PE20020394A1 - Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2 - Google Patents

Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2

Info

Publication number
PE20020394A1
PE20020394A1 PE2001000819A PE2001000819A PE20020394A1 PE 20020394 A1 PE20020394 A1 PE 20020394A1 PE 2001000819 A PE2001000819 A PE 2001000819A PE 2001000819 A PE2001000819 A PE 2001000819A PE 20020394 A1 PE20020394 A1 PE 20020394A1
Authority
PE
Peru
Prior art keywords
alkyl
alcoxy
alkenyl
hadh2
erab
Prior art date
Application number
PE2001000819A
Other languages
English (en)
Inventor
Melwyn A Abreo
Jerry J Meng
Charles S Agree
Original Assignee
Agouron Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharma filed Critical Agouron Pharma
Publication of PE20020394A1 publication Critical patent/PE20020394A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A90/00—Technologies having an indirect contribution to adaptation to climate change
    • Y02A90/10—Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

SE REFIERE A COMPUESTOS DE PIRAZOL DE FORMULA I DONDE X ES O, S; Y ES N, CH; R6 ES H, OH; R ES -(R1)(R7)C-C(=O)-NR2R3; C(R1)(R7)-C(=O)R5; C(R1)(R7)-C(=O)OR4; R1 ES H, ALQUILO, ALQUENILO, ALQUINILO, ALCOXI, ALILOXI, ARILO, ENTRE OTROS; R2 Y R3 SON H, ALQUILO, ALQUENILO, ALCOXI, ARILO, HETEROARILO, ENTRE OTROS; R4 ES H, ALQUILO, ALQUENILO, CICLOALQUILO, HETEROCICLOALQUILO; R5 ES H, ALQUILO, ALQUENILO, ALQUINILO, CICLOALQUILO, ENTRE OTROS; R7 ES H, ALQUILO C1-C3, HIDROXI, ALCOXI C1-C3. TAMBIEN SE REFIERE AL USO EN COMBINACION CON ESTROGENO, NSAIDS, RISPERIDONA, TIOBENZODIAZEPINA, AMPAQUINA, [N-(2,6-DIMETILFENIL)-2-(2-OXO-1-PIRROLIDINIL)ACETAMIDA, UN INHIBIDOR DE COLINESTERASA, DONEPEZIL, RIVASTIGMINA, GALANTAMINA, METRIFONATO. LOS COMPUESTOS SON INHIBIDORES DE LA PROTEINA AMILOIDE ß LIGADORA ASOCIADA CON EL RETICULO ENDOPLASMICO Y L-3-HIDROXIACIL-COA DESHIDROGENASA CLASE II ERAB/HADH2 QUE CATALIZA LA OXIDACION REVERSIBLE DEL L-3-HIDROXIACIL-COA Y PUEDE SER UTIL PARA EL TRATAMIENTO DE ENFERMEDADES NEURODEGENERATIVAS Y NEOPLASIAS MALIGNAS COMO CANCER DE MAMA O ENDOMETRIO
PE2001000819A 2000-08-18 2001-08-16 Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2 PE20020394A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22612300P 2000-08-18 2000-08-18

Publications (1)

Publication Number Publication Date
PE20020394A1 true PE20020394A1 (es) 2002-06-21

Family

ID=22847647

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2001000819A PE20020394A1 (es) 2000-08-18 2001-08-16 Compuestos de pirazol y composiciones farmaceuticas que los contienen, que modulan y/o inhiben la actividad de erab/hadh2

Country Status (14)

Country Link
US (2) US6964957B2 (es)
EP (2) EP1311511A1 (es)
JP (2) JP2004506737A (es)
AR (1) AR035486A1 (es)
AU (1) AU2001296854A1 (es)
BR (1) BR0113461A (es)
CA (2) CA2415182A1 (es)
GT (1) GT200100169A (es)
HK (1) HK1046288A1 (es)
MX (1) MXPA03001455A (es)
PA (1) PA8525801A1 (es)
PE (1) PE20020394A1 (es)
UY (1) UY26895A1 (es)
WO (1) WO2002016365A1 (es)

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DE10221052A1 (de) * 2002-05-10 2003-12-04 Transmit Technologietransfer Wirkstoffe zu Therapie, Diagnostik und Prophylaxe von Erkrankungen, bei denen abnorme Proteinstrukturen auftreten
EP1627323A4 (en) * 2003-05-06 2008-04-09 New Century Pharmaceuticals ALBUMIN FIXATION SITES FOR EVALUATING DRUG INTERACTIONS OR THE DEVELOPMENT OF MEDICAMENTS BASED ON THEIR ALBUMIN BINDING PROPERTIES
US20070043509A1 (en) * 2003-11-03 2007-02-22 Carter Daniel C Albumin binding sites for evaluating drug interactions and methods of evaluating or designing drugs based on their albumin binding properties
US20080274975A1 (en) * 2004-04-12 2008-11-06 The Trustees Of Columbia University In The City Of New Yourk Methods and Compositions for Inhibiting Abad/Abeta Protein Interaction
US9132135B2 (en) * 2004-09-24 2015-09-15 University Of Maryland, Baltimore Method of treating organophosphorous poisoning
PL1791904T3 (pl) * 2004-09-24 2015-02-27 Univ Maryland Sposób leczenia zatrucia związkami fosforoorganicznymi
WO2010118367A2 (en) * 2009-04-10 2010-10-14 Progenics Pharmaceuticals, Inc. Antiviral pyrimidines
TWI698436B (zh) * 2014-12-30 2020-07-11 美商佛瑪治療公司 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶
MA41291A (fr) 2014-12-30 2017-11-07 Forma Therapeutics Inc Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer
EP3253765A1 (en) 2015-02-05 2017-12-13 Forma Therapeutics, Inc. Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors
WO2016126935A1 (en) 2015-02-05 2016-08-11 Forma Therapeutics, Inc. Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors
US9840491B2 (en) 2015-02-05 2017-12-12 Forma Therapeutics, Inc. Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
WO2023146880A1 (en) * 2022-01-25 2023-08-03 Board Of Regents Of The University Of Nebraska Functionalized allopurinol derivatives for treatment of alzheimer's disease

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Also Published As

Publication number Publication date
WO2002016365A1 (en) 2002-02-28
PA8525801A1 (es) 2002-08-29
CA2354653A1 (en) 2002-02-18
CA2415182A1 (en) 2002-02-28
HK1046288A1 (zh) 2003-01-03
MXPA03001455A (es) 2004-05-04
EP1311511A1 (en) 2003-05-21
EP1223176A2 (en) 2002-07-17
AU2001296854A1 (en) 2002-03-04
UY26895A1 (es) 2002-04-26
BR0113461A (pt) 2003-07-01
US20020065292A1 (en) 2002-05-30
JP2004506737A (ja) 2004-03-04
GT200100169A (es) 2002-05-16
US6964957B2 (en) 2005-11-15
AR035486A1 (es) 2004-06-02
EP1223176A3 (en) 2002-10-23
US20020132319A1 (en) 2002-09-19
JP2002360269A (ja) 2002-12-17

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