DE69411625T2 - Benzofuranyl- und Thiophenylalkancarbonsäurederivate - Google Patents
Benzofuranyl- und ThiophenylalkancarbonsäurederivateInfo
- Publication number
- DE69411625T2 DE69411625T2 DE69411625T DE69411625T DE69411625T2 DE 69411625 T2 DE69411625 T2 DE 69411625T2 DE 69411625 T DE69411625 T DE 69411625T DE 69411625 T DE69411625 T DE 69411625T DE 69411625 T2 DE69411625 T2 DE 69411625T2
- Authority
- DE
- Germany
- Prior art keywords
- benzofuranyl
- carboxylic acid
- acid derivatives
- thiophenylalkane
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB939309324A GB9309324D0 (en) | 1993-05-06 | 1993-05-06 | Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69411625D1 DE69411625D1 (de) | 1998-08-20 |
DE69411625T2 true DE69411625T2 (de) | 1998-11-05 |
Family
ID=10735023
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69411625T Expired - Fee Related DE69411625T2 (de) | 1993-05-06 | 1994-04-22 | Benzofuranyl- und Thiophenylalkancarbonsäurederivate |
Country Status (21)
Country | Link |
---|---|
US (1) | US5504213A (de) |
EP (1) | EP0623607B1 (de) |
JP (1) | JP3452088B2 (de) |
CN (1) | CN1097749A (de) |
AT (1) | ATE168373T1 (de) |
AU (1) | AU678814B2 (de) |
CA (1) | CA2122788A1 (de) |
CZ (1) | CZ112994A3 (de) |
DE (1) | DE69411625T2 (de) |
DK (1) | DK0623607T3 (de) |
ES (1) | ES2118283T3 (de) |
FI (1) | FI942049A (de) |
GB (1) | GB9309324D0 (de) |
GR (1) | GR3027787T3 (de) |
HU (1) | HUT67847A (de) |
IL (1) | IL109526A0 (de) |
NO (1) | NO941662L (de) |
NZ (1) | NZ260445A (de) |
RU (1) | RU2125564C1 (de) |
SK (1) | SK53194A3 (de) |
ZA (1) | ZA943100B (de) |
Families Citing this family (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5721233A (en) * | 1992-04-06 | 1998-02-24 | Merrell Pharmaceuticals Inc. | Derivatives of 2,3-dihydro benzofuranols |
GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
GB9410877D0 (en) * | 1994-05-31 | 1994-07-20 | Bayer Ag | Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives |
EP0685475B1 (de) * | 1994-05-31 | 1999-01-13 | Bayer Ag | Aminobenzofuryl- und -thienylderivate |
HRP950288A2 (en) * | 1994-05-31 | 1997-08-31 | Bayer Ag | Oxalylamino-benzofuran- and benzothienyl-derivatives |
US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
US6043264A (en) * | 1995-01-06 | 2000-03-28 | Toray Industries, Inc. | Benzene-condensed heterocyclic derivatives and their uses |
GB9504460D0 (en) * | 1995-03-06 | 1995-04-26 | Bayer Ag | N-(3-Benzofuranyl)urea-derivatives |
US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
SK282676B6 (sk) * | 1996-05-20 | 2002-11-06 | Darwin Discovery Limited | Benzofuránové karboxamidy a tioamidy, farmaceutický prípravok s ich obsahom a ich použitie |
GB9614718D0 (en) * | 1996-07-12 | 1996-09-04 | Bayer Ag | 3-ureido-pyridofurans and -pyridothiophenes |
DE19642451A1 (de) * | 1996-10-15 | 1998-04-16 | Merck Patent Gmbh | Aminothiophencarbonsäureamide |
DE19706396A1 (de) * | 1996-12-09 | 1998-06-10 | Bayer Ag | Verfahren zur Herstellung von 3-(l-Hydroxiphenyl-l-alkoximinomethyl)dioxazinen |
GB2350109A (en) | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofuranyl sulfonates |
GB2350111A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives |
