SI9300114B - Antagonisti 5-HT4 receptorja - Google Patents

Antagonisti 5-HT4 receptorja Download PDF

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Publication number
SI9300114B
SI9300114B SI9300114A SI9300114A SI9300114B SI 9300114 B SI9300114 B SI 9300114B SI 9300114 A SI9300114 A SI 9300114A SI 9300114 A SI9300114 A SI 9300114A SI 9300114 B SI9300114 B SI 9300114B
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SI
Slovenia
Prior art keywords
pharmaceutically acceptable
oxazino
piperidyl
carboxamide
dihydro
Prior art date
Application number
SI9300114A
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English (en)
Other versions
SI9300114A (sl
Inventor
Laramie Mary Gaster
Paul Adrian Wyman
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929205428A external-priority patent/GB9205428D0/en
Priority claimed from GB929218846A external-priority patent/GB9218846D0/en
Priority claimed from GB929227045A external-priority patent/GB9227045D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of SI9300114A publication Critical patent/SI9300114A/sl
Publication of SI9300114B publication Critical patent/SI9300114B/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Spojine s formulo (I) in njihove farmacevtsko sprejemljive soli ter njihova uporaba kot farmacevtiki pri zdravljenju gastrointestinalnih, kardiovaskularnih motenj in CNS motenj .

Claims (8)

1 PATENTNI ZAHTEVKI 1. N-(l-nButil-4-piperidil)metil-3,4-dihidro-2H-[l,3]oksazino[3,2-a]indol-10-karboksamid ali njegova farmacevtsko sprejemljiva sol.
2. N-(l-nButil-4-piperidil)metil-3,4-dihidro-2H-[l,3]oksazino[3,2-a]indol-10-karboksamid.
3. Farmacevtsko sprejemljiva sol po zahtevku 1, ki je kislinska adicijska sol s klorovodikovo, bromovodikovo, borovo, fosforjevo ali žveplovo kislino ali s farmacevtsko sprejemljivo organsko kislino.
4. Farmacevtsko sprejemljiva sol po zahtevku 1, ki je kislinska adicijska sol s klorovodikovo, bromovodikovo, borovo, fosforjevo, žveplovo, ocetno, vinsko, maleinsko, citronsko, jantarno, benzojsko, askorbinsko, metansulfonsko, a-keto glutarjevo, α-glicerofosforjevo ali glukoza-1-fosforjevo kislino.
5. Hidrokloridna sol N-(l-nbutil-4-piperidil)metil-3,4-dihidro-2H-[l,3]oksazino[3,2-ajindol-10-karboksamida.
6. Farmacevtski sestavek, ki obsega N-(l-nbutil-4-piperidil)metil-3,4-dihidro-2H-[l,3]oksazino[3,2-a]indol-10-karboksamid ali njegovo farmacevtsko sprejemljivo sol po kateremkoli od zahtevkov 1 do 5 in farmacevtsko sprejemljiv nosilec.
7. N-( 1 -nButil-4-piperidil)metil-3,4-dihidro-2H-[ 1,3]oksazino[3,2-a]indol-10-karboksamid ali njegova farmacevtsko sprejemljiva sol po kateremkoli od zahtevkov 1 do 5 za uporabo kot učinkovita terapevtska substanca.
8. Uporaba N-( 1 -nbutil-4-piperidil)metil-3,4-dihidro-2H- [ 1,3]oksazino[3,2-a]indol-10-karboksamida za pripravo zdravila za uporabo kot antagonista 5-HT4 receptorja pri 2 zdravljenju ali profilaksi gastrointestinalnih motenj, kardiovaskularnih motenj in CNS motenj.
SI9300114A 1992-03-12 1993-03-10 Antagonisti 5-HT4 receptorja SI9300114B (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB929205428A GB9205428D0 (en) 1992-03-12 1992-03-12 Pharmaceuticals
GB929218846A GB9218846D0 (en) 1992-09-05 1992-09-05 Pharmaceuticals
GB929227045A GB9227045D0 (en) 1992-12-29 1992-12-29 Pharmaceuticals

Publications (2)

Publication Number Publication Date
SI9300114A SI9300114A (sl) 1993-12-31
SI9300114B true SI9300114B (sl) 2006-08-31

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ID=27266092

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9300114A SI9300114B (sl) 1992-03-12 1993-03-10 Antagonisti 5-HT4 receptorja

Country Status (30)

