ATE251163T1 - Bicyclische piperidin- und piperazin-verbindungen mit 5-ht6-rezeptor-affinität - Google Patents
Bicyclische piperidin- und piperazin-verbindungen mit 5-ht6-rezeptor-affinitätInfo
- Publication number
- ATE251163T1 ATE251163T1 AT99957059T AT99957059T ATE251163T1 AT E251163 T1 ATE251163 T1 AT E251163T1 AT 99957059 T AT99957059 T AT 99957059T AT 99957059 T AT99957059 T AT 99957059T AT E251163 T1 ATE251163 T1 AT E251163T1
- Authority
- AT
- Austria
- Prior art keywords
- group
- 6alkyl
- optionally substituted
- receptor affinity
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9700898A | 1998-06-15 | 1998-06-15 | |
US09/156,495 US6251893B1 (en) | 1998-06-15 | 1998-09-18 | Bicyclic piperidine and piperazine compounds having 5-HT6 receptor affinity |
PCT/CA1999/000543 WO1999065906A1 (en) | 1998-06-15 | 1999-06-10 | Bicyclic piperidine and piperazine compounds having 5-ht6 receptor affinity |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE251163T1 true ATE251163T1 (de) | 2003-10-15 |
Family
ID=26792298
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99957059T ATE251163T1 (de) | 1998-06-15 | 1999-06-10 | Bicyclische piperidin- und piperazin-verbindungen mit 5-ht6-rezeptor-affinität |
Country Status (11)
Country | Link |
---|---|
US (1) | US6251893B1 (de) |
EP (1) | EP1105393B1 (de) |
JP (1) | JP4505773B2 (de) |
AT (1) | ATE251163T1 (de) |
AU (1) | AU765256B2 (de) |
CA (1) | CA2335285C (de) |
DE (1) | DE69911798T2 (de) |
DK (1) | DK1105393T3 (de) |
ES (1) | ES2209525T3 (de) |
MX (1) | MXPA00012561A (de) |
WO (1) | WO1999065906A1 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6562809B1 (en) * | 1998-09-18 | 2003-05-13 | Nps Allelix Corp. | 3-bicycloindole compounds |
US6686374B1 (en) * | 1999-08-12 | 2004-02-03 | Nps Allelix Corp. | Azaindoles having serotonin receptor affinity |
US6897215B1 (en) * | 1999-11-05 | 2005-05-24 | Nps Allelix Corp. | Compounds having 5-HT6 receptor antagonist activity |
US6818639B2 (en) | 2000-07-21 | 2004-11-16 | Biovitrum Ab | Pharmaceutical combination formulation and method of treatment with the combination |
SE0002754D0 (sv) * | 2000-07-21 | 2000-07-21 | Pharmacia & Upjohn Ab | New pharmaceutical combination formulation and method of treatment with the combination |
SE0003810D0 (sv) * | 2000-10-20 | 2000-10-20 | Pharmacia Ab | Novel compounds their use and preparations |
AU2001296193B2 (en) * | 2000-10-20 | 2006-04-27 | Biovitrum Ab | 2-, 3-, 4-, or 5-substituted-N1-(benzensulfonyl)indoles and their use in therapy |
US7034029B2 (en) * | 2000-11-02 | 2006-04-25 | Wyeth | 1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands |
CN1222511C (zh) * | 2000-11-02 | 2005-10-12 | 惠氏公司 | 作为5-羟色胺-6配体的1-芳基-或1-烷基磺酰基-杂环基吲哚 |
HUP0400684A2 (hu) | 2000-12-22 | 2004-07-28 | Wyeth | 5-Hidroxitriptamin-6-ligandumként használható heterociklilindazol- és -azaindazol-származékok, előállításuk és ezeket tartalmazó gyógyszerkészítmények |
DE60119982T2 (de) | 2000-12-22 | 2006-12-21 | Wyeth | Heterozyklylalkylindole oder -azaindole als 5-hydroxytryptamine-6 liganden |
US6713479B2 (en) * | 2001-03-02 | 2004-03-30 | Sepracor Inc. | Piperidine-piperazine ligands for neurotransmitter receptors |
KR20040010709A (ko) | 2001-06-15 | 2004-01-31 | 에프. 호프만-라 로슈 아게 | 5-ht6 수용체 친화력을 갖는 4-피페라지닐인돌 유도체 |
