RU94015838A - Производные бензофуранил- или бензотиофенилалкан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли - Google Patents

Производные бензофуранил- или бензотиофенилалкан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли

Info

Publication number
RU94015838A
RU94015838A RU94015838/04A RU94015838A RU94015838A RU 94015838 A RU94015838 A RU 94015838A RU 94015838/04 A RU94015838/04 A RU 94015838/04A RU 94015838 A RU94015838 A RU 94015838A RU 94015838 A RU94015838 A RU 94015838A
Authority
RU
Russia
Prior art keywords
isomers
benzofuranyl
derivatives
salts
mixture
Prior art date
Application number
RU94015838/04A
Other languages
English (en)
Other versions
RU2125564C1 (ru
Inventor
Фишер Рюдигер
De]
Бройнлих Габриеле
Морс Клаус-Хельмут
Ханко Рудольф
Батлер-Рэнсохофф Джон-Эдвард
Эс-Зайед Мэзен
Стертон Грахем
Тадхоуп Стив
Эбрем Тревор
Do]
Мэк Дональд-Гибсон Уэнди
Gb]
Original Assignee
Байер АГ (DE)
Байер Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Байер АГ (DE), Байер Аг filed Critical Байер АГ (DE)
Publication of RU94015838A publication Critical patent/RU94015838A/ru
Application granted granted Critical
Publication of RU2125564C1 publication Critical patent/RU2125564C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/80—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Объектом изобретения являются производные бензофуранил- или бензотиофенил алкан-карбоновой кислоты общей формулы 1, приведенной в описании, смесь их изомеров или отдельные изомеры и их соли, которые можно применять в качестве лекарственных препаратов для лечения острых и хронических воспалительных процессов.

Claims (1)

  1. Объектом изобретения являются производные бензофуранил- или бензотиофенил алкан-карбоновой кислоты общей формулы 1, приведенной в описании, смесь их изомеров или отдельные изомеры и их соли, которые можно применять в качестве лекарственных препаратов для лечения острых и хронических воспалительных процессов.
RU94015838A 1993-05-06 1994-05-05 Производные бензофуранилалкан-карбоновой кислоты, или смесь их изомеров, или отдельные изомеры, или их соли RU2125564C1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB9309324.3 1993-05-06
GB939309324A GB9309324D0 (en) 1993-05-06 1993-05-06 Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives

Publications (2)

Publication Number Publication Date
RU94015838A true RU94015838A (ru) 1997-02-20
RU2125564C1 RU2125564C1 (ru) 1999-01-27

Family

ID=10735023

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94015838A RU2125564C1 (ru) 1993-05-06 1994-05-05 Производные бензофуранилалкан-карбоновой кислоты, или смесь их изомеров, или отдельные изомеры, или их соли

Country Status (21)