Country Link
EP (2) EP0630376B1 (sl)
JP (1) JP2831467B2 (sl)
KR (1) KR100282730B1 (sl)
CN (2) CN1043893C (sl)
AP (1) AP401A (sl)
AT (2) ATE180785T1 (sl)
AU (1) AU671102B2 (sl)
CA (1) CA2131797C (sl)
CY (1) CY2510B1 (sl)
CZ (1) CZ286194B6 (sl)
DE (2) DE69333504T2 (sl)
DK (2) DK0630376T3 (sl)
ES (2) ES2219813T3 (sl)
FI (1) FI107158B (sl)
GR (1) GR3030668T3 (sl)
HK (1) HK1012352A1 (sl)
HU (1) HU219121B (sl)
IL (1) IL105003A (sl)
MA (1) MA22819A1 (sl)
MX (1) MX9301348A (sl)
MY (1) MY110110A (sl)
NO (1) NO303638B1 (sl)
NZ (1) NZ249565A (sl)
PT (1) PT884319E (sl)
RU (1) RU2104279C1 (sl)
SG (1) SG50693A1 (sl)
SI (1) SI9300114B (sl)
SK (1) SK281423B6 (sl)
UA (1) UA41311C2 (sl)
WO (1) WO1993018036A1 (sl)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
US5998409A (en) * 1992-03-12 1999-12-07 Smithkline Beecham Plc Condensed indole derivatives as 5HT4 -receptor antagonists
GB9316195D0 (en) * 1993-08-05 1993-09-22 Smithkline Beecham Plc Pharmaceuticals
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
EP0664794A1 (en) * 1992-10-16 1995-08-02 Smithkline Beecham Plc N-alkylpiperidinyl-4-methyl carboxylic esters/amides of condensed ring systems as 5-ht4 receptor antagonists
NZ257545A (en) * 1992-11-05 1997-01-29 Smithkline Beecham Plc Heterocyclic (especially piperidine) derivatives and pharmaceutical compositions
FR2699921B1 (fr) * 1992-12-30 1995-02-10 Synthelabo Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.
GB9303340D0 (en) * 1993-02-19 1993-04-07 Smithkline Beecham Plc Pharmaceuticals
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) * 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
US6013666A (en) * 1996-07-02 2000-01-11 Sang Sup Jew Oxirane carboxylic acid derivative and its manufacturing method
SI0922048T1 (en) * 1996-08-16 2001-02-28 Smithkline Beecham Plc PROCESS FOR THE PREPARATION OF N- (1-n-BUTYL-4-PIPERIDINYL)METHYL) -3,4-DIHYDRO -2H-(1,3) OXAZINO(3,2-a) INDOLE-10-CARBOXAMIDE AND SALTS AND INTERMEDIATES IN THE PROCESS
US6100397A (en) * 1996-08-16 2000-08-08 Smithkline Beecham Plc Process for the preparation of N-[(1-n butyl-4-piperidyl)methyl]-3,4-dihydro-2H-[1,3]oxazino[3,2-a] indole-10-carboxamide and salts and intermediates in the process
GB9618967D0 (en) 1996-09-11 1996-10-23 Smithkline Beecham Plc Pharmaceuticals
GB9725933D0 (en) * 1997-12-05 1998-02-04 Smithkline Beecham Plc Pharmaceuticals
US6251893B1 (en) * 1998-06-15 2001-06-26 Nps Allelix Corp. Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity
US20020091271A1 (en) 1998-07-16 2002-07-11 Smithkline Beecham Plc Process for the preparation of an indole derivative
GB9819035D0 (en) * 1998-09-01 1998-10-28 Cerebrus Res Ltd Chemical compounds VII
TR200100698T2 (tr) * 1998-09-10 2001-07-23 F.Hoffmann-La Roche Ag 5-HT4 alıcı-Antagonistleri olarak Dihidrobenzodioksin Karboksamit ve Keton türevleri
GB9820294D0 (en) * 1998-09-17 1998-11-11 Smithkline Beecham Plc Pharmaceuticals
US6545004B1 (en) 1999-10-27 2003-04-08 Cytokinetics, Inc. Methods and compositions utilizing quinazolinones
AU782870C (en) * 2000-08-07 2007-03-15 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782863C (en) * 2000-08-07 2006-08-31 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU2005203196B9 (en) * 2000-08-07 2009-04-09 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
CN100413539C (zh) * 2000-08-07 2008-08-27 葛兰素史密斯克莱实验室公司 5-ht4受体拮抗剂在制备治疗电生理心房改型的药物中的应用
NZ535261A (en) * 2000-08-08 2004-12-24 Smithkline Beecham P A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide
WO2002011733A1 (en) * 2000-08-08 2002-02-14 Smithkline Beecham P.L.C. Pharmaceutical composition comprising condensed indole compound
US20050075335A1 (en) * 2002-02-14 2005-04-07 Buxton Philip Christopher Pharmaceutical composition comprising n((1-n-butyl-4-piperidinyl)methyl)-3,4-dihydro-2h-(1,3)oxazino(3,2-a)indole-10-carboxamide or salt and process therefor comprising dry granulation
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
ITMI20031467A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco attivo nel dolore neuropatico
ITMI20031468A1 (it) 2003-07-18 2005-01-19 Acraf Farmaco ativo nel dolore neuropatico
AU2004303722B2 (en) 2003-12-23 2010-02-18 Serodus As Modulators of peripheral 5-HT receptors
JP4612301B2 (ja) * 2003-12-26 2011-01-12 広栄化学工業株式会社 １−アルキル−４−アミノメチルピペリジンの製造法
CA2704282A1 (en) 2007-06-22 2008-12-31 Arqule, Inc. Quinazolinone compounds and methods of use thereof
GB0905641D0 (en) * 2009-04-01 2009-05-13 Serodus As Compounds
WO2021116487A1 (en) 2019-12-13 2021-06-17 Som Innovation Biotech, S.A. Compounds for use in the treatment of niemann-pick c disease

