DE69911798D1 - Bicyclische piperidin- und piperazin-verbindungen mit 5-ht6-rezeptor-affinität - Google Patents

Bicyclische piperidin- und piperazin-verbindungen mit 5-ht6-rezeptor-affinität

Info

Publication number
DE69911798D1
DE69911798D1 DE69911798T DE69911798T DE69911798D1 DE 69911798 D1 DE69911798 D1 DE 69911798D1 DE 69911798 T DE69911798 T DE 69911798T DE 69911798 T DE69911798 T DE 69911798T DE 69911798 D1 DE69911798 D1 DE 69911798D1
Authority
DE
Germany
Prior art keywords
group
6alkyl
optionally substituted
receptor affinity
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69911798T
Other languages
English (en)
Other versions
DE69911798T2 (de
Inventor
Shawn Maddaford
Tao Xin
Abdelmalik Slassi
Ashok Tehim
Qi Qiao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NPS Allelix Corp Canada
Original Assignee
NPS Allelix Corp Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NPS Allelix Corp Canada filed Critical NPS Allelix Corp Canada
Application granted granted Critical
Publication of DE69911798D1 publication Critical patent/DE69911798D1/de
Publication of DE69911798T2 publication Critical patent/DE69911798T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Psychiatry (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE69911798T 1998-06-15 1999-06-10 Bicyclische piperidin- und piperazin-verbindungen mit 5-ht6-rezeptor-affinität Expired - Lifetime DE69911798T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US156495 1993-11-23
US9700898A 1998-06-15 1998-06-15
US97008 1998-06-15
US09/156,495 US6251893B1 (en) 1998-06-15 1998-09-18 Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
PCT/CA1999/000543 WO1999065906A1 (en) 1998-06-15 1999-06-10 Bicyclic piperidine and piperazine compounds having 5-ht6 receptor affinity

Publications (2)

Publication Number Publication Date
DE69911798D1 true DE69911798D1 (de) 2003-11-06
DE69911798T2 DE69911798T2 (de) 2004-07-01

Family

ID=26792298

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69911798T Expired - Lifetime DE69911798T2 (de) 1998-06-15 1999-06-10 Bicyclische piperidin- und piperazin-verbindungen mit 5-ht6-rezeptor-affinität

Country Status (11)

Country Link
US (1) US6251893B1 (de)
EP (1) EP1105393B1 (de)
JP (1) JP4505773B2 (de)
AT (1) ATE251163T1 (de)
AU (1) AU765256B2 (de)
CA (1) CA2335285C (de)
DE (1) DE69911798T2 (de)
DK (1) DK1105393T3 (de)
ES (1) ES2209525T3 (de)
MX (1) MXPA00012561A (de)
WO (1) WO1999065906A1 (de)

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SE0002754D0 (sv) * 2000-07-21 2000-07-21 Pharmacia & Upjohn Ab New pharmaceutical combination formulation and method of treatment with the combination
SE0003810D0 (sv) * 2000-10-20 2000-10-20 Pharmacia Ab Novel compounds their use and preparations
AU2001296193B2 (en) * 2000-10-20 2006-04-27 Biovitrum Ab 2-, 3-, 4-, or 5-substituted-N1-(benzensulfonyl)indoles and their use in therapy
US7034029B2 (en) * 2000-11-02 2006-04-25 Wyeth 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
CN1222511C (zh) * 2000-11-02 2005-10-12 惠氏公司 作为5－羟色胺－6配体的1－芳基－或1－烷基磺酰基－杂环基吲哚
HUP0400684A2 (hu) 2000-12-22 2004-07-28 Wyeth 5-Hidroxitriptamin-6-ligandumként használható heterociklilindazol- és -azaindazol-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények
DE60119982T2 (de) 2000-12-22 2006-12-21 Wyeth Heterozyklylalkylindole oder -azaindole als 5-hydroxytryptamine-6 liganden
US6713479B2 (en) * 2001-03-02 2004-03-30 Sepracor Inc. Piperidine-piperazine ligands for neurotransmitter receptors
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Also Published As

Publication number Publication date
DE69911798T2 (de) 2004-07-01
JP2003523922A (ja) 2003-08-12
WO1999065906A1 (en) 1999-12-23
AU4253199A (en) 2000-01-05
AU765256B2 (en) 2003-09-11
ATE251163T1 (de) 2003-10-15
EP1105393A1 (de) 2001-06-13
US6251893B1 (en) 2001-06-26
DK1105393T3 (da) 2004-02-09
JP4505773B2 (ja) 2010-07-21
CA2335285A1 (en) 1999-12-23
EP1105393B1 (de) 2003-10-01
CA2335285C (en) 2009-07-14
MXPA00012561A (es) 2002-04-24
ES2209525T3 (es) 2004-06-16

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