Country Link
US (1) US5504213A (ru)
EP (1) EP0623607B1 (ru)
JP (1) JP3452088B2 (ru)
CN (1) CN1097749A (ru)
AT (1) ATE168373T1 (ru)
AU (1) AU678814B2 (ru)
CA (1) CA2122788A1 (ru)
CZ (1) CZ112994A3 (ru)
DE (1) DE69411625T2 (ru)
DK (1) DK0623607T3 (ru)
ES (1) ES2118283T3 (ru)
FI (1) FI942049A (ru)
GB (1) GB9309324D0 (ru)
GR (1) GR3027787T3 (ru)
HU (1) HUT67847A (ru)
IL (1) IL109526A0 (ru)
NO (1) NO941662L (ru)
NZ (1) NZ260445A (ru)
RU (1) RU2125564C1 (ru)
SK (1) SK53194A3 (ru)
ZA (1) ZA943100B (ru)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5721233A (en) * 1992-04-06 1998-02-24 Merrell Pharmaceuticals Inc. Derivatives of 2,3-dihydro benzofuranols
GB9312853D0 (en) 1993-06-22 1993-08-04 Euro Celtique Sa Chemical compounds
GB9410877D0 (en) * 1994-05-31 1994-07-20 Bayer Ag Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives
HRP950288A2 (en) * 1994-05-31 1997-08-31 Bayer Ag Oxalylamino-benzofuran- and benzothienyl-derivatives
ATE175667T1 (de) * 1994-05-31 1999-01-15 Bayer Ag Aminobenzofuryl- und -thienylderivate
US5591776A (en) 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
US5922751A (en) 1994-06-24 1999-07-13 Euro-Celtique, S.A. Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same
EP0751126A4 (en) * 1995-01-06 1998-05-13 Toray Industries BENZOCONDENSE HETEROCYCLIC DERIVATIVE AND ITS USE
GB9504460D0 (en) * 1995-03-06 1995-04-26 Bayer Ag N-(3-Benzofuranyl)urea-derivatives
US6166041A (en) 1995-10-11 2000-12-26 Euro-Celtique, S.A. 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma
US6075016A (en) 1996-04-10 2000-06-13 Euro-Celtique S.A. 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity
CZ371998A3 (cs) * 1996-05-20 1999-03-17 Darwin Discovery Limited Benzofuranové karboxamidy a jejich terapeutické použití
GB9614718D0 (en) 1996-07-12 1996-09-04 Bayer Ag 3-ureido-pyridofurans and -pyridothiophenes
DE19642451A1 (de) * 1996-10-15 1998-04-16 Merck Patent Gmbh Aminothiophencarbonsäureamide
DE19706396A1 (de) * 1996-12-09 1998-06-10 Bayer Ag Verfahren zur Herstellung von 3-(l-Hydroxiphenyl-l-alkoximinomethyl)dioxazinen
GB2350111A (en) * 1999-05-17 2000-11-22 Bayer Ag Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives
GB2350109A (en) 1999-05-17 2000-11-22 Bayer Ag Pharmaceutically active benzofuranyl sulfonates
KR100701904B1 (ko) 1999-08-21 2007-04-02 알타나 파마 아게 Ｐｄｅ 억제제 및 베타 2 아드레날린수용체 작동제의상승적 조합
KR100854424B1 (ko) 2001-01-29 2008-08-27 3-디멘져널 파마슈티칼즈 인코오포레이티드 치환된 인돌 및 인테그린 길항제로서의 이들의 용도
US6872730B2 (en) 2001-04-27 2005-03-29 3-Dimensional Pharmaceuticals, Inc. Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists
CA2447618A1 (en) 2001-05-23 2002-11-28 Tanabe Seiyaku Co., Ltd. A composition for regenerative treatment of cartilage disease
CN1520313A (zh) 2001-05-23 2004-08-11 ������ҩ��ʽ���� 一种加速骨折愈合的组合物
US7144885B2 (en) 2002-02-22 2006-12-05 Bayer Pharmaceuticals Corporation Fused tricyclic heterocycles useful for treating hyper-proliferative disorders
US7351735B2 (en) * 2002-02-22 2008-04-01 Bayer Pharmaceuticals Corporation Benzofuran and benzothiophene derivatives useful in the treatment of hyper-proliferative disorders
US7772188B2 (en) 2003-01-28 2010-08-10 Ironwood Pharmaceuticals, Inc. Methods and compositions for the treatment of gastrointestinal disorders
KR20050115331A (ko) 2003-04-01 2005-12-07 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. 불임증 포스포디에스터라제의 억제제
EP1627873A4 (en) * 2003-05-29 2007-12-05 New Ind Res Organization BENZOFURAN-BASED COMPOUND AND MEDICINAL COMPOSITION CONTAINING THE SAME
JP2005008631A (ja) * 2003-05-29 2005-01-13 New Industry Research Organization ベンゾフラン化合物、およびそれを含有してなる医薬組成物
US7576122B2 (en) * 2003-09-02 2009-08-18 Merck & Co. Inc. Ophthalmic compositions for treating ocular hypertension
AR051780A1 (es) * 2004-11-29 2007-02-07 Japan Tobacco Inc Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos
ME00535B (me) * 2006-06-27 2011-10-10 Takeda Pharmaceuticals Co Fuzionisana ciklična jedinjenja
WO2008025509A1 (en) * 2006-09-01 2008-03-06 Bayer Schering Pharma Aktiengesellschaft Benzofuran and benzothiophene derivatives useful in the treatment of cancers of the central nervous system
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
AU2008261102B2 (en) 2007-06-04 2013-11-28 Bausch Health Ireland Limited Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
CA2930674A1 (en) 2008-06-04 2009-12-10 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
JP2011528375A (ja) 2008-07-16 2011-11-17 シナジー ファーマシューティカルズ インコーポレイテッド 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
CN108676076A (zh) 2011-03-01 2018-10-19 辛纳吉制药公司 制备鸟苷酸环化酶c激动剂的方法
EP3718557A3 (en) 2013-02-25 2020-10-21 Bausch Health Ireland Limited Guanylate cyclase receptor agonist sp-333 for use in colonic cleansing
JP2016514670A (ja) 2013-03-15 2016-05-23 シナジー ファーマシューティカルズ インコーポレイテッド 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト
CA2905438A1 (en) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
JP6606491B2 (ja) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法
NZ717739A (en) 2013-08-09 2023-12-22 Ardelyx Inc Compounds and methods for inhibiting phosphate transport
WO2015029062A1 (en) 2013-08-25 2015-03-05 Council Of Scientific And Industrial Rsearch A process for the preparation of anti-inflammatory aroylbenzofuran compounds
JP6449915B2 (ja) * 2014-02-25 2019-01-09 エコラボ ユーエスエー インコーポレイティド 衛生洗剤
CN105254611B (zh) * 2015-11-09 2017-10-31 江西仁明医药化工有限公司 苯并噻吩‑2‑羧酸的制备方法
CN107935972B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 5-[2-羟基-3-(异丙胺基)丙氧基]苯并呋喃类衍生物及其应用
CN107857748B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 5-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用
CN107827849B (zh) * 2017-11-14 2020-06-02 沈阳药科大学 6-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用
US20200368223A1 (en) 2019-05-21 2020-11-26 Ardelyx, Inc. Methods for inhibiting phosphate transport
CN110938035B (zh) * 2019-10-28 2022-07-01 广西师范大学 9-苯磺酸-10-咪蒽腙及其合成方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0019955A1 (en) * 1979-05-16 1980-12-10 Shell Internationale Researchmaatschappij B.V. Benzofurancarboxylic acid derivatives, their preparation and their inclusion in lipogenesis inhibiting compositions
EP0146243A1 (en) * 1983-10-31 1985-06-26 Merck Frosst Canada Inc. Lipoxygenase inhibitors
US4663347A (en) * 1983-10-31 1987-05-05 Merck Frosst Canada, Inc. Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis
US4482772A (en) * 1983-11-03 1984-11-13 Mobil Oil Corporation Multistage process for converting oxygenates to hydrocarbons

