UA41311C2 - КОНДЕНСОВАНІ ІНДОЛЬНІ ПОХІДНІ ЯК АНТАГОНІСТИ 5НТ<sub>4</sub> РЕЦЕПТОРА, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ - Google Patents

КОНДЕНСОВАНІ ІНДОЛЬНІ ПОХІДНІ ЯК АНТАГОНІСТИ 5НТ<sub>4</sub> РЕЦЕПТОРА, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ

Info

Publication number
UA41311C2
UA41311C2 UA94095780A UA94095780A UA41311C2 UA 41311 C2 UA41311 C2 UA 41311C2 UA 94095780 A UA94095780 A UA 94095780A UA 94095780 A UA94095780 A UA 94095780A UA 41311 C2 UA41311 C2 UA 41311C2
Authority
UA
Ukraine
Prior art keywords
receptor
pharmaceutical composition
antagonists
indole derivatives
condensed indole
Prior art date
Application number
UA94095780A
Other languages
English (en)
Russian (ru)
Inventor
Леремі Мері Гастер
Лереми Мэри Гастер
Пол Адріан Уімен
Пол Адриан Уимен
Original Assignee
Смітклайн Бічем Плс
Смитклайн Бичем Плс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929205428A external-priority patent/GB9205428D0/en
Priority claimed from GB929218846A external-priority patent/GB9218846D0/en
Priority claimed from GB929227045A external-priority patent/GB9227045D0/en
Application filed by Смітклайн Бічем Плс, Смитклайн Бичем Плс filed Critical Смітклайн Бічем Плс
Publication of UA41311C2 publication Critical patent/UA41311C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Цей винахід належить до нових сполук, що мають фармакологічну активність, способу їх отримання і застосування як фармацевтичних препаратів. Запропонована фармацевтична композиція, що проявляє активність антагоніста 5-НТ4 рецептора, містить активний інгредієнт і допоміжні добавки. Як активний компонент містить ефективну кількість сполуки.
UA94095780A 1992-03-12 1993-03-10 КОНДЕНСОВАНІ ІНДОЛЬНІ ПОХІДНІ ЯК АНТАГОНІСТИ 5НТ<sub>4</sub> РЕЦЕПТОРА, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ UA41311C2 (uk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB929205428A GB9205428D0 (en) 1992-03-12 1992-03-12 Pharmaceuticals
GB929218846A GB9218846D0 (en) 1992-09-05 1992-09-05 Pharmaceuticals
GB929227045A GB9227045D0 (en) 1992-12-29 1992-12-29 Pharmaceuticals
PCT/GB1993/000506 WO1993018036A1 (en) 1992-03-12 1993-03-10 Condensed indole derivatives as 5ht4-receptor antagonists

Publications (1)

Publication Number Publication Date
UA41311C2 true UA41311C2 (uk) 2001-09-17

Family

ID=27266092

Family Applications (1)

Application Number Title Priority Date Filing Date
UA94095780A UA41311C2 (uk) 1992-03-12 1993-03-10 КОНДЕНСОВАНІ ІНДОЛЬНІ ПОХІДНІ ЯК АНТАГОНІСТИ 5НТ<sub>4</sub> РЕЦЕПТОРА, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ

Country Status (30)

Country Link
EP (2) EP0884319B1 (uk)
JP (1) JP2831467B2 (uk)
KR (1) KR100282730B1 (uk)
CN (2) CN1043893C (uk)
AP (1) AP401A (uk)
AT (2) ATE266033T1 (uk)
AU (1) AU671102B2 (uk)
CA (1) CA2131797C (uk)
CY (1) CY2510B1 (uk)
CZ (1) CZ286194B6 (uk)
DE (2) DE69325167T2 (uk)
DK (2) DK0884319T3 (uk)
ES (2) ES2132223T3 (uk)
FI (1) FI107158B (uk)
GR (1) GR3030668T3 (uk)
HK (1) HK1012352A1 (uk)
HU (1) HU219121B (uk)
IL (1) IL105003A (uk)
MA (1) MA22819A1 (uk)
MX (1) MX9301348A (uk)
MY (1) MY110110A (uk)
NO (1) NO303638B1 (uk)
NZ (1) NZ249565A (uk)
PT (1) PT884319E (uk)
RU (1) RU2104279C1 (uk)
SG (1) SG50693A1 (uk)
SI (1) SI9300114B (uk)
SK (1) SK281423B6 (uk)
UA (1) UA41311C2 (uk)
WO (1) WO1993018036A1 (uk)

