EE04313B1 - 1,2,4-triasolo[4,3-b]pürido[3,2-d]püridasiini derivaadid, nende valmistamismeetod ja farmatseutiline kompositsioon ning nende kasutamine - Google Patents

1,2,4-triasolo[4,3-b]pürido[3,2-d]püridasiini derivaadid, nende valmistamismeetod ja farmatseutiline kompositsioon ning nende kasutamine

Info

Publication number
EE04313B1
EE04313B1 EEP200000052A EEP200000052A EE04313B1 EE 04313 B1 EE04313 B1 EE 04313B1 EE P200000052 A EEP200000052 A EE P200000052A EE P200000052 A EEP200000052 A EE P200000052A EE 04313 B1 EE04313 B1 EE 04313B1
Authority
EE
Estonia
Prior art keywords
triazolo
pyrido
preparation
pharmaceutical composition
pyridazine derivatives
Prior art date
Application number
EEP200000052A
Other languages
English (en)
Inventor
Gracia Ferrer Jordi
Isabel Crespo Crespo Ma
Vega Noverola Armando
Fernandez Garcia Andr�s
Original Assignee
Almirall Prodesfarma, S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Almirall Prodesfarma, S.A. filed Critical Almirall Prodesfarma, S.A.
Publication of EE200000052A publication Critical patent/EE200000052A/et
Publication of EE04313B1 publication Critical patent/EE04313B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/14—Decongestants or antiallergics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
EEP200000052A 1997-07-29 1998-07-13 1,2,4-triasolo[4,3-b]pürido[3,2-d]püridasiini derivaadid, nende valmistamismeetod ja farmatseutiline kompositsioon ning nende kasutamine EE04313B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES009701670A ES2137113B1 (es) 1997-07-29 1997-07-29 Nuevos derivados de triazolo-piridazinas heterociclicos.
PCT/EP1998/004340 WO1999006404A1 (en) 1997-07-29 1998-07-13 1,2,4-triazolo[4,3-b]pyrido[3,2-d]pyridazine derivatives and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
EE200000052A EE200000052A (et) 2000-10-16
EE04313B1 true EE04313B1 (et) 2004-06-15

Family

ID=8300216

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200000052A EE04313B1 (et) 1997-07-29 1998-07-13 1,2,4-triasolo[4,3-b]pürido[3,2-d]püridasiini derivaadid, nende valmistamismeetod ja farmatseutiline kompositsioon ning nende kasutamine

Country Status (36)

Country Link
US (2) US6407108B1 (et)
EP (1) EP1001955B1 (et)
JP (1) JP4320118B2 (et)
KR (1) KR20010022353A (et)
CN (1) CN1135231C (et)
AR (1) AR015927A1 (et)
AT (1) ATE207069T1 (et)
AU (1) AU737709B2 (et)
BG (1) BG64448B1 (et)
BR (1) BR9810829B1 (et)
CA (1) CA2298935A1 (et)
CO (1) CO4970780A1 (et)
CZ (1) CZ290208B6 (et)
DE (1) DE69802100T2 (et)
DK (1) DK1001955T3 (et)
EE (1) EE04313B1 (et)
EG (1) EG24041A (et)
ES (2) ES2137113B1 (et)
HK (1) HK1024914A1 (et)
HU (1) HUP0004708A3 (et)
ID (1) ID24506A (et)
IL (1) IL134081A (et)
MY (1) MY118796A (et)
NO (1) NO315118B1 (et)
NZ (1) NZ502356A (et)
PE (1) PE111099A1 (et)
PL (1) PL191031B1 (et)
PT (1) PT1001955E (et)
RU (1) RU2202552C2 (et)
SI (1) SI1001955T1 (et)
SK (1) SK284046B6 (et)
TR (1) TR200000243T2 (et)
TW (1) TW542837B (et)
UA (1) UA60339C2 (et)
WO (1) WO1999006404A1 (et)
ZA (1) ZA986248B (et)