IL147688A0 (en) | 1999-08-21 | 2002-08-14 | Byk Gulden Lomberg Chem Fab | Synergistic combination |
NZ539682A (en) | 2001-01-29 | 2006-03-31 | Dimensional Pharm Inc | Substituted indoles and their use as integrin antagonists |
US6872730B2 (en) * | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
KR20040007596A (ko) | 2001-05-23 | 2004-01-24 | 다나베 세이야꾸 가부시키가이샤 | 골절 치료 촉진용 조성물 |
JP4510383B2 (ja) | 2001-05-23 | 2010-07-21 | 田辺三菱製薬株式会社 | 軟骨疾患修復治療用組成物 |
EP1478639A1 (de) * | 2002-02-22 | 2004-11-24 | Bayer Pharmaceuticals Corporation | Kondensierte trizyklische heterozyklen zur behandlung von proliferativen erkrankungen |
US7144885B2 (en) | 2002-02-22 | 2006-12-05 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
KR20050115331A (ko) | 2003-04-01 | 2005-12-07 | 어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이. | 불임증 포스포디에스터라제의 억제제 |
JP2005008631A (ja) * | 2003-05-29 | 2005-01-13 | New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
WO2004106317A1 (ja) * | 2003-05-29 | 2004-12-09 | The New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
CA2537119A1 (en) * | 2003-09-02 | 2005-03-10 | Merck & Co., Inc. | Ophthalmic compositions for treating ocular hypertension |
AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
AR061644A1 (es) | 2006-06-27 | 2008-09-10 | Takeda Pharmaceutical | Derivados de benzofurano |
CA2666469A1 (en) * | 2006-09-01 | 2008-03-06 | Bayer Healthcare Ag | Benzofuran and benzothiophene derivatives useful in the treatment of cancers of the central nervous system |
WO2008151257A2 (en) | 2007-06-04 | 2008-12-11 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
AU2009256157B2 (en) | 2008-06-04 | 2014-12-18 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
EP2321341B1 (de) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
EA201391254A1 (ru) | 2011-03-01 | 2014-02-28 | Синерджи Фармасьютикалз Инк. | Способ получения агонистов гуанилатциклазы c |
CA2902348C (en) | 2013-02-25 | 2021-11-30 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
WO2014151206A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
AU2014235209B2 (en) | 2013-03-15 | 2018-06-14 | Bausch Health Ireland Limited | Guanylate cyclase receptor agonists combined with other drugs |
WO2014197720A2 (en) | 2013-06-05 | 2014-12-11 | Synergy Pharmaceuticals, Inc. | Ultra-pure agonists of guanylate cyclase c, method of making and using same |
US20160184387A1 (en) | 2013-08-09 | 2016-06-30 | Dominique Charmot | Compounds and methods for inhibiting phosphate transport |
US9890132B2 (en) | 2013-08-25 | 2018-02-13 | Council Of Scientific & Industrial Research | Process for the preparation of anti-inflammatory aroylbenzofuran compounds |
BR112016019549B1 (pt) * | 2014-02-25 | 2022-08-02 | Ecolab Usa Inc | Composição e solução de limpeza sanitária aquosa, método para limpar uma superfície sanitária, e, uso de uma composição de limpeza sanitária ou uma solução de limpeza sanitária aquosa |
CN105254611B (zh) * | 2015-11-09 | 2017-10-31 | 江西仁明医药化工有限公司 | 苯并噻吩‑2‑羧酸的制备方法 |
CN107935972B (zh) * | 2017-11-14 | 2020-06-02 | 沈阳药科大学 | 5-[2-羟基-3-(异丙胺基)丙氧基]苯并呋喃类衍生物及其应用 |
CN107857748B (zh) * | 2017-11-14 | 2020-06-02 | 沈阳药科大学 | 5-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用 |