ITRM20010356A1 (it) * | 2001-06-21 | 2002-12-23 | Sigma Tau Ind Farmaceuti | "5-alogeno derivati della triptamina utili come ligandi del recettore5-ht6 e/o 5-ht7 della serotonina. |
US7838518B2 (en) * | 2002-02-12 | 2010-11-23 | N.V. Organon | 1-arylsulfonyl-3-substituted indole and indoline derivatives useful in the treatment of central nervous system disorders |
DE60309852T2 (de) * | 2002-03-27 | 2007-06-06 | Glaxo Group Ltd., Greenford | Chinolin- und aza-indolderivate und deren verwendung als 5-ht6 liganden |
BRPI0308696B8 (pt) | 2002-03-27 | 2021-05-25 | Axovant Sciences Gmbh | composto derivado de quinolina, seu processo de preparação, sua composição farmacêutica e seus usos |
WO2005012254A1 (en) | 2003-07-22 | 2005-02-10 | Arena Pharmaceuticals, Inc. | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related therto |
GB0321473D0 (en) * | 2003-09-12 | 2003-10-15 | Glaxo Group Ltd | Novel compounds |
WO2005110982A2 (en) * | 2004-04-07 | 2005-11-24 | Neurogen Corporation | Substituted 1-benzyl-4-substituted piperazine analogues |
US20050239791A1 (en) * | 2004-04-07 | 2005-10-27 | Hutchison Alan J | Substituted 1-heteroaryl-4-substituted piperazine and piperidine analogues |
TW200609219A (en) * | 2004-06-17 | 2006-03-16 | Neurogen Corp | Aryl-substituted piperazine derivatives |
EP1676841A1 (de) * | 2004-12-30 | 2006-07-05 | Esteve Laboratorios Dr. Esteve S.A. | Substituierte Indazolsulfonamid- und 2,3-Dihydroindolyl-Sulfonamidverbindungen, deren Herstellung und Verwendung in Medikamenten |
US7538110B2 (en) * | 2005-10-27 | 2009-05-26 | Adolor Corporation | Opioid antagonists |
CA2637531A1 (en) * | 2006-02-17 | 2007-08-30 | Memory Pharmaceuticals Corporation | Compounds having 5-ht6 receptor affinity |
US20080200471A1 (en) * | 2007-02-16 | 2008-08-21 | Memory Pharmaceuticals Corporation | 6' substituted compounds having 5-ht6 receptor affinity |
US20080318941A1 (en) * | 2007-05-24 | 2008-12-25 | Memory Pharmaceuticals Corporation | 4' substituted compounds having 5-ht6 receptor affinity |
AU2008286760A1 (en) * | 2007-08-15 | 2009-02-19 | Memory Pharmaceuticals Corporation | 3' substituted compounds having 5-HT6 receptor affinity |
EP2508177A1 (de) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Kombinationen mit 3-phenylsulfonyl-8-piperazinyl-1yl-chinolin |
US8546381B2 (en) | 2008-03-24 | 2013-10-01 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US20100016297A1 (en) * | 2008-06-24 | 2010-01-21 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
US20100022581A1 (en) * | 2008-07-02 | 2010-01-28 | Memory Pharmaceuticals Corporation | Pyrrolidine-substituted azaindole compounds having 5-ht6 receptor affinity |
US20100029629A1 (en) * | 2008-07-25 | 2010-02-04 | Memory Pharmaceuticals Corporation | Acyclic compounds having 5-ht6 receptor affinity |
US20100056531A1 (en) * | 2008-08-22 | 2010-03-04 | Memory Pharmaceuticals Corporation | Alkyl-substituted 3' compounds having 5-ht6 receptor affinity |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
UA100192C2 (en) * | 2008-11-11 | 2012-11-26 | УАЙТ ЭлЭлСи | 1-(arylsulfonyl)-4-(piperazin-1-yl)-1h-benzimidazoles as 5-hydroxytryptamine-6 ligands |
