AR002011A1 - Compuestos derivados de piperidina, sus sales y n-oxidos, procedimiento de preparacion y composiciones farmaceuticas. - Google Patents
Compuestos derivados de piperidina, sus sales y n-oxidos, procedimiento de preparacion y composiciones farmaceuticas.Info
- Publication number
- AR002011A1 AR002011A1 ARP950100629A AR10062995A AR002011A1 AR 002011 A1 AR002011 A1 AR 002011A1 AR P950100629 A ARP950100629 A AR P950100629A AR 10062995 A AR10062995 A AR 10062995A AR 002011 A1 AR002011 A1 AR 002011A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- alkoxy
- piperidine
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se describen nuevos derivados de piperidina de fórmula (I), proceso para su preparación, composiciones farmacéuticas que las contienen y su uso comomedicamentos en donde R1 es hidrógeno, halógeno, alquilo, ciclo-alquilo, alquil-CO, alcoxi, hidroxi, hidroxialquilo, hidroxialcoxi, alcoxi-alcoxi,acilo, nitro, trifluorometilo, ciano, SR9, SOR9, SO2R9, SO2NR10R11, CO2R10, NR10SO2R11, CONR10R11, CO2NR10R11, CONR10(CH2)pCO2R11, (CH2)pNR10R11,(CH2)pCONR10R11, (CH2)pNR10COR11, (CH2)pCO2-alquilo, CO2-(CH2)pOR10, CONHNR10R11, NR10R11, NR10CO2R11, NR10CO(CH2)pNR10R11, NR10CONR10R11,CR10=NOR11, CNR10=NOR11, en donde R9, R10 y R11 son independientemente hidrógeno o alquilo y p es 1 a 4; o R1 es un anillo heterocíclico de 5a 7miembros opcionalmente sustituido conteniendo 1 a 4 heteroátomos seleccionados de oxígeno, nitrógeno y azufre; R2 y R3 son hidrógeno, halógeno, alquilo,cicloalquilo, cicloalquenilo, alcoxi, hidroxialquilo, alcoxialquilo, acilo, arilo, aciloxi, hidroxi, nitro, trifluorometilo, ciano, CO2R10, CONR10R11,NR10R11, donde R10 y R11 son hidrógeno o alquilo; R4, R5 y R6 son hidrógeno o alquilo; A es (CR13R14)q donde q es 2, 3 ó 4 y R13 y R14 son hidrógeno oalquilo o A es (CR13R14)r-D, donde r es 0, 1, 2, ó 3 y D es oxígeno, azufre o CR13=CR14, B es oxígeno, CR15R16 o NR17 donde R15, R16 y R17 son hidrógeno oalquilo o B es S(O)b donde b es 0, 1 ó 2; m es 1, 2 ó 3 y n es 1, 2 ó 3.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9426029.6A GB9426029D0 (en) | 1994-12-22 | 1994-12-22 | Novel compounds |
| GBGB9512920.1A GB9512920D0 (en) | 1995-06-24 | 1995-06-24 | Novel compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR002011A1 true AR002011A1 (es) | 1998-01-07 |
Family
ID=26306239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP950100629A AR002011A1 (es) | 1994-12-22 | 1995-12-19 | Compuestos derivados de piperidina, sus sales y n-oxidos, procedimiento de preparacion y composiciones farmaceuticas. |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5972951A (es) |
| EP (1) | EP0799226B1 (es) |
| JP (1) | JPH10510821A (es) |
| CN (1) | CN1175256A (es) |
| AP (1) | AP757A (es) |
| AR (1) | AR002011A1 (es) |
| AT (1) | ATE199085T1 (es) |
| AU (1) | AU697361B2 (es) |
| BG (1) | BG61977B1 (es) |
| BR (1) | BR9510419A (es) |
| CA (1) | CA2208244A1 (es) |
| CZ (1) | CZ192397A3 (es) |
| DE (1) | DE69520075T2 (es) |
| DZ (1) | DZ1957A1 (es) |
| ES (1) | ES2153907T3 (es) |
| FI (1) | FI972583A (es) |
| HU (1) | HUT77650A (es) |
| IL (1) | IL116486A0 (es) |
| MA (1) | MA23753A1 (es) |
| MX (1) | MX9704777A (es) |
| NO (1) | NO972910L (es) |
| NZ (1) | NZ298036A (es) |
| OA (1) | OA10610A (es) |
| PL (1) | PL321048A1 (es) |
| SK (1) | SK80297A3 (es) |
| TR (1) | TR199501597A2 (es) |
| WO (1) | WO1996019477A1 (es) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9519033D0 (en) * | 1995-09-18 | 1995-11-15 | Smithkline Beecham Plc | Treatment |
| GB9522845D0 (en) * | 1995-11-08 | 1996-01-10 | Smithkline Beecham Plc | Novel compounds |