CN107827849B (zh) * | 2017-11-14 | 2020-06-02 | 沈阳药科大学 | 6-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用 |
CN114340631A (zh) | 2019-05-21 | 2022-04-12 | 阿德利克斯股份有限公司 | 用于降低患者的血清磷酸盐的组合 |
CN110938035B (zh) * | 2019-10-28 | 2022-07-01 | 广西师范大学 | 9-苯磺酸-10-咪蒽腙及其合成方法和应用 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0019955A1 (de) * | 1979-05-16 | 1980-12-10 | Shell Internationale Researchmaatschappij B.V. | Benzofurancarbonsäure-Derivate, ihre Herstellung und ihre Verwendung in Lipogenese inhibierenden Zusammensetzungen |
US4663347A (en) * | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
EP0146243A1 (de) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase-Inhibitoren |
US4482772A (en) * | 1983-11-03 | 1984-11-13 | Mobil Oil Corporation | Multistage process for converting oxygenates to hydrocarbons |
-
1993
- 1993-05-06 GB GB939309324A patent/GB9309324D0/en active Pending
-
1994
- 1994-04-19 AU AU60558/94A patent/AU678814B2/en not_active Ceased
- 1994-04-22 DK DK94106320T patent/DK0623607T3/da active
- 1994-04-22 AT AT94106320T patent/ATE168373T1/de active
- 1994-04-22 ES ES94106320T patent/ES2118283T3/es not_active Expired - Lifetime
- 1994-04-22 DE DE69411625T patent/DE69411625T2/de not_active Expired - Fee Related
- 1994-04-22 EP EP94106320A patent/EP0623607B1/de not_active Expired - Lifetime
- 1994-04-29 US US08/236,796 patent/US5504213A/en not_active Expired - Fee Related
- 1994-05-02 JP JP11592394A patent/JP3452088B2/ja not_active Expired - Fee Related
- 1994-05-03 NZ NZ260445A patent/NZ260445A/en unknown
- 1994-05-03 CA CA002122788A patent/CA2122788A1/en not_active Abandoned
- 1994-05-03 IL IL10952694A patent/IL109526A0/xx unknown
- 1994-05-04 FI FI942049A patent/FI942049A/fi unknown
- 1994-05-05 ZA ZA943100A patent/ZA943100B/xx unknown
- 1994-05-05 RU RU94015838A patent/RU2125564C1/ru active
- 1994-05-05 NO NO941662A patent/NO941662L/no unknown
- 1994-05-06 CZ CZ941129A patent/CZ112994A3/cs unknown
- 1994-05-06 CN CN94104909A patent/CN1097749A/zh active Pending
- 1994-05-06 SK SK531-94A patent/SK53194A3/sk unknown
- 1994-05-06 HU HU9401415A patent/HUT67847A/hu unknown
-
1998
- 1998-08-31 GR GR980401965T patent/GR3027787T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CN1097749A (zh) | 1995-01-25 |
US5504213A (en) | 1996-04-02 |
DE69411625D1 (de) | 1998-08-20 |
HUT67847A (en) | 1995-05-29 |
DK0623607T3 (da) | 1999-04-19 |
EP0623607A1 (de) | 1994-11-09 |
FI942049A0 (fi) | 1994-05-04 |
AU6055894A (en) | 1994-11-10 |
RU2125564C1 (ru) | 1999-01-27 |
JPH06329652A (ja) | 1994-11-29 |
HU9401415D0 (en) | 1994-08-29 |
AU678814B2 (en) | 1997-06-12 |
ATE168373T1 (de) | 1998-08-15 |
RU94015838A (ru) | 1997-02-20 |
EP0623607B1 (de) | 1998-07-15 |
FI942049A (fi) | 1994-11-07 |
ES2118283T3 (es) | 1998-09-16 |
IL109526A0 (en) | 1994-08-26 |
ZA943100B (en) | 1995-01-09 |
CA2122788A1 (en) | 1994-11-07 |
NZ260445A (en) | 1995-08-28 |
NO941662D0 (no) | 1994-05-05 |
SK53194A3 (en) | 1995-02-08 |
GB9309324D0 (en) | 1993-06-16 |
GR3027787T3 (en) | 1998-11-30 |
CZ112994A3 (en) | 1994-11-16 |
NO941662L (no) | 1994-11-07 |
JP3452088B2 (ja) | 2003-09-29 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: BAYER HEALTHCARE AG, 51373 LEVERKUSEN, DE |
|
8339 | Ceased/non-payment of the annual fee |