US20100311782A1 (en) * | 2009-06-08 | 2010-12-09 | Adolor Corporation | Substituted piperidinylpropanoic acid compounds and methods of their use |
CA2775216A1 (en) | 2009-09-23 | 2011-03-31 | Medivation Technologies, Inc. | Bridged heterocyclic compounds and methods of use |
AU2010298166B2 (en) * | 2009-09-23 | 2015-09-17 | Medivation Technologies, Inc. | Pyrido[4,3-b]indoles and methods of use |
CN103476417A (zh) | 2011-02-18 | 2013-12-25 | 梅迪维新技术公司 | 治疗糖尿病的化合物和方法 |
CA2857344C (en) | 2011-12-21 | 2019-02-12 | Novira Therapeutics, Inc. | Hepatitis b antiviral agents |
SG10201605291WA (en) | 2012-08-28 | 2016-08-30 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
HUE034820T2 (en) | 2013-02-28 | 2018-02-28 | Janssen Sciences Ireland Uc | Sulphamoyl arylamides and their use as medicaments for the treatment of hepatitis B |
US8993771B2 (en) | 2013-03-12 | 2015-03-31 | Novira Therapeutics, Inc. | Hepatitis B antiviral agents |
EA027068B1 (ru) | 2013-04-03 | 2017-06-30 | Янссен Сайенсиз Айрлэнд Юси | Производные n-фенилкарбоксамида и их применение в качестве лекарственных препаратов для лечения гепатита b |
JO3603B1 (ar) | 2013-05-17 | 2020-07-05 | Janssen Sciences Ireland Uc | مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي |
TR201807090T4 (tr) | 2013-07-25 | 2018-06-21 | Janssen Sciences Ireland Uc | Glioksamid sübstitüeli pirrolamid deriveleri ve bunun hepatitin tedavisine yönelik ilaçlar olarak kullanımı. |
WO2015059212A1 (en) | 2013-10-23 | 2015-04-30 | Janssen R&D Ireland | Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
US9181288B2 (en) | 2014-01-16 | 2015-11-10 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
AU2015214096B2 (en) | 2014-02-05 | 2021-02-11 | Novira Therapeutics, Inc. | Combination therapy for treatment of HBV infections |
CN110483484A (zh) | 2014-02-06 | 2019-11-22 | 爱尔兰詹森科学公司 | 氨磺酰基吡咯酰胺衍生物及其作为药物用于治疗乙型肝炎的用途 |
US9400280B2 (en) | 2014-03-27 | 2016-07-26 | Novira Therapeutics, Inc. | Piperidine derivatives and methods of treating hepatitis B infections |
JP2018510159A (ja) | 2015-03-19 | 2018-04-12 | ノヴィラ・セラピューティクス・インコーポレイテッド | アゾカン及びアゾナン誘導体及びb型肝炎感染症の治療法 |
MX2017016413A (es) | 2015-06-12 | 2018-08-01 | Axovant Sciences Gmbh | Derivados de diaril y arilheteroaril urea como moduladores del receptor 5ht2a de serotonina útiles para la profilaxis y el tratamineto de un trastorno conductual del sueño rem. |
US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
MX2018000465A (es) | 2015-07-15 | 2018-09-17 | Axovant Sciences Gmbh | Derivados de diaril y arilheteroaril urea como moduladores del receptor de serotonina 5-ht2a útiles para la profilaxis y el tratamiento de alucinaciones asociadas con una enfermedad neurodegenerativa. |
CA3000197A1 (en) | 2015-09-29 | 2017-04-06 | Novira Therapeutics, Inc. | Crystalline forms of a hepatitis b antiviral agent |
EP3848026A1 (de) | 2016-04-15 | 2021-07-14 | Novira Therapeutics Inc. | Kombinationen und verfahren mit einem kapsid-anordnungsinhibitor |
MA52019A (fr) | 2018-03-14 | 2021-01-20 | Janssen Sciences Ireland Unlimited Co | Schéma posologique de modulateur d'assemblage de capside |
JP2022521081A (ja) | 2019-02-22 | 2022-04-05 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | Hbv感染若しくはhbv誘導性疾患の治療において有用なアミド誘導体 |
