 1996-03-05 HU HU9801336A patent/HUP9801336A3/hu unknown
- 1996-03-11 ZA ZA961947A patent/ZA961947B/xx unknown
-
1997
- 1997-03-26 US US08/824,600 patent/US5977118A/en not_active Expired - Fee Related
- 1997-09-09 NO NO974151A patent/NO974151L/no unknown
Also Published As
Publication number | Publication date |
---|---|
WO1996028429A1 (en) | 1996-09-19 |
HUP9801336A3 (en) | 2000-07-28 |
KR19980702891A (ko) | 1998-08-05 |
HUP9801336A2 (hu) | 1998-10-28 |
NZ306035A (en) | 1999-07-29 |
AU5418896A (en) | 1996-10-02 |
CZ280597A3 (cs) | 1998-04-15 |
EP0813527A4 (en) | 1998-09-09 |
PL322380A1 (en) | 1998-01-19 |
EP0813527A1 (en) | 1997-12-29 |
AU708750B2 (en) | 1999-08-12 |
NO974151L (no) | 1997-11-04 |
ZA961947B (en) | 1996-10-07 |
CA2211669A1 (en) | 1996-09-19 |
JPH11501923A (ja) | 1999-02-16 |
US5977118A (en) | 1999-11-02 |
MX9706876A (es) | 1998-06-28 |
US5656629A (en) | 1997-08-12 |
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