RU94041836A - Производные амидина, смесь их изомеров или отдельные изомеры и их соли, фармацевтическая композиция с антагонистической в отношении лейкотриена в*004 активностью - Google Patents

Производные амидина, смесь их изомеров или отдельные изомеры и их соли, фармацевтическая композиция с антагонистической в отношении лейкотриена в*004 активностью

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Publication number
RU94041836A
RU94041836A RU94041836/04A RU94041836A RU94041836A RU 94041836 A RU94041836 A RU 94041836A RU 94041836/04 A RU94041836/04 A RU 94041836/04A RU 94041836 A RU94041836 A RU 94041836A RU 94041836 A RU94041836 A RU 94041836A
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Russia
Prior art keywords
isomers
mixture
activity
pharmaceutical composition
leukotriene
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RU94041836/04A
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English (en)
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RU2124002C1 (ru
Inventor
Андерскевитц Ральф
De]
Шромм Курт
Рент Эрнет-Отто
Химмельсбах Франк
Бирке Франц
Фюгнер Армин
Original Assignee
Берингер Ингельхейм КГ (DE)
Берингер Ингельхейм КГ
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Priority claimed from DE4203201A external-priority patent/DE4203201A1/de
Priority claimed from DE4224289A external-priority patent/DE4224289A1/de
Priority claimed from DE4244241A external-priority patent/DE4244241A1/de
Application filed by Берингер Ингельхейм КГ (DE), Берингер Ингельхейм КГ filed Critical Берингер Ингельхейм КГ (DE)
Publication of RU94041836A publication Critical patent/RU94041836A/ru
Application granted granted Critical
Publication of RU2124002C1 publication Critical patent/RU2124002C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
    • C07C257/18—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines having carbon atoms of amidino groups bound to carbon atoms of six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/18—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)

Abstract

Объектом изобретения являются производные амидина обшей формулы 1, приведенной в описании. Другим объектом изобретения является фармацевтическая композиция с антагонистической в отношении лейкотриена Вактивностью, содержащая активное вещество и по меньшей мере один фармацевтически переносимый твердый или жидкий носитель, при этом в качестве активного вещества она содержит соединение вышеуказанной общей формулы 1, смесь его изомеров или отдельные изомеры, или его физиологически переносимую соль в эффективном количестве.

Claims (1)

  1. Объектом изобретения являются производные амидина обшей формулы 1, приведенной в описании. Другим объектом изобретения является фармацевтическая композиция с антагонистической в отношении лейкотриена В4 активностью, содержащая активное вещество и по меньшей мере один фармацевтически переносимый твердый или жидкий носитель, при этом в качестве активного вещества она содержит соединение вышеуказанной общей формулы 1, смесь его изомеров или отдельные изомеры, или его физиологически переносимую соль в эффективном количестве.
RU94041836A 1992-02-05 1993-01-14 Производные амидина, смесь их изомеров или отдельные изомеры и их соли, фармацевтическая композиция, обладающая антагонистическим действием в отношении лейкотриена b4 RU2124002C1 (ru)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE4203201A DE4203201A1 (de) 1992-02-05 1992-02-05 Neue amidinderivate, ihre herstellung und verwendung
DEP4203201.6 1992-02-05
DEP4224289.4 1992-07-23
DE4224289A DE4224289A1 (de) 1992-07-23 1992-07-23 Neue Amidinderivate, ihre Herstellung und Verwendung
DEP4244241.9 1992-12-24
DE4244241A DE4244241A1 (de) 1992-12-24 1992-12-24 Neue Verbindungen, ihre Herstellung und ihre Verwendung

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU95101020/11A Addition RU95101020A (ru) 1995-01-24 1995-01-24 Устройство для транспортировки грузов на поддонах в летательном аппарате

Publications (2)

Publication Number Publication Date
RU94041836A true RU94041836A (ru) 1997-02-20
RU2124002C1 RU2124002C1 (ru) 1998-12-27

Family

ID=27203364

Family Applications (1)

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RU94041836A RU2124002C1 (ru) 1992-02-05 1993-01-14 Производные амидина, смесь их изомеров или отдельные изомеры и их соли, фармацевтическая композиция, обладающая антагонистическим действием в отношении лейкотриена b4

Country Status (29)

