IL111526A0 - 7H-imidazo (1,2-a) pyrazin-8-one derivatives and their preparation and use - Google Patents

7H-imidazo (1,2-a) pyrazin-8-one derivatives and their preparation and use

Info

Publication number
IL111526A0
IL111526A0 IL11152694A IL11152694A IL111526A0 IL 111526 A0 IL111526 A0 IL 111526A0 IL 11152694 A IL11152694 A IL 11152694A IL 11152694 A IL11152694 A IL 11152694A IL 111526 A0 IL111526 A0 IL 111526A0
Authority
IL
Israel
Prior art keywords
pyrazin
imidazo
derivatives
preparation
Prior art date
Application number
IL11152694A
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Publication of IL111526A0 publication Critical patent/IL111526A0/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
IL11152694A 1993-11-05 1994-11-03 7H-imidazo (1,2-a) pyrazin-8-one derivatives and their preparation and use IL111526A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9313164A FR2711993B1 (en) 1993-11-05 1993-11-05 Drugs containing 7H-imidazol [1,2-a] pyrazine-8-one derivatives, new compounds and their preparation.

Publications (1)

Publication Number Publication Date
IL111526A0 true IL111526A0 (en) 1995-01-24

Family

ID=9452533

Family Applications (1)

Application Number Title Priority Date Filing Date
IL11152694A IL111526A0 (en) 1993-11-05 1994-11-03 7H-imidazo (1,2-a) pyrazin-8-one derivatives and their preparation and use

Country Status (7)