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FR2792938B1 (fr) * 1999-04-28 2001-07-06 Warner Lambert Co NOUVELLES 1-AMINO TRIAZOLO [4,3-a] QUINAZOLINE-5-ONES INHIBITRICES DE PHOSPHODIESTERASES IV
TR200909479T2 (tr) 1999-08-21 2012-02-21 Nycomed Gmbh Sinerjistik kombinasyon.
WO2002080974A1 (fr) * 2001-04-04 2002-10-17 Sankyo Company, Limited Utilisation medicale d'inhibiteur de production de cytokine
US20040242597A1 (en) * 2001-09-19 2004-12-02 Thomas Klein Combination
FR2832711B1 (fr) * 2001-11-26 2004-01-30 Warner Lambert Co Derives de triazolo [4,3-a] pyrido [2,3-d] pyrimidin-5-ones, compositions les contenant, procede de preparation et utilisation
WO2004041819A1 (ja) * 2002-11-06 2004-05-21 Grelan Pharmaceutical Co., Ltd. ピラゾロナフチリジン誘導体
ES2211344B1 (es) 2002-12-26 2005-10-01 Almirall Prodesfarma, S.A. Nuevos derivados de piridazin-3(2h)-ona.
US20050187278A1 (en) * 2003-08-28 2005-08-25 Pharmacia Corporation Treatment or prevention of vascular disorders with Cox-2 inhibitors in combination with cyclic AMP-specific phosphodiesterase inhibitors
RU2246496C1 (ru) * 2003-09-12 2005-02-20 Тец Виктор Вениаминович Вещество с противовирусной и антибактериальной активностью на основе производных 2,8-дитиоксо-1h-пирано[2,3-d, 6,5-d`] дипиримидина и их 10-аза-аналогов
ES2251866B1 (es) 2004-06-18 2007-06-16 Laboratorios Almirall S.A. Nuevos derivados de piridazin-3(2h)-ona.
EP1898903B8 (en) * 2005-06-10 2013-05-15 Merck Sharp & Dohme Corp. Inhibitors of akt activity
WO2007025177A2 (en) 2005-08-26 2007-03-01 Braincells, Inc. Neurogenesis by muscarinic receptor modulation
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
EP1925617B1 (en) * 2005-09-15 2012-11-14 ASKA Pharmaceutical Co., Ltd. Heterocyclic compound, and production process and use thereof
JP2009512711A (ja) 2005-10-21 2009-03-26 ブレインセルス，インコーポレイティド Ｐｄｅ阻害による神経新生の調節
CA2625210A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
US7678808B2 (en) 2006-05-09 2010-03-16 Braincells, Inc. 5 HT receptor mediated neurogenesis
EP2382975A3 (en) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenesis by modulating angiotensin
TW200817410A (en) 2006-08-07 2008-04-16 Incyte Corp Triazolotriazines as kinase inhibitors
AU2007292848A1 (en) 2006-09-08 2008-03-13 Braincells, Inc. Combinations containing a 4-acylaminopyridine derivative
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
MY188338A (en) 2006-11-22 2021-11-30 Incyte Holdings Corp Imidazotriazines and imidazopyrimidines as kinase inhibitors
WO2009089027A1 (en) * 2008-01-09 2009-07-16 Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Service, National Institutes Of Health Phosphodiesterase inhibitors
EP2300455B1 (en) 2008-05-21 2017-07-19 Incyte Holdings Corporation Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
EP2196465A1 (en) 2008-12-15 2010-06-16 Almirall, S.A. (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
EP2226323A1 (en) 2009-02-27 2010-09-08 Almirall, S.A. New tetrahydropyrazolo[3,4-c]isoquinolin-5-amine derivatives
AU2010338038B2 (en) 2009-12-31 2015-07-09 Fundación Del Sector Público Estatal Centro Nacional De Investigaciones Oncológicas Carlos III (F.S.P. CNIO) Tricyclic compounds for use as kinase inhibitors
EA025304B1 (ru) 2010-02-03 2016-12-30 Инсайт Холдингс Корпорейшн ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИНЫ В КАЧЕСТВЕ c-Met ИНГИБИТОРОВ
EP2380890A1 (en) 2010-04-23 2011-10-26 Almirall, S.A. New 7,8-dihydro-1,6-naphthyridin-5(6h)-one-derivatives as PDE4 inhibitors
EP2394998A1 (en) 2010-05-31 2011-12-14 Almirall, S.A. 3-(5-Amino-6-oxo-1,6-dihydropyridazin-3-yl)-biphenyl derivatives as PDE4 inhibitors
WO2012098387A1 (en) 2011-01-18 2012-07-26 Centro Nacional De Investigaciones Oncológicas (Cnio) 6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
WO2013005041A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) Tricyclic heterocyclic compounds as kinase inhibitors
WO2013004984A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncologicas (Cnio) Tricyclic compounds for use as kinase inhibitors
WO2013005057A1 (en) 2011-07-07 2013-01-10 Centro Nacional De Investigaciones Oncológicas (Cnio) New compounds
US20150119399A1 (en) 2012-01-10 2015-04-30 President And Fellows Of Harvard College Beta-cell replication promoting compounds and methods of their use