Country Link
US (3) US6037377A (ru)
EP (2) EP0902013B1 (ru)
JP (2) JP3487851B2 (ru)
KR (1) KR0163222B1 (ru)
AT (2) ATE180770T1 (ru)
AU (1) AU673343B2 (ru)
CA (2) CA2427890A1 (ru)
CZ (2) CZ287209B6 (ru)
DE (2) DE59309630D1 (ru)
DK (2) DK0902013T3 (ru)
ES (2) ES2165122T3 (ru)
FI (1) FI943618A0 (ru)
GR (1) GR3030468T3 (ru)
HR (1) HRP930102B1 (ru)
HU (1) HU216191B (ru)
IL (1) IL104589A0 (ru)
MX (1) MX9300630A (ru)
NO (1) NO301540B1 (ru)
NZ (1) NZ246593A (ru)
PL (2) PL173781B1 (ru)
PT (1) PT902013E (ru)
RU (1) RU2124002C1 (ru)
SG (1) SG44837A1 (ru)
SI (1) SI9300066B (ru)
SK (1) SK281016B6 (ru)
TW (1) TW232005B (ru)
UA (1) UA43318C2 (ru)
WO (1) WO1993016036A1 (ru)
YU (1) YU49038B (ru)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5488160A (en) * 1991-06-11 1996-01-30 Ciba-Geigy Corporation Amidino compounds, their manufacture and method of treatment
US5451700A (en) * 1991-06-11 1995-09-19 Ciba-Geigy Corporation Amidino compounds, their manufacture and methods of treatment
US5455274A (en) * 1992-12-09 1995-10-03 Ciba-Geigy Corporation Hydroxyamidine derivatives
DE4309285A1 (de) * 1993-03-23 1994-09-29 Boehringer Ingelheim Kg Heterocyclen enthaltende Amidinderivate, ihre Herstellung und Verwendung
DE4424714A1 (de) * 1994-07-13 1996-01-18 Boehringer Ingelheim Kg Neue chemische Verbindung, ihre Herstellung und ihre Verwendung als Arnzneistoff
DE4424713A1 (de) * 1994-07-13 1996-01-18 Boehringer Ingelheim Kg Substituierte Benzamidine, ihre Herstellung und Verwendung als Arnzneistoffe
DE19546452A1 (de) * 1995-12-13 1997-06-19 Boehringer Ingelheim Kg Neue Phenylamidinderivate, Verfahren zu ihrer Herstelung und ihre Verwendung als Arzneimittel
EP0883405B1 (en) 1995-12-29 2004-02-25 3-Dimensional Pharmaceuticals, Inc. Amidino protease inhibitors
US5942544A (en) * 1996-02-22 1999-08-24 Dupont Pharmaceuticals Company α-branched anilines, toluenes, and analogs thereof as factor Xa inhibitors
DE19636689A1 (de) 1996-09-10 1998-03-12 Boehringer Ingelheim Kg Neue Benzamidinderivate
DE19637123A1 (de) * 1996-09-12 1998-03-19 Boehringer Ingelheim Kg Neue Pyranosidderivate
WO1998013347A1 (en) * 1996-09-26 1998-04-02 Novartis Ag Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity
US6670398B2 (en) * 1997-05-14 2003-12-30 Atherogenics, Inc. Compounds and methods for treating transplant rejection
DE69829966T2 (de) * 1997-05-14 2006-02-09 Atherogenics, Inc. Ein monoether von probucol und methoden zur hemmung der vcam-1 expression
US5872122A (en) * 1997-10-16 1999-02-16 Monsanto Company Pyrimidinylamidino β-amino acid derivatives useful as inhibitors of platelet aggregation
ID24720A (id) 1997-12-12 2000-08-03 Novartis Ag Senyawa amidino tersubstitusi dalam perawatan penyakit gangguan paru-paru kronis
IL136461A0 (en) * 1997-12-23 2001-06-14 Schering Corp Composition for treating respiratory and skin diseases, comprising at least one leukotriene antagonist and at least one antihistamine
US6291514B1 (en) 1998-02-09 2001-09-18 3-Dimensional Pharmaceuticals, Inc. Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors
DE19948428A1 (de) * 1999-10-07 2001-04-12 Boehringer Ingelheim Pharma Neuer LTB¶4¶-Antagonist, Verfahren zu dessen Herstellung und dessen Verwendung als Arzneimittel
FR2801053B1 (fr) * 1999-11-16 2004-06-25 Sod Conseils Rech Applic Nouveaux derives d'amidines, leur preparation et leur application a titre de medicaments
DE10052333A1 (de) * 2000-10-24 2002-05-02 Boehringer Ingelheim Pharma Neue Sulfooxybenzamide
US6528491B2 (en) * 2000-10-24 2003-03-04 Boehringer Ingelheim Pharma Kg Pyranoside derivatives
WO2002087556A2 (en) * 2001-04-11 2002-11-07 Atherogenics, Inc. Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality
RU2004102399A (ru) * 2001-07-14 2005-05-27 Берингер Ингельхайм Фарма Гмбх Ко.Кг (De) Лекарственная композиция, содержащая ltb4-антагонист
US20030119901A1 (en) * 2001-07-14 2003-06-26 Boehringer Ingelheim Pharma Kg Pharmaceutical formulation containing an LTB4 antagonist
US20040006092A1 (en) * 2001-08-31 2004-01-08 Neurochem, Inc. Amidine derivatives for treating amyloidosis
US20060229335A1 (en) * 2002-12-24 2006-10-12 Bradley Teegarden Diarylamine and arylheteroarylamine pyrazole derivatives as modulators of 5ht2a
EP1493739A1 (fr) * 2003-07-03 2005-01-05 Warner-Lambert Company LLC Dérivés thiophényliques d'aminoacides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent
US7262223B2 (en) 2004-01-23 2007-08-28 Neurochem (International) Limited Amidine derivatives for treating amyloidosis
GB2445920A (en) * 2007-01-25 2008-07-30 Mucokinetica Ltd Amidino compounds for treatment of respiratory disease
WO2008118948A1 (en) * 2007-03-26 2008-10-02 Atherogenics, Inc. Methods and compositions of derivatives of probucol for the treatment of diabetes
WO2008118946A1 (en) * 2007-03-27 2008-10-02 Atherogenics, Inc. Methods and compositions using certain phenolic derivatives for the treatment of diabetes
US8691866B2 (en) 2008-12-10 2014-04-08 The General Hospital Corporation HIF inhibitors and use thereof
AR094929A1 (es) 2013-02-28 2015-09-09 Bristol Myers Squibb Co Derivados de fenilpirazol como inhibidores potentes de rock1 y rock2
CN105102448B (zh) 2013-02-28 2018-03-06 百时美施贵宝公司 作为rock1和rock2抑制剂的苯基吡唑衍生物
CA3121202A1 (en) 2018-11-30 2020-06-04 Nuvation Bio Inc. Pyrrole and pyrazole compounds and methods of use thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4889871A (en) * 1987-05-29 1989-12-26 G. D. Searle & Co. Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives
AU626033B2 (en) * 1988-10-25 1992-07-23 Government Of The United States Of America, As Represented By The Secretary Of The Army, The Methods for the treatment and prophylaxis of pneumocystis carinii pneumonia and other diseases and compounds and formulations for use in said methods
US5246965A (en) * 1991-06-11 1993-09-21 Ciba-Geigy Arylethers, their manufacture and methods of treatment
EP0518818A3 (en) * 1991-06-11 1993-04-28 Ciba-Geigy Ag Arylethers, their manufacture and use as medicament
EP0518819B1 (en) * 1991-06-11 1995-08-02 Ciba-Geigy Ag Amidino compounds, their manufacture and use as medicament
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors

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SI9300066B (sl) 2003-02-28
TW232005B (ru) 1994-10-11
FI943618A (fi) 1994-08-04
DK0902013T3 (da) 2002-03-25
WO1993016036A1 (de) 1993-08-19
JP3487851B2 (ja) 2004-01-19
CZ188694A3 (en) 1995-03-15
CZ287209B6 (en) 2000-10-11
KR950700241A (ko) 1995-01-16
UA43318C2 (ru) 2001-12-17
HRP930102A2 (en) 1998-12-31
CA2427890A1 (en) 1993-08-19
AU3349793A (en) 1993-09-03
SG44837A1 (en) 1997-12-19
DE59309630D1 (de) 1999-07-08
DK0625138T3 (da) 1999-11-15
EP0902013B1 (de) 2001-12-12
ATE180770T1 (de) 1999-06-15
NZ246593A (en) 1997-07-27
EP0625138A1 (de) 1994-11-23
NO301540B1 (no) 1997-11-10
AU673343B2 (en) 1996-11-07
EP0902013A1 (de) 1999-03-17
IL104589A0 (en) 1993-06-10
DE59310252D1 (de) 2002-01-24
HUT68419A (en) 1995-06-28
MX9300630A (es) 1993-09-01
GR3030468T3 (en) 1999-10-29
NO942903L (no) 1994-10-03
US6489365B1 (en) 2002-12-03
CZ287173B6 (cs) 2000-10-11
SK91494A3 (en) 1995-02-08
ES2132216T3 (es) 1999-08-16
HU9402291D0 (en) 1994-10-28
CA2129526A1 (en) 1993-08-06
ATE210634T1 (de) 2001-12-15
EP0625138B1 (de) 1999-06-02
JPH07503718A (ja) 1995-04-20
PT902013E (pt) 2002-06-28
KR0163222B1 (ko) 1999-01-15
PL173781B1 (pl) 1998-04-30
US20030130232A1 (en) 2003-07-10
SI9300066A (en) 1993-09-30
PL173789B1 (pl) 1998-04-30
YU49038B (sh) 2003-07-07
US6037377A (en) 2000-03-14
JP2002322143A (ja) 2002-11-08
HRP930102B1 (en) 2000-02-29
NO942903D0 (ru) 1994-08-04
RU2124002C1 (ru) 1998-12-27
FI943618A0 (fi) 1994-08-04
HU216191B (hu) 1999-05-28
ES2165122T3 (es) 2002-03-01
SK281016B6 (sk) 2000-10-09
YU6393A (sh) 1996-10-09

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