Country Link
EP (1) EP0726900A1 (en)
JP (1) JPH09504539A (en)
AU (1) AU8109794A (en)
FR (1) FR2711993B1 (en)
IL (1) IL111526A0 (en)
WO (1) WO1995012594A1 (en)
ZA (1) ZA948592B (en)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040155A1 (en) * 1995-06-07 1996-12-19 The Johns Hopkins University Use of specific acpa derivative (npc-17742) for the treatment of ischemia
BR0309398A (en) 2002-04-19 2005-02-01 Cellular Genomics Inc A compound or a salt, hydrate, solvate, crystalline form thereof, diastereomer, pharmaceutically acceptable prodrug, or mixtures thereof, pharmaceutical composition, and methods for treating a condition involved with kinase in a mammal, for treating cancer, and for identifying a kinase.
WO2004022562A1 (en) 2002-09-09 2004-03-18 Cellular Genomics, Inc. 6-ARYL-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINES, METHOD OF MAKING, AND METHOD OF USE THEREOF
US7160885B2 (en) 2003-02-10 2007-01-09 Cgi Pharmaceuticals, Inc. Certain 6, 8-(heteroaryl or aryl) disubstituted imidazo[1,2-a]pyrazines as modulators of Hsp90 complex activity
US7732162B2 (en) 2003-05-05 2010-06-08 Probiodrug Ag Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases
US7405295B2 (en) 2003-06-04 2008-07-29 Cgi Pharmaceuticals, Inc. Certain imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of Bruton's tyrosine kinase by such compounds
WO2005005429A1 (en) 2003-06-30 2005-01-20 Cellular Genomics, Inc. Certain heterocyclic substituted imidazo[1,2-a]pyrazin-8-ylamines and methods of inhibition of bruton’s tyrosine kinase by such compounds
US7259164B2 (en) 2003-08-11 2007-08-21 Cgi Pharmaceuticals, Inc. Certain substituted imidazo[1,2-a]pyrazines, as modulators of kinase activity
WO2007024294A2 (en) 2005-05-03 2007-03-01 Cgi Pharmaceuticals, Inc. Certain substituted ureas, as modulators of kinase activity
EP1928237A4 (en) 2005-09-02 2011-03-09 Abbott Lab Novel imidazo based heterocycles
WO2008055945A1 (en) 2006-11-09 2008-05-15 Probiodrug Ag 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
SI2091948T1 (en) 2006-11-30 2012-07-31 Probiodrug Ag Novel inhibitors of glutaminyl cyclase
EP2481408A3 (en) 2007-03-01 2013-01-09 Probiodrug AG New use of glutaminyl cyclase inhibitors
DK2142514T3 (en) 2007-04-18 2015-03-23 Probiodrug Ag Thiourea derivatives as glutaminyl cyclase inhibitors
US20090221612A1 (en) 2008-02-13 2009-09-03 Mitchell Scott A Certain substituted amides, method of making, and method of use thereof
US8450321B2 (en) 2008-12-08 2013-05-28 Gilead Connecticut, Inc. 6-(1H-indazol-6-yl)-N-[4-(morpholin-4-yl)phenyl]imidazo-[1,2-A]pyrazin-8-amine, or a pharmaceutically acceptable salt thereof, as a SYK inhibitor
LT2716157T (en) 2008-12-08 2016-09-12 Gilead Connecticut, Inc. Imidazopyrazine Syk inhibitors
SG10201707798SA (en) 2008-12-08 2017-10-30 Gilead Connecticut Inc Imidazopyrazine syk inhibitors
AU2010294214B2 (en) 2009-09-11 2015-05-07 Vivoryon Therapeutics N.V. Heterocylcic derivatives as inhibitors of glutaminyl cyclase
JP6026284B2 (en) 2010-03-03 2016-11-16 プロビオドルグ エージー Inhibitors of glutaminyl cyclase
AU2011226074B2 (en) 2010-03-10 2015-01-22 Vivoryon Therapeutics N.V. Heterocyclic inhibitors of glutaminyl cyclase (QC, EC 2.3.2.5)
ES2530449T3 (en) 2010-03-11 2015-03-02 Gilead Connecticut Inc Imidazopyridine Syk inhibitors
EP2560953B1 (en) 2010-04-21 2016-01-06 Probiodrug AG Inhibitors of glutaminyl cyclase
JP6050264B2 (en) 2011-03-16 2016-12-21 プロビオドルグ エージー Benzimidazole derivatives as inhibitors of glutaminyl cyclase
US9657023B2 (en) 2013-07-30 2017-05-23 Gilead Connecticut, Inc. Polymorph of Syk inhibitors
EP3027171B1 (en) 2013-07-30 2020-03-25 Gilead Connecticut, Inc. Formulation of syk inhibitors
KR20180002888A (en) 2013-12-04 2018-01-08 길리애드 사이언시즈, 인코포레이티드 Methods for treating cancers
US9290505B2 (en) 2013-12-23 2016-03-22 Gilead Sciences, Inc. Substituted imidazo[1,2-a]pyrazines as Syk inhibitors
UY35898A (en) 2013-12-23 2015-07-31 Gilead Sciences Inc ? SYK INHIBITING COMPOUNDS AND COMPOSITIONS THAT UNDERSTAND THEM ?.
HUE045725T2 (en) 2014-02-13 2020-01-28 Incyte Corp Cyclopropylamines as lsd1 inhibitors
US9527835B2 (en) 2014-02-13 2016-12-27 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
EP3392244A1 (en) 2014-02-13 2018-10-24 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
AU2015217073B2 (en) 2014-02-13 2019-08-22 Incyte Holdings Corporation Cyclopropylamines as LSD1 inhibitors
TWI687419B (en) 2014-07-10 2020-03-11 美商英塞特公司 Imidazopyridines and imidazopyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
WO2016007736A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines as lsd1 inhibitors
WO2016007727A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
NZ726365A (en) 2014-07-14 2018-06-29 Gilead Sciences Inc Combinations for treating cancers
TWI714567B (en) 2015-04-03 2021-01-01 美商英塞特公司 Heterocyclic compounds as lsd1 inhibitors
MY189367A (en) 2015-08-12 2022-02-08 Incyte Corp Salts of an lsd1 inhibitor
EP3445339B1 (en) 2016-04-22 2023-08-23 Incyte Corporation Formulations of an lsd1 inhibitor
JP6986624B2 (en) 2017-08-25 2021-12-22 ギリアード サイエンシーズ， インコーポレイテッド Polymorph of Syk inhibitor
PL3461819T3 (en) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitors of glutaminyl cyclase
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same
KR20210131372A (en) 2019-02-22 2021-11-02 크로노스 바이오, 인코포레이티드 Solid Form of Condensed Pyrazine as Syk Inhibitor
WO2023042887A1 (en) 2021-09-15 2023-03-23 国立大学法人 琉球大学 Pharmaceutical composition for use in treating cognitive decline, excess weight, or obesity
WO2023042888A1 (en) 2021-09-15 2023-03-23 国立大学法人 琉球大学 Pharmaceutical composition for treating cognitive decline or for treating overweightness or obesity