Also Published As

Publication number Publication date
ATE168373T1 (de) 1998-08-15
CN1097749A (zh) 1995-01-25
JP3452088B2 (ja) 2003-09-29
DE69411625T2 (de) 1998-11-05
ES2118283T3 (es) 1998-09-16
JPH06329652A (ja) 1994-11-29
CZ112994A3 (en) 1994-11-16
HU9401415D0 (en) 1994-08-29
DE69411625D1 (de) 1998-08-20
NO941662L (no) 1994-11-07
FI942049A0 (fi) 1994-05-04
NO941662D0 (no) 1994-05-05
EP0623607A1 (en) 1994-11-09
EP0623607B1 (en) 1998-07-15
IL109526A0 (en) 1994-08-26
AU6055894A (en) 1994-11-10
GR3027787T3 (en) 1998-11-30
DK0623607T3 (da) 1999-04-19
FI942049A (fi) 1994-11-07
HUT67847A (en) 1995-05-29
ZA943100B (en) 1995-01-09
GB9309324D0 (en) 1993-06-16
RU2125564C1 (ru) 1999-01-27
NZ260445A (en) 1995-08-28
CA2122788A1 (en) 1994-11-07
US5504213A (en) 1996-04-02
SK53194A3 (en) 1995-02-08
AU678814B2 (en) 1997-06-12

