MX9704777A - Compuestos espiro tetraciclicos, procedimiento para su preparacion y composiciones que los contienen. - Google Patents

Compuestos espiro tetraciclicos, procedimiento para su preparacion y composiciones que los contienen.

Info

Publication number
MX9704777A
MX9704777A MX9704777A MX9704777A MX9704777A MX 9704777 A MX9704777 A MX 9704777A MX 9704777 A MX9704777 A MX 9704777A MX 9704777 A MX9704777 A MX 9704777A MX 9704777 A MX9704777 A MX 9704777A
Authority
MX
Mexico
Prior art keywords
preparation
receptor antagonists
spiro compounds
5ht1d receptor
tetracyclic spiro
Prior art date
Application number
MX9704777A
Other languages
English (en)
Inventor
Laramie Mary Gaster
Francis David King
Paul Adrian Wyman
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9426029.6A external-priority patent/GB9426029D0/en
Priority claimed from GBGB9512920.1A external-priority patent/GB9512920D0/en
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of MX9704777A publication Critical patent/MX9704777A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Se describen derivados novedosos de piperidina de la formula (I): procedimientos para su preparacion, composiciones farmacéuticas que los contienen y su uso en la preparacion de medicamentos para el tratamiento de perturbaciones del sistema nervioso central.
MX9704777A 1994-12-22 1995-12-06 Compuestos espiro tetraciclicos, procedimiento para su preparacion y composiciones que los contienen. MX9704777A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9426029.6A GB9426029D0 (en) 1994-12-22 1994-12-22 Novel compounds
GBGB9512920.1A GB9512920D0 (en) 1995-06-24 1995-06-24 Novel compounds
PCT/EP1995/004889 WO1996019477A1 (en) 1994-12-22 1995-12-06 Tetracyclic spiro compounds, process for their preparation and their use as 5ht1d receptor antagonists

Publications (1)

Publication Number Publication Date
MX9704777A true MX9704777A (es) 1997-10-31

Family

ID=26306239

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9704777A MX9704777A (es) 1994-12-22 1995-12-06 Compuestos espiro tetraciclicos, procedimiento para su preparacion y composiciones que los contienen.

Country Status (27)