| US6166034A (en) * | 1995-11-08 | 2000-12-26 | Smithkline Beecham P. L. C | Spiro piperidine derivatives as 5HT1D receptor antagonists |
| US5972979A (en) * | 1995-11-22 | 1999-10-26 | Smithkline Beecham P.L.C. | Tricyclic spiro compounds as 5HT1D receptor antagonists |
| GB9605883D0 (en) * | 1996-03-20 | 1996-05-22 | Smithkline Beecham Plc | Novel compounds |
| GB9606396D0 (en) * | 1996-03-27 | 1996-06-05 | Smithkline Beecham Plc | Novel compounds |
| US6156783A (en) * | 1996-04-30 | 2000-12-05 | Smithkline Beecham P.L.C. | Spiroazabicyclic compounds, processes for their preparation, and their pharmaceutical use |
| FR2761069A1 (fr) * | 1997-03-20 | 1998-09-25 | Pf Medicament | Spiroamines derivees de dihydrobenzofuranes, leur preparation et leur application comme medicaments |
| CA2347095A1 (en) * | 1998-10-16 | 2000-04-27 | Takeda Chemical Industries, Ltd. | Nitrogen-containing condensed heterocyclic derivatives, their production and agent |
| DE10051981A1 (de) | 2000-10-20 | 2002-05-02 | Bayer Ag | Substituierte Phenyluracile |
| US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
| US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
| US7144911B2 (en) | 2002-12-31 | 2006-12-05 | Deciphera Pharmaceuticals Llc | Anti-inflammatory medicaments |
| JP5043428B2 (ja) * | 2003-06-03 | 2012-10-10 | リブ−エックス ファーマシューティカルズ，インコーポレイテッド | ビアリール複素環式化合物ならびにその製造および使用方法 |
| US20050165025A1 (en) * | 2004-01-22 | 2005-07-28 | Recordati Ireland Ltd. | Combination therapy with 5HT 1A and 5HT 1B-receptor antagonists |
| JP5304981B2 (ja) | 2005-12-26 | 2013-10-02 | 日産化学工業株式会社 | １，３−ビス（置換フェニル）−３−ヒドロキシプロパン−１−オンおよび２−プロペン−１−オン化合物およびその塩 |
| JP2010524970A (ja) | 2007-04-20 | 2010-07-22 | デシフェラ ファーマシューティカルズ，エルエルシー | 骨髄増殖性疾患及びその他の増殖性疾患の治療に有用なキナーゼ阻害剤 |
| ES2601856T3 (es) | 2007-06-08 | 2017-02-16 | Mannkind Corporation | Inhibidores de la IRE-1A |
| WO2009001942A1 (ja) | 2007-06-27 | 2008-12-31 | Nissan Chemical Industries, Ltd. | ３－ヒドロキシプロパン－１－オン化合物、２－プロペン－１－オン化合物およびイソキサゾリン化合物の製造方法 |
| PL2350090T3 (pl) | 2008-10-17 | 2015-11-30 | Xenon Pharmaceuticals Inc | Związki spiro-oksindolowe i ich zastosowanie jako środków terapeutycznych |
| AR077252A1 (es) | 2009-06-29 | 2011-08-10 | Xenon Pharmaceuticals Inc | Enantiomeros de compuestos de espirooxindol y sus usos como agentes terapeuticos |
| PE20170202A1 (es) | 2009-10-14 | 2017-03-24 | Xenon Pharmaceuticals Inc | Metodos sinteticos para compuestos espiro-oxoindol |
| EP2538919B1 (en) | 2010-02-26 | 2017-07-12 | Xenon Pharmaceuticals Inc. | Pharmaceutical compositions of spiro-oxindole compound for topical administration and their use as therapeutic agents |
| US8461179B1 (en) | 2012-06-07 | 2013-06-11 | Deciphera Pharmaceuticals, Llc | Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases |
| US9682033B2 (en) | 2015-02-05 | 2017-06-20 | Teva Pharmaceuticals International Gmbh | Methods of treating postherpetic neuralgia with a topical formulation of a spiro-oxindole compound |
| US11498903B2 (en) | 2017-08-17 | 2022-11-15 | Bristol-Myers Squibb Company | 2-(1,1′-biphenyl)-1H-benzodimidazole derivatives and related compounds as apelin and APJ agonists for treating cardiovascular diseases |
| WO2019152711A1 (en) | 2018-01-31 | 2019-08-08 | Diciphera Pharmaceuticals Llc. | Combination therapy for the treatment of gastrointestinal stromal tumors |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
| MX2022001863A (es) | 2019-08-12 | 2022-05-30 | Deciphera Pharmaceuticals Llc | Metodos para tratar los tumores del estroma gastrointestinal. |
| WO2021030405A1 (en) | 2019-08-12 | 2021-02-18 | Deciphera Pharmaceuticals, Llc | Ripretinib for treating gastrointestinal stromal tumors |