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DE3122670A1 (de) 1981-06-06 1982-12-23 Dr. Karl Thomae Gmbh, 7950 Biberach "neue 1,4,9,10-tetrahydro-pyrazolo(4,3-e) pyrido(3,2-b)(1,4)diazepin-10-one, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von pharmazeutischen wirkstoffen"
FI81350C (fi) * 1982-01-18 1990-10-10 Lepetit Spa Analogfoerfarande foer framstaellning av nya, farmakologiskt aktiva 6-substituerade s-triatsolo/3,4-a/ ftalazinderivat.
AU7238191A (en) * 1990-02-19 1991-09-03 Chugai Seiyaku Kabushiki Kaisha Novel fused heterocyclic compound and antiasthmatic agent prepared therefrom
ES2135416T3 (es) * 1991-10-09 1999-11-01 Syntex Inc Compuestos de piridopiridazinonas y piridazintionas con actividad inhibidora de la pde iv.
GB9514465D0 (en) 1995-07-14 1995-09-13 Glaxo Lab Sa Chemical compounds

Also Published As

Publication number Publication date
SI1001955T1 (en) 2002-02-28
EG24041A (en) 2008-04-03
CZ290208B6 (cs) 2002-06-12
EE200000052A (et) 2000-10-16
SK862000A3 (en) 2000-07-11
ES2162466T3 (es) 2001-12-16
TR200000243T2 (tr) 2000-07-21
US20020183326A1 (en) 2002-12-05
ID24506A (id) 2000-07-20
AR015927A1 (es) 2001-05-30
CN1266434A (zh) 2000-09-13
ZA986248B (en) 1999-02-05
ES2137113B1 (es) 2000-09-16
RU2202552C2 (ru) 2003-04-20
DE69802100D1 (de) 2001-11-22
CZ2000333A3 (cs) 2000-05-17
BR9810829A (pt) 2000-07-25
US6407108B1 (en) 2002-06-18
UA60339C2 (uk) 2003-10-15
HUP0004708A3 (en) 2002-11-28
PT1001955E (pt) 2002-02-28
SK284046B6 (sk) 2004-08-03
TW542837B (en) 2003-07-21
JP4320118B2 (ja) 2009-08-26
DE69802100T2 (de) 2002-03-14
ES2137113A1 (es) 1999-12-01
PL338214A1 (en) 2000-10-09
PL191031B1 (pl) 2006-03-31
JP2001512121A (ja) 2001-08-21
NO20000394L (no) 2000-03-27
EP1001955B1 (en) 2001-10-17
DK1001955T3 (da) 2001-11-19
NO315118B1 (no) 2003-07-14
CA2298935A1 (en) 1999-02-11
HUP0004708A2 (hu) 2001-07-30
PE111099A1 (es) 1999-11-18
EP1001955A1 (en) 2000-05-24
HK1024914A1 (en) 2000-10-27
ATE207069T1 (de) 2001-11-15
IL134081A (en) 2004-02-08
AU8861298A (en) 1999-02-22
WO1999006404A1 (en) 1999-02-11
KR20010022353A (ko) 2001-03-15
CO4970780A1 (es) 2000-11-07
CN1135231C (zh) 2004-01-21
MY118796A (en) 2005-01-31
NO20000394D0 (no) 2000-01-26
AU737709B2 (en) 2001-08-30
NZ502356A (en) 2001-03-30
BG64448B1 (en) 2005-02-28
BG104112A (en) 2001-01-31
IL134081A0 (en) 2001-04-30
BR9810829B1 (pt) 2009-08-11

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