Country Link
US (1) US5972951A (es)
EP (1) EP0799226B1 (es)
JP (1) JPH10510821A (es)
CN (1) CN1175256A (es)
AP (1) AP757A (es)
AR (1) AR002011A1 (es)
AT (1) ATE199085T1 (es)
AU (1) AU697361B2 (es)
BG (1) BG61977B1 (es)
BR (1) BR9510419A (es)
CA (1) CA2208244A1 (es)
CZ (1) CZ192397A3 (es)
DE (1) DE69520075T2 (es)
DZ (1) DZ1957A1 (es)
ES (1) ES2153907T3 (es)
FI (1) FI972583A (es)
HU (1) HUT77650A (es)
IL (1) IL116486A0 (es)
MA (1) MA23753A1 (es)
MX (1) MX9704777A (es)
NO (1) NO972910L (es)
NZ (1) NZ298036A (es)
OA (1) OA10610A (es)
PL (1) PL321048A1 (es)
SK (1) SK80297A3 (es)
TR (1) TR199501597A2 (es)
WO (1) WO1996019477A1 (es)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9519033D0 (en) * 1995-09-18 1995-11-15 Smithkline Beecham Plc Treatment
GB9522845D0 (en) * 1995-11-08 1996-01-10 Smithkline Beecham Plc Novel compounds
EP0861257A1 (en) * 1995-11-08 1998-09-02 Smithkline Beecham Plc Spiro piperidine derivatives as 5mt receptor antagonists
US5972979A (en) * 1995-11-22 1999-10-26 Smithkline Beecham P.L.C. Tricyclic spiro compounds as 5HT1D receptor antagonists
GB9605883D0 (en) * 1996-03-20 1996-05-22 Smithkline Beecham Plc Novel compounds
GB9606396D0 (en) * 1996-03-27 1996-06-05 Smithkline Beecham Plc Novel compounds
US6156783A (en) * 1996-04-30 2000-12-05 Smithkline Beecham P.L.C. Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use
FR2761069A1 (fr) * 1997-03-20 1998-09-25 Pf Medicament Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments
EP1122252A4 (en) * 1998-10-16 2002-06-26 Takeda Chemical Industries Ltd CONDENSED HEREROCYCLIC NITROGEN COMPOUNDS; MANUFACTURING PROCESS AND AGENTS CONTAINING THEM
DE10051981A1 (de) 2000-10-20 2002-05-02 Bayer Ag Substituierte Phenyluracile
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
AR045690A1 (es) * 2003-06-03 2005-11-09 Rib X Pharmaceuticals Inc Compuestos biaril heterociclicos y metodos para preparar y utilizar los mismos
US20050165025A1 (en) * 2004-01-22 2005-07-28 Recordati Ireland Ltd. Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists
US7700808B2 (en) 2005-12-26 2010-04-20 Nissan Chemical Industries, Ltd. 1-3-bis(substituted phenyl)-3-hydroxypropan-1-one or 2-propen-1-one compound, and salt thereof
AU2008242697A1 (en) 2007-04-20 2008-10-30 Deciphera Pharmaceuticals, Llc Kinase inhibitors useful for the treatment of myleoproliferative diseases and other proliferative diseases
CN103450077B (zh) 2007-06-08 2016-07-06 满康德股份有限公司 IRE-1α抑制剂
JP5349303B2 (ja) 2007-06-27 2013-11-20 日産化学工業株式会社 ３−ヒドロキシプロパン−１−オン化合物、２−プロペン−１−オン化合物およびイソキサゾリン化合物の製造方法
CA2741029A1 (en) 2008-10-17 2010-04-22 Xenon Pharmaceuticals Inc. Spiro-oxindole compounds and their use as therapeutic agents
AR077252A1 (es) 2009-06-29 2011-08-10 Xenon Pharmaceuticals Inc Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos
NZ712378A (en) 2009-10-14 2017-05-26 Xenon Pharmaceuticals Inc Synthetic methods for spiro-oxindole compounds
EP2538919B1 (en) 2010-02-26 2017-07-12 Xenon Pharmaceuticals Inc. Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
TW201636017A (zh) 2015-02-05 2016-10-16 梯瓦製藥國際有限責任公司 以螺吲哚酮化合物之局部調配物治療帶狀疱疹後遺神經痛之方法
US11498903B2 (en) 2017-08-17 2022-11-15 Bristol-Myers Squibb Company 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases
CA3089566A1 (en) 2018-01-31 2019-08-08 Deciphera Pharmaceuticals, Llc Combination therapy for the treatment of gastrointestinal stromal tumors
WO2020183011A1 (en) 2019-03-14 2020-09-17 Institut Curie Htr1d inhibitors and uses thereof in the treatment of cancer
WO2021030405A1 (en) 2019-08-12 2021-02-18 Deciphera Pharmaceuticals, Llc Ripretinib for treating gastrointestinal stromal tumors
JP2022544234A (ja) 2019-08-12 2022-10-17 デシフェラ・ファーマシューティカルズ，エルエルシー 胃腸間質腫瘍を治療するためのリプレチニブ
EP4084778B1 (en) 2019-12-30 2023-11-01 Deciphera Pharmaceuticals, LLC Amorphous kinase inhibitor formulations and methods of use thereof
KR20220123058A (ko) 2019-12-30 2022-09-05 데시페라 파마슈티칼스, 엘엘씨. 1-(4-브로모-5-(1-에틸-7-(메틸아미노)-2-옥소-1,2-디히드로-1,6-나프티리딘-3-일)-2-플루오로페닐)-3-페닐우레아의 조성물
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2162792T3 (es) 1991-09-18 2002-01-16 Glaxo Group Ltd Derivados de benzanilida como antagonistas de 5-ht1d.
GB9119932D0 (en) * 1991-09-18 1991-10-30 Glaxo Group Ltd Chemical compounds