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GB9316195D0 (en) * 1993-08-05 1993-09-22 Smithkline Beecham Plc Pharmaceuticals
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
US5726187A (en) * 1992-10-16 1998-03-10 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-HT4 receptor antagonists
EP0667867A1 (en) * 1992-11-05 1995-08-23 Smithkline Beecham Plc Piperidine derivatives as 5-ht4 receptor antagonists
FR2699921B1 (fr) * 1992-12-30 1995-02-10 Synthelabo Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.
GB9303340D0 (en) * 1993-02-19 1993-04-07 Smithkline Beecham Plc Pharmaceuticals
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) * 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
US6013666A (en) * 1996-07-02 2000-01-11 Sang Sup Jew Oxirane carboxylic acid derivative and its manufacturing method
AU717177B2 (en) * 1996-08-16 2000-03-16 Smithkline Beecham Plc Process for the preparation of N-((1-Nbutyl-4- piperidyl)methyl) -3,4-dihydro -2H-(1,3) oxazino(3,2-a) indole-10-carboxamide and salts and intermediates in the process
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AU782870C (en) * 2000-08-07 2007-03-15 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
MXPA03001210A (es) * 2000-08-07 2004-08-12 Smithkline Beecham Corp Uso de antagonista del receptor 5-ht4 en la fabricacion de un medicamento para la profilaxis o tratamiento de fibrilacion atrial.
AU2001276558B2 (en) * 2000-08-08 2005-11-24 Smithkline Beecham P.L.C. Pharmaceutical composition comprising condensed indole compound
NZ535261A (en) * 2000-08-08 2004-12-24 Smithkline Beecham P A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide
US20050075335A1 (en) * 2002-02-14 2005-04-07 Buxton Philip Christopher Pharmaceutical composition comprising n((1-n-butyl-4-piperidinyl)methyl)-3,4-dihydro-2h-(1,3)oxazino(3,2-a)indole-10-carboxamide or salt and process therefor comprising dry granulation
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Also Published As

Publication number Publication date
CN1085083A (zh) 1994-04-13
KR100282730B1 (ko) 2001-02-15
ATE266033T1 (de) 2004-05-15
DK0630376T3 (da) 1999-06-23
MA22819A1 (fr) 1993-10-01
CY2510B1 (en) 2005-12-23
EP0884319A3 (en) 1999-02-10
EP0630376A1 (en) 1994-12-28
FI944204A0 (fi) 1994-09-12
CA2131797C (en) 2010-05-18
NZ249565A (en) 1997-07-27
AU3644893A (en) 1993-10-05
DE69333504T2 (de) 2005-05-12
JPH07504433A (ja) 1995-05-18
MY110110A (en) 1998-01-27
MX9301348A (es) 1993-09-01
GR3030668T3 (en) 1999-10-29
RU2104279C1 (ru) 1998-02-10
CA2131797A1 (en) 1993-09-16
EP0884319B1 (en) 2004-05-06
FI107158B (fi) 2001-06-15
DK0884319T3 (da) 2004-08-30
IL105003A0 (en) 1993-07-08
NO303638B1 (no) 1998-08-10
HU219121B (hu) 2001-02-28
NO943348L (no) 1994-11-09
SG50693A1 (en) 1998-07-20
WO1993018036A1 (en) 1993-09-16
SI9300114A (sl) 1993-12-31
CN1078471A (zh) 1993-11-17
EP0630376B1 (en) 1999-06-02
HK1012352A1 (en) 1999-07-30
HUT71121A (en) 1995-11-28
DE69325167T2 (de) 2000-01-20
KR950700304A (ko) 1995-01-16
CN1043893C (zh) 1999-06-30
JP2831467B2 (ja) 1998-12-02
NO943348D0 (no) 1994-09-09
ES2132223T3 (es) 1999-08-16
AU671102B2 (en) 1996-08-15
AP9300494A0 (en) 1993-04-30
FI944204A (fi) 1994-09-12
PT884319E (pt) 2004-09-30
SI9300114B (sl) 2006-08-31
IL105003A (en) 1996-09-12
AP401A (en) 1995-08-29
EP0884319A2 (en) 1998-12-16
SK107894A3 (en) 1995-04-12
DE69333504D1 (de) 2004-06-09
DE69325167D1 (de) 1999-07-08
RU94040864A (ru) 1996-07-20
ES2219813T3 (es) 2004-12-01
SK281423B6 (sk) 2001-03-12
ATE180785T1 (de) 1999-06-15
HU9402601D0 (en) 1994-12-28
CZ286194B6 (cs) 2000-02-16
CZ221094A3 (en) 1995-09-13

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