| IL293864A (en) | 2019-12-30 | 2022-08-01 | Deciphera Pharmaceuticals Llc | Preparations of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3- phenylurea |
| HRP20231699T1 (hr) | 2019-12-30 | 2024-05-10 | Deciphera Pharmaceuticals, Llc | Formulacije inhibitora amorfne kinaze i postupci njihove primjene |
| US11779572B1 (en) | 2022-09-02 | 2023-10-10 | Deciphera Pharmaceuticals, Llc | Methods of treating gastrointestinal stromal tumors |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0533268T3 (da) | 1991-09-18 | 2001-12-03 | Glaxo Group Ltd | Benzanilidderivater som 5HT-1D antagonister |
| GB9119932D0 (en) * | 1991-09-18 | 1991-10-30 | Glaxo Group Ltd | Chemical compounds |
-
1995
- 1995-12-06 CA CA002208244A patent/CA2208244A1/en not_active Abandoned
- 1995-12-06 US US08/849,932 patent/US5972951A/en not_active Expired - Fee Related
- 1995-12-06 EP EP95942116A patent/EP0799226B1/en not_active Expired - Lifetime
- 1995-12-06 PL PL95321048A patent/PL321048A1/xx unknown
- 1995-12-06 ES ES95942116T patent/ES2153907T3/es not_active Expired - Lifetime
- 1995-12-06 DE DE69520075T patent/DE69520075T2/de not_active Expired - Fee Related
- 1995-12-06 CN CN95197616A patent/CN1175256A/zh active Pending
- 1995-12-06 AP APAP/P/1997/001006A patent/AP757A/en active
- 1995-12-06 CZ CZ971923A patent/CZ192397A3/cs unknown
- 1995-12-06 JP JP8519477A patent/JPH10510821A/ja active Pending
- 1995-12-06 AU AU43433/96A patent/AU697361B2/en not_active Ceased
- 1995-12-06 WO PCT/EP1995/004889 patent/WO1996019477A1/en not_active Application Discontinuation
- 1995-12-06 NZ NZ298036A patent/NZ298036A/en unknown
- 1995-12-06 BR BR9510419A patent/BR9510419A/pt not_active Application Discontinuation
- 1995-12-06 HU HU9800158A patent/HUT77650A/hu unknown
- 1995-12-06 MX MX9704777A patent/MX9704777A/es unknown
- 1995-12-06 SK SK802-97A patent/SK80297A3/sk unknown
- 1995-12-06 AT AT95942116T patent/ATE199085T1/de active
- 1995-12-19 TR TR95/01597A patent/TR199501597A2/xx unknown
- 1995-12-19 AR ARP950100629A patent/AR002011A1/es unknown
- 1995-12-20 MA MA24106A patent/MA23753A1/fr unknown
- 1995-12-20 DZ DZ950140A patent/DZ1957A1/fr active
- 1995-12-21 IL IL11648695A patent/IL116486A0/xx unknown
-
1997
- 1997-06-17 FI FI972583A patent/FI972583A/fi unknown
- 1997-06-20 NO NO972910A patent/NO972910L/no unknown
- 1997-06-20 OA OA70033A patent/OA10610A/en unknown
- 1997-07-01 BG BG101715A patent/BG61977B1/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AP9701006A0 (en) | 1997-07-31 |
| AP757A (en) | 1999-09-06 |
| CZ192397A3 (en) | 1997-09-17 |
| EP0799226A1 (en) | 1997-10-08 |
| CN1175256A (zh) | 1998-03-04 |
| SK80297A3 (en) | 1998-12-02 |
| AU4343396A (en) | 1996-07-10 |
| FI972583A0 (fi) | 1997-06-17 |
| BG101715A (en) | 1998-02-27 |
| NZ298036A (en) | 1998-11-25 |
| ES2153907T3 (es) | 2001-03-16 |
| MX9704777A (es) | 1997-10-31 |
| MA23753A1 (fr) | 1996-07-01 |
| PL321048A1 (en) | 1997-11-24 |
| NO972910L (no) | 1997-08-14 |
| IL116486A0 (en) | 1997-08-14 |
| BR9510419A (pt) | 1998-05-19 |
| US5972951A (en) | 1999-10-26 |
| ATE199085T1 (de) | 2001-02-15 |
| BG61977B1 (bg) | 1998-11-30 |
| OA10610A (en) | 2002-09-06 |
| CA2208244A1 (en) | 1996-06-27 |
| WO1996019477A1 (en) | 1996-06-27 |
| EP0799226B1 (en) | 2001-02-07 |
| DZ1957A1 (fr) | 2002-02-17 |
| AU697361B2 (en) | 1998-10-01 |
| NO972910D0 (no) | 1997-06-20 |
| FI972583A (fi) | 1997-08-19 |
| TR199501597A2 (tr) | 1996-07-21 |
| JPH10510821A (ja) | 1998-10-20 |
| DE69520075D1 (de) | 2001-03-15 |
| HUT77650A (hu) | 1998-07-28 |
| DE69520075T2 (de) | 2001-08-02 |
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