Also Published As

Publication number Publication date
AU4343396A (en) 1996-07-10
AP757A (en) 1999-09-06
EP0799226B1 (en) 2001-02-07
BR9510419A (pt) 1998-05-19
FI972583A (fi) 1997-08-19
WO1996019477A1 (en) 1996-06-27
BG61977B1 (bg) 1998-11-30
ES2153907T3 (es) 2001-03-16
PL321048A1 (en) 1997-11-24
CA2208244A1 (en) 1996-06-27
IL116486A0 (en) 1997-08-14
AR002011A1 (es) 1998-01-07
AP9701006A0 (en) 1997-07-31
EP0799226A1 (en) 1997-10-08
FI972583A0 (fi) 1997-06-17
OA10610A (en) 2002-09-06
CN1175256A (zh) 1998-03-04
ATE199085T1 (de) 2001-02-15
TR199501597A2 (tr) 1996-07-21
AU697361B2 (en) 1998-10-01
NZ298036A (en) 1998-11-25
DE69520075T2 (de) 2001-08-02
DZ1957A1 (fr) 2002-02-17
DE69520075D1 (de) 2001-03-15
BG101715A (en) 1998-02-27
MA23753A1 (fr) 1996-07-01
US5972951A (en) 1999-10-26
JPH10510821A (ja) 1998-10-20
CZ192397A3 (en) 1997-09-17
HUT77650A (hu) 1998-07-28
NO972910L (no) 1997-08-14
SK80297A3 (en) 1998-12-02
NO972910D0 (no) 1997-06-20

Similar Documents

Publication Publication Date Title
MX9704777A (es) Compuestos espiro tetraciclicos, procedimiento para su preparacion y composiciones que los contienen.
RO115522B1 (ro) Derivaţi de indolină, procedee pentru prepararea acestora, compoziţii farmaceutice care îi conţin şi metodă de tratament
MY118163A (en) Aryl fused azapolycyclic compounds
IL72120A (en) 2-pyrimidinyl-1-piperazine derivatives,their preparation and pharmaceutical compositions containing them
AU6461600A (en) Substituted piperidine compounds useful as modulators of chemokine receptor activity
IL127244A (en) Substituted amines, methods of their preparation and pharmaceutical compositions containing them
CA2258548A1 (en) Phenylamino-substituted tricyclic derivatives for treatment of hyperproliferative diseases
HUP9802036A3 (en) Novel substituted piperazine derivatives having tachykinin receptor antagonists activity, process for producing them an pharmaceutical compositions containing them
HUP9601033A2 (en) Benzofurane derivatives, process for their preparation, use of them as intermediate and pharmaceutical compositions containing the compounds
GB9322643D0 (en) Lactam derivatives
HUP0200284A3 (en) 1-arenesulfonyl-2-aryl-pyrrolidine and piperidine derivatives for the treatment of cns disorders, process for their preparation and pharmaceutical compositions containing them
ES2087038A1 (es) Nuevas piperidinas con actividad antagonista del paf.
HK1046902A1 (zh) 新型哌嗪基烷基硫代嘧啶衍生物，包含該衍生物的藥物組合物以及製備該活性物質的方法
ZA200110540B (en) Novel diphenyl-piperidine derivate.
WO1996023769A3 (en) Heterocyclic compounds possessing 5ht2c receptor antagonist activity
ATE205480T1 (de) 2,5-dioxo-2,5-dihydro-1h-benz(b)azepine als nmda rezeptor antagonisten
YU64400A (sh) Aril fuzirana azapoliciklična jedinjenja
NO963331L (no) 5-Heteroarylindol-derivater som benzodiazepin-reseptorsete-agonister og antagonister
GR3034354T3 (en) IMIDAZO 1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF
IL113365A (en) 5-Heterocyclo-1,5-benzodiazepine derivatives their preparation and pharmaceutical compositions containing them
IL109076A0 (en) Imidazolo-quinoxalinones, their preparation and pharmaceutical compositions containing them
NZ513053A (en) (1-phenacy-3-phenyl-3-piperidylethyl)piperidine derivatives, method for the production thereof and pharmaceutical compositions containing the same
PT950053E (pt) Novos derivados de benzoilalquil-1,2,3,6-tetra-hidropiridinas
TW367320B (en) Novel aryl compounds having CNS activity, process for their preparation and their use as medicaments
UA27738C2 (uk) 2,3,4,5,6,7-гексагідро-1-[4-[1-[4-(2метоксифеніл)піперазиніл]]-2-фенілбутирил]-1н-азепін або його фармацевтично прийнятна кислотно-адитивна сіль, що мають властивість пов'язувати рецептор 5нт1а, спосіб (варіанти) їх одержання, фармацевтична композиція