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2557342A1 (de) * 1975-12-19 1977-06-30 Hoechst Ag Basisch substituierte indolderivate und verfahren zu ihrer herstellung
AU622330B2 (en) * 1989-06-23 1992-04-02 Takeda Chemical Industries Ltd. Condensed heterocyclic compounds having a nitrogen atom in the bridgehead for use as fungicides
CA2030051C (en) * 1989-11-17 2001-08-07 Haruhiko Kikuchi Indole derivatives
US5189041A (en) * 1990-11-16 1993-02-23 Syntex (U.S.A.) Inc. Tricyclic 5-ht3 receptor antagonists
GB9103862D0 (en) * 1991-02-25 1991-04-10 Glaxo Group Ltd Chemical compounds
US5206382A (en) * 1991-06-27 1993-04-27 Fidia Georgetown Institute For The Neurosciences Indole derivatives, pharmaceutical compositions and methods of treating neurological and psychiatric disorders

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Publication number Publication date
RU94040864A (ru) 1996-07-20
AU3644893A (en) 1993-10-05
EP0884319A2 (en) 1998-12-16
HK1012352A1 (en) 1999-07-30
NZ249565A (en) 1997-07-27
FI944204A0 (fi) 1994-09-12
EP0630376A1 (en) 1994-12-28
CA2131797C (en) 2010-05-18
FI944204A (fi) 1994-09-12
SK281423B6 (sk) 2001-03-12
HU9402601D0 (en) 1994-12-28
CN1085083A (zh) 1994-04-13
CZ286194B6 (cs) 2000-02-16
MA22819A1 (fr) 1993-10-01
UA41311C2 (uk) 2001-09-17
SI9300114A (sl) 1993-12-31
ES2132223T3 (es) 1999-08-16
KR950700304A (ko) 1995-01-16
JP2831467B2 (ja) 1998-12-02
AP401A (en) 1995-08-29
ATE180785T1 (de) 1999-06-15
GR3030668T3 (en) 1999-10-29
DE69325167T2 (de) 2000-01-20
RU2104279C1 (ru) 1998-02-10
DE69325167D1 (de) 1999-07-08
CZ221094A3 (en) 1995-09-13
CY2510B1 (en) 2005-12-23
NO943348L (no) 1994-11-09
ES2219813T3 (es) 2004-12-01
KR100282730B1 (ko) 2001-02-15
IL105003A (en) 1996-09-12
CA2131797A1 (en) 1993-09-16
JPH07504433A (ja) 1995-05-18
AU671102B2 (en) 1996-08-15
PT884319E (pt) 2004-09-30
EP0630376B1 (en) 1999-06-02
MX9301348A (es) 1993-09-01
SG50693A1 (en) 1998-07-20
IL105003A0 (en) 1993-07-08
EP0884319B1 (en) 2004-05-06
WO1993018036A1 (en) 1993-09-16
DK0630376T3 (da) 1999-06-23
NO303638B1 (no) 1998-08-10
MY110110A (en) 1998-01-27
HU219121B (hu) 2001-02-28
DK0884319T3 (da) 2004-08-30
HUT71121A (en) 1995-11-28
DE69333504D1 (de) 2004-06-09
CN1043893C (zh) 1999-06-30
EP0884319A3 (en) 1999-02-10
ATE266033T1 (de) 2004-05-15
SK107894A3 (en) 1995-04-12
DE69333504T2 (de) 2005-05-12
AP9300494A0 (en) 1993-04-30
FI107158B (fi) 2001-06-15
CN1078471A (zh) 1993-11-17
NO943348D0 (no) 1994-09-09

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