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3767793A (en) * 1992-04-03 1993-11-08 Yamanouchi Pharmaceutical Co., Ltd. Fused quinoxalinone derivative and pharmaceutical composition containing the same
FR2696466B1 (en) * 1992-10-02 1994-11-25 Rhone Poulenc Rorer Sa 5H, 10H-imidazo [1,2-a] indeno [1,2-e] pyrazine-4-one derivatives, their preparation and the medicaments containing them.

Also Published As

Publication number Publication date
AU8109794A (en) 1995-05-23
JPH09504539A (en) 1997-05-06
FR2711993B1 (en) 1995-12-01
WO1995012594A1 (en) 1995-05-11
FR2711993A1 (en) 1995-05-12
ZA948592B (en) 1995-06-23
EP0726900A1 (en) 1996-08-21

Similar Documents

Publication Publication Date Title
IL111526A0 (en) 7H-imidazo (1,2-a) pyrazin-8-one derivatives and their preparation and use
IL116769A0 (en) 2, 9-disubstituted purin 6-one compounds their preparation and use
NZ288609A (en) Substituted (4-thiopyridinyl) methylthio-benzimidazole (or 1h-imidazo-[2,3-b]-pyridine) and medicaments
EP0584487A3 (en) 4,5-dihydro-4-oxopyrrolo (1,2-a) quinoxalines and aza-analoges and process for their preparation
HU9502726D0 (en) [1,2,4]triazolo[4,3-a]qunoxaline derivatives, their preparation and use
ZA926189B (en) Beta-Phenylisoserine derivatives and their preparation and use.
AU2141695A (en) Imidazo{1,2-a}pyrazine-4-one derivatives, preparation thereof and drugs containing same
KR970000398B1 (en) Process for the preparation of 1,1,1,2-tetrafluoro-2-chloroethan and pentafluorethane
EG21121A (en) 13 Substituted milbemycin derivatives their preparation and use
IL109437A0 (en) 2-Amino-4-quinolyldihydropyridines, processes for their preparation and their use
IL108343A0 (en) 9H-imidazo [1,2-a] benzimidazole-3-acetamide derivatives, their preparation and their therapeutic application
ZA868752B (en) 6,7,8,9-tetrahydro-10-methylpyrido(1,2-a)indol-9-amines and derivatives thereof
ZA932576B (en) 1,2,4-benzothiadiazine-3-carboxylic acid derivatives, their preparation and their use
IL104449A0 (en) N-cyanopyridazinones,their preparation and their use as herbicides
EP0701557A4 (en) Lavendamycin analogs, their use and preparation
AU647559B2 (en) Pyrimidinyl- and triazinyl-salicylamides and their use and preparation
ZA926937B (en) Substituted aminopropanes,processes for their preparation and their use
AU1850092A (en) 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
EP0442086A3 (en) Graftcopolymers, their preparation and their use
AU5095693A (en) Multi-purpose exercise chair
GB9301928D0 (en) Footrest
AU5975094A (en) 1,2,4-triazinone derivatives and their use in therapy
EP0459198A3 (en) Thioalkanones, procedure for their preparation and their use
GB2205565B (en) Imidazo-[1,2-a]-pyrimidin-2-oyl and imidazo-[1,2-a]quinazolin-2-oyl cyclopropane derivatives
GB2270313B (en) 1,3,4-Benzotriazepin-5 (4H)-one derivatives and process for the preparation thereof