ATE168373T1 - Benzofuranyl- und thiophenylalkancarbonsäurederivate - Google Patents
Benzofuranyl- und thiophenylalkancarbonsäurederivateInfo
- Publication number
- ATE168373T1 ATE168373T1 AT94106320T AT94106320T ATE168373T1 AT E168373 T1 ATE168373 T1 AT E168373T1 AT 94106320 T AT94106320 T AT 94106320T AT 94106320 T AT94106320 T AT 94106320T AT E168373 T1 ATE168373 T1 AT E168373T1
- Authority
- AT
- Austria
- Prior art keywords
- benzofuranyl
- acid derivatives
- thiophenylalkanecarbonic
- compounds
- cyclisation
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB939309324A GB9309324D0 (en) | 1993-05-06 | 1993-05-06 | Venzofuranyl-and-thiophenyl-alkanecarboxyclic acids derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE168373T1 true ATE168373T1 (de) | 1998-08-15 |
Family
ID=10735023
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT94106320T ATE168373T1 (de) | 1993-05-06 | 1994-04-22 | Benzofuranyl- und thiophenylalkancarbonsäurederivate |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US5504213A (de) |
| EP (1) | EP0623607B1 (de) |
| JP (1) | JP3452088B2 (de) |
| CN (1) | CN1097749A (de) |
| AT (1) | ATE168373T1 (de) |
| AU (1) | AU678814B2 (de) |
| CA (1) | CA2122788A1 (de) |
| CZ (1) | CZ112994A3 (de) |
| DE (1) | DE69411625T2 (de) |
| DK (1) | DK0623607T3 (de) |
| ES (1) | ES2118283T3 (de) |
| FI (1) | FI942049L (de) |
| GB (1) | GB9309324D0 (de) |
| GR (1) | GR3027787T3 (de) |
| HU (1) | HUT67847A (de) |
| IL (1) | IL109526A0 (de) |
| NO (1) | NO941662L (de) |
| NZ (1) | NZ260445A (de) |
| RU (1) | RU2125564C1 (de) |
| SK (1) | SK53194A3 (de) |
| ZA (1) | ZA943100B (de) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5721233A (en) * | 1992-04-06 | 1998-02-24 | Merrell Pharmaceuticals Inc. | Derivatives of 2,3-dihydro benzofuranols |
| GB9312853D0 (en) | 1993-06-22 | 1993-08-04 | Euro Celtique Sa | Chemical compounds |
| DK0685475T3 (da) * | 1994-05-31 | 1999-08-30 | Bayer Ag | Amino-benzofuryl- og thienylderivater |
| HRP950288A2 (en) * | 1994-05-31 | 1997-08-31 | Bayer Ag | Oxalylamino-benzofuran- and benzothienyl-derivatives |
| GB9410877D0 (en) * | 1994-05-31 | 1994-07-20 | Bayer Ag | Heterocyclycarbonyl substituted benzoduranyl-and-thiophenyl-alkanecarboxyclic acid derivatives |
| US5591776A (en) | 1994-06-24 | 1997-01-07 | Euro-Celtique, S.A. | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV |
| US5922751A (en) | 1994-06-24 | 1999-07-13 | Euro-Celtique, S.A. | Aryl pyrazole compound for inhibiting phosphodiesterase IV and methods of using same |
| US6043264A (en) * | 1995-01-06 | 2000-03-28 | Toray Industries, Inc. | Benzene-condensed heterocyclic derivatives and their uses |
| GB9504460D0 (en) * | 1995-03-06 | 1995-04-26 | Bayer Ag | N-(3-Benzofuranyl)urea-derivatives |
| US6166041A (en) | 1995-10-11 | 2000-12-26 | Euro-Celtique, S.A. | 2-heteroaryl and 2-heterocyclic benzoxazoles as PDE IV inhibitors for the treatment of asthma |
| US6075016A (en) | 1996-04-10 | 2000-06-13 | Euro-Celtique S.A. | 6,5-fused aromatic ring systems having enhanced phosphodiesterase IV inhibitory activity |
| CZ371998A3 (cs) * | 1996-05-20 | 1999-03-17 | Darwin Discovery Limited | Benzofuranové karboxamidy a jejich terapeutické použití |
| GB9614718D0 (en) * | 1996-07-12 | 1996-09-04 | Bayer Ag | 3-ureido-pyridofurans and -pyridothiophenes |
| DE19642451A1 (de) * | 1996-10-15 | 1998-04-16 | Merck Patent Gmbh | Aminothiophencarbonsäureamide |
| DE19706396A1 (de) * | 1996-12-09 | 1998-06-10 | Bayer Ag | Verfahren zur Herstellung von 3-(l-Hydroxiphenyl-l-alkoximinomethyl)dioxazinen |
| GB2350111A (en) * | 1999-05-17 | 2000-11-22 | Bayer Ag | Oligohydroxyl substituted 3-urea-benzofuran and pyridofuran derivatives |
