RU94040864A - Конденсированные индольные производные, их получение, фармацевтическая композиция - Google Patents

Конденсированные индольные производные, их получение, фармацевтическая композиция

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Publication number
RU94040864A
RU94040864A RU94040864/04A RU94040864A RU94040864A RU 94040864 A RU94040864 A RU 94040864A RU 94040864/04 A RU94040864/04 A RU 94040864/04A RU 94040864 A RU94040864 A RU 94040864A RU 94040864 A RU94040864 A RU 94040864A
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RU
Russia
Prior art keywords
synthesis
pharmaceutical composition
indole derivatives
fused indole
fused
Prior art date
Application number
RU94040864/04A
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English (en)
Other versions
RU2104279C1 (ru
Inventor
Мэри Гастер Лэрами
Gb]
Адриан Вайман Пол
Original Assignee
Смитклайн Бичам ПЛС. (GB)
Смитклайн Бичам ПЛС.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB929205428A external-priority patent/GB9205428D0/en
Priority claimed from GB929218846A external-priority patent/GB9218846D0/en
Priority claimed from GB929227045A external-priority patent/GB9227045D0/en
Application filed by Смитклайн Бичам ПЛС. (GB), Смитклайн Бичам ПЛС. filed Critical Смитклайн Бичам ПЛС. (GB)
Publication of RU94040864A publication Critical patent/RU94040864A/ru
Application granted granted Critical
Publication of RU2104279C1 publication Critical patent/RU2104279C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A61K31/245—Amino benzoic acid types, e.g. procaine, novocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4453—Non condensed piperidines, e.g. piperocaine only substituted in position 1, e.g. propipocaine, diperodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/452—Piperidinium derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Emergency Medicine (AREA)
  • Neurosurgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Предложены соединения формулы I, указанной в описании, и фармацевтически приемлемые их соли, которые можно применять в качестве лекарств для лечения желудочно-кишечных, сердечно-сосудистых расстройств и расстройства центральной нервной системы.

Claims (1)

  1. Предложены соединения формулы I, указанной в описании, и фармацевтически приемлемые их соли, которые можно применять в качестве лекарств для лечения желудочно-кишечных, сердечно-сосудистых расстройств и расстройства центральной нервной системы.
RU94040864A 1992-03-12 1993-03-10 Конденсированное индольное производное или его фармацевтически приемлемая соль, фармацевтическая композиция, проявляющая активность антагониста 5-нт*004-рецептора RU2104279C1 (ru)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB929205428A GB9205428D0 (en) 1992-03-12 1992-03-12 Pharmaceuticals
GB9205428.7 1992-03-12
GB929218846A GB9218846D0 (en) 1992-09-05 1992-09-05 Pharmaceuticals
GB9218846.5 1992-09-05
GB929227045A GB9227045D0 (en) 1992-12-29 1992-12-29 Pharmaceuticals
GB9227045.3 1992-12-29
PCT/GB1993/000506 WO1993018036A1 (en) 1992-03-12 1993-03-10 Condensed indole derivatives as 5ht4-receptor antagonists

Publications (2)

Publication Number Publication Date
RU94040864A true RU94040864A (ru) 1996-07-20
RU2104279C1 RU2104279C1 (ru) 1998-02-10

Family

ID=27266092

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94040864A RU2104279C1 (ru) 1992-03-12 1993-03-10 Конденсированное индольное производное или его фармацевтически приемлемая соль, фармацевтическая композиция, проявляющая активность антагониста 5-нт*004-рецептора

Country Status (30)

Country Link
EP (2) EP0630376B1 (ru)
JP (1) JP2831467B2 (ru)
KR (1) KR100282730B1 (ru)
CN (2) CN1043893C (ru)
AP (1) AP401A (ru)
AT (2) ATE180785T1 (ru)
AU (1) AU671102B2 (ru)
CA (1) CA2131797C (ru)
CY (1) CY2510B1 (ru)
CZ (1) CZ286194B6 (ru)
DE (2) DE69325167T2 (ru)
DK (2) DK0884319T3 (ru)
ES (2) ES2219813T3 (ru)
FI (1) FI107158B (ru)
GR (1) GR3030668T3 (ru)
HK (1) HK1012352A1 (ru)
HU (1) HU219121B (ru)
IL (1) IL105003A (ru)
MA (1) MA22819A1 (ru)
MX (1) MX9301348A (ru)
MY (1) MY110110A (ru)
NO (1) NO303638B1 (ru)
NZ (1) NZ249565A (ru)
PT (1) PT884319E (ru)
RU (1) RU2104279C1 (ru)
SG (1) SG50693A1 (ru)
SI (1) SI9300114B (ru)
SK (1) SK281423B6 (ru)
UA (1) UA41311C2 (ru)
WO (1) WO1993018036A1 (ru)