Similar Documents

Publication Publication Date Title
RU94015838A (ru) Производные бензофуранил- или бензотиофенилалкан-карбоновой кислоты, смесь их изомеров или отдельные изомеры и их соли
RU94040864A (ru) Конденсированные индольные производные, их получение, фармацевтическая композиция
RU94046306A (ru) Производные индолокарбазолимида, смесь их изомеров или отдельные изомеры и их соли и фармацевтическая композиция с активностью, ингибирующей протеинкиназу с или киназу легкой миозиновой цепи или подавляющей иммунные реакции
RU94029662A (ru) Фосфонооксиметиловые эфиры производных таксана, фармацевтическая композиция, способы лечения
RU94040170A (ru) Изохинолины
IT8848441A0 (it) Derivato di 4h-benzopiran-4-one o suo sale, procedimento per produrlo e composizione farmaceutica che lo contiene come ingrediente attivo
RU94045141A (ru) Гетероциклические производные карбоновой кислоты и их соли и фармацевтическая композиция с антифибротической или тормозящей пролилгидроксилазу или биосинтез коллагена активностью
EA200100524A1 (ru) Амиды антраниловой кислоты и их применение в качестве лекарственных средств
RU95104885A (ru) 1h-индол-3-глиоксиламиды, ингибирующие spla2-медируемое выделение жирных кислот, фармацевтическая композиция
MX9604378A (es) Amidas de acido quinolin-2-carboxilico sustituidas, su preparacion y su empleo como medicamentos, asi como productos intermedios.
NO963499L (no) Hydroksaminsyre- og karboksylsyrederivater, fremgangsmåte for deres fremstilling og anvendelse derav
RU94041836A (ru) Производные амидина, смесь их изомеров или отдельные изомеры и их соли, фармацевтическая композиция с антагонистической в отношении лейкотриена в*004 активностью
RU94041950A (ru) Использование соединений ряда 3-аролоксипропиламинов в лечении недержания
RU94046149A (ru) Новые n-арил и n-гетероарил производные мочевины как ингибиторы ацил кофермента а:холестерин ацил трансферазы (асат) фармацевтическая композиция, способ ингибирования (асат)
NO302366B1 (no) 4-merkaptoacetylamino-£2|benzazepinon(3)-derivater, og farmasöytisk preparat
ES2065701T3 (es) Furoato de mometasona monohidrato, procedimiento para fabricar el mismo y composiciones farmaceuticas.
BR9507073A (pt) Composto processos para preparar o mesmo e para tratar uma doença no sistema nervoso central composiçao farmacêutica e uso do composto
ATE171935T1 (de) 2-amino-4-phenyl-4-oxo-buttersäure-derivate mit kynureninase und/oder kynurenin-3-hydroxylase inhibierender wirkung
RU93045145A (ru) Замещенные производные циклогексана и их применение для лечения заболеваний, содержащее их лекарственное средство
BE895991A (fr) Nouvelles modifications cristallines, procede pour leur production, et preparations pharmaceutiques les contenant
RU94040886A (ru) Применение производных мелатонина для лечения нарушений сна, фармацевтическая композиция
ATE225171T1 (de) Aminosäurederivate zur behandlung von schlaganfall
ES2188908T3 (es) Derivados de cis-3,4-cromano utiles para la prevencion o tratamiento de sindromes relacionados con el estrogenos.
AR002191A1 (es) Composicion farmaceutica oral de compuestos de piperidinoalcanol en forma de solucion, procedimiento para su preparacion
ITMI922742A0 (it) Composti ad attivita' terapeutica utili per il trattamento di malattieconnesse ad una carenza di glutatione, procedimento per la loro preparazione e composizioni farmaceutiche che li contengono.