| GB2350109A (en) | 1999-05-17 | 2000-11-22 | Bayer Ag | Pharmaceutically active benzofuranyl sulfonates |
| CZ302882B6 (cs) | 1999-08-21 | 2012-01-04 | Nycomed Gmbh | Farmaceutický prostredek |
| CA2436130A1 (en) | 2001-01-29 | 2002-08-08 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted indoles and their use as integrin antagonists |
| US6872730B2 (en) | 2001-04-27 | 2005-03-29 | 3-Dimensional Pharmaceuticals, Inc. | Substituted benzofurans and benzothiophenes, methods of making and methods of use as integrin antagonists |
| JP4510384B2 (ja) | 2001-05-23 | 2010-07-21 | 田辺三菱製薬株式会社 | 骨折治癒促進用組成物 |
| EP1389467B1 (de) | 2001-05-23 | 2013-07-03 | Mitsubishi Tanabe Pharma Corporation | Therapeutische Zusammensetzungen für die regenerative Behandlung von Knorpelerkrankungen |
| AU2003215380B2 (en) * | 2002-02-22 | 2008-10-02 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
| US7144885B2 (en) | 2002-02-22 | 2006-12-05 | Bayer Pharmaceuticals Corporation | Fused tricyclic heterocycles useful for treating hyper-proliferative disorders |
| RU2211034C1 (ru) * | 2002-07-22 | 2003-08-27 | Закрытое Акционерное Общество Научно-Производственный Центр "Борщаговский Химико-Фармацевтический Завод" | Гепатозащитное средство |
| US7772188B2 (en) | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7153824B2 (en) | 2003-04-01 | 2006-12-26 | Applied Research Systems Ars Holding N.V. | Inhibitors of phosphodiesterases in infertility |
| JP2005008631A (ja) * | 2003-05-29 | 2005-01-13 | New Industry Research Organization | ベンゾフラン化合物、およびそれを含有してなる医薬組成物 |
| EP1627873A4 (de) * | 2003-05-29 | 2007-12-05 | New Ind Res Organization | Benzofuranverbindung und medizinische zusammensetzung, die diese enthält |
| EP1664011A4 (de) * | 2003-09-02 | 2009-02-25 | Merck & Co Inc | Ophthalmische zusammensetzungen zur behandlung der okularen hypertonie |
| AR051780A1 (es) * | 2004-11-29 | 2007-02-07 | Japan Tobacco Inc | Compuestos en anillo fusionados que contienen nitrogeno y utilizacion de los mismos |
| ES2379661T3 (es) * | 2006-06-27 | 2012-04-30 | Takeda Pharmaceutical Company Limited | Compuestos cíclicos condensados |
| WO2008025509A1 (en) * | 2006-09-01 | 2008-03-06 | Bayer Schering Pharma Aktiengesellschaft | Benzofuran and benzothiophene derivatives useful in the treatment of cancers of the central nervous system |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| MX354786B (es) | 2007-06-04 | 2018-03-21 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa utiles para el tratamiento de trastornos gastrointestinales, inflamacion, cancer y otros trastornos. |
| CA2726917C (en) | 2008-06-04 | 2018-06-26 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| EP2321341B1 (de) | 2008-07-16 | 2017-02-22 | Synergy Pharmaceuticals Inc. | Zur behandlung von erkrankungen des magen-darm-trakts, entzündlichen erkrankungen, krebs und anderen erkrankungen geeignete agonisten von guanylatcyclase |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| EA201391254A1 (ru) | 2011-03-01 | 2014-02-28 | Синерджи Фармасьютикалз Инк. | Способ получения агонистов гуанилатциклазы c |
| JP6499591B2 (ja) | 2013-02-25 | 2019-04-10 | シナジー ファーマシューティカルズ インコーポレイテッド | 結腸洗浄において用いるためのグアニル酸シクラーゼ受容体アゴニスト |
| WO2014151200A2 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| JP2016514671A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| CN105764916B (zh) | 2013-06-05 | 2021-05-18 | 博士医疗爱尔兰有限公司 | 鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法 |
| EP3492106B1 (de) | 2013-08-09 | 2021-02-17 | Ardelyx, Inc. | Verbindungen und verfahren zur hemmung eines phosphattransports |
| US9890132B2 (en) | 2013-08-25 | 2018-02-13 | Council Of Scientific & Industrial Research | Process for the preparation of anti-inflammatory aroylbenzofuran compounds |