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GB9316195D0 (en) * 1993-08-05 1993-09-22 Smithkline Beecham Plc Pharmaceuticals
US5852014A (en) * 1992-03-12 1998-12-22 Smithkline Beecham P.L.C. Condensed indole derivatives as 5HT4 -receptor antagonists
MX9305947A (es) * 1992-09-29 1994-06-30 Smithkline Beecham Plc Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen.
JPH08502283A (ja) * 1992-10-16 1996-03-12 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ▲下４▼レセプターアンタゴニスト用の縮合環系ｎ−アルキルピペリジニル−４−メチルカルボン酸エステル／アミド
WO1994010174A1 (en) * 1992-11-05 1994-05-11 Smithkline Beecham Plc Piperidine derivatives as 5-ht4 receptor antagonists
FR2699921B1 (fr) * 1992-12-30 1995-02-10 Synthelabo Dérivés d'acide 2-(thien-2-yl)imidazo[2,1-b]benzothiazole-3-acétique, leur préparation et leur application en thérapeutique.
GB9303340D0 (en) * 1993-02-19 1993-04-07 Smithkline Beecham Plc Pharmaceuticals
GB9310582D0 (en) * 1993-05-22 1993-07-07 Smithkline Beecham Plc Pharmaceuticals
GB9312348D0 (en) * 1993-06-16 1993-07-28 Smithkline Beecham Plc Pharmaceuticals
KR100219922B1 (ko) * 1996-05-16 1999-09-01 이서봉 신규한 항바이러스성 6-아릴옥시 및 6-아릴카르보닐 2,4-피리미딘디온 유도체 및 그의 제조 방법
KR980009260A (ko) * 1996-07-02 1998-04-30 주상섭 오시란카르복실산 유도체 및 그의 제조방법
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AU2005203196B9 (en) * 2000-08-07 2009-04-09 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
CN100413539C (zh) * 2000-08-07 2008-08-27 葛兰素史密斯克莱实验室公司 5-ht4受体拮抗剂在制备治疗电生理心房改型的药物中的应用
AU782863C (en) * 2000-08-07 2006-08-31 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
AU782870C (en) * 2000-08-07 2007-03-15 Glaxo Group Limited The use of 5HT4 receptor antagonists in the prophylaxis or treatment of certain cardiovascular conditions
NZ535261A (en) * 2000-08-08 2004-12-24 Smithkline Beecham P A tablet comprising the hydrochloride salt of N-(1-nbutyl-4-piperidinyl)methyl]-3,4-[1,3]oxazino[3,2-a] indole-10-carboxamide
ES2294012T3 (es) * 2000-08-08 2008-04-01 Smithkline Beecham Plc Composicion farmaceutica que comprende un compuesto de indol condensado.
BR0307666A (pt) * 2002-02-14 2005-01-11 Glaxo Group Ltd Composição farmacêutica compreendendo n-[(1-n-butil-4-piperidinil)metil]-3,4-diidro-2h[1-3]oxazi no(3,2-a) indol-10-carboxamida ou sal e processo para esta compreendendo granulação seca
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ITMI20031467A1 (it) * 2003-07-18 2005-01-19 Acraf Farmaco attivo nel dolore neuropatico
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JP4612301B2 (ja) * 2003-12-26 2011-01-12 広栄化学工業株式会社 １−アルキル−４−アミノメチルピペリジンの製造法
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Also Published As

Publication number Publication date
NZ249565A (en) 1997-07-27
NO943348D0 (no) 1994-09-09
DE69333504D1 (de) 2004-06-09
HU219121B (hu) 2001-02-28
EP0630376B1 (en) 1999-06-02
IL105003A (en) 1996-09-12
PT884319E (pt) 2004-09-30
AU671102B2 (en) 1996-08-15
NO303638B1 (no) 1998-08-10
CY2510B1 (en) 2005-12-23
IL105003A0 (en) 1993-07-08
AU3644893A (en) 1993-10-05
GR3030668T3 (en) 1999-10-29
SI9300114A (sl) 1993-12-31
UA41311C2 (ru) 2001-09-17
CA2131797A1 (en) 1993-09-16
FI107158B (fi) 2001-06-15
DE69325167T2 (de) 2000-01-20
SK107894A3 (en) 1995-04-12
MX9301348A (es) 1993-09-01
EP0630376A1 (en) 1994-12-28
KR100282730B1 (ko) 2001-02-15
JP2831467B2 (ja) 1998-12-02
DE69333504T2 (de) 2005-05-12
AP401A (en) 1995-08-29
RU2104279C1 (ru) 1998-02-10
EP0884319A3 (en) 1999-02-10
CN1043893C (zh) 1999-06-30
EP0884319B1 (en) 2004-05-06
JPH07504433A (ja) 1995-05-18
ES2219813T3 (es) 2004-12-01
ES2132223T3 (es) 1999-08-16
WO1993018036A1 (en) 1993-09-16
HUT71121A (en) 1995-11-28
KR950700304A (ko) 1995-01-16
FI944204A (fi) 1994-09-12
DK0884319T3 (da) 2004-08-30
CN1078471A (zh) 1993-11-17
MA22819A1 (fr) 1993-10-01
HU9402601D0 (en) 1994-12-28
SK281423B6 (sk) 2001-03-12
DK0630376T3 (da) 1999-06-23
CN1085083A (zh) 1994-04-13
ATE180785T1 (de) 1999-06-15
NO943348L (no) 1994-11-09
FI944204A0 (fi) 1994-09-12
CZ221094A3 (en) 1995-09-13
AP9300494A0 (en) 1993-04-30
SI9300114B (sl) 2006-08-31
CZ286194B6 (cs) 2000-02-16
EP0884319A2 (en) 1998-12-16
DE69325167D1 (de) 1999-07-08
HK1012352A1 (en) 1999-07-30
SG50693A1 (en) 1998-07-20
CA2131797C (en) 2010-05-18
MY110110A (en) 1998-01-27
ATE266033T1 (de) 2004-05-15

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