CN113795486A (zh) | 2019-05-06 | 2021-12-14 | 爱尔兰詹森科学公司 | 用于治疗hbv感染或hbv诱发的疾病的酰胺衍生物 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1990008148A1 (en) * | 1989-01-23 | 1990-07-26 | Pfizer Inc. | Bis-aza-bicyclic anxiolytic agents |
EP0494774A1 (de) * | 1991-01-11 | 1992-07-15 | MERCK SHARP & DOHME LTD. | Indazol-substituierte 5-Kettenglieder heteroaromatische Verbindungen |
US5234931A (en) * | 1991-02-04 | 1993-08-10 | Hoechst-Roussel Pharmaceuticals Incorporated | Heteroaryl-8-azabicyclo[3.2.1]octanes as antipsychotic agents, 5-HT3 receptor antagonists and inhibitors of the reuptake of serotonin |
NZ241481A (en) * | 1991-02-04 | 1994-06-27 | Hoechst Roussel Pharma | Derivatives of 8-aza-bicyclo[3.2.1]octane and pharmaceutical compositions thereof |
UA41311C2 (uk) * | 1992-03-12 | 2001-09-17 | Смітклайн Бічем Плс | КОНДЕНСОВАНІ ІНДОЛЬНІ ПОХІДНІ ЯК АНТАГОНІСТИ 5НТ<sub>4</sub> РЕЦЕПТОРА, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ |
DK55192D0 (da) * | 1992-04-28 | 1992-04-28 | Lundbeck & Co As H | 1-piperazino-1,2-dihydroindenderivater |
US5602124A (en) * | 1994-12-12 | 1997-02-11 | Allelix Biopharmaceuticals, Inc. | 5-HT2 receptor ligands |
US5576314A (en) * | 1994-12-12 | 1996-11-19 | Allelix Biopharmaceuticals Inc. | Bicyclic nonane and decane compounds having dopamine receptor affinity |
AU2759597A (en) * | 1996-05-16 | 1997-12-05 | Allelix Biopharmaceuticals Inc. | Thiophene- and furan-tryptamine derivatives |
US5654431A (en) * | 1996-05-30 | 1997-08-05 | Meng; Qingchang | 5-alkoxy tryptamine derivatives |
US5939451A (en) * | 1996-06-28 | 1999-08-17 | Hoffmann-La Roche Inc. | Use of sulfonamides |
EP0944595B1 (de) * | 1996-11-26 | 2003-10-01 | NPS Allelix Corp. | 5-cyclo-indolverbindungen als 5-ht1d rezeptor liganden |
EP0875513A1 (de) * | 1997-04-14 | 1998-11-04 | Eli Lilly And Company | Substituierte heteroaromatische 5-HT1F Agoniste |
-
1998
- 1998-09-18 US US09/156,495 patent/US6251893B1/en not_active Expired - Lifetime
-
1999
- 1999-06-10 JP JP2000554731A patent/JP4505773B2/ja not_active Expired - Fee Related
- 1999-06-10 DE DE69911798T patent/DE69911798T2/de not_active Expired - Lifetime
- 1999-06-10 CA CA002335285A patent/CA2335285C/en not_active Expired - Fee Related
- 1999-06-10 MX MXPA00012561A patent/MXPA00012561A/es not_active IP Right Cessation
- 1999-06-10 AU AU42531/99A patent/AU765256B2/en not_active Ceased
- 1999-06-10 ES ES99957059T patent/ES2209525T3/es not_active Expired - Lifetime
- 1999-06-10 WO PCT/CA1999/000543 patent/WO1999065906A1/en active IP Right Grant
- 1999-06-10 DK DK99957059T patent/DK1105393T3/da active
- 1999-06-10 EP EP99957059A patent/EP1105393B1/de not_active Expired - Lifetime
- 1999-06-10 AT AT99957059T patent/ATE251163T1/de active
Also Published As
Publication number | Publication date |
---|---|
DE69911798T2 (de) | 2004-07-01 |
JP2003523922A (ja) | 2003-08-12 |
WO1999065906A1 (en) | 1999-12-23 |
AU4253199A (en) | 2000-01-05 |
AU765256B2 (en) | 2003-09-11 |
EP1105393A1 (de) | 2001-06-13 |
US6251893B1 (en) | 2001-06-26 |
DK1105393T3 (da) | 2004-02-09 |
JP4505773B2 (ja) | 2010-07-21 |
CA2335285A1 (en) | 1999-12-23 |
EP1105393B1 (de) | 2003-10-01 |
CA2335285C (en) | 2009-07-14 |
MXPA00012561A (es) | 2002-04-24 |
DE69911798D1 (de) | 2003-11-06 |
ES2209525T3 (es) | 2004-06-16 |
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