| WO2015127962A1 (en) * | 2014-02-25 | 2015-09-03 | Ecolab Inc. | Sanitary cleaner |
| CN105254611B (zh) * | 2015-11-09 | 2017-10-31 | 江西仁明医药化工有限公司 | 苯并噻吩‑2‑羧酸的制备方法 |
| CN107827849B (zh) * | 2017-11-14 | 2020-06-02 | 沈阳药科大学 | 6-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用 |
| CN107857748B (zh) * | 2017-11-14 | 2020-06-02 | 沈阳药科大学 | 5-[2-羟基-3-(烷胺基)丙氧基]苯并呋喃类化合物及其应用 |
| CN107935972B (zh) * | 2017-11-14 | 2020-06-02 | 沈阳药科大学 | 5-[2-羟基-3-(异丙胺基)丙氧基]苯并呋喃类衍生物及其应用 |
| EP3972599B1 (de) | 2019-05-21 | 2025-10-22 | Ardelyx, Inc. | Kombination zur senkung des serum-phosphatspiegels bei einem patienten |
| CN110938035B (zh) * | 2019-10-28 | 2022-07-01 | 广西师范大学 | 9-苯磺酸-10-咪蒽腙及其合成方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| EP0019955A1 (de) * | 1979-05-16 | 1980-12-10 | Shell Internationale Researchmaatschappij B.V. | Benzofurancarbonsäure-Derivate, ihre Herstellung und ihre Verwendung in Lipogenese inhibierenden Zusammensetzungen |
| EP0146243A1 (de) * | 1983-10-31 | 1985-06-26 | Merck Frosst Canada Inc. | Lipoxygenase-Inhibitoren |
| US4663347A (en) * | 1983-10-31 | 1987-05-05 | Merck Frosst Canada, Inc. | Benzofuran 2-carboxylic acid esters useful as inhibitors of leukotriene biosynthesis |
| US4482772A (en) * | 1983-11-03 | 1984-11-13 | Mobil Oil Corporation | Multistage process for converting oxygenates to hydrocarbons |
-
1993
- 1993-05-06 GB GB939309324A patent/GB9309324D0/en active Pending
-
1994
- 1994-04-19 AU AU60558/94A patent/AU678814B2/en not_active Ceased
- 1994-04-22 DK DK94106320T patent/DK0623607T3/da active
- 1994-04-22 AT AT94106320T patent/ATE168373T1/de active
- 1994-04-22 DE DE69411625T patent/DE69411625T2/de not_active Expired - Fee Related
- 1994-04-22 ES ES94106320T patent/ES2118283T3/es not_active Expired - Lifetime
- 1994-04-22 EP EP94106320A patent/EP0623607B1/de not_active Expired - Lifetime
- 1994-04-29 US US08/236,796 patent/US5504213A/en not_active Expired - Fee Related
- 1994-05-02 JP JP11592394A patent/JP3452088B2/ja not_active Expired - Fee Related
- 1994-05-03 CA CA002122788A patent/CA2122788A1/en not_active Abandoned
- 1994-05-03 IL IL10952694A patent/IL109526A0/xx unknown
- 1994-05-03 NZ NZ260445A patent/NZ260445A/en unknown
- 1994-05-04 FI FI942049A patent/FI942049L/fi unknown
- 1994-05-05 RU RU94015838A patent/RU2125564C1/ru active
- 1994-05-05 ZA ZA943100A patent/ZA943100B/xx unknown
- 1994-05-05 NO NO941662A patent/NO941662L/no unknown
- 1994-05-06 SK SK531-94A patent/SK53194A3/sk unknown
- 1994-05-06 CN CN94104909A patent/CN1097749A/zh active Pending
- 1994-05-06 CZ CZ941129A patent/CZ112994A3/cs unknown
- 1994-05-06 HU HU9401415A patent/HUT67847A/hu unknown
-
1998
- 1998-08-31 GR GR980401965T patent/GR3027787T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO941662D0 (no) | 1994-05-05 |
| RU94015838A (ru) | 1997-02-20 |
| HUT67847A (en) | 1995-05-29 |
| DE69411625T2 (de) | 1998-11-05 |
| DK0623607T3 (da) | 1999-04-19 |
| FI942049A7 (fi) | 1994-11-07 |
| FI942049L (fi) | 1994-11-07 |
| JPH06329652A (ja) | 1994-11-29 |
| CN1097749A (zh) | 1995-01-25 |
| US5504213A (en) | 1996-04-02 |
| AU6055894A (en) | 1994-11-10 |
| AU678814B2 (en) | 1997-06-12 |
| ES2118283T3 (es) | 1998-09-16 |
| EP0623607B1 (de) | 1998-07-15 |
| IL109526A0 (en) | 1994-08-26 |
| SK53194A3 (en) | 1995-02-08 |
| ZA943100B (en) | 1995-01-09 |
| EP0623607A1 (de) | 1994-11-09 |
| FI942049A0 (fi) | 1994-05-04 |
| CA2122788A1 (en) | 1994-11-07 |
| GB9309324D0 (en) | 1993-06-16 |
| DE69411625D1 (de) | 1998-08-20 |
| NO941662L (no) | 1994-11-07 |
| JP3452088B2 (ja) | 2003-09-29 |
| GR3027787T3 (en) | 1998-11-30 |
| HU9401415D0 (en) | 1994-08-29 |
| CZ112994A3 (en) | 1994-11-16 |
| RU2125564C1 (ru) | 1999-01-27 |
| NZ260445A (en) | 1995-08-28 |
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